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Article ; Online: "Influencing the influencers:" a field experimental approach to promoting effective mental health communication on TikTok.

Motta, Matt / Liu, Yuning / Yarnell, Amanda

2024 Volume 14, Issue 1, Page(s) 5864

Abstract: A substantial body of social scientific research considers the negative mental health consequences of social media use on TikTok. Fewer, however, consider the potentially positive impact that mental health content creators ("influencers") on TikTok can ... ...

Abstract	A substantial body of social scientific research considers the negative mental health consequences of social media use on TikTok. Fewer, however, consider the potentially positive impact that mental health content creators ("influencers") on TikTok can have to improve health outcomes; including the degree to which the platform exposes users to evidence-based mental health communication. Our novel, influencer-led approach remedies this shortcoming by attempting to change TikTok creator content-producing behavior via a large, within-subject field experiment (N = 105 creators with a reach of over 16.9 million viewers; N = 3465 unique videos). Our randomly-assigned field intervention exposed influencers on the platform to either (a) asynchronous digital (.pdf) toolkits, or (b) both toolkits and synchronous virtual training sessions that aimed to promote effective evidence-based mental health communication (relative to a control condition, exposed to neither intervention). We find that creators treated with our asynchronous toolkits-and, in some cases, those also attending synchronous training sessions-were significantly more likely to (i) feature evidence-based mental health content in their videos and (ii) generate video content related to mental health issues. Moderation analyses further reveal that these effects are not limited to only those creators with followings under 2 million users. Importantly, we also document large system-level effects of exposure to our interventions; such that TikTok videos featuring evidence-based content received over half a million additional views in the post-intervention period in the study's treatment groups, while treatment group mental health content (in general) received over three million additional views. We conclude by discussing how simple, cost-effective, and influencer-led interventions like ours can be deployed at scale to influence mental health content on TikTok.
MeSH term(s)	Humans ; Health Communication ; Mental Health ; Research Design ; Social Media
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56578-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dendritic cell maturation in the tumor microenvironment

Miao Yuhui / Liu Yuning / Tang Haidong / Zhang Zemin

National Science Open, Vol

2023 Volume 2

Abstract: Maturation is essential for dendritic cells (DCs) to function as a bridge between innate and adaptive immunity. The plastic maturation states correspond to the multifaceted roles of DCs in the initiation of protective, tolerogenic and pathogenic immune ... ...

Abstract	Maturation is essential for dendritic cells (DCs) to function as a bridge between innate and adaptive immunity. The plastic maturation states correspond to the multifaceted roles of DCs in the initiation of protective, tolerogenic and pathogenic immune responses. The formation of a distinct maturation state of DCs involves the complex crosstalk between the intrinsic differences in their ontogeny and the immune environments. Recent studies have defined a universal mature DC population in the tumor microenvironment (TME), but their ontogenesis and functions remain unclear. Here, we summarize recent advances in DC maturation and attempt to dissect the complex functions of mature DCs in the TME. We highlighted that there is a distinct similarity and heterogeneity of mature DCs in the TME, in which the environment and development are both important. These help us revisit the diversity of DC maturation and to better dissect the complex functions of DCs in the TME.
Keywords	dendritic cells ; tumor microenvironment ; tumor-associated mature DCs ; tolerogenic DCs ; tertiary lymphatic structures ; immunotherapy ; Science ; Q ; Engineering (General). Civil engineering (General) ; TA1-2040
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Science Press
Document type	Article ; Online
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Article ; Online: Distinct regulation of ASCL1 by the cell cycle and chemotherapy in small cell lung cancer.

Liu, Yuning / Wu, Qingzhe / Jiang, Bin / Hou, Tingting / Wu, Chuanqiang / Wu, Ming / Song, Hai

Molecular cancer research : MCR

2024

Abstract: Small cell lung cancer (SCLC) is an aggressive and lethal malignancy. Achaete-scute homolog 1 (ASCL1) is essential for the initiation of SCLC in mice and the development of pulmonary neuroendocrine cells (PNECs) which are the major cells of origin for ... ...

Abstract	Small cell lung cancer (SCLC) is an aggressive and lethal malignancy. Achaete-scute homolog 1 (ASCL1) is essential for the initiation of SCLC in mice and the development of pulmonary neuroendocrine cells (PNECs) which are the major cells of origin for SCLC. However, the regulatory mechanism of ASCL1 in SCLC remains elusive. Here, we found that ASCL1 expression gradually increases as the tumors grow in a mouse SCLC model and is regulated by the cell cycle. Mechanistically CDK2-CyclinA2 complex phosphorylates ASCL1, which results in increased proteasome-mediated ASCL1 protein degradation by E3 ubiquitin ligase HUWE1 during mitosis. TCF3 promotes the multi-site phosphorylation of ASCL1 through the CDK2-CyclinA2 complex and the interaction between ASCL1 and TCF3 protects ASCL1 from degradation. The dissociation of TCF3 from ASCL1 during mitosis accelerates the degradation of ASCL1. In addition, chemotherapy drugs greatly reduce the transcription of ASCL1 in SCLC cells. Depletion of ASCL1 sensitizes SCLC cells to chemotherapy drugs. Together, our study demonstrates that ASCL1 is a cell-cycle regulated protein and provides a theoretical basis for applying cell-cycle related antitumor drugs in SCLC treatment. Implications: Our study revealed a novel regulatory mechanism of ASCL1 by cell cycle and chemotherapy drugs in SCLC. Treating SCLC patients with a combination of ASCL1-targeting therapy and chemotherapy drugs could potentially be beneficial.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2098788-2
ISSN	1557-3125 ; 1541-7786
ISSN (online)	1557-3125
ISSN	1541-7786
DOI	10.1158/1541-7786.MCR-23-0405
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Article ; Online: Reliable detection of malachite green by self-assembled SERS substrates based on gold-silicon heterogeneous nano pineapple structures.

Liu, Yu-Ning / Li, Jian-Jun / Weng, Guo-Jun / Zhu, Jian / Zhao, Jun-Wu

Food chemistry

2024 Volume 451, Page(s) 139454

Abstract: Morphology regulation of heterodimer nanoparticles and the use of their asymmetric features for further practical applications are crucial because of the rich optical properties and various combinations of heterodimers. This work used silicon to ... ...

Abstract	Morphology regulation of heterodimer nanoparticles and the use of their asymmetric features for further practical applications are crucial because of the rich optical properties and various combinations of heterodimers. This work used silicon to asymmetrically wrap half of a gold sphere and grew gold branches on the bare gold surface to form heterogeneous nano pineapples (NPPs) which can effectively improve Surface-enhanced Raman scattering (SERS) properties through chemical enhancement and lightning-rod effect respectively. The asymmetric structures of NPPs enabled them to self-assemble into the monolayer membrane with consistent branch orientation. The prepared substrate had high homogeneity and better SERS ability than disorganized substrates, and achieved reliable detection of malachite green (MG) in clams with a detection limit of 7.8 × 10
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.139454
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Article: Structural elucidation approaches in carbohydrates: A comprehensive review on techniques and future trends

Liu, Yuning / Huang, Yajun / Zhu, Ruiyu / Farag, Mohamed A. / Capanoglu, Esra / Zhao, Chao

Food chemistry. 2023 Jan. 30, v. 400

2023

Abstract: Carbohydrates and their implications for human health have been the subject to a rapidly growing interest. Substantial advances in analytical methods have enabled a more effective assessment of carbohydrates and their pharmacological effects. Developing ... ...

Abstract	Carbohydrates and their implications for human health have been the subject to a rapidly growing interest. Substantial advances in analytical methods have enabled a more effective assessment of carbohydrates and their pharmacological effects. Developing a carbohydrate profile technology would surely aid the understanding of carbohydrate dietary impacts. With the advances in technology for characterization, as well as exploration of complex structure, it is becoming more feasible to synthesize such compounds, rather than isolation. Several technological developments, including improved analytical tools, glycomics, and automation technology, have opened up new opportunities to globally assess most carbohydrates in envisaged samples. The main analytical methods applied to carbohydrates are described. And then the development of automation technology in glycan synthesis are introduced. This review concludes by considering the limitations of the existing technologies and required future developments for overcoming these limitations and improving identification score and/or yield.
Keywords	automation ; carbohydrates ; food chemistry ; glycomics ; human health
Language	English
Dates of publication	2023-0130
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.134118
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Article: Associations between cognitive function and marital status in the United States, South Africa, Mexico, and China.

Jennings, Elyse A / Farrell, Meagan T / Liu, Yuning / Montana, Livia

SSM - population health

2022 Volume 20, Page(s) 101288

Abstract: We investigate the associations between marital status and cognitive well-being among adults aged 50 and older across four settings: the United States, rural South Africa, Mexico, and China. Using a standardized measure of immediate word recall, we ... ...

Abstract	We investigate the associations between marital status and cognitive well-being among adults aged 50 and older across four settings: the United States, rural South Africa, Mexico, and China. Using a standardized measure of immediate word recall, we assess whether people in each non-married status have worse cognitive function than their married counterparts, and the extent to which these associations vary across settings. We theorize that the practices around marriage in each setting, as well as the social stigma attached to marital dissolution, will reveal differing associations between marital status and cognition. Results suggest that, among women, being in a widowed marital status is associated with lower cognitive function in each setting except Mexico (after accounting for education and employment), while being separated/divorced or never married is associated with lower cognitive function only among women in the U.S. and Mexico. Among men, being widowed is associated with lower cognitive function relative to being married in each setting except South Africa (after accounting for education and employment), and being never married is associated with lower cognitive function in the U.S. and China (but not in South Africa or Mexico, after accounting for education and employment). Men also face relatively lower cognitive function if separated/divorced in the U.S. and South Africa. We discuss possible reasons for these associations across settings.
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article
ISSN	2352-8273
ISSN	2352-8273
DOI	10.1016/j.ssmph.2022.101288
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Article ; Online: Gut microbiota-derived trimethylamine N-oxide is associated with the risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a systematic review and dose-response meta-analysis.

Li, Yachun / Lu, Hongmei / Guo, Jing / Zhang, Meiling / Zheng, Huijuan / Liu, Yuning / Liu, Weijing

Annals of medicine

2023 Volume 55, Issue 1, Page(s) 2215542

Abstract: Background: Trimethylamine N-oxide (TMAO) derived from gut microbiota causes kidney-heart damage in chronic kidney disease (CKD) patients. However, it is controversial whether CKD patients with higher TMAO are associated with a higher risk of death. We ... ...

Abstract	Background: Trimethylamine N-oxide (TMAO) derived from gut microbiota causes kidney-heart damage in chronic kidney disease (CKD) patients. However, it is controversial whether CKD patients with higher TMAO are associated with a higher risk of death. We aimed to assess the correlation between circulating TMAO concentration and the risk of all-cause and cardiovascular death in CKD patients of different dialysis statuses and different races by dose-response analyses, and the underlying mechanisms were also explored by analyzing the correlations of TMAO with glomerular filtration rate (GFR) and inflammation. Method: PubMed, Web of Science, and EMBASE were systematically searched up to 1 July 2022. A total of 21 studies involving 15,637 individuals were included. Stata 15.0 was used to perform the meta-analyses and dose-response analyses with extracted data. Subgroup analyses were conducted to recognize possible sources of heterogeneity. Results: The risk of all-cause mortality was increased in non-dialysis CKD patients (RR = 1.26, 95%CI = 1.03-1.54, Conclusions: Increased circulating TMAO concentrations increase the risk of all-cause mortality in non-dialysis and non-black dialysis CKD patients. Moreover, elevated TMAO levels raise the cardiovascular mortality risk in non-black dialysis patients.Key messagesNon-dialysis and non-black dialysis CKD patients with higher circulating TMAO concentrations are associated with an increased risk of all-cause mortality.Non-black dialysis patients with higher concentrations of TMAO are associated with an increased risk of cardiovascular mortality.Circulating TMAO concentrations have a strong negative correlation with GFR and a positive correlation with inflammation biomarkers in non-dialysis CKD patients.
MeSH term(s)	Humans ; Cardiovascular Diseases/etiology ; Gastrointestinal Microbiome/physiology ; Inflammation/complications ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy
Chemical Substances	trimethyloxamine (FLD0K1SJ1A)
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2023.2215542
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Article: Corrigendum: Transcriptome analyses reveal photosynthesis-related genes involved in photosynthetic regulation under low temperature stress in

Li, Ling / Liang, Yuchen / Liu, Yinan / Sun, Zeyi / Liu, Yuning / Yuan, Zening / Fu, Chang

Frontiers in plant science

2023 Volume 14, Page(s) 1339454

Abstract: This corrects the article DOI: 10.3389/fpls.2023.1268666.]. ...

Abstract	[This corrects the article DOI: 10.3389/fpls.2023.1268666.].
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1339454
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Article: The habitual characteristic of smart phone use under relevant cues among Chinese college students.

Li, Ming / Duan, Jieyue / Liu, Yuning / Zou, Jingxin / Yang, Xuesong / Zeng, Hong

Frontiers in psychology

2023 Volume 14, Page(s) 1218886

Abstract: Excessive smartphone use may be habitual behavior induced by cues associated with the phone. Habitual behavior occurs outside of awareness and is characterized by lack of control. It is not like problematic smartphone use (PSU) (Brand et al., 2016), ... ...

Abstract	Excessive smartphone use may be habitual behavior induced by cues associated with the phone. Habitual behavior occurs outside of awareness and is characterized by lack of control. It is not like problematic smartphone use (PSU) (Brand et al., 2016), which is used to either limit behavior or produce pleasure and relieve feelings of pain, stress, and failure despite significant harmful consequences. 62 college students participated in experiments to test the effects of visual cues and self-control, which are the important characteristic of habitual behavior in smartphone-related behavior. The results showed that a significantly larger amount of cue-related phone use behavior occurred in the setting where participants (a) had their smartphones in sight and (b) were given no instructions to exert self-control, compared to when neither of the two conditions was imposed. The habitual model is a useful framework for understanding PSU and can help people avoid it with less stress. The results provide substantial implications for reducing the frequency and duration of smartphone use among college populations.
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1218886
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Article ; Online: Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (<em>Citellus dauricus</em> Brandt).

Gao, Qingjing / Xie, Wenqian / Lu, Wenjing / Liu, Yuning / Zhang, Haolin / Han, Yingying / Weng, Qiang

European journal of histochemistry : EJH

2023 Volume 67, Issue 4

Abstract: Prolactin (PRL) is a hormone crucial for normal reproduction, functioning as an autocrine, paracrine, and endocrine factor. This study aimed to examine the immunolocalization and expression patterns of PRL, prolactin receptor (PRLR), and signal ... ...

Abstract	Prolactin (PRL) is a hormone crucial for normal reproduction, functioning as an autocrine, paracrine, and endocrine factor. This study aimed to examine the immunolocalization and expression patterns of PRL, prolactin receptor (PRLR), and signal transducer and activator of transcription 5 (STAT5) in the ovaries of wild ground squirrels during both breeding and non-breeding periods. Significant seasonal variations were observed in ovarian weights, with higher values during the breeding season and relatively lower values during the nonbreeding season. PRL, PRLR, STAT5, and p-STAT5 were immunolocalized in granulosa cells and luteal cells during the breeding season, whereas they were exclusively found in granulosa cells during the non-breeding season. The mRNA expression levels of Prl, Prlr, and Stat5 were increased in ovarian tissues during the breeding season compared to the non-breeding season. Moreover, the mean mRNA levels of Prl, Prlr, and Stat5 exhibited a positive correlation with ovarian weights. Both circulating PRL and ovarian PRL concentrations were significantly elevated during the breeding season. Additionally, transcriptomic analysis of ovarian tissues revealed differentially expressed genes possibly associated with ovarian function and mammary gland development, including ovarian follicle development, steroid synthesis, and regulation of reproductive process. These findings suggest that PRL might play an essential endocrine, autocrine, or paracrine role in the regulation of seasonal changes in the ovarian functions in wild ground squirrels.
MeSH term(s)	Female ; Animals ; Prolactin ; Receptors, Prolactin/genetics ; Receptors, Prolactin/metabolism ; Seasons ; Ovary/metabolism ; STAT5 Transcription Factor/metabolism ; Sciuridae/genetics ; Sciuridae/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Prolactin (9002-62-4) ; Receptors, Prolactin ; STAT5 Transcription Factor ; RNA, Messenger
Language	English
Publishing date	2023-10-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1109511-8
ISSN	2038-8306 ; 0391-7258 ; 1121-4201 ; 1121-760X
ISSN (online)	2038-8306
ISSN	0391-7258 ; 1121-4201 ; 1121-760X
DOI	10.4081/ejh.2023.3825
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