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  1. Article: [Glutamate and its ionotropic receptor agonists inhibit the response to acute hypoxia in carotid body of rats].

    Li, Chao-Hong / Liu, Yu-Zhen

    Sheng li xue bao : [Acta physiologica Sinica

    2023  Volume 75, Issue 4, Page(s) 537–543

    Abstract: The purpose of this study was to investigate the effect of glutamate and its ionotropic receptor agonists on the response to acute hypoxia in rat carotid body in vitro. Briefly, after SD rats were anesthetized and decapitated, the bilateral carotid ... ...

    Abstract The purpose of this study was to investigate the effect of glutamate and its ionotropic receptor agonists on the response to acute hypoxia in rat carotid body in vitro. Briefly, after SD rats were anesthetized and decapitated, the bilateral carotid bifurcations were rapidly isolated. Then bifurcation was placed into a recording chamber perfused with 95% O
    MeSH term(s) Rats ; Animals ; Glutamic Acid/pharmacology ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology ; N-Methylaspartate/pharmacology ; Carotid Body ; Rats, Sprague-Dawley ; Carbon Dioxide ; Receptors, N-Methyl-D-Aspartate ; Receptors, AMPA ; Hypoxia
    Chemical Substances Glutamic Acid (3KX376GY7L) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0) ; N-Methylaspartate (6384-92-5) ; Carbon Dioxide (142M471B3J) ; Receptors, N-Methyl-D-Aspartate ; Receptors, AMPA
    Language Chinese
    Publishing date 2023-08-15
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Molecular Mechanism of Ion Selectivity in Nanopores.

    Chen, Yan-Nan / Liu, Yu-Zhen / Sun, Qiang

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 4

    Abstract: Ion channels exhibit strong selectivity for specific ions over others under electrochemical potentials, such as KcsA for ... ...

    Abstract Ion channels exhibit strong selectivity for specific ions over others under electrochemical potentials, such as KcsA for K
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29040853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  3. Article: [Activation of metabotropic glutamate receptor 1 inhibits chronic intermittent hypoxia-induced carotid body plasticity in rats].

    Li, Chao-Hong / Zhao, Chen-Lu / Liu, Yu-Zhen

    Sheng li xue bao : [Acta physiologica Sinica

    2023  Volume 75, Issue 5, Page(s) 629–635

    Abstract: The purpose of the present study was to explore the role of carotid body metabotropic glutamate receptor 1 (mGluR1) in chronic intermittent hypoxia (CIH)-induced carotid body plasticity. Sprague Dawley (SD) rats were exposed to CIH (6%-21% ... ...

    Abstract The purpose of the present study was to explore the role of carotid body metabotropic glutamate receptor 1 (mGluR1) in chronic intermittent hypoxia (CIH)-induced carotid body plasticity. Sprague Dawley (SD) rats were exposed to CIH (6%-21% O
    MeSH term(s) Rats ; Animals ; Carotid Body/metabolism ; Rats, Sprague-Dawley ; Hypoxia ; Receptors, Metabotropic Glutamate/metabolism ; RNA, Messenger/metabolism
    Chemical Substances metabotropic glutamate receptor type 1 ; Receptors, Metabotropic Glutamate ; RNA, Messenger
    Language Chinese
    Publishing date 2023-11-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: [Role of group II and III mGluRs in carotid body plasticity induced by chronic intermittent hypoxia in rats].

    Zhao, Chen-Lu / Li, Chao-Hong / Liu, Yu-Zhen

    Sheng li xue bao : [Acta physiologica Sinica

    2023  Volume 75, Issue 4, Page(s) 529–536

    Abstract: The aim of the present study was to explore the role of group II and III metabotropic glutamate receptors (mGluRs) in carotid body plasticity induced by chronic intermittent hypoxia (CIH) in rats. Sprague Dawley (SD) rats were treated with CIH in ... ...

    Abstract The aim of the present study was to explore the role of group II and III metabotropic glutamate receptors (mGluRs) in carotid body plasticity induced by chronic intermittent hypoxia (CIH) in rats. Sprague Dawley (SD) rats were treated with CIH in Oxycycler A84 hypoxic chamber for 4 weeks, and the tail artery blood pressure was measured at the end of model preparation. RT-qPCR was performed to examine the mRNA expression levels of mGluR2/3/8 in rat carotid body. Carotid sinus nerve activity was detected by ex vivo carotid sinus nerve discharge recording technique, and acute intermittent hypoxia (AIH) was administered to induce carotid body sensory long-term facilitation (sLTF), in order to observe the role of group II and group III mGluRs in carotid body plasticity induced by CIH. The results showed that: 1) After 4 weeks of CIH exposure, the blood pressure of rats increased significantly; 2) CIH down-regulated the mRNA levels of mGluR2/3, and up-regulated the mRNA level of mGluR8 in the carotid body; 3) AIH induced sLTF in carotid body of CIH group. In the CIH group, activation of group II mGluRs had no effect on sLTF of carotid body, while activation of group III mGluRs completely inhibited sLTF. These results suggest that CIH increases blood pressure in rats, and group III mGluRs play an inhibitory role in CIH-induced carotid body plasticity in rats.
    MeSH term(s) Rats ; Animals ; Carotid Body/metabolism ; Rats, Sprague-Dawley ; Hypoxia ; Receptors, Metabotropic Glutamate/genetics ; Receptors, Metabotropic Glutamate/metabolism ; RNA, Messenger/metabolism
    Chemical Substances Receptors, Metabotropic Glutamate ; RNA, Messenger
    Language Chinese
    Publishing date 2023-08-15
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].

    Jin, Jia-Hao / Zhao, Bao-Sheng / Liu, Yu-Zhen

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2022  Volume 38, Issue 1, Page(s) 68–74

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) A549 Cells ; Acetyl-CoA Carboxylase ; Adenocarcinoma of Lung ; Cell Hypoxia/physiology ; Cell Line, Tumor ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit ; Lung Neoplasms ; RNA/metabolism ; RNA, Messenger/metabolism ; Sterol Regulatory Element Binding Protein 1/metabolism
    Chemical Substances HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; RNA, Messenger ; SREBF1 protein, human ; Sterol Regulatory Element Binding Protein 1 ; RNA (63231-63-0) ; ACACA protein, human (EC 6.4.1.2) ; Acetyl-CoA Carboxylase (EC 6.4.1.2)
    Language Chinese
    Publishing date 2022-05-25
    Publishing country China
    Document type Journal Article
    ISSN 1000-6834
    ISSN 1000-6834
    DOI 10.12047/j.cjap.6200.2022.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Effects of TOFA on growth of Eca109 and KYSE-450 cells in human esophageal squamous cell carcinoma].

    Gu, Cheng-Wei / Qian, He / Liu, Yu-Zhen / Zhao, Bao-Sheng

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2022  Volume 38, Issue 4, Page(s) 317–321

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Caspase 3 ; Esophageal Neoplasms/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Dimethyl Sulfoxide ; Cell Line, Tumor ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Caspase 3 (EC 3.4.22.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; 5-(tetradecyloxy)-2-furancarboxylic acid (54857-86-2) ; Dimethyl Sulfoxide (YOW8V9698H) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language Chinese
    Publishing date 2022-11-22
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1000-6834
    ISSN 1000-6834
    DOI 10.12047/j.cjap.6236.2022.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Effects of propranolol on biological function of human esophageal squamous cell carcinoma cells].

    Zhuo, Qing-Ya / Qian, He / Zhao, Bao-Sheng / Qi, Bo / Liu, Yu-Zhen

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2023  Volume 38, Issue 6, Page(s) 754–759

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Animals ; Mice ; Esophageal Squamous Cell Carcinoma ; Mice, Nude ; Propranolol ; Esophageal Neoplasms ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt
    Chemical Substances Propranolol (9Y8NXQ24VQ) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language Chinese
    Publishing date 2023-06-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1000-6834
    ISSN 1000-6834
    DOI 10.12047/j.cjap.6374.2022.137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Effects of knockdown ACC1 on glioma U251 cell migration and its mechanisms].

    Zhang, Lin / Qian, He / Zhao, Bao-Sheng / Gao, Man-Qi / Liu, Yu-Zhen

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2023  Volume 38, Issue 6, Page(s) 745–753

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Fibronectins ; Vimentin ; Histones ; Plasminogen Activator Inhibitor 1 ; Cadherins ; Cell Movement ; Glioma
    Chemical Substances Fibronectins ; Vimentin ; Histones ; Plasminogen Activator Inhibitor 1 ; Cadherins
    Language Chinese
    Publishing date 2023-06-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1000-6834
    ISSN 1000-6834
    DOI 10.12047/j.cjap.6357.2022.136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Amlodipine inhibits the proliferation and migration of esophageal carcinoma cells through the induction of endoplasmic reticulum stress.

    Chen, Yan-Min / Yang, Wen-Qian / Gu, Cheng-Wei / Fan, Ying-Ying / Liu, Yu-Zhen / Zhao, Bao-Sheng

    World journal of gastroenterology

    2024  Volume 30, Issue 4, Page(s) 367–380

    Abstract: Background: L-type calcium channels are the only protein channels sensitive to calcium channel blockers, and are expressed in various cancer types. The Cancer Genome Atlas database shows that the mRNA levels of multiple L-type calcium channel subunits ... ...

    Abstract Background: L-type calcium channels are the only protein channels sensitive to calcium channel blockers, and are expressed in various cancer types. The Cancer Genome Atlas database shows that the mRNA levels of multiple L-type calcium channel subunits in esophageal squamous cell carcinoma tumor tissue are significantly higher than those in normal esophageal epithelial tissue. Therefore, we hypothesized that amlodipine, a long-acting dihydropyridine L-type calcium channel blocker, may inhibit the occurrence and development of esophageal cancer (EC).
    Aim: To investigate the inhibitory effects of amlodipine on EC through endoplasmic reticulum (ER) stress.
    Methods: Cav1.3 protein expression levels in 50 pairs of EC tissues and corresponding paracancerous tissues were examined. Subsequently, the inhibitory effects of amlodipine on proliferation and migration of EC cells
    Results: The expression level of Cav1.3 in esophageal carcinoma was 1.6 times higher than that in paracancerous tissues. Amlodipine treatment decreased the viability of esophageal carcinoma cells in a dose- and time-dependent manner.
    Conclusion: Collectively, we demonstrate for the first time that amlodipine promotes apoptosis, induces autophagy, and inhibits migration through ER stress, thereby exerting anti-tumor effects in EC.
    MeSH term(s) Humans ; Mice ; Animals ; Amlodipine/pharmacology ; Amlodipine/therapeutic use ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma ; Apoptosis ; Cell Proliferation ; Endoplasmic Reticulum Stress ; Cell Line, Tumor
    Chemical Substances Amlodipine (1J444QC288)
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i4.367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  10. Article: Ecosystem service tradeoff and synergistic relationship in the Yellow River Delta High-Efficiency Eco-Economic Zone.

    Lu, Chang / Cai, Xue-Qin / Hao, Can-Shu / Liu, Yu-Zhen / Wang, Zhi-Yu / Ma, Ya-Nan

    Ying yong sheng tai xue bao = The journal of applied ecology

    2024  Volume 35, Issue 2, Page(s) 457–468

    Abstract: Exploring the tradeoff and synergy relationship among ecosystem services in the Yellow River Delta High-Efficiency Eco-Economic Zone is of great practical significance for regional ecosystem service function zoning and high-quality development. Using the ...

    Title translation 黄河三角洲高效生态经济区生态系统服务权衡协同关系.
    Abstract Exploring the tradeoff and synergy relationship among ecosystem services in the Yellow River Delta High-Efficiency Eco-Economic Zone is of great practical significance for regional ecosystem service function zoning and high-quality development. Using the InVEST model, spatial auto-correlation and trade-off synergism (ESTD) model, we analyzed the spatial and temporal variations of five ecosystem services (habitat quality, carbon storage, soil conservation, water conservation, and water purification), as well as their trade-off and synergistic relationships at the township scale from 2000 to 2020. The results showed that habitat quality, carbon storage, and nitrogen and phosphorus output decreased as a whole from 2000 to 2020, and soil conservation and water purification increased. Habitat quality showed a distribution pattern of high in the north and low in the south, and carbon sto-rage, nitrogen and phosphorus output, soil conservation and water purification showed a pattern of low in the north and high in the south. During the study period, synergistic relationships among the five ecosystem services were predominant in both time cross-section and time period, but there were still differences, with synergistic relationships mainly between carbon storage and other services in time cross-section, and between habitat quality and other ser-vices in time period. Our results can provide theoretical guidance and practical reference for the enhancement of ecosystem services and the zoning of ecosystem functions, as well as basic support for the optimization of spatial patterns of national territory.
    MeSH term(s) Ecosystem ; Rivers ; Conservation of Natural Resources/methods ; Soil ; Carbon ; Nitrogen ; Phosphorus ; China
    Chemical Substances Soil ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2024-03-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202402.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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