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Article: Application effect of phloroglucinol injection in elderly patients with spastic abdominal pain in emergency department.

Liu, Yu-Fei / Chen, Jian

World journal of clinical cases

2023 Volume 11, Issue 23, Page(s) 5440–5446

Abstract: Background: Although norepinephrine injection is commonly used in emergency situations, it is associated with risks for elderly patients with spasmodic liver pain. This study explores the safety and effectiveness of mebendazole injection, an alternative ...

Abstract	Background: Although norepinephrine injection is commonly used in emergency situations, it is associated with risks for elderly patients with spasmodic liver pain. This study explores the safety and effectiveness of mebendazole injection, an alternative treatment option, for the emergency management of spasmodic abdominal pain, while minimizing adverse reactions, in elderly patients. Aim: To explore the development of norepinephrine injection and the adverse reactions of this drug in emergency elderly patients with spasmodic liver pain. Methods: The control group consisted of 56 elderly patients visiting our hospital from January 2021 to December 2021. After hospital admission, the control group was intravenously administered tolopin. The experimental group consisted of 56 emergency patients with spasmodic abdominal pain who visited our hospital until June 2022. After hospital admission, the experimental group was intravenously administered toloxazole. The two groups were treated for 3 d. The disappearance of clinical symptoms was observed before and after the treatment, and the difference in adverse reactions between the two groups was compared. Results: The pain of the wife, fire, diarrhea, drowning, and surrounding time disappeared in the experimental group. No statistical difference was observed between the experimental and control groups in visual pain analog scale (VAS) scores before and after the treatment ( Conclusion: During emergency, mebendazole injection exhibited a good therapeutic value when used for the clinical treatment of elderly patients with spasmodic stomach pain. It accelerated the disappearance of clinical symptoms such as stomach pain, reduced the stomach weight, and improved clinical activity. Reducing and promoting the frequency of high treatment safety with mebendazole injection is worthwhile.
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i23.5440
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Article ; Online: Visual motion processing in Chinese children with developmental dyslexia: An fMRI study.

Liu, Yu-Fei / Qian, Yi / Bi, Hong-Yan

Dyslexia (Chichester, England)

2022 Volume 28, Issue 4, Page(s) 431–447

Abstract: Dorsal stream is an important pathway for visual information transmission. As a part of the dorsal pathway, the middle temporal visual motion areas (V5/MT+) are mainly responsible for visual motion processing and the ability of visual motion processing ... ...

Abstract	Dorsal stream is an important pathway for visual information transmission. As a part of the dorsal pathway, the middle temporal visual motion areas (V5/MT+) are mainly responsible for visual motion processing and the ability of visual motion processing is closely related to reading. Compared with alphabetic scripts, the visual structure of Chinese characters is more complex and there are no clear grapheme-phoneme correspondence rules. So the ability of visual analysis plays an important role in Chinese character processing. This study first investigated the brain activation of Chinese dyslexic children and children of the same chronological age when they observed coherent motion stimuli. ROI analysis indicated that only the activation of left V5/MT+ was significantly weaker in dyslexics than that in the control group. The activity of the magnocellular-dorsal stream was closely related to orthographic awareness in the combined data (two groups) and the typical children. In dyslexia group, the stronger the activation of V5/MT+ was, the worse the phonological awareness, rapid naming performance and orthographic awareness were. In short, Chinese dyslexic children were deficient in the activation of the left V5/MT+ and the activity of the magnocellular-dorsal pathway was closely related to orthographic awareness in Chinese pupils.
MeSH term(s)	Child ; Humans ; Dyslexia/diagnostic imaging ; Magnetic Resonance Imaging ; Visual Perception/physiology ; Reading ; China
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1501502-6
ISSN	1099-0909 ; 1076-9242
ISSN (online)	1099-0909
ISSN	1076-9242
DOI	10.1002/dys.1726
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Article ; Online: Two new β-carboline alkaloids from the roots of Anemone altaica

Du, Kun / Zeng, Meng-Nan / Wang, Yan-Zhi / Liu, Yu-Fei / Feng, Wei-Sheng

J Nat Med. 2023 Mar., v. 77, no. 2 p.397-402

2023

Abstract: Two new β-carboline alkaloids, anemonilins A and B (1–2), and two known β-carboline alkaloids, flazine (3) and 4-(9H-β-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were ... ...

Abstract	Two new β-carboline alkaloids, anemonilins A and B (1–2), and two known β-carboline alkaloids, flazine (3) and 4-(9H-β-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1D and 2DNMR, HRESIMS). Compounds 2 and 4 significantly attenuated the growth inhibition induced by lipopolysaccharide (LPS) in normal rat kidney tubule epithelioid (NRK52e) cells (p < 0.05 or p < 0.01). Furthermore, compound 2 significantly reduced the apoptosis (p < 0.05) and the caspase-3/9 expression of NRK52e cells induced by LPS.
Keywords	apoptosis ; growth retardation ; kidneys ; lipopolysaccharides ; rats ; spectroscopy
Language	English
Dates of publication	2023-03
Size	p. 397-402.
Publishing place	Springer Nature Singapore
Document type	Article ; Online
ZDB-ID	1201350-x
ISSN	1340-3443
ISSN	1340-3443
DOI	10.1007/s11418-023-01679-w
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Article: Xiaozheng pill exerts an anti-mammary hyperplasia effect through Raf/ERK/ELK and HIF-1α/bFGF pathways.

Liu, Yu-Fei / An, Tian / Yu, Hong / Fan, Ying-Yi / Pei, Xiao-Hua

Journal of traditional and complementary medicine

2023 Volume 13, Issue 6, Page(s) 600–610

Abstract: Background and aim: The purpose of this study is to explore whether the Xiaozheng pill (XZP) has the effect of anti-hyperplasia of mammary glands (HMG) and to identify the related signaling pathways.: Experimental procedure: We analyzed the effective ...

Abstract	Background and aim: The purpose of this study is to explore whether the Xiaozheng pill (XZP) has the effect of anti-hyperplasia of mammary glands (HMG) and to identify the related signaling pathways. Experimental procedure: We analyzed the effective chemical components of the XZP, as well as the key chemical components, key proteins, main biological processes, and pathways in the treatment of HMG; Secondly, the levels of Estradiol (E2), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), Progesterone (P), Raf/ERK/ELK and HIF-1α/bFGF pathways related proteins were detected; Finally, the effect of XZP on metabolites was analyzed by metabolomics. Results and conclusion: In this study, we identified key targets and pathways for XZP therapy of HMG, including EGFR, VEGFA, ER, and Ras signaling pathways. Animal experiments show that XZP can reduce the levels of E2, LH, and FSH and increase the expression of P in HMG mice. XZP can restore the normal structure of breast tissue and reduce ERα, ERβ, and PR expression in breast tissue. In addition, metabolomics results show that XZP also regulates HMG metabolites, including HIF-1α and metabolic pathways. The Western blot results showed that XZP intervention can reduce the protein expression of
Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2709698-1
ISSN	2225-4110
ISSN	2225-4110
DOI	10.1016/j.jtcme.2023.05.002
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Article ; Online: Two new β-carboline alkaloids from the roots of Anemone altaica.

Du, Kun / Zeng, Meng-Nan / Wang, Yan-Zhi / Liu, Yu-Fei / Feng, Wei-Sheng

Journal of natural medicines

2023 Volume 77, Issue 2, Page(s) 397–402

Abstract: Two new β-carboline alkaloids, anemonilins A and B (1-2), and two known β-carboline alkaloids, flazine (3) and 4-(9H-β-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were ... ...

Abstract	Two new β-carboline alkaloids, anemonilins A and B (1-2), and two known β-carboline alkaloids, flazine (3) and 4-(9H-β-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1D and 2DNMR, HRESIMS). Compounds 2 and 4 significantly attenuated the growth inhibition induced by lipopolysaccharide (LPS) in normal rat kidney tubule epithelioid (NRK52e) cells (p < 0.05 or p < 0.01). Furthermore, compound 2 significantly reduced the apoptosis (p < 0.05) and the caspase-3/9 expression of NRK52e cells induced by LPS.
MeSH term(s)	Rats ; Animals ; Anemone ; Lipopolysaccharides/pharmacology ; Alkaloids/chemistry ; Carbolines/chemistry ; Molecular Structure
Chemical Substances	Lipopolysaccharides ; Alkaloids ; Carbolines
Language	English
Publishing date	2023-01-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-023-01679-w
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Article ; Online: Identification of prognostic melatonin-related lncRNA signature in tumor immune microenvironment and drug resistance for breast cancer.

Gao, Shou-Cui / Wu, Meng-Di / Zhang, Xiao-Xuan / Liu, Yu-Fei / Wang, Chen-Long

Asian journal of surgery

2023 Volume 46, Issue 9, Page(s) 3529–3541

Abstract: Background: Melatonin is a neurohormone involved in diverse physiological processes, including regulation of circadian rhythm, oncogenesis and immune function. More attention are focused on the molecular events surrounding the occurrence of abnormally ... ...

Abstract	Background: Melatonin is a neurohormone involved in diverse physiological processes, including regulation of circadian rhythm, oncogenesis and immune function. More attention are focused on the molecular events surrounding the occurrence of abnormally expressed lncRNAs leading to breast cancer. The purpose of this study was to evaluate the role of melatonin-related lncRNAs in the clinical management of BRCA patients and their immune responses. Methods: The transcriptome data and clinical data of BRCA patients were acquired from TCGA database. A total of 1103 patients were randomly assigned to either training set or validation set. A melatonin-related lncRNA signature was constructed in the training set and verified in the validation set. Functional analysis, immune microenvironment and drug resistance analysis associated to melatonin-related lncRNAs were performed by utilizing GO&KEGG, ESTIMATE and TIDE analysis. A nomogram based on the signature score and clinical characteristics was established, which was calibrated to increase prediction probability of 1-year, 3-year and 5-year survival for BRCA patients. Results: BRCA patients were divided into two signature groups based on a 17-melatonin-related lncRNA signature. High-signature patients had worse prognosis than low-signature patients (p < 0.001). Univariate and multivariate Cox regression analysis proved that the signature score was an independent prognostic factor for BRCA patients. Functional analysis indicated that high-signature BRCA involved in regulation of processing and maturation of mRNA and misfolded protein response. Remarkably, immune microenvironment analysis showed that the proportion of tumor-infiltrating M2 macrophage and the expression of CTLA4 were significantly higher in high-signature BRCA. The calibration curves for the probability of invasive BRCA showed optimal agreement between the probability as predicted by the nomogram and the actual probability. Conclusions: A novel melatonin-related lncRNA signature was considered as an independent prognostic indicator for BRCA patients. Melatonin-related lncRNAs were potentially associated with tumor immune microenvironment and might be therapeutic targets for BRCA patients.
MeSH term(s)	Humans ; Female ; Prognosis ; Breast Neoplasms ; RNA, Long Noncoding ; Melatonin ; Nomograms ; Tumor Microenvironment
Chemical Substances	RNA, Long Noncoding ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2023-06-15
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.05.174
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Article ; Online: Poor sleep quality in schizophrenia patients: A systematic review and meta-analyses of epidemiological and case-control studies.

Chen, Meng-Yi / Wang, Yue-Ying / Si, Tong Leong / Liu, Yu-Fei / Su, Zhaohui / Cheung, Teris / Ungvari, Gabor S / Jackson, Todd / Zhang, Qinge / Xiang, Yu-Tao

Schizophrenia research

2024 Volume 264, Page(s) 407–415

Abstract: Objective: Poor sleep quality is common in patients with schizophrenia but estimated prevalence rates in this population have been mixed. This systematic review and meta-analysis examined the prevalence of poor sleep quality in schizophrenia samples and ...

Abstract	Objective: Poor sleep quality is common in patients with schizophrenia but estimated prevalence rates in this population have been mixed. This systematic review and meta-analysis examined the prevalence of poor sleep quality in schizophrenia samples and moderators of prevalence from epidemiological studies as well as the risk of poor sleep quality in schizophrenia patients based on case-control studies. Methods: Both international (PubMed, Web of Science, PsycINFO, EMBASE) and Chinese databases [Chinese Nation knowledge Infrastructure (CNKI) and WANFANG] were systematically searched. Studies that estimated the prevalence of poor sleep quality in schizophrenia were analyzed using a random effects model. Funnel plots and Egger's tests were used to assess publication bias. Statistical analyses were performed using R software. Results: In total, 23 epidemiological studies and nine case-control studies were included. Based on the epidemiological studies, the pooled overall prevalence of poor sleep quality was 63.4 % [95 % confidence interval (CI): 57.0 %-69.9 %]. Additionally, based on the nine case-control studies, schizophrenia patients had a significantly higher risk for poor sleep quality compared to healthy controls [odd ratio (OR) = 4.5; 95%CI: 2.4-8.3; P < 0.0001]. Conclusion: Poor sleep quality is common among schizophrenia patients. Considering negative outcomes caused by poor sleep quality, regular screening on poor sleep quality should be conducted and effective interventions should be provided to those in need.
MeSH term(s)	Humans ; Schizophrenia/epidemiology ; Sleep Quality ; Case-Control Studies ; Research Design ; Prevalence
Language	English
Publishing date	2024-01-18
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2024.01.011
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Article ; Online: Three-Motif Molecular Junction Type Covalent Organic Frameworks for Efficient Photocatalytic Aerobic Oxidation.

Yang, Ming-Yi / Zhang, Shuai-Bing / Zhang, Mi / Li, Ze-Hui / Liu, Yu-Fei / Liao, Xing / Lu, Meng / Li, Shun-Li / Lan, Ya-Qian

Journal of the American Chemical Society

2024 Volume 146, Issue 5, Page(s) 3396–3404

Abstract: Covalent organic frameworks (COFs), with the features of flexible structure regulation and easy introduction of functional groups, have aroused broad interest in the field of photocatalysis. However, due to the low light absorption intensity, low ... ...

Abstract	Covalent organic frameworks (COFs), with the features of flexible structure regulation and easy introduction of functional groups, have aroused broad interest in the field of photocatalysis. However, due to the low light absorption intensity, low photoelectron conversion efficiency, and lack of suitable active sites, it remains a great challenge to achieve efficient photocatalytic aerobic oxidation reactions. Herein, based on reticular chemistry, we rationally designed a series of three-motif molecular junction type COFs, which formed dual photosensitizer coupled redox molecular junctions containing multifunctional COF photocatalysts. Significantly, due to the strong light adsorption ability of dual photosensitizer units and integrated oxidation and reduction features, the PY-BT COF exhibited the highest activity for photocatalytic aerobic oxidation. Especially, it achieved a photocatalytic benzylamine conversion efficiency of 99.9% in 2.5 h, which is much higher than that of the two-motif molecular junctions with only one photosensitizer or redox unit lacking COFs. The mechanism of selective aerobic oxidation was studied through comprehensive experiments and density functional theory calculations. The results showed that the photoinduced electron transfer occurred from PY and then through triphenylamine to BT. Furthermore, the thermodynamics energy for benzylamine oxidation on PY-BT COF was much lower than that for others, which confirmed the synergistic effect of dual photosensitizer coupled redox molecular junction COFs. This work provided a new strategy for the design of functional COFs with three-motif molecular junctions and also represented a new insight into the multifunctional COFs for organic catalytic reactions.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c12724
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Article ; Online: Correction: Chen et al. Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing.

Chen, Yue-Hua / Rao, Zhou-Feng / Liu, Yu-Jie / Liu, Xiang-Sheng / Liu, Yu-Fei / Xu, Lan-Ju / Wang, Ze-Qi / Guo, Jing-Yue / Zhang, Lin / Dong, Yun-Sheng / Qi, Chun-Xiao / Yang, Chao / Wang, Shu-Fang

Biomolecules

2024 Volume 14, Issue 3

Abstract: The authors would like to replace Figure 4A of the following published paper [ ... ]. ...

Abstract	The authors would like to replace Figure 4A of the following published paper [...].
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14030283
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Article ; Online: Five new compounds from Zingiberis Rhizoma Recens and their anti-apoptotic activity

Zhang, Xiao-Juan / Song, Zhi-Min / Yuan, Beibei / Wang, Yan-Zhi / Li, Man-Qian / Liu, Yu-Fei / Hu, Xue-Yu / Feng, Wei-Sheng

Journal of Asian Natural Products Research. 2023 Jan. 2, v. 25, no. 1 p.1-10

2023

Abstract: Five new compounds, named gingerol A (1a and 1b), gingerol B (2), diphenylheptane glycoside A (3) and diphenylheptane glycoside B (4), were isolated from the acetone extract of Zingiberis Rhizoma Recens. The structures of new compounds were elucidated on ...

Abstract	Five new compounds, named gingerol A (1a and 1b), gingerol B (2), diphenylheptane glycoside A (3) and diphenylheptane glycoside B (4), were isolated from the acetone extract of Zingiberis Rhizoma Recens. The structures of new compounds were elucidated on the basis of spectroscopic methods including UV, IR, 1D NMR, 2D NMR and HR-ESI-MS. Compounds 2–4 could significantly decrease the apoptosis rate and increase the survival rate of human normal lung epithelial cells (BEAS-2B) at the concentration of 10 μM.
Keywords	acetone ; apoptosis ; epithelium ; glycosides ; humans ; lungs ; research ; rhizomes ; spectroscopy ; survival rate ; Zingiberis Rhizoma Recens ; gingerol A (1) ; gingerol B (2) ; diphenylheptane glycoside A (3) ; diphenylheptane glycoside B (4) ; anti-apoptotic activity
Language	English
Dates of publication	2023-0102
Size	p. 1-10.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2022.2026335
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