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Article ; Online: Multigene and Improved Anti-Collision RRT* Algorithms for Unmanned Aerial Vehicle Task Allocation and Route Planning in an Urban Air Mobility Scenario.

Zhou, Qiang / Feng, Houze / Liu, Yueyang

Biomimetics (Basel, Switzerland)

2024 Volume 9, Issue 3

Abstract: Compared to terrestrial transportation systems, the expansion of urban traffic into airspace can not only mitigate traffic congestion, but also foster establish eco-friendly transportation networks. Additionally, unmanned aerial vehicle (UAV) task ... ...

Abstract	Compared to terrestrial transportation systems, the expansion of urban traffic into airspace can not only mitigate traffic congestion, but also foster establish eco-friendly transportation networks. Additionally, unmanned aerial vehicle (UAV) task allocation and trajectory planning are essential research topics for an Urban Air Mobility (UAM) scenario. However, heterogeneous tasks, temporary flight restriction zones, physical buildings, and environment prerequisites put forward challenges for the research. In this paper, multigene and improved anti-collision RRT* (IAC-RRT) algorithms are proposed to address the challenge of task allocation and path planning problems in UAM scenarios by tailoring the chance of crossover and mutation. It is proved that multigene and IAC-RRT algorithms can effectively minimize energy consumption and tasks' completion duration of UAVs. Simulation results demonstrate that the strategy of this work surpasses traditional optimization algorithms, i.e., RRT algorithm and gene algorithm, in terms of numerical stability and convergence speed.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics9030125
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: E2F3 renders an immunosuppressive tumor microenvironment in nasopharyngeal carcinoma: Involvements of the transcription activation of PRC1 and BIRC5.

Wang, Qiang / Yu, Qi / Liu, Yueyang

Immunity, inflammation and disease

2023 Volume 11, Issue 8, Page(s) e987

Abstract: Background: E2F transcription factors are well-recognized oncogenic molecules, and their correlation with immune cell infiltration has recently been reported. This work studies the impacts and mechanism of E2F transcription factor 3 (E2F3) in the growth ...

Abstract	Background: E2F transcription factors are well-recognized oncogenic molecules, and their correlation with immune cell infiltration has recently been reported. This work studies the impacts and mechanism of E2F transcription factor 3 (E2F3) in the growth and tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC). Methods: Aberrantly expressed transcription factors in NPC were screened by abundant bioinformatics analyses. Gene expression in NPC cells was analyzed by reverse transcription-quantitative polymerase chain reaction and Western blot analyses. Malignant behaviors of NPC cells were analyzed by cell counting kit-8, 5-ethynyl-2'-deoxyuridine labeling, Transwell assays, and xenograft tumor models. TPA-induced THP-1 cells (macrophages) were cultured in the conditioned medium of NPC cells to mimic tumor-associated macrophages (TAMs) in vivo, and these TAMs were cocultured with CD8 Results: E2F3 was highly expressed in NPC cells, and its knockdown suppressed malignant behavior and tumorigenic ability of the cells. The E2F3 knockdown condition downregulated M2 cytokines CD163 and interleukin-10 in TAMs, which further enhanced proliferation and activation of the cocultured CD8 Conclusion: This work suggests that E2F3 renders an immunosuppressive TME in NPC by activating PRC1 and BIRC5. Suppression of any member involved might favor tumor elimination.
MeSH term(s)	Humans ; Cytokinesis ; Transcriptional Activation ; CD8-Positive T-Lymphocytes ; Nasopharyngeal Carcinoma/genetics ; Tumor Microenvironment ; Immunosuppressive Agents ; Nasopharyngeal Neoplasms/genetics ; Cell Cycle Proteins ; E2F3 Transcription Factor ; Survivin
Chemical Substances	Immunosuppressive Agents ; PRC1 protein, human ; Cell Cycle Proteins ; E2F3 protein, human ; E2F3 Transcription Factor ; BIRC5 protein, human ; Survivin
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.987
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Article ; Online: E2F1-EP300 co-activator complex potentiates immune escape in nasopharyngeal carcinoma through the mediation of MELK.

Wang, Qiang / Yu, Qi / Liu, Yueyang

Histology and histopathology

2023 Volume 39, Issue 4, Page(s) 511–523

Abstract: Background: Nasopharyngeal carcinoma (NPC) is characterized by a highly suppressive microenvironment that protects tumor cells against immune attack and facilitates tumor progression. MELK is upregulated in various tumors, whereas its function in the ... ...

Abstract	Background: Nasopharyngeal carcinoma (NPC) is characterized by a highly suppressive microenvironment that protects tumor cells against immune attack and facilitates tumor progression. MELK is upregulated in various tumors, whereas its function in the immune escape remains largely unknown. In this study, we investigated the role of MELK during immune escape in NPC. Methods: Differentially expressed genes were filtered using GEO datasets and PPI network analysis. NPC cell colony formation and motility were examined, and the impact of CD8⁺ T cells on NPC cells was evaluated. A xenograft model was constructed to detect the growth of tumor cells and the T-cell phenotype of tumor infiltration. ChIP-qPCR and dual-luciferase assays were used to verify the transcriptional regulation of MELK by EP300/E2F1. Findings: MELK was overexpressed in NPC, and sh-MELK suppressed the clonogenic ability, migration, and invasion of NPC cells and promoted the killing effects of CD8⁺ T cells. These Interpretation: EP300 coordinated with E2F1 to promote the transcription of MELK which promoted the growth of NPC cells and repressed the killing effect of CD8⁺ T cells. Blockage of MELK may be a potential way to suppress the immune escape of NPC cells.
MeSH term(s)	Humans ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Cell Movement ; Tumor Microenvironment ; Protein Serine-Threonine Kinases/genetics ; E2F1 Transcription Factor/genetics ; E2F1 Transcription Factor/metabolism ; E2F1 Transcription Factor/pharmacology ; E1A-Associated p300 Protein/genetics ; E1A-Associated p300 Protein/pharmacology
Chemical Substances	MELK protein, human (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; E2F1 protein, human ; E2F1 Transcription Factor ; EP300 protein, human (EC 2.3.1.48) ; E1A-Associated p300 Protein (EC 2.3.1.48)
Language	English
Publishing date	2023-09-06
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-662
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Article ; Online: Efficacy of respiratory rehabilitation in patients with COVID-19: a retrospective study.

Zhang, Zhiyou / Wang, Congcong / Li, Zhendong / Liu, Yueyang / Nie, Yutong / Zhang, Jianwei / Li, Dawei

BMC pulmonary medicine

2024 Volume 24, Issue 1, Page(s) 152

Abstract: Objective: The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of confirmed cases and deaths globally. The purpose of this study was to investigate the therapeutic effect of airway clearance technology combined with prone ... ...

Abstract	Objective: The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of confirmed cases and deaths globally. The purpose of this study was to investigate the therapeutic effect of airway clearance technology combined with prone ventilation on patients infected with COVID-19. Methods: 38 patients with COVID-19 (severe) who were treated in the intensive rehabilitation group of Shengli Oilfield Central Hospital. They were randomly divided into a control group and an observation group. The control group received prone position ventilation intervention, and the observation group received airway clearance technology combined with prone position ventilation intervention. The changes of oxygen and index, procalcitonin (PCT), interleukin-6 (IL-6) and chest X-ray image indexes were compared between the two groups. Result: There was no significant difference in age, gender and other general data between the control group and the observation group. The results showed that oxygen index, PCT, IL-6 and chest X-ray image index in the observation group were better than that indexes in the control group. Conclusion: Airway clearance technology combined with prone ventilation intervention in patients with COVID-19 can improve the total effective rate and oxygenation index, improve the inflammatory indicators and respiratory function of patients. And it may be widely promoted and used in the treatment of patients with COVID-19 (severe).
MeSH term(s)	Humans ; COVID-19 ; Retrospective Studies ; Interleukin-6 ; Respiration, Artificial ; Oxygen
Chemical Substances	Interleukin-6 ; Oxygen (S88TT14065)
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-024-02969-z
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Article ; Online: Age-period-cohort analysis of ischemic stroke deaths attributable to physical inactivity in different income regions.

Liu, Junjiao / Liu, Yueyang / Ma, Wenjun / Liu, Jie / Tong, Yan / Wang, Cui / Zheng, Jianzhong

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6547

Abstract: This study assessed the global and regional burden of IS (ischemic stroke) deaths due to LPA (low physical activity) from 1990 to 2019, analyzed regional, sex, and age differences in ASMR (age-standardized mortality rate), and provided a comprehensive ... ...

Abstract	This study assessed the global and regional burden of IS (ischemic stroke) deaths due to LPA (low physical activity) from 1990 to 2019, analyzed regional, sex, and age differences in ASMR (age-standardized mortality rate), and provided a comprehensive understanding of the impact of age, period, and cohort on low physical activity related ischemic stroke ASMR. We conducted an APC (age-period-cohort) analysis of the global and four World Bank income level regions' IS mortality data attributed to LPA from 1990 to 2019, using the GBD2019 database, and the results showed that the global net drift of the Ischemic stroke age-standardized mortality attributable to low physical activity was - 1.085%[95% CI: - 1.168, - 1.003].The ASMR drop is most pronounced in the high-income zone, with a net drift of - 2.473% [95% CI: - 2.759, - 2.187] across the four income groups. The influence of age on mortality is increasing in the worldwide old population, while the period and cohort effects are decreasing. We also performed a Joinpoint regression analysis, which revealed that the specific time of considerable drop in ASMR of IS in the global LPA population was 2002-2007, with an APC of -2.628%. The specific period of considerable drop in ASMR in high-income regions with the highest variation was 1999-2007, with an APC = - 4.726%. The global burden of public health deaths caused by LPA is diminishing, with the most notable progress observed in high-income regions. However, in low and lower-middle income areas, the situation continues to deteriorate. Within the global elderly population, the effects of age on mortality is increasing, while the effects of period and cohort are diminishing. These trends vary across income levels, highlighting the necessity for enhanced international collaboration to formulate context-specific public health strategies aimed at enhancing cardiovascular health on a global, regional, and national scale.
MeSH term(s)	Humans ; Aged ; Ischemic Stroke ; Sedentary Behavior ; Income ; Public Health ; Cohort Studies ; Global Health
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57309-2
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Book ; Online: A Definition of Non-Stationary Bandits

Liu, Yueyang / Van Roy, Benjamin / Xu, Kuang

2023

Abstract: The subject of non-stationary bandit learning has attracted much recent attention. However, non-stationary bandits lack a formal definition. Loosely speaking, non-stationary bandits have typically been characterized in the literature as those for which ... ...

Abstract	The subject of non-stationary bandit learning has attracted much recent attention. However, non-stationary bandits lack a formal definition. Loosely speaking, non-stationary bandits have typically been characterized in the literature as those for which the reward distribution changes over time. We demonstrate that this informal definition is ambiguous. Further, a widely-used notion of regret -- the dynamic regret -- is motivated by this ambiguous definition and thus problematic. In particular, even for an optimal agent, dynamic regret can suggest poor performance. The ambiguous definition also motivates a measure of the degree of non-stationarity experienced by a bandit, which often overestimates and can give rise to extremely loose regret bounds. The primary contribution of this paper is a formal definition that resolves ambiguity. This definition motivates a new notion of regret, an alternative measure of the degree of non-stationarity, and a regret analysis that leads to tighter bounds for non-stationary bandit learning. The regret analysis applies to any bandit, stationary or non-stationary, and any agent.
Keywords	Computer Science - Machine Learning ; Statistics - Machine Learning
Subject code	005
Publishing date	2023-02-23
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: A Semi-Supervised Framework for Misinformation Detection

Liu, Yueyang / Boukouvalas, Zois / Japkowicz, Nathalie

2023

Abstract: The spread of misinformation in social media outlets has become a prevalent societal problem and is the cause of many kinds of social unrest. Curtailing its prevalence is of great importance and machine learning has shown significant promise. However, ... ...

Abstract	The spread of misinformation in social media outlets has become a prevalent societal problem and is the cause of many kinds of social unrest. Curtailing its prevalence is of great importance and machine learning has shown significant promise. However, there are two main challenges when applying machine learning to this problem. First, while much too prevalent in one respect, misinformation, actually, represents only a minor proportion of all the postings seen on social media. Second, labeling the massive amount of data necessary to train a useful classifier becomes impractical. Considering these challenges, we propose a simple semi-supervised learning framework in order to deal with extreme class imbalances that has the advantage, over other approaches, of using actual rather than simulated data to inflate the minority class. We tested our framework on two sets of Covid-related Twitter data and obtained significant improvement in F1-measure on extremely imbalanced scenarios, as compared to simple classical and deep-learning data generation methods such as SMOTE, ADASYN, or GAN-based data generation.
Keywords	Computer Science - Artificial Intelligence
Subject code	006
Publishing date	2023-04-22
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of respiratory training on respiratory failure secondary to unilateral phrenic nerve injury: A case report.

Li, Dawei / Li, Zhendong / Zhang, Zhiyou / Liu, Yueyang / Wang, Congcong / Cheng, Aixia

Medicine

2023 Volume 102, Issue 7, Page(s) e32566

Abstract: Introduction: Diaphragm is one of the most important respiratory muscles dominated by the phrenic nerve. Phrenic nerve injury would induce a series of clinical symptoms, including respiratory failure. Respiratory training could assist in regular ... ...

Abstract	Introduction: Diaphragm is one of the most important respiratory muscles dominated by the phrenic nerve. Phrenic nerve injury would induce a series of clinical symptoms, including respiratory failure. Respiratory training could assist in regular treatment in improving the respiratory function and daily ability of respiratory failure patients. Case presentation: A 71-years-old female was enrolled for the disorders of consciousness of 4.5 hours observed by her family and was diagnosed with respiratory failure secondary to unilateral phrenic nerve injury. The patient received basic therapy combined with rehabilitation training, including the training of aspirate muscle, limb resistance, thoracic loosening, aerobic training, electrical stimulation on respiratory nerves, and airway clearance. The combining therapeutic strategy significantly improved the daily ability and respiratory of the patient. The ultrasound showed that after therapy, the diaphragmatic muscles were thickened and the range of diaphragmatic movement was also enhanced. The pulmonary function was also improved after therapy. Conclusion: The combination of rehabilitation is suitable for the treatment of respiratory failure patients with clear causes of phrenic nerve injury. For patients with unexplained causes, rehabilitation could also be performed before the diagnosis. Patients with irreversible injury need long-term and family rehabilitation prescriptions.
MeSH term(s)	Humans ; Female ; Aged ; Phrenic Nerve/injuries ; Respiratory Insufficiency/therapy ; Respiratory Insufficiency/complications ; Diaphragm ; Respiratory Muscles ; Lung ; Peripheral Nerve Injuries ; Respiratory Paralysis/etiology
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032566
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Article: Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats.

Wang, Huiyang / Liu, Yueyang / Guo, Zhenkun / Cui, Minghui / Pang, Peng / Yang, Jingyu / Wu, Chunfu

Acta pharmaceutica Sinica. B

2023 Volume 13, Issue 5, Page(s) 2107–2123

Abstract: Cognitive impairment caused by chronic cerebral hypoperfusion (CCH) is associated with white matter injury (WMI), possibly through the alteration of autophagy. Here, the autophagy-lysosomal pathway (ALP) dysfunction in white matter (WM) and its ... ...

Abstract	Cognitive impairment caused by chronic cerebral hypoperfusion (CCH) is associated with white matter injury (WMI), possibly through the alteration of autophagy. Here, the autophagy-lysosomal pathway (ALP) dysfunction in white matter (WM) and its relationship with cognitive impairment were investigated in rats subjected to two vessel occlusion (2VO). The results showed that cognitive impairment occurred by the 28th day after 2VO. Injury and autophagy activation of mature oligodendrocytes and neuronal axons sequentially occurred in WM by the 3rd day. By the 14th day, abnormal accumulation of autophagy substrate, lysosomal dysfunction, and the activation of mechanistic target of rapamycin (MTOR) pathway were observed in WM, paralleled with mature oligodendrocyte death. This indicates autophagy activation was followed by ALP dysfunction caused by autophagy inhibition or lysosomal dysfunction. To target the ALP dysfunction, enhanced autophagy by systemic rapamycin treatment or overexpression of Beclin1 (BECN1) in oligodendrocytes reduced mature oligodendrocyte death, and subsequently alleviated the WMI and cognitive impairment after CCH. These results reveal that early autophagy activation was followed by ALP dysfunction in WM after 2VO, which was associated with the aggravation of WMI and cognitive impairment. This study highlights that alleviating ALP dysfunction by enhancing oligodendrocyte autophagy has benefits for cognitive recovery after CCH.
Language	English
Publishing date	2023-03-15
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2023.03.014
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Article ; Online: Polarization Reversal of Group IV-VI Semiconductors with Pucker-Like Structure: Mechanism Dissecting and Function Demonstration.

Yu, Yali / Xiong, Tao / Liu, Yue-Yang / Yang, Juehan / Xia, Jian-Bai / Wei, Zhongming

Advanced materials (Deerfield Beach, Fla.)

2023 Volume 36, Issue 3, Page(s) e2307769

Abstract: Polarization imaging presents advantages in capturing spatial, spectral, and polarization information across various spectral bands. It can improve the perceptual ability of image sensors and has garnered more applications. Despite its potential, ... ...

Abstract	Polarization imaging presents advantages in capturing spatial, spectral, and polarization information across various spectral bands. It can improve the perceptual ability of image sensors and has garnered more applications. Despite its potential, challenges persist in identifying band information and implementing image enhancement using polarization imaging. These challenges often necessitate integrating spectrometers or other components, resulting in increased complexities within image processing systems and hindering device miniaturization trends. Here, the characteristics of anisotropic absorption reversal are systematically elucidated in pucker-like group IV-VI semiconductors MX (M = Ge, Sn; X = S, Se) through theoretical predictions and experimental validations. Additionally, the fundamental mechanisms behind anisotropy reversal in different bands are also explored. The photodetector is constructed by utilizing MX as a light-absorbing layer, harnessing polarization-sensitive photoresponse for virtual imaging. The results indicate that the utilization of polarization reversal photodetectors holds advantages in achieving further multifunctional integration within the device structure while simplifying its configuration, including band information identification and image enhancement. This study provides a comprehensive analysis of polarization reversal mechanisms and presents a promising and reliable approach for achieving dual-band image band identification and image enhancement without additional auxiliary components.
Language	English
Publishing date	2023-11-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202307769
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