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Article ; Online: Contribution of the language network to the comprehension of Python programming code.

Liu, Yun-Fei / Wilson, Colin / Bedny, Marina

2024 Volume 251, Page(s) 105392

Abstract: Does the perisylvian language network contribute to comprehension of programming languages, like Python? Univariate neuroimaging studies find high responses to code in fronto-parietal executive areas but not in fronto-temporal language areas, suggesting ... ...

Abstract	Does the perisylvian language network contribute to comprehension of programming languages, like Python? Univariate neuroimaging studies find high responses to code in fronto-parietal executive areas but not in fronto-temporal language areas, suggesting the language network does little. We used multivariate-pattern-analysis to test whether the language network encodes Python functions. Python programmers read functions while undergoing fMRI. A linear SVM decoded for-loops from if-conditionals based on activity in lateral temporal (LT) language cortex. In searchlight analysis, decoding accuracy was higher in LT language cortex than anywhere else. Follow up analysis showed that decoding was not driven by presence of different words across functions, "for" vs "if," but by compositional program properties. Finally, univariate responses to code peaked earlier in LT language-cortex than in the fronto-parietal network. We propose that the language system forms initial "surface meaning" representations of programs, which input to the reasoning network for processing of algorithms.
MeSH term(s)	Humans ; Comprehension/physiology ; Brain/diagnostic imaging ; Brain/physiology ; Language ; Temporal Lobe/physiology ; Magnetic Resonance Imaging/methods ; Brain Mapping/methods
Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	7448-2
ISSN	1090-2155 ; 0093-934X
ISSN (online)	1090-2155
ISSN	0093-934X
DOI	10.1016/j.bandl.2024.105392
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Article ; Online: Reading Braille by Touch Recruits Posterior Parietal Cortex.

Liu, Yun-Fei / Rapp, Brenda / Bedny, Marina

Journal of cognitive neuroscience

2023 Volume 35, Issue 10, Page(s) 1593–1616

Abstract: Blind readers use a tactile reading system consisting of raised dot arrays: braille/⠃⠗⠇. How do human brains implement reading by touch? The current study looked for signatures of reading-specific orthographic processes in braille, separate from low- ... ...

Abstract	Blind readers use a tactile reading system consisting of raised dot arrays: braille/⠃⠗⠇. How do human brains implement reading by touch? The current study looked for signatures of reading-specific orthographic processes in braille, separate from low-level somatosensory responses and semantic processes. Of specific interest were responses in posterior parietal cortices (PPCs), because of their role in high-level tactile perception. Congenitally blind, proficient braille readers read real words and pseudowords by touch while undergoing fMRI. We leveraged the system of contractions in English braille, where one braille cell can represent multiple English print letters (e.g., "ing" ⠬, "one" ⠐⠕), making it possible to separate physical and orthographic word length. All words in the study consisted of four braille cells, but their corresponding Roman letter spellings varied from four to seven letters (e.g., "con-c-er-t" ⠒⠉⠻⠞. contracted: four cells; uncontracted: seven letters). We found that the bilateral supramarginal gyrus in the PPC increased its activity as the uncontracted word length increased. By contrast, in the hand region of primary somatosensory cortex (S1), activity increased as a function of a low-level somatosensory feature: dot-number per word. The PPC also showed greater response to pseudowords than real words and distinguished between real and pseudowords in multivariate-pattern analysis. Parieto-occipital, early visual and ventral occipito-temporal, as well as prefrontal cortices also showed sensitivity to the real-versus-pseudoword distinction. We conclude that PPC is involved in orthographic processing for braille, that is, braille character and word recognition, possibly because of braille's tactile modality.
MeSH term(s)	Humans ; Touch/physiology ; Reading ; Brain ; Touch Perception ; Parietal Lobe/diagnostic imaging ; Blindness
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1007410-7
ISSN	1530-8898 ; 0898-929X ; 1096-8857
ISSN (online)	1530-8898
ISSN	0898-929X ; 1096-8857
DOI	10.1162/jocn_a_02041
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Zs.A 2623: Show issues

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Article: Thermo-Electro-Mechanical Vibrations of Porous Functionally Graded Piezoelectric Nanoshells.

Liu, Yun Fei / Wang, Yan Qing

Nanomaterials (Basel, Switzerland)

2019 Volume 9, Issue 2

Abstract: In this work, we aim to study free vibration of functionally graded piezoelectric material (FGPM) cylindrical nanoshells with nano-voids. The present model incorporates the small scale effect and thermo-electro-mechanical loading. Two types of porosity ... ...

Abstract	In this work, we aim to study free vibration of functionally graded piezoelectric material (FGPM) cylindrical nanoshells with nano-voids. The present model incorporates the small scale effect and thermo-electro-mechanical loading. Two types of porosity distribution, namely, even and uneven distributions, are considered. Based on Love's shell theory and the nonlocal elasticity theory, governing equations and corresponding boundary conditions are established through Hamilton's principle. Then, natural frequencies of FGPM nanoshells with nano-voids under different boundary conditions are analyzed by employing the Navier method and the Galerkin method. The present results are verified by the comparison with the published ones. Finally, an extensive parametric study is conducted to examine the effects of the external electric potential, the nonlocal parameter, the volume fraction of nano-voids, the temperature rise on the vibration of porous FGPM cylindrical nanoshells.
Language	English
Publishing date	2019-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano9020301
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Article ; Online: A case of gynandromorphy in Ducetia japonica (Thunberg, 1815) (Orthoptera: Tettigoniidae: Phaneropterinae).

Huang, Jiang-Rong / Liu, Yun-Fei / He, Zhu-Qing

Zootaxa

2021 Volume 4970, Issue 1, Page(s) 182188

Abstract: In this paper, we described an example of gynandromorphy in a katydid, Ducetia japonica. Its color is brown, while normal individuals are green. Its left maxilla is smaller, and left maxillary palpus is shorter. Left forewing as male is shorter than ... ...

Abstract	In this paper, we described an example of gynandromorphy in a katydid, Ducetia japonica. Its color is brown, while normal individuals are green. Its left maxilla is smaller, and left maxillary palpus is shorter. Left forewing as male is shorter than right one as female. Hindwing is also shorter in left. Cercus, epiproct and subgenital plate are left in male and right in female.
MeSH term(s)	Animals ; Female ; Male ; Orthoptera/anatomy & histology
Language	English
Publishing date	2021-05-13
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4970.1.10
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Article ; Online: Minisci-Type Dehydrogenative Coupling of N-Heteroaromatic Rings with Inert C(sp

Yang, Jun-Feng / Liu, Yun-Fei / Wei, Lin-Lin / Qiao, Kai-Kai / Zhao, Yan-Qiu / Shi, Lei

The Journal of organic chemistry

2024 Volume 89, Issue 6, Page(s) 4249–4260

Abstract: The Minisci-type dehydrogenative coupling of N-heteroaromatic rings with inert C-H or Si-H partners via visible-light-catalyzed hydrogen atom transfer has been reported. This methodology allows the coupling reactions to be carried out in water as a ... ...

Abstract	The Minisci-type dehydrogenative coupling of N-heteroaromatic rings with inert C-H or Si-H partners via visible-light-catalyzed hydrogen atom transfer has been reported. This methodology allows the coupling reactions to be carried out in water as a solvent under air atmospheric conditions with visible-light illumination. A wide range of inert C-H and Si-H partners could be directly coupled with various N-aromatic heterocycles to deliver products in good to excellent yields.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.4c00093
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Zs.A 4473: Show issues

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Article: A comparison of computed tomography imaging with histopathology in the sensitivity and correlation of evaluating coronary arterial calcification.

Liu, Yun-Fei / Ma, Yan-He / Wang, Chang-Yue / Zhang, Xiang-Li / Liang, Ke-Ke / Tao, Jing / Guo, Lin / Gao, Bu-Lang

Quantitative imaging in medicine and surgery

2023 Volume 13, Issue 4, Page(s) 2426–2440

Abstract: Background: The sensitivity and correlation of coronary computed tomography angiography (CTA) as compared with histopathology are unknown in evaluating coronary arterial calcification. In this study, we retrospectively evaluated qualitatively and ... ...

Abstract	Background: The sensitivity and correlation of coronary computed tomography angiography (CTA) as compared with histopathology are unknown in evaluating coronary arterial calcification. In this study, we retrospectively evaluated qualitatively and quantitatively the sensitivity and correlation of coronary CTA compared with histopathology in assessing coronary arterial calcification. Methods: This study was conducted on 12 randomly selected cadavers aged over 40 years at the time of death, and 53 segments of coronary arteries from these 12 cadavers were obtained from the Human Anatomy Laboratory of Tianjin Medical University. The artery segments were scanned using contrasted-enhanced dual-source computed tomography (DSCT) with an axial slice thickness of 0.6 mm. Coronary artery calcification in a coronary segment was defined as the presence of 1 or more voxels with a CT density >130 Hounsfield units. According to the arc of calcification in the cross section of the coronary artery wall, calcified plaques were divided into three categories: mild, moderate, and severe calcification. The coronary artery stenosis caused by calcified plaque was observed and calculated with multiplanar reconstruction (MPR), maximum density projection, volume rendering (VR), and cross-sectional reconstruction. After CT enhancement scanning, the coronary artery specimens were cut into 4-mm long segments and embedded in paraffin for pathological staining. Pathological classification and coronary artery stenosis measured with pathological analysis were used as comparison criteria. Results: Histopathology detected 69 Vb-type plaques, while DSCT detected 57 calcified plaques. The sensitivity of CT for detecting mild, moderate, and severe calcified plaques were 88.3% [95% confidence interval (CI): 74.1-95.6%], 100% (95% CI: 69.8-100%), and 100% (95% CI: 73.2-100%), respectively. DSCT had a significant (P<0.001) correlation with histopathology in quantifying coronary artery stenosis caused by mild, moderate, and severe calcified plaques (R Conclusions: DSCT contrast enhancement scanning can detect and characterize coronary artery calcification with a good correlation with histopathologic quantification of coronary artery stenosis caused by different types of calcified plaques, even though coronary CTA may overestimate the stenosis.
Language	English
Publishing date	2023-02-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-22-603
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Article ; Online: Computer code comprehension shares neural resources with formal logical inference in the fronto-parietal network.

Liu, Yun-Fei / Kim, Judy / Wilson, Colin / Bedny, Marina

eLife

2020 Volume 9

Abstract: Despite the importance of programming to modern society, the cognitive and neural bases of code comprehension are largely unknown. Programming languages might 'recycle' neurocognitive mechanisms originally developed for natural languages. Alternatively, ... ...

Abstract	Despite the importance of programming to modern society, the cognitive and neural bases of code comprehension are largely unknown. Programming languages might 'recycle' neurocognitive mechanisms originally developed for natural languages. Alternatively, comprehension of code could depend on fronto-parietal networks shared with other culturally-invented symbol systems, such as formal logic and symbolic math such as algebra. Expert programmers (average 11 years of programming experience) performed code comprehension and memory control tasks while undergoing fMRI. The same participants also performed formal logic, symbolic math, executive control, and language localizer tasks. A left-lateralized fronto-parietal network was recruited for code comprehension. Patterns of activity within this network distinguish between 'for' loops and 'if' conditional code functions. In terms of the underlying neural basis, code comprehension overlapped extensively with formal logic and to a lesser degree math. Overlap with executive processes and language was low, but laterality of language and code covaried across individuals. Cultural symbol systems, including code, depend on a distinctive fronto-parietal cortical network.
MeSH term(s)	Adult ; Brain Mapping ; Cognition ; Comprehension ; Executive Function ; Female ; Frontal Lobe/diagnostic imaging ; Frontal Lobe/physiology ; Functional Laterality ; Humans ; Magnetic Resonance Imaging ; Male ; Neural Pathways/physiology ; Parietal Lobe/diagnostic imaging ; Parietal Lobe/physiology ; Software ; Young Adult
Language	English
Publishing date	2020-12-15
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.59340
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Article ; Online: PVT1 Knockdown Inhibits Autophagy and Improves Gemcitabine Sensitivity by Regulating the MiR-143/HIF-1α/VMP1 Axis in Pancreatic Cancer.

Liu, Yun-Fei / Luo, Dong / Li, Xia / Li, Zhi-Qiang / Yu, Xiao / Zhu, Hong-Wei

Pancreas

2021 Volume 50, Issue 2, Page(s) 227–234

Abstract: Objectives: Elucidation of the regulatory mechanisms of gemcitabine sensitivity is needed to improve the therapeutic effects of this drug in pancreatic cancer.: Methods: PANC-1 cells were transfected with small hairpin RNA against PVT1 or microRNA ( ... ...

Abstract	Objectives: Elucidation of the regulatory mechanisms of gemcitabine sensitivity is needed to improve the therapeutic effects of this drug in pancreatic cancer. Methods: PANC-1 cells were transfected with small hairpin RNA against PVT1 or microRNA (miR)-143 mimics or inhibitor. The gemcitabine sensitivity of pancreatic cancer was evaluated. Autophagosomes were analyzed with an immunofluorescence assay. Cell viability and proliferation were examined with MTT assays. Quantitative reverse transcription-polymerase chain reaction and Western blotting were used to analyze the expression of PVT1, miR-143, HIF-1α, VMP1, LC3I/II, p62, and Beclin-1. The interactions of PVT1/miR-143 and miR-143/HIF-1α were assessed by dual-luciferase reporter assays. Results: PVT1 was upregulated while miR-143 was downregulated in pancreatic cancer. Both PVT1 knockdown and miR-143 overexpression suppressed autophagy and improved gemcitabine sensitivity in pancreatic cancer. PVT1 directly sponged miR-143 to regulate HIF-1α expression. MiR-143 inhibitor reversed the effect of PVT1 knockdown on autophagy and gemcitabine sensitivity. Conclusions: PVT1 knockdown inhibited autophagy and improved gemcitabine sensitivity via the miR-143/HIF-1α/VMP1 axis in pancreatic cancer. Our investigation elucidated a novel regulatory mechanism of gemcitabine sensitivity and may contribute to improve the therapeutic effects of chemotherapy drugs on pancreatic cancer.
MeSH term(s)	Antimetabolites, Antineoplastic/pharmacology ; Autophagy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Down-Regulation ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Signal Transduction ; Gemcitabine
Chemical Substances	Antimetabolites, Antineoplastic ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; MIRN143 microRNA, human ; Membrane Proteins ; MicroRNAs ; PVT1 long-non-coding RNA, human ; RNA, Long Noncoding ; VMP1 protein, human ; Deoxycytidine (0W860991D6) ; Gemcitabine
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001747
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Article: Evaluation of the potential of ultrasound-mediated drug delivery for the treatment of ovarian cancer through preclinical studies.

Wang, Yi-Chao / Tian, Jing-Yan / Han, Ying-Ying / Liu, Yun-Fei / Chen, Si-Yao / Guo, Feng-Jun

Frontiers in oncology

2022 Volume 12, Page(s) 978603

Abstract: Ovarian cancer (OC) has the greatest mortality rate among gynecological cancers, with a five-year survival rate of <50%. Contemporary adjuvant chemotherapy mostly fails in the case of OCs that are refractory, metastatic, recurrent, and drug-resistant. ... ...

Abstract	Ovarian cancer (OC) has the greatest mortality rate among gynecological cancers, with a five-year survival rate of <50%. Contemporary adjuvant chemotherapy mostly fails in the case of OCs that are refractory, metastatic, recurrent, and drug-resistant. Emerging ultrasound (US)-mediated technologies show remarkable promise in overcoming these challenges. Absorption of US waves by the tissue results in the generation of heat due to its thermal effect causing increased diffusion of drugs from the carriers and triggering sonoporation by increasing the permeability of the cancer cells. Certain frequencies of US waves could also produce a cavitation effect on drug-filled microbubbles (MBs, phospholipid bilayers) thereby generating shear force and acoustic streaming that could assist drug release from the MBs, and promote the permeability of the cell membrane. A new class of nanoparticles that carry therapeutic agents and are guided by US contrast agents for precision delivery to the site of the ovarian tumor has been developed. Phase-shifting of nanoparticles by US sonication has also been engineered to enhance the drug delivery to the ovarian tumor site. These technologies have been used for targeting the ovarian cancer stem cells and protein moieties that are particularly elevated in OCs including luteinizing hormone-releasing hormone, folic acid receptor, and vascular endothelial growth factor. When compared to healthy ovarian tissue, the homeostatic parameters at the tissue microenvironment including pH, oxygen levels, and glucose metabolism differ significantly in ovarian tumors. US-based technologies have been developed to take advantage of these tumor-specific alterations for precision drug delivery. Preclinical efficacy of US-based targeting of currently used clinical chemotherapies presented in this review has the potential for rapid human translation, especially for formulations that use all substances that are deemed to be generally safe by the U.S. Food and Drug Administration.
Language	English
Publishing date	2022-09-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.978603
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Article ; Online: A new genus of cricket with one new species from western Yunnan, China (Orthoptera: Gryllidae: Gryllinae).

Liu, Yun-Fei / Shen, Chu-Ze / Zhang, Ling / He, Zhu-Qing

Zootaxa

2019 Volume 4577, Issue 2, Page(s) zootaxa.4577.2.12

Abstract: Most male crickets can produce songs mostly for attracting females. Songs are specific among species,. this depending on physiology and the structural characteristics of the forewings. Nevertheless, some species belonging to subfamily Gryllinae have lost ...

Abstract	Most male crickets can produce songs mostly for attracting females. Songs are specific among species,. this depending on physiology and the structural characteristics of the forewings. Nevertheless, some species belonging to subfamily Gryllinae have lost their singing abilities (mute species). Chinese examples include Agryllus spp., Conoblemmus spp., Goniogryllus spp. and Callogryllus yunnanus. Males of these genera are either wingless or have forwings similar to those of females. These crickets have been poorly studied in China. In this study, we describe one new genus Asonicogryllus He gen. nov. with a new species Asonicogryllus kwanghua sp. nov. from western Yunnan. The type specimens are deposited in Museum of Biology, East China Normal University (ECNU).
MeSH term(s)	Animal Distribution ; Animal Structures ; Animals ; Body Size ; China ; Female ; Gryllidae ; Male ; Organ Size ; Orthoptera
Language	English
Publishing date	2019-04-05
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4577.2.12
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