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Article: Changes in the etiology of liver cirrhosis and the corresponding management strategies.

Dai, Jin-Jin / Liu, Yue-Ying / Zhang, Zhen-Hua

2024 Volume 16, Issue 2, Page(s) 146–151

Abstract: We read with interest the article by Xing Wang, which was published in the recent issue of ... ...

Abstract	We read with interest the article by Xing Wang, which was published in the recent issue of the
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Editorial
ZDB-ID	2573703-X
ISSN	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v16.i2.146
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Article ; Online: Effect of acute stress on working memory in pilots: Investigating the modulatory role of memory load.

Liang, Yaowei / Peng, Xing / Meng, Yu / Liu, Yueying / Zhu, Qi / Xu, Zhi / Yang, Jiazhong

PloS one

2024 Volume 19, Issue 1, Page(s) e0288221

Abstract: Many practitioners, such as pilots, frequently face working memory (WM) demands under acute stress environments, while the effect of acute stress on WM has not been conclusively studied because it is moderated by a variety of factors. The current study ... ...

Abstract	Many practitioners, such as pilots, frequently face working memory (WM) demands under acute stress environments, while the effect of acute stress on WM has not been conclusively studied because it is moderated by a variety of factors. The current study investigated how acute stress affects pilots' WM under different memory load conditions. There are 42 pilots conducting the experiments, consisting of 21 stress group participants experiencing the Trier Social Stress Test (TSST) and 21 control group participants experiencing the controlled TSST (C-TSST). Subsequently, both groups performed N-back tasks under three memory load conditions (0-back, 1-back, and 2-back). State Anxiety Inventory (S-AI), heart rate (HR), and salivary cortisol concentrations (SCC) were collected to analyze acute stress induction. The results revealed that (1) the TSST could effectively induce acute stress with higher S-AI, HR, and SCC; (2) higher memory load reduces WM accuracy (ACC) and delays response times (RT); (3) acute stress increases WM ACC under moderate load conditions (1-back task). These results suggest that acute stress may not necessarily impair WM and even improve WM performance under certain memory load conditions. Potential mechanisms of acute stress effects on WM and alternative explanations for the modulatory role of memory load consistent with the emotion and motivation regulation theory are discussed. These findings not only provide insight into the field of acute stress and WM but are also beneficial for pilot training and the development of stress management strategies.
MeSH term(s)	Humans ; Memory, Short-Term/physiology ; Memory Disorders ; Cognition ; Reaction Time/physiology ; Anxiety Disorders ; Hydrocortisone
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288221
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Article ; Online: Erratum: [Corrigendum] Relationship between changes in mitochondrial function and hippocampal neuronal apoptosis after recurrent convulsion during developmental stage.

Liu, Yueying / Chen, Jieru / Jin, Meifang / Li, Zhenhong / Tian, Tian / Li, Lili / Ni, Hong

Experimental and therapeutic medicine

2024 Volume 27, Issue 4, Page(s) 141

Abstract: This corrects the article DOI: 10.3892/etm.2018.6147.]. ...

Abstract	[This corrects the article DOI: 10.3892/etm.2018.6147.].
Language	English
Publishing date	2024-02-15
Publishing country	Greece
Document type	Published Erratum
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2024.12429
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Article ; Online: Screening for unilateral aldosteronism should be combined with the maximum systolic blood pressure, history of stroke and typical nodules.

Meng, Yumin / Chen, Kequan / Xie, Aixin / Liu, Yueying / Huang, Jiangnan

Medicine

2022 Volume 101, Issue 43, Page(s) e31313

Abstract: To determine factors associated with lateralization in primary aldosteronism (PA). The clinical data for PA patients hospitalized at the First Affiliated Hospital of Guangxi Medical University from October 2016 to March 2021 were included in this study. ... ...

Abstract	To determine factors associated with lateralization in primary aldosteronism (PA). The clinical data for PA patients hospitalized at the First Affiliated Hospital of Guangxi Medical University from October 2016 to March 2021 were included in this study. They were classified according to results derived from computed tomography (CT): bilaterally normal nodules (no typical nodules were found in either adrenal glands, only changes in unilateral adrenal hyperplasia thickening or bilateral adrenal hyperplasia thickening), unilateral nodules (typical nodule appears in unilateral adrenal gland, and there are no abnormalities in the contralateral adrenal gland or only thickening of unilateral adrenal hyperplasia) and bilateral nodules (typical nodule like changes in bilateral adrenal glands). Multivariate logistic regression and receiver operating characteristic (ROC) were used to analyze the factors associated with lateralization of PA and consistencies between adrenal CT images and adrenal venous sampling (AVS) results. A total of 269 patients with PA were recruited, with an average age of 46 years and 112 cases had typical nodules. Results from CT scans revealed that there were 49 bilateral normal cases, 177 cases were unilateral abnormal and 43 cases were bilateral abnormal. In all of the PA patients, multifactorial logistic regression analysis showed that the maximum systolic blood pressure (OR = 1.03, P < .001), history of stroke (OR = 2.61, P = .028), and typical nodules (OR = 1.9, P = .017) were all relevant factors in unilateral primary aldosteronism (UPA). In the unilateral nodule group, multivariate logistic regression analysis suggested that maximum systolic blood pressure (OR = 1.03, P < .001) and typical nodules (OR = 2.37, P = .008) were the related factors for UPA. However, the consistency between adrenal CT and AVS was only 40.68%, while maximum systolic blood pressure (OR = 1.02, P < .001) and plasma aldosterone renin ratio (OR = 1.001, P = .027) were the relevant consistent factors between AVS and CT results. Maximum systolic blood pressure, typical nodules, and history of stroke are important factors to consider when screening for UPA. It is recommended to combine medical history and imaging findings when looking at different subgroups before a clinical decision is made. Patients with PA in the absence of lesions or bilateral lesions on CT should be diagnosed by AVS as far as possible.
MeSH term(s)	Humans ; Middle Aged ; Hyperplasia/diagnosis ; Hyperplasia/pathology ; Blood Pressure ; China/epidemiology ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Adrenal Glands/diagnostic imaging ; Adrenal Glands/pathology ; Stroke/diagnosis ; Stroke/pathology ; Aldosterone ; Retrospective Studies
Chemical Substances	Aldosterone (4964P6T9RB)
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031313
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Ua VI Zs.171: Show issues

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Article ; Online: Retrospective Study of the Relationship between Variable Benign Epilepsy of Childhood with Centrotemporal Spikes and the Changes of Zinc, MRS, VEEG, and IQ Test.

Li, Zhenhong / Ni, Hong / Liu, Yueying / Li, Fei / Zeng, Haijiang

publication RETRACTED

Disease markers

2022 Volume 2022, Page(s) 3132824

Abstract: Benign epilepsy in childhood with centrotemporal spikes (VBECT) has been associated with electroencephalography (EEG), but the relationship of VBECT with zinc, magnetic resonance spectroscopy (MRS), and intelligence quotient (IQ) tests is unclear. The ... ...

Abstract	Benign epilepsy in childhood with centrotemporal spikes (VBECT) has been associated with electroencephalography (EEG), but the relationship of VBECT with zinc, magnetic resonance spectroscopy (MRS), and intelligence quotient (IQ) tests is unclear. The aim of this study was to investigate the association of VBECT with zinc, MRS, EEG, and IQ tests. In this retrospective study, we selected 58 children with variable benign epilepsy with centrotemporal spikes as the experimental group. A total of 120 children with typical benign childhood epilepsy with centrotemporal spikes were selected as the control group. The zinc, MRS, EEG, and IQ test results of 178 children were measured and analyzed. The results showed that the zinc, MRS, and IQ test results of the patients in the experimental group decreased significantly. The spinal slow wave results in the experimental group showed a significant upward trend. Linear correlation analysis of zinc with MRS, EEG, and IQ tests showed that 13 pairs of indicators were significantly negatively correlated. Our results suggest the importance of zinc, MRS, EEG, and IQ during VBECT.
MeSH term(s)	Child ; Electroencephalography/methods ; Epilepsy, Rolandic ; Humans ; Magnetic Resonance Spectroscopy ; Retrospective Studies ; Zinc
Chemical Substances	Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-07-09
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2022/3132824
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Theoretical Study of the Defects and Doping in Tuning the Electrocatalytic Activity of Graphene for CO

Su, Xiao / Meng, Fanqi / Li, Xiang / Liu, Yueying / Tan, Hongwei / Chen, Guangju

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 15

Abstract: The application of graphene-based catalysts in the electrocatalytic ... ...

Abstract	The application of graphene-based catalysts in the electrocatalytic CO
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13152273
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Article: The Complex Role of Chaperone-Mediated Autophagy in Cancer Diseases.

Liu, Jing / Wang, Lijuan / He, Hua / Liu, Yueying / Jiang, Yiqun / Yang, Jinfeng

Biomedicines

2023 Volume 11, Issue 7

Abstract: Chaperone-mediated autophagy (CMA) is a process that rapidly degrades proteins labeled with KFERQ-like motifs within cells via lysosomes to terminate their cellular functioning. Meanwhile, CMA plays an essential role in various biological processes ... ...

Abstract	Chaperone-mediated autophagy (CMA) is a process that rapidly degrades proteins labeled with KFERQ-like motifs within cells via lysosomes to terminate their cellular functioning. Meanwhile, CMA plays an essential role in various biological processes correlated with cell proliferation and apoptosis. Previous studies have shown that CMA was initially found to be procancer in cancer cells, while some theories suggest that it may have an inhibitory effect on the progression of cancer in untransformed cells. Therefore, the complex relationship between CMA and cancer has aroused great interest in the application of CMA activity regulation in cancer therapy. Here, we describe the basic information related to CMA and introduce the physiological functions of CMA, the dual role of CMA in different cancer contexts, and its related research progress. Further study on the mechanism of CMA in tumor development may provide novel insights for tumor therapy targeting CMA. This review aims to summarize and discuss the complex mechanisms of CMA in cancer and related potential strategies for cancer therapy.
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11072050
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Article ; Online: GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas.

He, Hua / Liang, Lu / Jiang, Shiyao / Liu, Yueying / Huang, Jingjing / Sun, Xiaoyan / Li, Yi / Jiang, Yiqun / Cong, Li

Cell death & disease

2024 Volume 15, Issue 3, Page(s) 205

Abstract: Temozolomide (TMZ), a DNA alkylating agent, has become the primary treatment for glioma, the most common malignancy of the central nervous system. Although TMZ-containing regimens produce significant clinical response rates, some patients inevitably ... ...

Abstract	Temozolomide (TMZ), a DNA alkylating agent, has become the primary treatment for glioma, the most common malignancy of the central nervous system. Although TMZ-containing regimens produce significant clinical response rates, some patients inevitably suffer from inferior treatment outcomes or disease relapse, likely because of poor chemosensitivity of glioma cells due to a robust DNA damage response (DDR). GINS2, a subunit of DNA helicase, contributes to maintaining genomic stability and is highly expressed in various cancers, promoting their development. Here, we report that GINS2 was upregulated in TMZ-treated glioma cells and co-localized with γH2AX, indicating its participation in TMZ-induced DDR. Furthermore, GINS2 regulated the malignant phenotype and TMZ sensitivity of glioma cells, mostly by promoting DNA damage repair by affecting the mRNA stability of early growth response factor 1 (EGR1), which in turn regulates the transcription of epithelial cell-transforming sequence 2 (ECT2). We constructed a GINS2-EGR1-ECT2 prognostic model, which accurately predicted patient survival. Further, we screened Palbociclib/BIX-02189 which dampens GINS2 expression and synergistically inhibits glioma cell proliferation with TMZ. These findings delineate a novel mechanism by which GINS2 regulates the TMZ sensitivity of glioma cells and propose a promising combination therapy to treat glioma.
MeSH term(s)	Humans ; Temozolomide/therapeutic use ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Neoplasm Recurrence, Local/drug therapy ; Glioma/drug therapy ; Glioma/genetics ; Glioma/metabolism ; Epithelial Cells/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Early Growth Response Protein 1/genetics ; Proto-Oncogene Proteins/pharmacology ; Chromosomal Proteins, Non-Histone
Chemical Substances	Temozolomide (YF1K15M17Y) ; Antineoplastic Agents, Alkylating ; EGR1 protein, human ; Early Growth Response Protein 1 ; ECT2 protein, human ; Proto-Oncogene Proteins ; GINS2 protein, human ; Chromosomal Proteins, Non-Histone
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-024-06586-w
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Article ; Online: Lipocalin family proteins and their diverse roles in cardiovascular disease.

Yang, Hui-Hui / Wang, Xiaohong / Li, Siru / Liu, Yueying / Akbar, Rubab / Fan, Guo-Chang

Pharmacology & therapeutics

2023 Volume 244, Page(s) 108385

Abstract: The lipocalin (LCN) family members, a group of small extracellular proteins with 160-180 amino acids in length, can be detected in all kingdoms of life from bacteria to human beings. They are characterized by low similarity of amino acid sequence but ... ...

Abstract	The lipocalin (LCN) family members, a group of small extracellular proteins with 160-180 amino acids in length, can be detected in all kingdoms of life from bacteria to human beings. They are characterized by low similarity of amino acid sequence but highly conserved tertiary structures with an eight-stranded antiparallel β-barrel which forms a cup-shaped ligand binding pocket. In addition to bind small hydrophobic ligands (i.e., fatty acids, odorants, retinoids, and steroids) and transport them to specific cells, lipocalins (LCNs) can interact with specific cell membrane receptors to activate their downstream signaling pathways, and with soluble macromolecules to form the complex. Consequently, LCNs exhibit great functional diversity. Accumulating evidence has demonstrated that LCN family proteins exert multiple layers of function in the regulation of many physiological processes and human diseases (i.e., cancers, immune disorders, metabolic disease, neurological/psychiatric disorders, and cardiovascular disease). In this review, we firstly introduce the structural and sequence properties of LCNs. Next, six LCNs including apolipoprotein D (ApoD), ApoM, lipocalin 2 (LCN2), LCN10, retinol-binding protein 4 (RBP4), and Lipocalin-type prostaglandin D synthase (L-PGDS) which have been characterized so far are highlighted for their diagnostic/prognostic values and their potential effects on coronary artery disease and myocardial infarction injury. The roles of these 6 LCNs in cardiac hypertrophy, heart failure, diabetes-induced cardiac disorder, and septic cardiomyopathy are also summarized. Finally, their therapeutic potential for cardiovascular disease is discussed in each section.
MeSH term(s)	Humans ; Cardiovascular Diseases ; Lipocalins/chemistry ; Lipocalins/metabolism ; Amino Acid Sequence ; Receptors, Cell Surface/metabolism ; Ligands ; Retinol-Binding Proteins, Plasma/metabolism
Chemical Substances	Lipocalins ; Receptors, Cell Surface ; Ligands ; RBP4 protein, human ; Retinol-Binding Proteins, Plasma
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2023.108385
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Zs.A 1183: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Analysis of PANoptosis-Related LncRNA-miRNA-mRNA Network Reveals LncRNA SNHG7 Involved in Chemo-Resistance in Colon Adenocarcinoma.

Huang, Jingjing / Jiang, Shiyao / Liang, Lu / He, Hua / Liu, Yueying / Cong, Li / Jiang, Yiqun

Frontiers in oncology

2022 Volume 12, Page(s) 888105

Abstract: Colon adenocarcinoma (COAD) is one of the most common malignancies, and its metastatic lesions are the leading cause of death in COAD patients. PANoptosis is a recently identified pathway for programmed cell death implicated in developing COAD. Long non- ... ...

Abstract	Colon adenocarcinoma (COAD) is one of the most common malignancies, and its metastatic lesions are the leading cause of death in COAD patients. PANoptosis is a recently identified pathway for programmed cell death implicated in developing COAD. Long non-coding RNAs (lncRNAs) are key regulators of cancer occurrence and progress. Although their function has captured much attention in COAD, the relationship between COAD metastasis-associated lncRNA expression and PANoptosis remains elusive. Therefore, this study aimed to explore the potential regulatory roles of metastasis- and PANoptosis-associated lncRNAs in COAD. Nine lncRNAs associated with metastasis and PANoptosis in COAD were identified from The Cancer Genome Atlas (TCGA) and GEO databases. Their functions were analyzed by multiple bioinformatics methods, and the lncRNA-miRNA-mRNA network was constructed. Multivariate Cox analysis identified one lncRNA (SNHG7) significantly related to COAD prognosis. Subsequent analyses showed its expression correlated with tumor stage and lymph node metastasis. Moreover, drug sensitivity analysis and
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.888105
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