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  1. Article ; Online: Identification of Active Components for Sports Supplements: Machine Learning-Driven Classification and Cell-Based Validation.

    Ji, Xiaoning / Li, Qiuyun / Liu, Zhaoping / Wu, Weiliang / Zhang, Chaozheng / Sui, Haixia / Chen, Min

    ACS omega

    2024  Volume 9, Issue 10, Page(s) 11347–11355

    Abstract: The identification of active components is critical for the development of sports supplements. However, high-throughput screening of active components remains a challenge. This study sought to construct prediction models to screen active components from ... ...

    Abstract The identification of active components is critical for the development of sports supplements. However, high-throughput screening of active components remains a challenge. This study sought to construct prediction models to screen active components from herbal medicines via machine learning and validate the screening by using cell-based assays. The six constructed models had an accuracy of >0.88. Twelve randomly selected active components from the screening were tested for their active potency on C2C12 cells, and 11 components induced a significant increase in myotube diameters and protein synthesis. The effect and mechanism of luteolin among the 11 active components as potential sports supplements were then investigated by using immunofluorescence staining and high-content imaging analysis. It showed that luteolin increased the skeletal muscle performance via the activation of PGC-1α and MAPK signaling pathways. Thus, high-throughput prediction models can be effectively used to screen active components as sports supplements.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Electrochemical Atomic Force Microscopy Study on the Dynamic Evolution of Lithium Deposition.

    Shi, Xixiu / Yang, Jingru / Wang, Wenyang / Liu, Zhaoping / Shen, Cai

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: Lithium metal is one of the most promising anode materials for lithium-ion batteries; however, lithium dendrite growth hinders its large-scale development. So far, the dendrite formation mechanism is unclear. Herein, the dynamic evolution of lithium ... ...

    Abstract Lithium metal is one of the most promising anode materials for lithium-ion batteries; however, lithium dendrite growth hinders its large-scale development. So far, the dendrite formation mechanism is unclear. Herein, the dynamic evolution of lithium deposition in etheryl-based and ethylene carbonate (EC)-based electrolytes was obtained by combining an in situ electrochemical atomic force microscope (EC-AFM) with an electrochemical workstation. Three growth modes of lithium particles are proposed: preferential, merged, and independent growth. In addition, a lithium deposition schematic is proposed to clearly describe the morphological changes in lithium deposition. This schematic shows the process of lithium deposition, thus providing a theoretical basis for solving the problem of lithium dendrite growth.
    Language English
    Publishing date 2023-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16062278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 Outbreaks Linked to Imported Frozen Food in China: Status and Challege.

    Wang, Jiahui / Li, Fengqin / Liu, Zhaoping / Li, Ning

    China CDC weekly

    2022  Volume 4, Issue 22, Page(s) 483–487

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA contamination was reported on China's imported frozen foods and packaging materials. However, there was no evidence of this disease initiated by environment-to-human transmission until the ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA contamination was reported on China's imported frozen foods and packaging materials. However, there was no evidence of this disease initiated by environment-to-human transmission until the outbreak of coronavirus disease 2019 (COVID-19) in Beijing in June 2020. This article aimed to analyze and summarize COVID-19 outbreaks related to cold-chain foods to provide a scientific basis for tracing the epidemiological trajectory of the pandemic, providing risk assessments, and mitigation policies. Overall, 37 COVID-19 outbreaks and 5,741 infected cases were reported within the study period. It was found that 7 outbreaks and 689 cases were linked to imported frozen foods. The first index case among the 7 outbreaks was exposed to SARS-CoV-2-contaminated outer packaging of frozen food, triggering the subsequent community transmission. This study supported the speculation that cold-chain foods act as a pathway for SARS-CoV-2 and might present a risk for virus transmission between countries and regions. Handlers and processors exposed to the imported frozen foods should be effectively self-protected, daily monitored for clinical manifestations of COVID-19, and tested for SARS-CoV-2 nucleic acid at regular intervals.
    Language English
    Publishing date 2022-06-22
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2022.072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tuning Local Structural Configurations to Improve Oxygen-Redox Reversibility of Li-Rich Layered Oxides.

    Gong, Yan / Li, Xiao / Zeng, Lingcai / Huang, Yuanfei / Qiu, Bao / Liu, Zhaoping

    The journal of physical chemistry letters

    2023  Volume 14, Issue 19, Page(s) 4575–4582

    Abstract: Li-rich layered oxides (LLOs) are regarded as one of the most desirable cathode materials due to their high specific capacity. Nevertheless, the irreversible oxygen release associated with low oxygen stability prevents their widespread application. ... ...

    Abstract Li-rich layered oxides (LLOs) are regarded as one of the most desirable cathode materials due to their high specific capacity. Nevertheless, the irreversible oxygen release associated with low oxygen stability prevents their widespread application. Herein, an improved oxygen redox reversibility was achieved by constructing Ni
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c00616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Growth of Low-Defect Nitrogen-Doped Graphene Film Using Condensation-Assisted Chemical Vapor Deposition Method.

    Guo, Zhichao / Ye, Zhenya / Yin, Mengqing / Dai, Shixun / Zhang, Xiaohui / Wang, Wei / Liu, Zhaoping

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 3

    Abstract: It is significantly important to modulate the electrical properties of graphene films through doping for building desired electronic devices. One of the effective doping methods is the chemical vapor deposition (CVD) of graphene films with heteroatom ... ...

    Abstract It is significantly important to modulate the electrical properties of graphene films through doping for building desired electronic devices. One of the effective doping methods is the chemical vapor deposition (CVD) of graphene films with heteroatom doping during the process, but this usually results in nitrogen-doped graphene with low doping levels, high defect density, and low carrier mobility. In this work, we developed a novel condensation-assisted CVD method for the synthesis of high-quality nitrogen-doped graphene (NG) films at low temperatures of 400 °C using solid 3,4,5-trichloropyridine as a carbon and nitrogen source. The condensation system was employed to reduce the volatilization of the solid source during the non-growth stage, which leads to a great improvement of quality of as-prepared NG films. Compared to the one synthesized using conventional CVD methods, the NG films synthesized using condensation-assisted CVD present extremely low defects with a ratio of from D- to G-peak intensity (
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16031120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Alkali-Etched NiCoAl-LDH with Improved Electrochemical Performance for Asymmetric Supercapacitors.

    Hou, Liyin / Zhou, Xufeng / Kong, Lina / Ma, Zhipeng / Su, Li / Liu, Zhaoping / Shao, Guangjie

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 7

    Abstract: Hydrotalcite, first found in natural ores, has important applications in supercapacitors. NiCoAl-LDH, as a hydrotalcite-like compound with good crystallinity, is commonly synthesized by a hydrothermal method. Al3+ plays an important role in the ... ...

    Abstract Hydrotalcite, first found in natural ores, has important applications in supercapacitors. NiCoAl-LDH, as a hydrotalcite-like compound with good crystallinity, is commonly synthesized by a hydrothermal method. Al3+ plays an important role in the crystallization of hydrotalcite and can provide stable trivalent cations, which is conducive to the formation of hydrotalcite. However, aluminum and its hydroxides are unstable in a strong alkaline electrolyte; therefore, a secondary alkali treatment is proposed in this work to produce cation vacancies. The hydrophilicity of the NiCoAl-OH surface with cation vacancy has been greatly improved, which is conducive to the wetting and infiltration of electrolyte in water-based supercapacitors. At the same time, cation vacancies generate a large number of defects as active sites for energy storage. As a result, the specific capacity of the NiCoAl-OH electrode after 10,000 cycles can be maintained at 94.1%, which is much better than the NiCoAl-LDH material of 74%.
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13071192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Advancing food safety risk assessment in China: development of new approach methodologies (NAMs).

    Yang, Daoyuan / Yang, Hui / Shi, Miaoying / Jia, Xudong / Sui, Haixia / Liu, Zhaoping / Wu, Yongning

    Frontiers in toxicology

    2023  Volume 5, Page(s) 1292373

    Abstract: Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools for the next- ... ...

    Abstract Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools for the next-generation risk assessment (NGRA), using non-animal methodologies such as
    Language English
    Publishing date 2023-11-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2023.1292373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Surveillance of SARS-CoV-2 Contamination in Frozen Food-Related Samples - China, July 2020 - July 2021.

    Li, Fengqin / Wang, Jiahui / Liu, Zhaoping / Li, Ning

    China CDC weekly

    2021  Volume 4, Issue 22, Page(s) 465–470

    Abstract: Introduction: Current evidence shows that coronavirus disease 2019 (COVID-19) is neither a food safety issue nor a foodborne disease. However, the outbreaks of this disease in workers of meat- or poultry-processing plants and food markets have been ... ...

    Abstract Introduction: Current evidence shows that coronavirus disease 2019 (COVID-19) is neither a food safety issue nor a foodborne disease. However, the outbreaks of this disease in workers of meat- or poultry-processing plants and food markets have been reported in many countries. Systematic reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contamination in food-related samples worldwide are lacking so far. This study aimed to survey and monitor SARS-CoV-2 contamination in samples of foods or their packaging, storage environment, and employees, as well as explore the possible potential for virus transmission via frozen foods.
    Methods: Swabs of frozen food-related samples were collected between July 2020 and July 2021 in 31 provincial-level administrative divisions (PLADs) and Xinjiang Construction Corps in China. The SARS-CoV-2 RNAs were extracted and analyzed by real-time quantitative polymerase chain reaction using the commercially available SARS-CoV-2 nucleic acid test kit.
    Results: More than 55.83 million samples were analyzed, and 1,455 (0.26 per 10,000) were found to be positive for SARS-CoV-2 nucleic acid. Among the virus-positive samples, 96.41% (1,398/1,450) and 3.59% (52/1,450) were food/food packaging materials and environment, respectively. As for 1,398 SARS-CoV-2-positive food and food packaging materials, 99.50%, (1,391/1,398) were imported and 7 were domestic. The outer packaging of food was frequently contaminated by the virus 78.75% ( 1,101/1,398).
    Conclusions: Our study supported speculation that cold-chain foods might act as the SARS-CoV-2 carrier, and food handlers/operators were at high risk of exposure to the virus. It is necessary to carry out a comprehensive mass testing for SARS-CoV-2 nuclei acid, along with contact tracing and symptom screening in cold-chain food handlers and processors so as to identify high proportions of asymptomatic or pre-symptomatic infections. Meanwhile, research and development of effective self-protection equipment available at a temperature below -18 ℃ is urgent.
    Language English
    Publishing date 2021-06-18
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2022.105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Analysis on the effect of intravenous anesthesia with dexmedetomidine and propofol combined with seaweed polysaccharides on hemodynamics and analgesia in pregnant females undergoing painless induced abortion.

    Wu, Jing / Han, Yi / Yang, Ling / Liu, Zhaoping

    Pakistan journal of pharmaceutical sciences

    2021  Volume 34, Issue 3(Special), Page(s) 1249–1254

    Abstract: This study attempted to investigate the effect of intravenous anesthesia with dexmedetomidine and propofol combined with seaweed polysaccharides on painless induced abortion. A total of 82 pregnant females were divided into study group and reference ... ...

    Abstract This study attempted to investigate the effect of intravenous anesthesia with dexmedetomidine and propofol combined with seaweed polysaccharides on painless induced abortion. A total of 82 pregnant females were divided into study group and reference group. The subjects in the study group took seaweed polysaccharides orally before surgery and received intravenous anesthesia with dexmedetomidine and propofol, while the subjects in the reference group received intravenous anesthesia with sufentanil combined with propofol. The onset time of anesthesia in the reference group was significantly shorter than that in the study group (P<0.001) and both recovery time and the dosage of propofol in the study group were significantly lower than those in the reference group (P<0.001). The values of MAP and HR at T3 and T4, clinical analgesia effective rate, ramsay sedation scores and incidence of adverse reactions of the subjects in study group was significantly better than those indexes of the subjects in reference group (P<0.05). The intravenous anesthesia with dexmedetomidine and propofol combined with seaweed polysaccharides is a promising strategy for painless induced abortion, which is worthy of application and popularization in clinical practice.
    MeSH term(s) Abortion, Induced/methods ; Adult ; Anesthetics, Intravenous/therapeutic use ; Arterial Pressure ; Carrageenan/therapeutic use ; Deep Sedation/methods ; Dexmedetomidine/therapeutic use ; Dizziness ; Female ; Heart Rate ; Hemodynamics ; Humans ; Pain, Procedural/drug therapy ; Postoperative Complications/epidemiology ; Postoperative Nausea and Vomiting/epidemiology ; Pregnancy ; Propofol/therapeutic use ; Seaweed ; Sufentanil/therapeutic use ; Young Adult
    Chemical Substances Anesthetics, Intravenous ; Dexmedetomidine (67VB76HONO) ; Carrageenan (9000-07-1) ; Sufentanil (AFE2YW0IIZ) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2021-09-09
    Publishing country Pakistan
    Document type Controlled Clinical Trial ; Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MicroRNA-155 influences cell damage in ischemic stroke via TLR4/MYD88 signaling pathway.

    Chen, Wei / Wang, Lingtong / Liu, Zhaoping

    Bioengineered

    2021  Volume 12, Issue 1, Page(s) 2449–2458

    Abstract: Cerebral ischemic stroke (CIS) is extremely harmful, and its treatment should be underpinned by understanding its pathogenic mechanism. This study was designed to determine the involvement of miR-155 in CIS development via the TLR4/MyD88 signaling ... ...

    Abstract Cerebral ischemic stroke (CIS) is extremely harmful, and its treatment should be underpinned by understanding its pathogenic mechanism. This study was designed to determine the involvement of miR-155 in CIS development via the TLR4/MyD88 signaling pathway. First, we quantified serum miR-155 in patients with CIS and healthy individuals, and found high expression of miR-155 in such patients and a decrease in it in the patients after therapy (
    MeSH term(s) Adult ; Animals ; Brain/pathology ; Cell Line, Tumor ; Gene Expression Regulation ; Humans ; Ischemic Stroke/genetics ; Ischemic Stroke/pathology ; Ischemic Stroke/physiopathology ; Memory ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Morris Water Maze Test ; Myeloid Differentiation Factor 88/metabolism ; Signal Transduction ; Spatial Learning ; Toll-Like Receptor 4/metabolism ; Mice
    Chemical Substances MIRN155 microRNA, human ; MicroRNAs ; Mirn155 microRNA, mouse ; Myeloid Differentiation Factor 88 ; Toll-Like Receptor 4
    Language English
    Publishing date 2021-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.1935066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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