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  1. Article ; Online: Giant gout stone with bone destruction in a Chinese man: A case report.

    Liu, Yuxi / Jiang, Rilei

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-04-22
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Multi-airport system flight slot optimization method based on absolute fairness.

    Li, Yafei / Liu, Yuxi

    Mathematical biosciences and engineering : MBE

    2023  Volume 20, Issue 10, Page(s) 17919–17948

    Abstract: With the rapid development of the civil aviation industry, the number of flights has increased rapidly. However, the availability of flight slot resources remains limited, and how to allocate flight slot resources effectively has been a hot research ... ...

    Abstract With the rapid development of the civil aviation industry, the number of flights has increased rapidly. However, the availability of flight slot resources remains limited, and how to allocate flight slot resources effectively has been a hot research topic in recent years. A comprehensive flight slot optimization method can significantly enhance the rationality of the allocation results. The effective allocation of flight slot is the key to improving the operational efficiency of the multi-airport system. We will optimize the flight schedule of the entire multi-airport system considering the fairness of each airport in it. The optimization results will provide an important reference for the reasonable allocation of flight slot within the multi-airport system. Based on the operation characteristics of the multi-airport system, we have established a multi-objective flight slot allocation optimization model. In this model, we set the airport capacity limit, shared waypoint capacity limit and aircraft turnaround time limit as the constraints. The optimization goal of the model is to minimize total flight schedule displacement and the maximum deviation of fairness from the absolute fairness. Gurobi solver is used to solve the model. We have innovatively incorporated the rolling capacity constraint method into our model to ensure more accurate flight slot allocation results. The Beijing-Tianjin-Hebei regional multi-airport system is selected as an example to verify the above model, and the flight slot optimization results have successfully met the fairness goal. The comparative analysis has demonstrated that the rolling capacity constraint method significantly improves the accuracy of solution results, leading to more stable flight slot allocation. The results also prove that the flight slot allocation method of multi-airport system based on absolute fairness of peak demand can improve the fairness of the allocation results. To achieve a higher level of fairness, we have found that the peak-demand based fairness method requires a smaller slot displacement compared to the non-peak demand-based method. Through the optimization of flight slot of the multi-airport system, the coordination between airports can be significantly improved. It can provide a new solution for the efficient operation of the multi-airport system.
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Digital Image Recognition Based on Improved Cognitive Neural Network.

    Liu, Yuxi

    Translational neuroscience

    2019  Volume 10, Page(s) 125–128

    Abstract: This paper presents an innovative cognitive neural network method application in digital image recognition. The following conclusion can be drawn. Each point of the graph is transformed, and the original color of the transformed new coordinates is given ... ...

    Abstract This paper presents an innovative cognitive neural network method application in digital image recognition. The following conclusion can be drawn. Each point of the graph is transformed, and the original color of the transformed new coordinates is given to the point. If after all the points have transformed, if there is a point and no point has converted to this point, the point is not given a color. Then this point will form a hole or a stripe, and the color is the color of the point initialization. The innovative method can effectively separate the digital image recognition signal from the mixed signal and maintain the waveform of the source signal with high accuracy, thus laying the foundation for the next step of recognition.
    Language English
    Publishing date 2019-04-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2019-0021
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  4. Article ; Online: The impact of carbon emissions from lag fertilization on wheat production.

    Rahim, Atif / Peng, Qianrui / Chen, Huashuai / Liu, Yuxi

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0299299

    Abstract: This study examines the influence of lag fertilization techniques on Pakistani wheat production, highlighting the need to understand and mitigate the environmental impacts of farming methods. The basic purpose of this study is to investigate the impact ... ...

    Abstract This study examines the influence of lag fertilization techniques on Pakistani wheat production, highlighting the need to understand and mitigate the environmental impacts of farming methods. The basic purpose of this study is to investigate the impact of CO2 emission from fertilization and other factors on wheat production in Pakistan, using a time series of data from 1990 to 2020. CO2 emission from fertilization (CO2EF) is estimated using the default values provided by the IPCC guidelines. The ARDL approach analyses the short-run and long-run effects of CO2EF, technology level, energy use, agricultural land, and agricultural labor on wheat production. The results show that all factors have significantly impacted wheat production in Pakistan at levels of 1% and 5% significance, both in the short and long run. These findings suggest that reducing CO2EF, technology level, energy use, agricultural land, and agricultural labor on wheat production can help to increase wheat production in Pakistan. The study also highlights the importance of adopting sustainable and efficient fertilization practices, exploring alternative fertilizers, and using crop rotation systems to mitigate the adverse effects of carbon emissions from nitrogen fertilization, energy use, and the use of technology. These measures can contribute to a more sustainable and climate-resilient agriculture sector in Pakistan.
    MeSH term(s) Triticum ; Carbon/analysis ; Carbon Dioxide/analysis ; Agriculture/methods ; Fertilization
    Chemical Substances Carbon (7440-44-0) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer.

    Zhang, Yin / Lindström, Sara / Kraft, Peter / Liu, Yuxi

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Importance: Early-onset cancer (diagnosed under 50 years of age) is associated with aggressive disease characteristics and its rising incidence is a global concern. The association between healthy lifestyle and early-onset cancer and whether it varies ... ...

    Abstract Importance: Early-onset cancer (diagnosed under 50 years of age) is associated with aggressive disease characteristics and its rising incidence is a global concern. The association between healthy lifestyle and early-onset cancer and whether it varies by common genetic variants is unknown.
    Objective: To examine the associations between genetic risk, lifestyle, and risk of early-onset cancers.
    Design setting and participants: We analyzed a prospective cohort of 66,308 white British participants who were under age 50 and free of cancer at baseline in the UK Biobank.
    Exposures: Sex-specific composite total cancer polygenic risk scores (PRSs), a breast cancer-specific PRS, and sex-specific health-associated lifestyle scores (HLSs, which summarize smoking status, body mass index [males only], physical activity, alcohol consumption, and diet).
    Main outcomes and measures: Hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset total and breast cancer.
    Results: A total of 1,247 incident invasive early-onset cancer cases (female: 820, male: 427, breast: 386) were documented. In multivariable-adjusted analyses with 2-year latency, higher genetic risk (highest vs. lowest tertile of PRS) was associated with significantly increased risks of early-onset total cancer in females (HR, 95% CI: 1.85, 1.50-2.29) and males (1.94, 1.45-2.59) as well as early-onset breast cancer in females (3.06, 2.20-4.25). An unfavorable lifestyle (highest vs. lowest category of HLS) was associated with higher risk of total cancer and breast cancer in females across genetic risk categories; the association with total cancer was stronger in the highest genetic risk category than the lowest: HRs in females and men were 1.85 (1.02, 3.36), 3.27 (0.78, 13.72) in the highest genetic risk category and 1.15 (0.44, 2.98), 1.16 (0.39, 3.40) in the lowest.
    Conclusions and relevance: Both genetic and lifestyle factors were independently associated with early-onset total and breast cancer risk. Compared to those with low genetic risk, individuals with a high genetic risk may benefit more from adopting a healthy lifestyle in preventing early-onset cancer.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.04.24305361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Spatio-Temporal Patterns and Driving Forces of Land Use in the Context of Urbanization in China: Evidence from Nanchang City.

    Liu, Yuxi / Huang, Cheng / Zhang, Lvshui

    International journal of environmental research and public health

    2023  Volume 20, Issue 3

    Abstract: Land use change has been one of the common problems in the context of urbanization in China. Social economy and land use interact with each other, and it is especially important for human society to adhere to sustainable development, and to deal with the ...

    Abstract Land use change has been one of the common problems in the context of urbanization in China. Social economy and land use interact with each other, and it is especially important for human society to adhere to sustainable development, and to deal with the contradictory relationship between the social-economic needs and land use change. The objectives of this study are: (1) Obtain time-series land-use classification data and its spatial distribution in Nanchang City; (2) Identify the characteristics and driving force of spatial-temporal land use changes in Nanchang City from 2000 to 2020; (3) Discuss the relationship between the urban expansion and social economy in Nanchang City. The results show that the spatial distribution of land use in Nanchang City has changed significantly from 2000 to 2020, and the largest area of land-use type in Nanchang City has been cropland. The cropland has continuously declined, and the urban area has increased significantly. A lot of cropland has been transformed into urban areas, and land use degree in Nanchang City has significantly increased. The spatial pattern of land use has greatly changed, and the city spatial pattern has become more aggregated, while the spatial distribution of cropland, forest and grassland has become more fragmented. Moreover, there has been an obvious correlation between social-economic development and the level of land use, and GDP has been the main driver of land use change. The central urban area of Nanchang city has been the main hotspot of land use change.
    MeSH term(s) Humans ; Urbanization ; Cities ; China ; Forests ; Sustainable Development ; Conservation of Natural Resources
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20032330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Germline Cancer Gene Expression Quantitative Trait Loci Are Associated with Local and Global Tumor Mutations.

    Liu, Yuxi / Gusev, Alexander / Kraft, Peter

    Cancer research

    2023  Volume 83, Issue 8, Page(s) 1191–1202

    Abstract: Somatic mutations drive cancer development and are relevant to patient responses to treatment. Emerging evidence shows that variations in the somatic genome can be influenced by the germline genetic background. However, the mechanisms underlying these ... ...

    Abstract Somatic mutations drive cancer development and are relevant to patient responses to treatment. Emerging evidence shows that variations in the somatic genome can be influenced by the germline genetic background. However, the mechanisms underlying these germline-somatic associations remain largely obscure. We hypothesized that germline variants can influence somatic mutations in a nearby cancer gene ("local impact") or a set of recurrently mutated cancer genes across the genome ("global impact") through their regulatory effect on gene expression. To test this hypothesis, tumor targeted sequencing data from 12,413 patients across 11 cancer types in the Dana-Farber Profile cohort were integrated with germline cancer gene expression quantitative trait loci (eQTL) from the Genotype-Tissue Expression Project. Variants that upregulate ATM expression were associated with a decreased risk of somatic ATM mutations across 8 cancer types. GLI2, WRN, and CBFB eQTL were associated with global tumor mutational burden of cancer genes in ovarian cancer, glioma, and esophagogastric carcinoma, respectively. An EPHA5 eQTL was associated with mutations in cancer genes specific to colorectal cancer, and eQTL related to expression of APC, WRN, GLI1, FANCA, and TP53 were associated with mutations in genes specific to endometrial cancer. These findings provide evidence that germline-somatic associations are mediated through expression of specific cancer genes, opening new avenues for research on the underlying biological processes.
    Significance: Analysis of associations between the germline genetic background and somatic mutations in patients with cancer suggests that germline variants can influence local and global tumor mutations by altering expression of cancer-related genes. See related commentary by Kar, p. 1165.
    MeSH term(s) Female ; Humans ; Quantitative Trait Loci ; Mutation ; Oncogenes ; Germ-Line Mutation ; Ovarian Neoplasms/genetics ; Gene Expression ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-2624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An algorithm combining sedimentation experiments for pipe erosion investigation

    Yao, Liming / Liu, Yuxi / Xiao, Zhongmin / Chen, Yang

    Energy. 20232023 May 07, Feb. 07, v. 270 p.126891-

    2023  

    Abstract: Hydraulic fracturing is an essential technology for continuously developing non-renewable energy, such as oil and gas. The erosion of solid-liquid two-phase flow in hydraulic fracturing is a theoretical problem that needs to be solved urgently. In the ... ...

    Abstract Hydraulic fracturing is an essential technology for continuously developing non-renewable energy, such as oil and gas. The erosion of solid-liquid two-phase flow in hydraulic fracturing is a theoretical problem that needs to be solved urgently. In the current computational fluid dynamics-discrete element method (CFD-DEM) research, we present calculation methods for the collision restitution coefficients of quartz particle in Newtonian fluids (1 mPa⋅s) and non-Newtonian fluids (10 mPa⋅s and 20 mPa⋅s). The influence of power-law fluid is considered in the algorithm, and the problem of particle penetration in the CFD-DEM method is optimized. These experimentally obtained collision restitution coefficients are incorporated into the optimized CFD-DEM method to consider the influence of fluid viscous forces on particle collisions. The accuracy of the numerical simulation method in this paper is verified by particle settlement and erosion experiments. The elbow erosion experiment is then used to validate the correctness of the erosion simulation. Finally, the erosion behavior of the fracturing pipe (elbow and tee junction) under different conditions is analyzed.
    Keywords algorithms ; energy ; mathematical models ; nonrenewable resources ; oils ; quartz ; Oil & gas ; Sand-carrying fracturing fluid ; Special-shaped pipe ; Particle collision ; CFD-DEM
    Language English
    Dates of publication 2023-0207
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2023.126891
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Determinants of subjective well-being among migrant and local elderly in China

    Chonghua Wan / Rassamee Sangthong / Liu Yuxi / Thammasin Ingviya

    BMJ Open, Vol 12, Iss

    a cross-sectional study

    2022  Volume 6

    Keywords Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Molecular insights into inhibiting effects of lignin on cellulase investigated by molecular dynamics simulation.

    Chen, Zhenjuan / Shi, Qingwen / Zhao, Tengfei / Liu, Yuxi / Hao, Jinhong / Li, Zhijian / Ning, Lulu

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–13

    Abstract: The hydrolysis of lignocellulose into fermentable monosaccharides using cellulases represents a critical stage in lignocellulosic bioconversion. However, the inactivation of cellulase in the presence of lignin is attributed to the high cost of biofinery. ...

    Abstract The hydrolysis of lignocellulose into fermentable monosaccharides using cellulases represents a critical stage in lignocellulosic bioconversion. However, the inactivation of cellulase in the presence of lignin is attributed to the high cost of biofinery. To address this challenge, a comprehensive investigation into the structure-function relationship underlying lignin-driven cellulase inactivation is essential. In this study, molecular docking and molecular dynamics (MD) simulations were employed to explore the impacts of lignin fragments on the catalytic efficiency of cellulase at the atomic level. The findings revealed that soluble lignin fragments and cellulose could spontaneously form stable complexes with cellulase, indicating a competitive binding scenario. The enzyme's structure remained unchanged upon binding to lignin. Furthermore, specific amino acid residues have been identified as involved in interactions with lignin and cellulose. Hydrophobic interactions were found to dominate the binding of lignin to cellulase. Based on the mechanisms underlying the interactions between lignin fragments and cellulase, decreased hydrophobicity and change in the charge of lignin may mitigate the inhibition of cellulase. Furthermore, site mutations and chemical modification are also feasible to improve the efficiency of cellulase. This study may contribute valuable insights into the design of more lignin-resistant enzymes and the optimization of lignocellulosic pretreatment technologies.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2328738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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