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Article: Studies of probe tip materials by atomic force microscopy: a review.

Xu, Ke / Liu, Yuzhe

2022 Volume 13, Page(s) 1256–1267

Abstract: As a tool that can test insulators' surface morphology and properties, the performance index of atomic force microscope (AFM) probes is the most critical factor in determining the resolution of microscopy, and the performance of probes varies in various ... ...

Abstract	As a tool that can test insulators' surface morphology and properties, the performance index of atomic force microscope (AFM) probes is the most critical factor in determining the resolution of microscopy, and the performance of probes varies in various modes and application requirements. This paper reviews the latest research results in metal, carbon nanotube, and colloidal probes and reviews their related methods and techniques, analyses the advantages and disadvantages of the improved probes compared with ordinary probes by comparing the differences in spatial resolution, sensitivity, imaging, and other performance aspects, and finally provides an outlook on the future development of AFM probes. This paper promotes the development of AFM probes in the direction of new probes and further promotes the broader and deeper application of scanning probe microscope (SPM).
Language	English
Publishing date	2022-11-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2583584-1
ISSN	2190-4286
ISSN	2190-4286
DOI	10.3762/bjnano.13.104
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Big Data in Stroke: How to Use Big Data to Make the Next Management Decision.

Liu, Yuzhe / Luo, Yuan / Naidech, Andrew M

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2023 Volume 20, Issue 3, Page(s) 744–757

Abstract: The last decade has seen significant advances in the accumulation of medical data, the computational techniques to analyze that data, and corresponding improvements in management. Interventions such as thrombolytics and mechanical thrombectomy improve ... ...

Abstract	The last decade has seen significant advances in the accumulation of medical data, the computational techniques to analyze that data, and corresponding improvements in management. Interventions such as thrombolytics and mechanical thrombectomy improve patient outcomes after stroke in selected patients; however, significant gaps remain in our ability to select patients, predict complications, and understand outcomes. Big data and the computational methods needed to analyze it can address these gaps. For example, automated analysis of neuroimaging to estimate the volume of brain tissue that is ischemic and salvageable can help triage patients for acute interventions. Data-intensive computational techniques can perform complex risk calculations that are too cumbersome to be completed by humans, resulting in more accurate and timely prediction of which patients require increased vigilance for adverse events such as treatment complications. To handle the accumulation of complex medical data, a variety of advanced computational techniques referred to as machine learning and artificial intelligence now routinely complement traditional statistical inference. In this narrative review, we explore data-intensive techniques in stroke research, how it has informed the management of stroke patients, and how current work could shape clinical practice in the future.
MeSH term(s)	Humans ; Artificial Intelligence ; Big Data ; Stroke/therapy ; Stroke/etiology ; Machine Learning ; Fibrinolytic Agents
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1007/s13311-023-01358-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Short tandem repeats of human genome are intrinsically unstable in cultured cells in vivo.

Liu, Yuzhe / Li, Jinhuan / Wu, Qiang

Gene

2023 Volume 877, Page(s) 147539

Abstract: Short tandem repeats (STRs) are a class of abundant structural or functional elements in the human genome and exhibit a polymorphic nature of repeat length and genetic variation within human populations. Interestingly, STR expansions underlie about 60 ... ...

Abstract	Short tandem repeats (STRs) are a class of abundant structural or functional elements in the human genome and exhibit a polymorphic nature of repeat length and genetic variation within human populations. Interestingly, STR expansions underlie about 60 neurological disorders. However, "stutter" artifacts or noises render it difficult to investigate the pathogenesis of STR expansions. Here, we systematically investigated STR instability in cultured human cells using GC-rich CAG and AT-rich ATTCT tandem repeats as examples. We found that triplicate bidirectional Sanger sequencing with PCR amplification under proper conditions can reliably assess STR length. In addition, we found that next-generation sequencing with paired-end reads bidirectionally covering STR regions can accurately and reliably assay STR length. Finally, we found that STRs are intrinsically unstable in cultured human cell populations and during single-cell cloning. Our data suggest a general method for accurately and reliably assessing STR length and have important implications in investigating pathogenesis of STR expansion diseases.
MeSH term(s)	Humans ; Genome, Human ; Microsatellite Repeats/genetics ; High-Throughput Nucleotide Sequencing/methods ; Polymerase Chain Reaction
Language	English
Publishing date	2023-06-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147539
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Zs.A 1357: Show issues

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Article ; Online: Short tandem repeats of human genome are intrinsically unstable in cultured cells in vivo

Liu, Yuzhe / Li, Jinhuan / Wu, Qiang

Gene. 2023 Aug., v. 877 p.147539-

2023

Abstract	Short tandem repeats (STRs) are a class of abundant structural or functional elements in the human genome and exhibit a polymorphic nature of repeat length and genetic variation within human populations. Interestingly, STR expansions underlie about 60 neurological disorders. However, “stutter” artifacts or noises render it difficult to investigate the pathogenesis of STR expansions. Here, we systematically investigated STR instability in cultured human cells using GC-rich CAG and AT-rich ATTCT tandem repeats as examples. We found that triplicate bidirectional Sanger sequencing with PCR amplification under proper conditions can reliably assess STR length. In addition, we found that next-generation sequencing with paired-end reads bidirectionally covering STR regions can accurately and reliably assay STR length. Finally, we found that STRs are intrinsically unstable in cultured human cell populations and during single-cell cloning. Our data suggest a general method for accurately and reliably assessing STR length and have important implications in investigating pathogenesis of STR expansion diseases.
Keywords	genes ; genetic variation ; humans ; pathogenesis ; Short tandem repeats (STRs) ; “Stutter” noises ; DNA polymerase slippage ; STR instability ; Next-generation sequencing ; STRs ; bp ; ALS ; HD ; SCA10 ; SCA12 ; ATXN10 ; PPP2R2B ; DMSO ; NGS ; ICE
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147539
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: 6-gingerol ameliorates ectopic lipid accumulation in skeletal muscle of middle-aged rats induced by fructose

LIU Yuzhe / ZHAN Quancao / ZENG Yan

Di-san junyi daxue xuebao, Vol 44, Iss 8, Pp 765-

2022 Volume 773

Abstract: Objective To investigate the effect and mechanism of 6-gingerol on improving ectopic lipid accumulation in skeletal muscle of middle-aged rats induced by fructose. Methods A total of 24 male SD rats (15 months old) were randomly and equally divided into ... ...

Abstract	Objective To investigate the effect and mechanism of 6-gingerol on improving ectopic lipid accumulation in skeletal muscle of middle-aged rats induced by fructose. Methods A total of 24 male SD rats (15 months old) were randomly and equally divided into 3 groups: control group (CON, with normal drinking water), model group (FRU, with 10% fructose water) and 6-gingerol group (GIN, with 10% fructose water+0.2 mg/kg 6-gingerol by gavage). Gavage was performed once a day for consecutive 49 days. Levels of plasma glucose (GLU), triglyceride (TG) and skeletal muscle TG were measured by GOD-PAP method; lipid accumulation in skeletal muscle was detected by oil red O staining (ORO); content of plasma insulin was determined by ELISA; protein levels of AMP-activated protein kinase (AMPK), p-AMPK, acetyl-coa carboxylase (ACC), p-ACC, carnitine palmitoyltransferase 1A (CPT1A), peroxisome proliferator activated receptor alpha (PPARα) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) in skeletal muscle were examined with Western blotting. L6 rat skeletal muscle cells were divided into 3 groups: control group (Con), model group (FRU, treated with 25 mmol/L fructose for 24 h) and 6-gingerol group (GIN, treated with 25 mmol/L fructose+10 μmol/L 6-gingerol for 24 h). TG level and lipid accumulation in L6 cells were determined by GOD-PAP and ORO staining, respectively. The expression of AMPK, p-AMPK, ACC, p-ACC and CPT1A was examined by Western blotting. Results As compared with control group, the rat model group had higher levels of plasma GLU, TG and insulin (P < 0.05), elevated TG content in both skeletal muscle tissues and cells (P < 0.05), as well as notable lipid accumulation in skeletal muscle tissues and cells (P < 0.05). Western blotting showed that the p-AMPK/AMPK ratio, p-ACC/ACC ratio, and the protein levels of CPT1A, PPARα and PGC1α were all decreased in the model group (P < 0.05). However, 6-gingerol significantly reduced the levels of plasma GLU, TG and insulin (P < ...
Keywords	6-gingerol ; fructose ; middle-aged rats ; skeletal muscle ; ectopic lipid accumulation ; Medicine (General) ; R5-920
Subject code	630
Language	Chinese
Publishing date	2022-04-01T00:00:00Z
Publisher	Editorial Office of Journal of Third Military Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effects of Ambient Temperature and Atmospheric Humidity on the Diffusion Dynamics of Hydrogen Fluoride Gas Leakage Based on the Computational Fluid Dynamics Method.

Zhou, Zhengqing / Liu, Yuzhe / Jiang, Huiling / Bai, Zhiming / Sun, Lingxia / Liu, Jia / Zhao, Wenwen

Toxics

2024 Volume 12, Issue 3

Abstract: In order to investigate the impact of environmental temperature and atmospheric humidity on the leakage and diffusion of hydrogen fluoride (HF) gas, this study focused on the real scenario of an HF chemical industrial park. Based on the actual dispersion ...

Abstract	In order to investigate the impact of environmental temperature and atmospheric humidity on the leakage and diffusion of hydrogen fluoride (HF) gas, this study focused on the real scenario of an HF chemical industrial park. Based on the actual dispersion scenario of HF gas, a proportionally scaled-down experimental platform for HF gas leakage was established to validate the accuracy and feasibility of numerical simulations under complex conditions. Using the validated model, the study calculated the complex scenarios of HF leakage and diffusion within the temperature range of 293 K to 313 K and the humidity range of 0% to 100%. The simulation results indicated that different environmental temperatures had a relatively small impact on the hazardous areas (the lethal area, severe injury area, light injury area, and maximum allowable concentration (MAC) area) formed by HF gas leakage. At 600 s of dispersion, the fluctuation range of hazardous area sizes under different temperature conditions was between 3.11% and 13.07%. In contrast to environmental temperature, atmospheric relative humidity had a more significant impact on the dispersion trend of HF leakage. Different relative humidity levels mainly affected the areas of the lethal zone, light injury zone, and MAC zone. When HF continued to leak and disperse for 600 s, compared to 0% relative humidity, 100% relative humidity reduced the lethal area by 35.7%, while increasing the light injury area and MAC area by 27.26% and 111.6%, respectively. The impact on the severe injury area was relatively small, decreasing by 1.68%. The results of this study are crucial for understanding the dispersion patterns of HF gas under different temperature and humidity conditions.
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12030184
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Robust point light source calibration method for near-field photometric stereo using feature points selection.

Ma, Long / Liu, Xu / Liu, Yuzhe / Pei, Xin / Guo, Shengwei

Applied optics

2023 Volume 62, Issue 36, Page(s) 9512–9522

Abstract: In this paper, we present a robust method for nonisotropic point light source calibration through feature points selection. By analyzing the relationship between the observed surface and its image intensity under near-field lighting, the feature points ... ...

Abstract	In this paper, we present a robust method for nonisotropic point light source calibration through feature points selection. By analyzing the relationship between the observed surface and its image intensity under near-field lighting, the feature points selection method is first developed to effectively address the noisy observations and improve calibration robustness. Afterward, to enhance efficiency and accuracy of the calibration, a cost function of
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.505234
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Finite element evaluation of an American football helmet featuring liquid shock absorbers for protecting against concussive and subconcussive head impacts.

Cecchi, Nicholas J / Vahid Alizadeh, Hossein / Liu, Yuzhe / Camarillo, David B

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1160387

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1160387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High Performance and Stable Organic Solar Cells Fabricated by Y-Series Small Molecular Materials as the Interfacial Modified Layer.

Liu, Yuzhe / Zhang, Dayong / Yang, Genjie / Wang, Rui / Yu, Junsheng

ACS applied materials & interfaces

2022 Volume 14, Issue 32, Page(s) 36910–36917

Abstract: The organic solar cell (OSC) has received tremendous consideration for the impressive increased power conversion efficiency (PCE) from 11% to over 18% in the last decade, but another main parameter, the stability, still needs further study to meet the ... ...

Abstract	The organic solar cell (OSC) has received tremendous consideration for the impressive increased power conversion efficiency (PCE) from 11% to over 18% in the last decade, but another main parameter, the stability, still needs further study to meet the requirements of commercialization. Generally, the inverted structure device shows more stability than the conventional one owing to the structure characteristics, but even so, the performance and stability of the OSC device still need further improvement because of some undesirable contact between the electron transport layer (typically transition metal oxide like ZnO) and the active layer. Here, three Y-series small molecular acceptor materials (Y6, BTP-eC9, and L8-BO) are used as an interfacial modified layer (IML), which could optimize the interfacial characterization of the devices and thus enhance both the performance and stability. As a result, the insertion of the IML improved the interlayer charge transport capacity by passivating the surface of ZnO, leading to the enhancement of short circuit current density (
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c09248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Planning of ecologically suitable areas for Ligusticum chuanxiong under background of soil cadmium pollution].

He, Ping / Li, Jia-Ying / Liu, Yu-Zhe / Meng, Fan-Yun

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 5, Page(s) 1196–1204

Abstract: Chuanxiong Rhizoma is a traditional Chinese medicinal material mainly produced in Sichuan and Chongqing of China. In recent years, the cadmium content in Chuanxiong Rhizoma produced in most of the genuine producing areas has exceeded the standard, which ... ...

Abstract	Chuanxiong Rhizoma is a traditional Chinese medicinal material mainly produced in Sichuan and Chongqing of China. In recent years, the cadmium content in Chuanxiong Rhizoma produced in most of the genuine producing areas has exceeded the standard, which makes Chuanxiong Rhizoma difficult to be exported. To solve the problem of excessive cadmium content in soil, this study employed the MaxEnt model to simulate the potential geographic distribution of Ligusticum chuanxiong and evaluate important environmental factors, and re-plan its ecologically suitable areas based on the mineral distribution characteristics and soil cadmium pollution status. The results showed that the places suitable for L. chuanxiong growing covered an area of 335 523.69 km~2, mainly in central and eastern Sichuan, southern Shaanxi and most parts of Chongqing. Among them, the highly suitable areas of L. chuanxiong were mainly concentrated in Chengdu, Ya'an, Deyang, and Mianyang. Solar radiation, annual precipitation, and annual range of temperature were evaluated as important variables affecting the distribution of L. chuanxiong, with the contribution rates of 62.3%, 13.3%, and 6.8%, respectively. In addition, Qionglai county, Chongqing county, Mianyang city(Youxian district and Fucheng district), Qingchuan county, and Xinjin county were classified into the first-class ecologically suitable zone, covering a total area of 2 768.87 km~2. The se-cond-class ecologically suitable zone was even wider, involving such counties as Tongjiang county, Renshou county, Jianyang county, and Nanjiang county, and the total area reached 43 616.92 km~2. The re-planning of the ecologically suitable areas for L. chuanxiong has provided strong data support for the cultivation and resource development of L. chuanxiong and also new ideas for solving the problem of excessive cadmium content in L. chuanxiong.
MeSH term(s)	Cadmium/toxicity ; Environmental Pollution ; Ligusticum ; Rhizome ; Soil
Chemical Substances	Soil ; Cadmium (00BH33GNGH)
Language	Chinese
Publishing date	2022-03-28
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20211222.101
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