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Article ; Online: Chiral Cp

Wang, Juanjuan / Luo, Mu-Peng / Gu, Yi-Jie / Liu, Yu-Ying / Yin, Qin / Wang, Shou-Guo

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 12, Page(s) e202400502

Abstract: Chiral cyclopentadienyl-rhodium(III) ... ...

Abstract	Chiral cyclopentadienyl-rhodium(III) Cp
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202400502
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Article ; Online: Stability analysis and Hopf bifurcation in a diffusive epidemic model with two delays.

Dai, Huan / Liu, Yu Ying / Wei, Jun Jie

Mathematical biosciences and engineering : MBE

2020 Volume 17, Issue 4, Page(s) 4127–4146

Abstract: A diffusive epidemic model with two delays subjecting to Neumann boundary conditions is considered. First we obtain the existence and the stability of the positive constant steady state. Then we investigate the existence of Hopf bifurcations by analyzing ...

Abstract	A diffusive epidemic model with two delays subjecting to Neumann boundary conditions is considered. First we obtain the existence and the stability of the positive constant steady state. Then we investigate the existence of Hopf bifurcations by analyzing the distribution of the eigenvalues. Furthermore, we derive the normal form on the center manifold near the Hopf bifurcation singularity. Finally, some numerical simulations are carried out to illustrate the theoretical results.
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1547-1063
ISSN (online)	1551-0018
ISSN	1547-1063
DOI	10.3934/mbe.2020229
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Article: [Preparation, Characterization and Pharmacokinetic Study of Arginine Deiminase Lipid Nanoparticles].

Zhong, Cai-Ling / Feng, Jiao / Liu, Yu-Ying / Yang, Qiang / Zhang, Jing-Qing

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2021 Volume 52, Issue 4, Page(s) 619–623

Abstract: Objective: To prepare and characterize D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) modified arginine deiminase (ADI) sulfobutyl-β-Cyclodextrin liposome nanoparticles (ATCL), and to investigate the pharmacokinetic characteristics of ATCL ...

Abstract	Objective: To prepare and characterize D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) modified arginine deiminase (ADI) sulfobutyl-β-Cyclodextrin liposome nanoparticles (ATCL), and to investigate the pharmacokinetic characteristics of ATCL in animals. Methods: The reverse evaporation method was used to prepare ATCL, and the particle size and Zeta potential of ATCL were measured. Thiosemicarbazone-diacetylmonooxime colorimetric method was used to measure the activity of ADI. After intravenous administration, blood was drawn at set intervals of time and the enzyme activity in the plasma was measured. Enzyme activity-time curve was drawn subsequently and Debris Assessment Software (DAS) 2.1.1 was used to analyze the pharmacokinetic characteristics. Results: The particle size and the potential of ATCL were (216.1±13.6) nm and (-19.4±2.1) mV, respectively. The optimal temperature and optimal pH for the catalytic reaction of ADI and ATCL were the same, both being 37 ℃ and pH6.5. Results of the analysis showed that the Conclusion: ATCL prepared in the study can effectively improve the enzyme activity and bioavailability of ADI in Sprague-Dawley rats.
MeSH term(s)	Animals ; Arginine ; Hydrolases ; Lipids ; Nanoparticles ; Polyethylene Glycols ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Lipids ; Polyethylene Glycols (3WJQ0SDW1A) ; Arginine (94ZLA3W45F) ; Hydrolases (EC 3.-) ; arginine deiminase (EC 3.5.3.6)
Language	Chinese
Publishing date	2021-07-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20210760503
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Article ; Online: Synthesis of low surface-energy polyepichlorohydrin triazoles thin film.

Liu, Yu-Ying / Cheng, Chih-Chia / Lee, Duu-Jong

Journal of colloid and interface science

2018 Volume 539, Page(s) 481–489

Abstract: In this investigation, a new polymer with low surface energy was synthesized by grafting a triazole group onto polyepichlorohydrin (PECH) rubber that contained no halogens. The chlorine on PECH was first replaced by an azide group, and this attached ... ...

Abstract	In this investigation, a new polymer with low surface energy was synthesized by grafting a triazole group onto polyepichlorohydrin (PECH) rubber that contained no halogens. The chlorine on PECH was first replaced by an azide group, and this attached azide was then converted to a triazole group with alkyl chains using the azide-alkyne Huisgen cycloaddition reaction. Analyses confirmed the structure of final product, PECH-triazole polymer. The grafting reactions increased the surface roughness. The static contact angles of water or CH
Language	English
Publishing date	2018-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2018.12.102
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Article: Gut microbiota-involved metabolism and intestinal absorption mechanisms in decreasing bioaccessibility of triadimefon in strawberry and grape

Liu, Yu-Ying / Zhang, Si-Dong / Xiao, Jin-Jing / Feng, Wen-Zhe / Wei, Dong / Deng, Ya-Jing / Cao, Hai-Qun / Shi, Yan-Hong

Food chemistry. 2022 Mar. 30, v. 373

2022

Abstract: Gut microbiota-involved metabolism and intestinal absorption affecting bioaccessibility of triadimefon in strawberry and grape were investigated for the first time by coupling the in vitro digestion model with the Caco-2 cell model. Results showed that ... ...

Abstract	Gut microbiota-involved metabolism and intestinal absorption affecting bioaccessibility of triadimefon in strawberry and grape were investigated for the first time by coupling the in vitro digestion model with the Caco-2 cell model. Results showed that the gut microbiota decreased the bioaccessibility of triadimefon in strawberry by 31.00% but failed in grape, probably due to a negative modulation of the colon bacterial activity by dietary components in grapes. A strain of triadimefon-degrading bacteria, Stenotrophomonas maltophilia, was isolated from the gut microbiota and its degradation products were profiled. This study also clarified a significant reduction in transepithelial transport (up to 32.81%) of triadimefon as a result of the barrier effect of gut microbiota. These findings provide new insights on the function of the gut microbiota in pesticide bioaccessibility and highlight the importance of including gut microbiota in pesticide residue risk assessments.
Keywords	Stenotrophomonas maltophilia ; bioavailability ; colon ; digestion ; food chemistry ; grapes ; human cell lines ; intestinal absorption ; intestinal microorganisms ; metabolism ; microbial activity ; models ; pesticide residues ; risk ; strawberries ; triadimefon
Language	English
Dates of publication	2022-0330
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131575
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Are parental rearing patterns and learning burnout correlated with empathy amongst undergraduate nursing students?

Li, Chao-Qun / Ma, Qian / Liu, Yu-Ying / Jing, Kun-Juan

International journal of nursing sciences

2018 Volume 5, Issue 4, Page(s) 409–413

Abstract: Objective: Empathy can help establish harmonious nurse-patient relationships. We aimed to assess the status of empathy, and explore the relationship between learning burnout, parental rearing patterns and empathy amongst nursing students.: Method: A ... ...

Abstract	Objective: Empathy can help establish harmonious nurse-patient relationships. We aimed to assess the status of empathy, and explore the relationship between learning burnout, parental rearing patterns and empathy amongst nursing students. Method: A questionnaire survey that employed the Learning Burnout Scale, the Short-Form Egna Minnenav Barndoms Uppfostran (s-EMBU) and the Jefferson Scale of Empathy was conducted amongst 562 nursing students. The data were analysed on the basis of descriptive statistic and correlation analysis was used. Results: Empathy is negatively correlated with learning burnout, parental rejection and overprotection and showed no positive correlation with parental emotional warmth. Conclusions: Educators should pay attention to nursing students' feelings and learning burnout status and take positive measures to improve the empathy level of the students. Positive parental rearing patterns also help cultivate empathy.
Language	English
Publishing date	2018-07-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2800296-9
ISSN	2352-0132 ; 2352-0132
ISSN (online)	2352-0132
ISSN	2352-0132
DOI	10.1016/j.ijnss.2018.07.005
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Article: Diagnostic and Prognostic Characteristics of Circulating Free DNA Methylation Detected by the Electrochemical Method in Malignant Tumors.

Sun, Li-Yue / Du, Zi-Ming / Liu, Yu-Ying / Li, Yan-Hong / Liu, Xiao-Min / Wang, Ting / Shao, Jian-Yong

Cancers

2021 Volume 13, Issue 4

Abstract: Prior research has established an electrochemical method based on the differential adsorption capacity of gold surfaces with different methylated DNA degrees and found that this method might be valuable for cancer diagnosis by detecting circulating free ... ...

Abstract	Prior research has established an electrochemical method based on the differential adsorption capacity of gold surfaces with different methylated DNA degrees and found that this method might be valuable for cancer diagnosis by detecting circulating free DNA methylation. However, further investigation on the underlying mechanism and validation of its diagnostic and prognostic values in a large cohort of malignant tumors was limited. We found that DNA with different methylation levels formed particles of diverse sizes on the gold surface. Hydrophobic bonds played a significant role in the binding process of methylated DNA to the gold surface. The detection condition of an adsorption time of 10 min and temperature of 20 °C was optimal. In a large cohort of plasma samples from the patients with different malignant tumors, as well as normal individuals, we found that the electrochemical detection method based on the differential adsorption capacity of methylated DNA degree on a gold surface could be used as a noninvasive tool for malignant tumor diagnosis and prognostic evaluation. The diagnostic efficiency of this method in malignant tumors was even slightly better than that of the current tumor biomarkers widely used in routine clinical practice (circulating free DNA (cfDNA) vs. carcinoembryonic antigen (CEA), 0.8131 vs. 0.7191 and cfDNA vs. CA19-9, 0.7687 vs. 0.6693).
Language	English
Publishing date	2021-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13040664
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Article ; Online: Gut microbiota-involved metabolism and intestinal absorption mechanisms in decreasing bioaccessibility of triadimefon in strawberry and grape.

Liu, Yu-Ying / Zhang, Si-Dong / Xiao, Jin-Jing / Feng, Wen-Zhe / Wei, Dong / Deng, Ya-Jing / Cao, Hai-Qun / Shi, Yan-Hong

Food chemistry

2021 Volume 373, Issue Pt B, Page(s) 131575

Abstract	Gut microbiota-involved metabolism and intestinal absorption affecting bioaccessibility of triadimefon in strawberry and grape were investigated for the first time by coupling the in vitro digestion model with the Caco-2 cell model. Results showed that the gut microbiota decreased the bioaccessibility of triadimefon in strawberry by 31.00% but failed in grape, probably due to a negative modulation of the colon bacterial activity by dietary components in grapes. A strain of triadimefon-degrading bacteria, Stenotrophomonas maltophilia, was isolated from the gut microbiota and its degradation products were profiled. This study also clarified a significant reduction in transepithelial transport (up to 32.81%) of triadimefon as a result of the barrier effect of gut microbiota. These findings provide new insights on the function of the gut microbiota in pesticide bioaccessibility and highlight the importance of including gut microbiota in pesticide residue risk assessments.
MeSH term(s)	Caco-2 Cells ; Fragaria ; Gastrointestinal Microbiome ; Humans ; Intestinal Absorption ; Triazoles ; Vitis
Chemical Substances	Triazoles ; triadimefon (1HW039CJF0)
Language	English
Publishing date	2021-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131575
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Article ; Online: Post-treatment with yiqifumai injection and its main ingredients attenuates lipopolysaccharide-induced microvascular disturbance in mesentery and ileum.

Ayididaer, Ayan / Sun, Kai / Pan, Chun-Shui / Yan, Li / Liu, Yu-Ying / Li, Dan-Tong / Fan, Jing-Yu / Han, Jing-Yan

Microcirculation (New York, N.Y. : 1994)

2021 Volume 28, Issue 4, Page(s) e12680

Abstract: Objective: To investigate the effect of Yiqifumai injection (YQFM), a compound Chinese medicine, and its main active ingredients on lipopolysaccharide (LPS)-induced microvascular disturbance in mesentery and ileum.: Methods: Rats were infused with ... ...

Abstract	Objective: To investigate the effect of Yiqifumai injection (YQFM), a compound Chinese medicine, and its main active ingredients on lipopolysaccharide (LPS)-induced microvascular disturbance in mesentery and ileum. Methods: Rats were infused with LPS (5 mg/kg/h) for 90 min. Thirty minutes after initiation of LPS administration, YQFM (160 mg/kg/h), Rb1 (5 mg/kg/h), Sch (2.5 mg/kg/h), or Rb1+Sch (5 mg/kg/h + 2.5 mg/kg/h) was infused until 90 min. Human umbilical vein endothelial cells (HUVECs) were incubated with LPS (100 ng/ml) for 90 min. YQFM (1 mg/ml), Rb1 (100 µM), Sch (100 µM), or Rb1+Sch (200 µM) was added 30 min after initiation of LPS stimulation. Results: Yiqifumai injection and Rb1+Sch inhibited mesenteric venule hyperpermeability, suppressed microvillar erosion and submucosal edema, and protected claudin-5 from downregulation and interleukin-1β from upregulation in ileal tissues after LPS. Study in HUVECs confirmed the effect of YQFM and Rb1+Sch on JAM-1 after LPS and revealed a similar effect on other junction proteins. Moreover, YQFM and Rb1+Sch attenuated the dysfunctional energy metabolism and the activation of TLR-4/Src/NF-κB signaling with Rb1 and Sch being partially effective. Conclusion: These results demonstrated the beneficial effect of post-treatment with YQFM, which is attributable to its main ingredient Rb1 and Sch, and likely mediated by targeting TLR-4/Src/NF-κB signaling pathway.
MeSH term(s)	Animals ; Cardiovascular Agents/administration & dosage ; Drugs, Chinese Herbal/administration & dosage ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Ileum/blood supply ; Lipopolysaccharides/toxicity ; Mesentery/blood supply ; Microvessels/drug effects ; NF-kappa B ; Rats ; Toll-Like Receptor 4 ; Vascular Diseases/drug therapy ; Vascular Diseases/etiology
Chemical Substances	Cardiovascular Agents ; Drugs, Chinese Herbal ; Lipopolysaccharides ; NF-kappa B ; Toll-Like Receptor 4 ; yi-qi-fu-mai
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217758-1
ISSN	1549-8719 ; 1073-9688
ISSN (online)	1549-8719
ISSN	1073-9688
DOI	10.1111/micc.12680
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Article ; Online: LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15.

Jia, You Chao / Wang, Jian Yi / Liu, Yu Ying / Li, Bin / Guo, Hui / Zang, Ai Min

Cell biology international

2019 Volume 43, Issue 4, Page(s) 384–393

Abstract: Non-small-cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in NSCLC tissues and cell ...

Abstract	Non-small-cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in NSCLC tissues and cell lines. Overexpression of MAFG-AS1 promoted the migration, invasion and enhanced epithelial-mesenchymal transition (EMT) of NSCLC cell. In addition, miR-339-5p was predicted to be a target of MAFG-AS1 and the level of miR-339-5p was down-regulated in NSCLC. Over-expression of MAFG-AS1 significantly decreased the level of miR-339-5p in NSCLC cell. Moreover, the matrix metalloproteinase 15 (MMP15) was identified to be a target of miR-339-5p. The level of MMP15 was negatively regulated by miR-339-5p whereas positively controlled by MAFG-AS1. In addition, up-regulation of miR-339-5p neutralized the promoting impact of MAFG-AS1 on the migration, invasion and EMT of NSCLC cell. Finally, the xenograft model suggested that MAFG-AS1 promoted the metastasis of NSCLC cell in vivo. Altogether, we proved that MAFG-AS1-miR-339-5p-MMP15 axis might be a promising therapeutic target for the treatment of patients with NSCLC.
MeSH term(s)	Animals ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Heterografts ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; MafG Transcription Factor/genetics ; MafG Transcription Factor/metabolism ; Matrix Metalloproteinase 15/genetics ; Matrix Metalloproteinase 15/metabolism ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; RNA, Antisense/genetics ; RNA, Antisense/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism
Chemical Substances	MAFG protein, human ; MIRN339 microRNA, human ; MMP15 protein, human ; MafG Transcription Factor ; MicroRNAs ; RNA, Antisense ; RNA, Long Noncoding ; Repressor Proteins ; Matrix Metalloproteinase 15 (EC 3.4.24.-)
Language	English
Publishing date	2019-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.11092
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