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Article ; Online: Notice of Retraction: Lin HX et al. Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial. JAMA Intern Med. 2024;184(3):291-299.

Liu, Zhao

2024

Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article ; Comment ; Retraction of Publication
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2024.1125
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Article: Mapping the research trends of third language acquisition: A bibliometric analysis based on Scopus.

Liu, Zhao

Frontiers in psychology

2022 Volume 13, Page(s) 1021517

Abstract: L3 acquisition is gaining prominence in the academic community. The cardinal aim of this study is to conduct a bibliometric analysis of research on L3 acquisition. 425 documents from the Scopus database were analyzed with Bibliometrix. To gain a general ... ...

Abstract	L3 acquisition is gaining prominence in the academic community. The cardinal aim of this study is to conduct a bibliometric analysis of research on L3 acquisition. 425 documents from the Scopus database were analyzed with Bibliometrix. To gain a general and systematic overview of research on L3 acquisition, we grounded our study on three main levels of bibliometric analysis: performance analysis, collaboration analysis, and thematic map. By doing so, we identified the most influential sources, authors, affiliations, countries, and documents, the scientific network among different constituents, as well as the evolution of research trends. The results suggest that L3 acquisition has experienced three periods: initial phase (1984-2008), development phase (2009-2014), and burst phase (2015-2022). The results also indicate that: (1) The
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.1021517
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prognosis and therapy in thyroid cancer by gene signatures related to natural killer cells.

Jin, Zhen / Han, Yadong / Zhang, Jiaxin / Liu, Zhao / Li, Ran / Liu, Zhao

The journal of gene medicine

2024 Volume 26, Issue 1, Page(s) e3657

Abstract: Background: Natural killer (NK) cells are crucial to cancer development and prognosis. However, the role of NK cell-related genes in immunotherapy and the tumor immune microenvironment (TIME) is not well understood. This study aimed to develop reliable ... ...

Abstract	Background: Natural killer (NK) cells are crucial to cancer development and prognosis. However, the role of NK cell-related genes in immunotherapy and the tumor immune microenvironment (TIME) is not well understood. This study aimed to develop reliable risk signatures associated with NK cell-related genes for predicting thyroid cancer (THCA). Methods: The single-cell RNA sequencing (scRNA-seq) data from seven THCA samples (GSE184362) and bulk-RNA-seq data of 502 THCA patients (TCGA-THCA) were included. The scRNA-seq data was analyzed using the "Seurat" R package to identify differentially expressed genes in NK cells. The clustering analysis was carried out using the R package "ConsensusClusterPlus". The gene set variation analysis (GSVA) algorithm was applied to assess the variations in biological pathways among subtypes. The ESTIMATE algorithm was utilized to calculate the scores for stromal, immune and estimate variables. In addition, we used the single sample Gene Set Enrichment Analysis and CIBERSORT algorithms to assess the degree to which immune cells and pathways related to immunity were enriched based on the meta-cohort. In the TCGA-THCA cohort, the "glmnet" R package was used for the gene selection, and LASSO Cox analysis was used to construct prognostic features. The "maftools" R package was used to examine the somatic mutation landscape of THCA in both low- and high-risk groups. Results: One-hundred and eighty-five NK cell marker genes were screened, and nine genes were associated with the THCA prognosis. KLF2, OSTF1 and TAPBP were finally identified and constructed a risk signature with significant prognostic value. KLF2 and OSTF1 were protective genes, and TAPBP was a risk gene. Patients at high risk had a considerably lower overall survival compared with those at low risk. Mutations in the TCGA-THCA cohort were predominantly C > T. Increased tumor mutation burden (TMB) levels were linked to overall survival. The low-risk H-TMB+ group had a better prognosis, while the high-risk L-TMB+ group had the worst prognosis. Conclusion: Natural killer cell-related genes KLF2, OSTF1 and TAPBP were used to develop a novel prognostic risk signature, offering a new perspective on the prognosis and treatment of THCA.
MeSH term(s)	Humans ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/therapy ; Immunotherapy ; Killer Cells, Natural ; Algorithms ; Cluster Analysis ; Tumor Microenvironment/genetics
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.3657
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Article ; Online: The impact of population characteristics on transportation CO

Cao, Puju / Liu, Zhao

Environmental science and pollution research international

2023 Volume 31, Issue 7, Page(s) 10148–10167

Abstract: Reducing transportation ... ...

Abstract	Reducing transportation CO
MeSH term(s)	Humans ; Vehicle Emissions ; Carbon Dioxide/analysis ; China ; Greenhouse Gases ; Economic Development ; Transportation ; Carbon
Chemical Substances	Vehicle Emissions ; Carbon Dioxide (142M471B3J) ; Greenhouse Gases ; Carbon (7440-44-0)
Language	English
Publishing date	2023-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-26465-9
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Article ; Online: Transportation infrastructure and eco-environmental quality: Evidence from China's high-speed rail.

Wei, Lan-Ye / Liu, Zhao

PloS one

2023 Volume 18, Issue 8, Page(s) e0290840

Abstract: Ecological civilization construction is China's national development strategy, and improving the urban eco-environmental quality is the key to accelerating this strategy, while the high-speed rail (HSR) opening is an important factor affecting the urban ... ...

Abstract	Ecological civilization construction is China's national development strategy, and improving the urban eco-environmental quality is the key to accelerating this strategy, while the high-speed rail (HSR) opening is an important factor affecting the urban eco-environmental quality. Using panel data of 290 cities in China from 2004 to 2020, this study explores the impact of HSR opening on urban eco-environmental quality and its heterogeneity from the perspective of direct impact and interaction between HSR connected cities. Compared with cities without HSR service, the eco-environmental quality of cities with HSR service has significantly increased by 0.023 standard deviations, which is about 4.11% of the total change in urban eco-environmental quality in the same period. Second, there is an inverted U-shaped relationship between eco-environmental quality and urban space expansion. Third, the impact of HSR on eco-environmental quality is heterogeneous, mainly manifested in different cities and urban agglomerations. It means that the government should focus on the differences in the economic foundation and development characteristics of various regions, steadily push forward the construction and operation of the HSR, and speed up the renovation of existing lines to help the green development of cities. The research results provide a policy basis for the government to handle the relationship between infrastructure construction and eco-environmental quality, and effectively promote green sustainable development.
MeSH term(s)	China ; Cities ; Civilization ; Government ; Orientation, Spatial
Language	English
Publishing date	2023-08-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0290840
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Article ; Online: Sortilin inhibition in microglial cells cannot alleviate ischemia and hypoxia-induced neuronal injury in co-culture.

Long, Shuang / Liu, Zhao / Wang, Yan

Neuroreport

2024 Volume 35, Issue 5, Page(s) 320–327

Abstract: Sortilin is a single-pass type I transmembrane protein which can bind to various cargo proteins, regulating their surface location, secretion, or degradation in lysosomes. In our previous study, we found that sortilin can regulate progranulin expression ... ...

Abstract	Sortilin is a single-pass type I transmembrane protein which can bind to various cargo proteins, regulating their surface location, secretion, or degradation in lysosomes. In our previous study, we found that sortilin can regulate progranulin expression by transporting it to lysosomes and reduce neuronal cell injury in hypoxia-ischemia, but the expression and function of sortilin in microglial cells during hypoxia-ischemia are unknown. The purpose of this study was to further investigate the function of sortilin in microglial cells and its effect on neuron cells. In rat BV2 microglial cells, sortilin was knocked down by lentivirus. After oxygen-glucose deprivation/reperfusion (OGD/R), expression of sortilin, progranulin (PGRN) and JNK pathway was detected by western blot, immunofluorescence was used to show the localization of PGRN, secretion of TNFα/IL-6 was measured by Elisa. Then co-culture microglial cells with neuron cells during hypoxia-ischemia and detected the neuron injury by CCK-8 and TUNEL. The expression of sortilin, mature and cleaved PGRN were all increased after OGD/R in microglial cells. Furthermore, sortilin inhibition accompany with less PGRN localization in lysosomes and more mature and less cleaved PGRN expression in microglial cells. Sortilin inhibition also can reduce the inflammatory response in microglial cells, but it does not alleviate neuronal injury in co-culture. This study demonstrated that sortilin can regulate the expression of PGRN and reduce the inflammatory response in microglial cells. However, only inhibiting sortilin in microglial cells did not have an impact on the survival of neurons during ischemia-hypoxia.
MeSH term(s)	Rats ; Animals ; Progranulins/metabolism ; Microglia ; Coculture Techniques ; Hypoxia/metabolism ; Adaptor Proteins, Vesicular Transport/metabolism ; Neurons/metabolism ; Ischemia/metabolism ; Oxygen/metabolism ; Glucose/metabolism ; Reperfusion Injury/metabolism
Chemical Substances	Progranulins ; sortilin (Z020Y8WIJ4) ; Adaptor Proteins, Vesicular Transport ; Oxygen (S88TT14065) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1049746-8
ISSN	1473-558X ; 0959-4965
ISSN (online)	1473-558X
ISSN	0959-4965
DOI	10.1097/WNR.0000000000002002
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Article ; Online: An anti-tumor protein PFAP specifically interacts with cholesterol-enriched membrane domains of A549 cells and induces paraptosis and endoplasmic reticulum stress.

Liu, Meng-Han / Liu, Zhao-Kun / Liu, Fang

International journal of biological macromolecules

2024 Volume 264, Issue Pt 2, Page(s) 130690

Abstract: Nowadays, non-small cell lung cancer (NSCLC) is still one of the most life-threatening diseases in the world. In previous studies, a fungal protein PFAP with anti-NSCLC properties was isolated and identified from Pleurotus ferulae lanzi. In this study, ... ...

Abstract	Nowadays, non-small cell lung cancer (NSCLC) is still one of the most life-threatening diseases in the world. In previous studies, a fungal protein PFAP with anti-NSCLC properties was isolated and identified from Pleurotus ferulae lanzi. In this study, the amino acid sequence of PFAP was analyzed and found to be highly homologous to the aegerolysin family. PFAP, like other members of the aegerolysin family, specifically recognizes lipid raft domains rich in cholesterol and sphingomyelin, which is probably its specific anti-tumor mechanism. Previous studies have shown that PFAP can induce AMPK-mediated autophagy and G1-phase cell cycle arrest in A549 lung cancer cells. This study further revealed that PFAP can also induce paraptosis and endoplasmic reticulum stress (ERS) in A549 cells in vitro by targeting AMPK. PFAP induces multi-pathway death of A549 cells, and thus demonstrates its potential value for developing new drugs for NSCLC.
MeSH term(s)	Humans ; A549 Cells ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Cell Line, Tumor ; Apoptosis ; Paraptosis ; AMP-Activated Protein Kinases ; Endoplasmic Reticulum Stress
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2024-03-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130690
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Article: Landscape design of agricultural theme park based on ecological concept

Liu, Zhao

Acta agriculturæ Scandinavica. 2021 Aug. 31, v. 71, no. 9

2021

Abstract: Chinese farming culture mostly starts from the angles of geography, history, sociology and folklore. However, there are relatively few systematic studies on farming culture from the perspective of landscape science, and the research direction mainly ... ...

Abstract	Chinese farming culture mostly starts from the angles of geography, history, sociology and folklore. However, there are relatively few systematic studies on farming culture from the perspective of landscape science, and the research direction mainly focuses on the concept, type, characteristics, function, and operation mode of farming culture. Under the background of the concept of agricultural ecology, it is necessary to improve the effect of the landscape design of agricultural theme parks. With the support of ecological concepts, this paper analyses the background requirements, public needs, design principles, design objectives, design essentials, and design elements of the agricultural theme park design based on the sustainable development and agricultural economic concepts. Moreover, this paper combines case studies to analyse the landscape design of agricultural theme park. From the design effect, it can be seen that the design method proposed in this paper has a certain effect, which can provide a reference for the subsequent landscape design of agricultural theme park.
Keywords	ecology ; geography ; landscapes ; landscaping ; sociology ; sustainable development
Language	English
Dates of publication	2021-0831
Size	p. 794-805.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	32458-9
ISSN	1651-1913 ; 0906-4710
ISSN (online)	1651-1913
ISSN	0906-4710
DOI	10.1080/09064710.2021.1949485
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Long-Term Changes in Water Body Area Dynamic and Driving Factors in the Middle-Lower Yangtze Plain Based on Multi-Source Remote Sensing Data

Wei Wang / Hongfen Teng / Liu Zhao / Lingyu Han

Remote Sensing, Vol 15, Iss 1816, p

2023 Volume 1816

Abstract: The accurate monitoring of long-term spatial and temporal changes in open-surface water bodies offers important guidance for water resource security and management. In the middle and lower reaches of the Yangtze River, the monitoring of water body ... ...

Abstract	The accurate monitoring of long-term spatial and temporal changes in open-surface water bodies offers important guidance for water resource security and management. In the middle and lower reaches of the Yangtze River, the monitoring of water body changes is especially critical due to the dense population and drastic climate change. Due to the complexity of the physical environment in which the water bodies are located, the advantages and disadvantages of various water body detection rules can vary in large-scale areas. In this paper, we use Landsat 5/7/8 data to extract the area of water bodies in the study area and analyze their spatial and temporal trends from 1984 to 2020 using the Google Earth Engine (GEE) platform. We propose an improved water body extraction rule based on an existing multi-indicator water body algorithm that combines impervious surface data and digital elevation model data. In this study, the performance of the improved algorithm was cross-validated using seven other water body indicator algorithms, and the results showed the following: (1) the rule accurately retained information about the water body while minimizing the interference of shadows on the extracted water body. (2) On the annual scale from 1984 to 2020, the open-surface water body dataset extracted using this improved rule showed that the turning point for the area of each water body type was 2011, with an overall decreasing trend in area before 2011 and an increasing trend in area after 2011, with the exception of special years, such as 1998. (3) The driving mechanism analysis showed that, overall, precipitation was positively correlated with the water body area and temperature was negatively correlated with the water body area. Additionally, human activities can have an impact on surface water dynamics. The key influencing factors are diverse for each water body type; it was found that seasonal water bodies were correlated with precipitation and paddy fields and permanent water bodies were correlated with temperature and ...
Keywords	open-surface water bodies ; water indices ; shadow ; water frequency ; the Middle-Lower Yangtze Plain (MLYP) ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Accident Liability Determination of Autonomous Driving Systems Based on Artificial Intelligence Technology and Its Impact on Public Mental Health.

Xiao, Yineng / Liu, Zhao

publication RETRACTED

Journal of environmental and public health

2022 Volume 2022, Page(s) 2671968

Abstract: With the rise of self-driving technology research, the establishment of a scientific and perfect legal restraint and supervision system for self-driving vehicles has been gradually paid attention to. The determination of tort liability subject of traffic ...

Abstract	With the rise of self-driving technology research, the establishment of a scientific and perfect legal restraint and supervision system for self-driving vehicles has been gradually paid attention to. The determination of tort liability subject of traffic accidents of self-driving cars is different from that of ordinary motor vehicle traffic accident tort, which challenges the application of traditional fault liability and product liability. The tort issue of self-driving cars should be discussed by distinguishing two kinds of situations: assisted driving cars and highly automated driving, and typological analysis of each situation is needed. When the car is in the assisted driving mode, the accident occurs due to the quality defect or product damage of the self-driving car, and there is no other fault cause; then, the producer and seller of the car should bear the product liability according to the no-fault principle; if the driver has a subjective fault and fails to exercise a high degree of care; the owner and user of the car should bear the fault liability. This paper analyzes the study of the impact of autonomous driving public on public psychological health, summarizes the key factors affecting the public acceptance of autonomous driving, and dissects its impact on public psychological acceptance. In order to fully study the responsibility determination of autonomous driving system accidents and their impact on public psychological health, this paper proposes an autonomous driving risk prediction model based on artificial intelligence technology, combined with a complex intelligent traffic environment vehicle autonomous driving risk prediction method, to complete the risk target detection. The experimental results in the relevant dataset demonstrate the effectiveness of the proposed method.
MeSH term(s)	Accidents, Traffic ; Artificial Intelligence ; Automobile Driving/psychology ; Mental Health ; Technology
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/2671968
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