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  1. Article ; Online: Effects of neighborhood built environment on cognitive function in older adults: a systematic review.

    Song, Yiling / Liu, Yunxi / Bai, Xiaotian / Yu, Hongjun

    BMC geriatrics

    2024  Volume 24, Issue 1, Page(s) 194

    Abstract: Background: In the background of an aging population, the risk of cognitive impairment in the older population is prominent. Exposure to complex neighborhood built environments may be beneficial to the cognitive health of older adults, and the purpose ... ...

    Abstract Background: In the background of an aging population, the risk of cognitive impairment in the older population is prominent. Exposure to complex neighborhood built environments may be beneficial to the cognitive health of older adults, and the purpose of this study was to systematically review the scientific evidence on the effects of neighborhood built environments on cognitive function in older adults.
    Methods: Keywords and references were searched in Web of Science, Pubmed, PsycINFO, and MEDLINE. Studies examining the relationship between the built environment and cognitive function in older adults were included. The neighborhood built environment as an independent variable was classified according to seven aspects: density, design, diversity, destination accessibility, public transportation distance, blue/green space, and built environment quality. The cognitive function as the dependent variable was classified according to overall cognitive function, domain-specific cognitive function, and incidence of dementia. The quality of the included literature was assessed using the National Institutes of Health's Observational Cohort and Cross-Sectional Study Quality Assessment Tool.
    Results: A total of 56 studies were included that met the inclusion criteria, including 31 cross-sectional studies, 23 longitudinal studies, 1 cross-sectional study design combined with a case-control design, and 1 longitudinal study design combined with a case-control design. Most of the studies reviewed indicate that the built environment factors that were positively associated with cognitive function in older adults were population density, street connectivity, walkability, number of public transportation stops around the residence, land use mix, neighborhood resources, green space, and quality of the neighborhood built environment. Built environment factors that were negatively associated with cognitive function in older adults were street integration, distance from residence to main road. The relationship between residential density, destination accessibility, and blue space with cognitive function in older adults needs to be further explored.
    Conclusion: Preliminary evidence suggests an association between the neighborhood built environment and cognitive function in older adults. The causal relationship between the built environment and cognitive function can be further explored in the future using standardized and combined subjective and objective assessment methods, and longitudinal or quasi-experimental study designs. For public health interventions on the cognitive health of older adults, it is recommended that relevant authorities include the neighborhood built environment in their intervention programs.
    MeSH term(s) Humans ; Aged ; Cross-Sectional Studies ; Longitudinal Studies ; Walking ; Environment Design ; Built Environment ; Cognition ; Residence Characteristics
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-024-04776-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effects of Soccer Exercise on Balance Ability and Kinesthesia of the Lower Limb Joints in Children Aged 5-6 Years.

    Shen, Kebin / Liu, Yunxi

    Motor control

    2022  Volume 26, Issue 2, Page(s) 213–225

    Abstract: Age-, height- and weight-matched children were recruited to the experimental group (EG; n = 31) and control group (n = 32). Following a 16-week soccer training program, balance ability and dominant-side lateral knee and ankle kinesthesia changes were ... ...

    Abstract Age-, height- and weight-matched children were recruited to the experimental group (EG; n = 31) and control group (n = 32). Following a 16-week soccer training program, balance ability and dominant-side lateral knee and ankle kinesthesia changes were tested. Regarding balance ability, the Sway Index, when children stood on a firm or foam surface with their eyes closed in the static balance test, and the dynamic balance test time were 13.5%, 11.6%, and 14.3% lower in the EG than in the control group, respectively. The scores in the left and right directions were 23.7% and 24.2% higher in the EG, respectively. Regarding kinesthesia, the angle of knee extension and ankle metatarsal flexion and dorsiflexion were 13.4%, 20.0%, and 16.8% lower in the EG than in the control group. These results indicate children in the EG had a better performance. After soccer exercise, children aged 5-6 years displayed improved balance in the left and right directions and improved knee extension, ankle plantarflexion, and dorsiflexion kinesthesia.
    MeSH term(s) Ankle ; Ankle Joint ; Child ; Humans ; Kinesthesis ; Lower Extremity ; Postural Balance ; Soccer
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 1087-1640
    ISSN 1087-1640
    DOI 10.1123/mc.2021-0093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An electrochemical microsensor based on a specific recognition element for the simultaneous detection of hydrogen peroxide and ascorbic acid in the live rat brain.

    Zhao, Fan / Tang, Xuan / Guo, Dongqing / Liu, Yunxi / Chen, Jing

    Analytical methods : advancing methods and applications

    2023  Volume 15, Issue 34, Page(s) 4289–4295

    Abstract: A novel electrochemical microsensor was developed for the ratiometric and simultaneous determination of hydrogen peroxide ( ... ...

    Abstract A novel electrochemical microsensor was developed for the ratiometric and simultaneous determination of hydrogen peroxide (H
    MeSH term(s) Animals ; Rats ; Ascorbic Acid ; Hydrogen Peroxide ; Amides ; Esters ; Nanotubes, Carbon ; Brain
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Hydrogen Peroxide (BBX060AN9V) ; Amides ; Esters ; Nanotubes, Carbon
    Language English
    Publishing date 2023-08-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay00488k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epidemiology, resistant pathogens, and causes of early death in cases of bloodstream infection in patients with hematological malignancies from 2012-2019.

    Li, Meng / Du, Mingmei / Li, Honghua / Liu, Daihong / Liu, Yunxi

    Infectious medicine

    2022  Volume 1, Issue 1, Page(s) 23–30

    Abstract: Purpose: To investigate the epidemiology, causative pathogen antibiotic susceptibility, and mortality risk factors of bloodstream infection (BSI) in patients with hematological malignancies (HMs).: Methods: Single-center retrospective analysis of BSI ...

    Abstract Purpose: To investigate the epidemiology, causative pathogen antibiotic susceptibility, and mortality risk factors of bloodstream infection (BSI) in patients with hematological malignancies (HMs).
    Methods: Single-center retrospective analysis of BSI cases in patients with HMs in a Chinese tertiary hospital from 2012-2019.
    Results: Among 17,796 analyzed admissions, 508 BSI episodes (2.9%; 95% confidence interval: 2.6%-3.2%) were identified. Of 522 resulting isolates, 326 (62.5%) were Gram-negative, 173 (33.1%) were Gram-positive. The BSI incidence among patients with different HMs (severe aplastic anemia: 6.7%; acute leukemia: 6.2%; myelodysplastic syndrome: 3.2%; multiple myeloma: 1.3%; and lymphoma: 1.0%) differed significantly (
    Conclusions: Gram-negative bacteria were the most common pathogens, with
    Language English
    Publishing date 2022-03-03
    Publishing country China
    Document type Journal Article
    ISSN 2772-431X
    ISSN (online) 2772-431X
    DOI 10.1016/j.imj.2022.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010-2019.

    Li, Meng / Yang, Shanshan / Yao, Hongwu / Liu, Yunxi / Du, Mingmei

    Infectious diseases and therapy

    2022  Volume 12, Issue 2, Page(s) 473–485

    Abstract: Introduction: In the present study, we aimed to describe the proportion of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes ... ...

    Abstract Introduction: In the present study, we aimed to describe the proportion of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI.
    Methods: We retrospectively analyzed clinical and microbiological data of patients with KP-BSI from January 2010 to December 2019 to identify risk factors, clinical features, and outcomes using multivariate logistic regression analysis. KP-BSI only included monomicrobial BSI and health care-acquired BSI.
    Results: Among the total 687 isolates of KP-BSI in this study, the rate of CRKP was 39.0% (268/687); this rate in the intensive care unit (ICU) was 65.6% and that in seven high-risk departments (including four ICUs, respiratory medicine, gastroenterology medicine, and hepatobiliary surgery) was 74.6%. The annual rate of CRKP in KP-BSI ranged from 0.0% in 2010 to 54.5% in 2019. The 28-day mortality was 36.2% in patients with CRKP-BSI and 11.7% in those with carbapenem-susceptible K. pneumoniae (CSKP) BSI. Multivariable logistic regression analysis showed that prior ICU stay (odds ratio [OR] 2.485, P < 0.001), hospital stay ≥ 30 days prior to BSI (OR 1.815, P = 0.007), prior mechanical ventilation (OR 2.020, P = 0.014), prior urinary catheter (OR 1.999, P = 0.003), prior carbapenem use (OR 3.840, P < 0.001), hepatobiliary disease (OR 2.943, P < 0.001), pancreatitis (OR 2.700, P = 0.026), and respiratory disease (OR 2.493, P = 0.009) were risk factors of CRKP-BSI. Patients with a first admission (OR 0.662, P = 0.046) had a lower percentage of CRKP-BSI.
    Conclusion: The rapidly rising rate of CRKP-BSI in KP with high mortality requires increased attention. Exposure to carbapenems, ICU stay, invasive mechanical ventilation or urinary catheter, prolonged hospital stay, hepatobiliary disease, pancreatitis, and respiratory disease were found to be risk factors for CRKP-BSI. Strict control measures should be implemented to prevent the emergence and spread of CRKP, especially in high-risk departments.
    Language English
    Publishing date 2022-12-15
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-022-00732-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Epidemiology and risk factors of nosocomial infections in a Chinese tertiary-care hospital: a 10-year retrospective case-control study.

    Wang, Zekun / Du, Mingmei / Cao, Hui / Yao, Hongwu / Liu, Bowei / Bai, Yanling / Geng, Huiling / Jia, Zhongwei / Liu, Yunxi

    Infectious diseases (London, England)

    2024  Volume 56, Issue 4, Page(s) 320–329

    Abstract: Background: Nosocomial infections (NIs) are the most frequent adverse events among patients and cause a heavy burden on both health and economics. To investigate epidemiology of NIs and identify risk factors for NIs by integrating continuous long-term ... ...

    Abstract Background: Nosocomial infections (NIs) are the most frequent adverse events among patients and cause a heavy burden on both health and economics. To investigate epidemiology of NIs and identify risk factors for NIs by integrating continuous long-term surveillance data.
    Methods: We performed an observational study among inpatients at the Chinese People's Liberation Army General Hospital between January 1, 2010, and December 31, 2019. Infection rates, mortality rates and percentage of NIs were calculated. Trends of yearly infection rates by pathogens were assessed using Mann-Kendall trend test. Controls were matched to cases (2:1) by age (±2 years), sex, admission date (±1 year) and admission diagnosis, and conditional logistic regression was used to estimate odds ratios.
    Results: A total of 1,534,713 inpatients were included among which 33,468 NIs cases occurred with an infection rate of 2.18%. The most common infections were respiratory system infection (52.22%), bloodstream infection (17.60%), and genitourinary system infection (15.62%).
    Conclusion: K. pneumoniae
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Case-Control Studies ; Cross Infection/epidemiology ; Cross Infection/drug therapy ; Drug Resistance, Bacterial ; Escherichia coli ; Klebsiella pneumoniae ; Retrospective Studies ; Risk Factors ; Tertiary Care Centers
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2024.2310647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Crykey: Comprehensive Identification of SARS-CoV-2 Cryptic Mutations in Wastewater

    Liu, Yunxi / Sapoval, Nicolae / Treangen, Todd J. / Stadler, Lauren B.

    medRxiv

    Abstract: We present Crykey, a computational tool for identifying SARS-CoV-2 cryptic mutations from wastewater. While previous exist for identifying cryptic mutations in specific regions of the SARS-CoV-2 genome, there is a need for computational tools capable of ... ...

    Abstract We present Crykey, a computational tool for identifying SARS-CoV-2 cryptic mutations from wastewater. While previous exist for identifying cryptic mutations in specific regions of the SARS-CoV-2 genome, there is a need for computational tools capable of tracking cryptic mutations across the entire genome and at scale. Crykey fills this gap and leverages the co-occurrence of single nucleotide variants on the same read combined with variant frequency information. We evaluated Crykey on SARS-CoV-2 sequences from 3175 wastewater samples and more than 14000 clinical samples. Our results are threefold, we show: 1) Crykey can accurately identify cryptic lineages that are rare or missing in existing databases

    2) the emergence of cryptic lineage can be related to increased transmission rates in the communities, and 3) some cryptic lineages in wastewater mirror intra-host low frequency co-occurring variants in individuals. In summary, Crykey facilitates rapid and comprehensive identification of SARS-CoV-2 cryptic mutations in wastewater samples.
    Keywords covid19
    Language English
    Publishing date 2023-06-20
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.06.16.23291524
    Database COVID19

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  8. Article ; Online: Susceptible-Infected-Removed Mathematical Model under Deep Learning in Hospital Infection Control of Novel Coronavirus Pneumonia.

    Liu, Ting / Bai, Yanling / Du, Mingmei / Gao, Yueming / Liu, Yunxi

    Journal of healthcare engineering

    2021  Volume 2021, Page(s) 1535046

    Abstract: Objective: This research aimed to explore the application of a mathematical model based on deep learning in hospital infection control of novel coronavirus (COVID-19) pneumonia.: Methods: First, the epidemic data of Beijing, China, were utilized to ... ...

    Abstract Objective: This research aimed to explore the application of a mathematical model based on deep learning in hospital infection control of novel coronavirus (COVID-19) pneumonia.
    Methods: First, the epidemic data of Beijing, China, were utilized to make a definite susceptible-infected-removed (SIR) model fitting to determine the estimated value of the COVID-19 removal intensity
    Results: There was a certain gap between the fitting of SIR to the remover and the actual data. The fitting of the number of infections was accurate. The growth rate of the number of infections decreased after measures, such as isolation, were taken. The effect of herd immunity was achieved after the overall immunity reached 70.9%.
    Conclusion: The SIR model based on deep learning and the stochastic SIR fitting model were accurate in judging the development trend of the epidemic, which can provide basis and reference for hospital epidemic infection control.
    MeSH term(s) COVID-19 ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Deep Learning ; Humans ; Models, Theoretical ; SARS-CoV-2
    Language English
    Publishing date 2021-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2545054-2
    ISSN 2040-2309 ; 2040-2295
    ISSN (online) 2040-2309
    ISSN 2040-2295
    DOI 10.1155/2021/1535046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Alcohol as an independent risk factor for obstructive sleep apnea.

    Yang, Shanshan / Guo, Xinhong / Liu, Wei / Li, Yanhua / Liu, Yunxi

    Irish journal of medical science

    2021  Volume 191, Issue 3, Page(s) 1325–1330

    Abstract: Background: To determine if alcohol consumption is a risk factor for obstructive sleep apnea (OSA) and nocturnal oxygen desaturation.: Methods: This case-control study evaluated patients with confirmed OSA and a control group using polysomnography ( ... ...

    Abstract Background: To determine if alcohol consumption is a risk factor for obstructive sleep apnea (OSA) and nocturnal oxygen desaturation.
    Methods: This case-control study evaluated patients with confirmed OSA and a control group using polysomnography (PSG). Two doctors who have worked in this field for more than 5 years provided a blinded interpretation of the patients' monitoring results. Logistic regression models were used to identify the odds ratio (OR) for alcohol consumption on OSA.
    Results: A total of 793 patients were enrolled in this study. Compared with those who did not consume alcohol, those consuming alcohol had a higher risk of OSA (OR 2.03, 95% CI 1.30-3.17) after adjustment. Regarding the risk of OSA after adjusting for former drinkers and current ones, the ORs were 1.96 (95% CI 1.19-3.22) and 2.22 (95% CI 1.06-4.63), respectively. And the P for trend = 0.002. The β of former drinkers and the current ones were 3.448 and 4.560 after adjustment; P for trend was 0.006. The relationship may have gender difference, and alcohol consumption was associated with AHI in female significantly (β = 10.190 and 15.395 for former and current drinkers, respectively, in females after adjustment, P for trend = 0.002).
    Conclusions: In this study, we found that alcohol consumption was an independent risk factor of OSA and OSA with hypoxia, and alcohol consumption was related to AHI significantly after adjustment, especially in female. In order to reduce the risk and severity of OSA, it is suggested that people should avoid drinking, and drinkers should abstain from drinking.
    MeSH term(s) Case-Control Studies ; Female ; Humans ; Polysomnography ; Retrospective Studies ; Risk Factors ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology
    Language English
    Publishing date 2021-06-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-021-02671-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Patients with COVID-19 and HBV Coinfection are at Risk of Poor Prognosis.

    Yang, Shanshan / Wang, Shengshu / Du, Mingmei / Liu, Miao / Liu, Yunxi / He, Yao

    Infectious diseases and therapy

    2022  Volume 11, Issue 3, Page(s) 1229–1242

    Abstract: Introduction: This study aimed to determine whether there is a difference in the risk of death/critical illness between different stages of hepatitis B virus (HBV) (resolved hepatitis B, HBeAg (-) chronic hepatitis B [CHB]/infection, HBeAg (+) CHB/ ... ...

    Abstract Introduction: This study aimed to determine whether there is a difference in the risk of death/critical illness between different stages of hepatitis B virus (HBV) (resolved hepatitis B, HBeAg (-) chronic hepatitis B [CHB]/infection, HBeAg (+) CHB/infection, and HBV reactivation) coinfected with coronavirus disease 2019 (COVID-19); and if there is a difference, whether it is due to abnormal liver function and to what extent.
    Methods: This cohort study included all COVID-19 inpatients of a single-center tertiary care academic hospital in Wuhan, Hubei, China, between February 4, 2020, and follow-up to April 14, 2020. A total of 2899 patients with COVID-19 were included as participants in this study, and they were divided into five groups based on hepatitis B infection status. Follow-up was conducted for mortality and ICU admission during hospitalization.
    Results: The median follow-up time was 39 days (IQR, 30-50), with 66 deaths and 126 ICU admissions. After adjustment, compared with patients without CHB, the hazard ratio (HR) for ICU admission was 1.86 (95% CI: 1.05-3.31) for patients with HBeAg (+) CHB/infection. The HR for death was 3.19 (95% CI: 1.62-6.25) for patients with HBeAg (+) CHB/infection. The results for the mediating effect indicated that the total effect of HBeAg (+) CHB/infection on death/ICU stay was partially mediated by abnormal liver function, which accounted for 79.60% and 73.53%, respectively.
    Conclusion: Patients with COVID-19 coinfected with HBV at the HBeAg (+) CHB/infection stage have an increased risk of poor prognosis, and abnormal liver function partially mediates this increased risk of poor prognosis caused by the coinfection.
    Language English
    Publishing date 2022-04-26
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-022-00638-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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