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  1. Book ; Online ; E-Book: Molecularly imprinted polymers as advanced drug delivery systems

    Liu, Zhaosheng / Huang, Yanping / Yang, Yi

    synthesis, character and application

    2021  

    Author's details Zhaosheng Liu, Yanping Huang, Yi Yang, editors
    Keywords Drug delivery systems/Technological innovations ; Dispositius d'administració de medicaments ; Polímers en medicina ; Biologia molecular ; Innovacions tecnològiques
    Subject code 615.6
    Language English
    Size 1 online resource (218 pages)
    Publisher Springer
    Publishing place Gateway East, Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-0227-1 ; 981-16-0226-3 ; 978-981-16-0227-6 ; 978-981-16-0226-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Accessing pyrrolo[1,2-

    Liu, Zhaosheng / Ji, Xiaochen / Duan, Lilan / Deng, Guo-Jun / Huang, Huawen

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 37, Page(s) 4902–4905

    Abstract: Pyrrolo[1,2- ...

    Abstract Pyrrolo[1,2-
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc01215a
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  3. Article ; Online: Preparation of carbon nanotubes and polyhedral oligomeric-reinforced molecularly imprinted polymer composites for drug delivery of gallic acid.

    Zhang, Xue / An, Dongyu / Zhang, Rongrong / Huang, Yanping / Liu, Zhaosheng

    International journal of pharmaceutics

    2022  Volume 615, Page(s) 121476

    Abstract: In this paper, an enhanced imprinting effect of utilizing single wall carbon nanotubes (SWCNT) and polyhedral oligomeric silsesquioxanes (POSS) was suggested to improve drug delivery. The combination of 1-butyl-3-methylimidazoliumtetrafluoroborate ([BMIM] ...

    Abstract In this paper, an enhanced imprinting effect of utilizing single wall carbon nanotubes (SWCNT) and polyhedral oligomeric silsesquioxanes (POSS) was suggested to improve drug delivery. The combination of 1-butyl-3-methylimidazoliumtetrafluoroborate ([BMIM]BF
    Language English
    Publishing date 2022-01-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.121476
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Boronate Avidity Assisted by Dendrimer-like Polyhedral Oligomeric Silsesquioxanes for a Microfluidic Platform for Selective Enrichment of Ubiquitination and Glycosylation

    Zhang, Xue / Wei, Qin / Meng, Xin / Zhao, Lili / Liu, Zhaosheng / Huang, Yanping

    Analytical Chemistry. 2022 Dec. 23, v. 95, no. 2 p.1241-1250

    2022  

    Abstract: A new strategy of improving boronate avidity with good accessibility of sites was suggested by utilizing a dendrimer-like structure of boron materials based on octavinyl-polyhedral oligomeric silsesquioxanes (Ov-POSS). 3-(Acrylamido)­phenylboronic acid ( ... ...

    Abstract A new strategy of improving boronate avidity with good accessibility of sites was suggested by utilizing a dendrimer-like structure of boron materials based on octavinyl-polyhedral oligomeric silsesquioxanes (Ov-POSS). 3-(Acrylamido)­phenylboronic acid (AAPBA) was used as a functional monomer and ethylene glycol dimethacrylate (EDMA) and Ov-POSS as cross-linkers. The resulting Ov-POSS cross-linked boron monolith exhibited 27 times stronger affinity for glycoproteins than the Ov-POSS-free monolith. Importantly, the bonding strength of the poly­(AAPBA-co-Ov-POSS-co-EDMA) monolith to the glycoproteins with multiple sugars, horseradish peroxidase (HRP) was 4 orders of magnitude higher than that of the single cis-diol-containing compound. The resulting monolith was used as a part of a microfluidic platform for online processing of the protein extracts from mouse liver, which integrated five functions, including protein grading, denaturation, enzymatic hydrolysis, and enrichment of glycopeptides and ubiquitin-modified peptides. The sample processing time can be reduced by nearly half compared to the offline method. Moreover, 86.7% of glycopeptides and 75% of glycoproteins were newly identified after treatment. All of the results indicated that the synergistic strategy of Ov-POSS cross-linking can significantly improve trace glycosylation’s binding capacity and enrichment performance. The microfluidic platform developed may provide a promising technical tool for automated, high-efficiency, high-throughput analysis for post-translational modification proteomics.
    Keywords analytical chemistry ; automation ; boron ; crosslinking ; denaturation ; enzymatic hydrolysis ; ethylene glycol ; glycopeptides ; glycoproteins ; glycosylation ; liver ; mice ; peroxidase ; proteomics ; silsesquioxanes ; ubiquitination
    Language English
    Dates of publication 2022-1223
    Size p. 1241-1250.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c04005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 52/94: Show issues
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  5. Article: Preparation of arctiin moleculary imprinted polymers with 4-vinylpyridine and Allyl-β-cyclodextrin as binary monomers under molecular crowding conditions

    Zhang, Xue / Yang, Jian / Liu, Zhaosheng / Huang, Yanping / Akber Aisa, Haji

    Journal of chromatography. 2022 Mar. 15, v. 1193

    2022  

    Abstract: This paper reported a feasible method to prepare molecularly imprinted polymer (MIPs) using 4-vinylpyridine (4-VP) and Allyl-β-cyclodextrin (β-CD) as binary functional monomer in the presence of polystyrene (PS). This is the first time that a surrounding ...

    Abstract This paper reported a feasible method to prepare molecularly imprinted polymer (MIPs) using 4-vinylpyridine (4-VP) and Allyl-β-cyclodextrin (β-CD) as binary functional monomer in the presence of polystyrene (PS). This is the first time that a surrounding of macromolecular crowding was established to improve the imprinting effect of cyclodextrins as monomer in organic solvents. The morphological and characteristics of the polymers with macromolecular crowding reagents were investigated by scanning electron microscope (SEM), fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and nitrogen adsorption experiments. The MIPs were synthesized with 4-VP and β-CD as binary functional monomers, a series of experiments were conducted to compare with the control groups. Furthermore, the selectivity of MIP for analogues experiment showed that the β-CD/4-VP MIP has higher specific recognition for arctiin than β-CD/4-VP NIP. A purification method by β-CD/4-VP MIPs coupled with macromolecular crowding reagents was developed for extraction arctiin from Arctium lappa L. In the MIP-SPE process, the optimal washing and eluting reagents are methanol/water (5:5) and methanol/acid (9:1), respectively. When using the β-CD/4-VP MIPs as SPE absorbent, the mean recoveries for arctiin were 87% with purity of 95%. All the results indicate that this synthetic method using 4-VP and β-CD as binary functional monomers in the presence of PS is a promising method for the preparation of selective adsorbents for arctiin analysis in Arctium lappa L.
    Keywords Arctium lappa ; Fourier transform infrared spectroscopy ; absorbents ; adsorbents ; adsorption ; chromatography ; cyclodextrins ; methanol ; molecular imprinting ; nitrogen ; polystyrenes ; purification methods ; thermogravimetry
    Language English
    Dates of publication 2022-0315
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2022.123172
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  6. Article ; Online: Boronate Avidity Assisted by Dendrimer-like Polyhedral Oligomeric Silsesquioxanes for a Microfluidic Platform for Selective Enrichment of Ubiquitination and Glycosylation.

    Zhang, Xue / Wei, Qin / Meng, Xin / Zhao, Lili / Liu, Zhaosheng / Huang, Yanping

    Analytical chemistry

    2022  Volume 95, Issue 2, Page(s) 1241–1250

    Abstract: A new strategy of improving boronate avidity with good accessibility of sites was suggested by utilizing a dendrimer-like structure of boron materials based on octavinyl-polyhedral oligomeric silsesquioxanes (Ov-POSS). 3-(Acrylamido)phenylboronic acid ( ... ...

    Abstract A new strategy of improving boronate avidity with good accessibility of sites was suggested by utilizing a dendrimer-like structure of boron materials based on octavinyl-polyhedral oligomeric silsesquioxanes (Ov-POSS). 3-(Acrylamido)phenylboronic acid (AAPBA) was used as a functional monomer and ethylene glycol dimethacrylate (EDMA) and Ov-POSS as cross-linkers. The resulting Ov-POSS cross-linked boron monolith exhibited 27 times stronger affinity for glycoproteins than the Ov-POSS-free monolith. Importantly, the bonding strength of the poly(AAPBA-
    MeSH term(s) Animals ; Mice ; Glycosylation ; Dendrimers ; Microfluidics ; Boron ; Glycoproteins/chemistry ; Glycopeptides/chemistry ; Ubiquitination
    Chemical Substances Dendrimers ; Boron (N9E3X5056Q) ; Glycoproteins ; Glycopeptides
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c04005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Improving identification of molecularly imprinted monolith to benzoylation modified peptides by a deep eutectic solvents monomer-induced cooperation.

    Pu, Wan-Rong / An, Dong-Yu / Wang, Yang / Zhang, Xue / Huang, Yan-Ping / Liu, Zhao-Sheng

    Analytica chimica acta

    2022  Volume 1204, Page(s) 339697

    Abstract: In this study, a strategy of improving imprinting performance was developed using an enhanced cooperation effect of functional monomers based on deep eutectic solvents (DESs) monomer for the specific enrichment of benzoylation modified peptides. Zinc ... ...

    Abstract In this study, a strategy of improving imprinting performance was developed using an enhanced cooperation effect of functional monomers based on deep eutectic solvents (DESs) monomer for the specific enrichment of benzoylation modified peptides. Zinc acrylate and DESs monomers were used as binary functional monomers, and ethylene glycol dimethacrylate was used as the cross-linking agent with SGRGKbz as template to prepare an imprinted monolith. It was observed that the use of DESs monomer significantly improveed the affinity of benzoylation imprinted monolith and increased the adsorption capacity. Under optimal conditions, the recovery and imprinting factor (IF) of the imprinted monolith for SGRGKbz can reach 93.0% and 10.58, respectively. The average recovery of SGRGKbz extracted from the spiked histone digestion solution can reach 88.4% (n = 5, RSD = 3.4%). After treatment with the benzoylation imprinted monolith, 12 benzoylation modified peptides, 13 benzoylation modified sites and 12 benzoylation proteins could be identified in the digestion of mouse liver protein, while only one of each benzoylation modified peptide, benzoylation modified site and benzoylation protein could be identified in the untreated digestion of mouse liver protein. The results indicated that the prepared imprinted monolith using DESs-based functional monomer was an effective method to increase the affinity of the resulting MIP.
    MeSH term(s) Adsorption ; Animals ; Deep Eutectic Solvents ; Mice ; Molecular Imprinting/methods ; Peptides ; Polymers ; Solvents
    Chemical Substances Deep Eutectic Solvents ; Peptides ; Polymers ; Solvents
    Language English
    Publishing date 2022-03-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2022.339697
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  8. Article ; Online: Improving sorption performance of a molecularly imprinted monolithic column by doping mesoporous molecular sieve SBA-15.

    An, Dong-Yu / Pu, Wan-Rong / Wang, Yang / Xue-Zhang / Huang, Yan-Ping / Liu, Zhao-Sheng

    Mikrochimica acta

    2022  Volume 189, Issue 3, Page(s) 85

    Abstract: For the first time a hybrid molecularly imprinted polymer (MIP) doped with 3-(trimethoxysilyl) propyl methacrylate (γ-MPS)-modified mesoporous molecular sieve SBA-15 for target peptide recognition has been developed. Zinc acrylate and methacrylic acid ... ...

    Abstract For the first time a hybrid molecularly imprinted polymer (MIP) doped with 3-(trimethoxysilyl) propyl methacrylate (γ-MPS)-modified mesoporous molecular sieve SBA-15 for target peptide recognition has been developed. Zinc acrylate and methacrylic acid were used as binary functional monomers, and ethylene dimethacrylate was used as cross-linking agent to prepare an imprinted monolith against Val-Tyr-Ala-Leu-Lys(glutarylation) (VYALK
    MeSH term(s) Adsorption ; Methacrylates/chemistry ; Molecularly Imprinted Polymers/chemistry ; Organosilicon Compounds/chemistry ; Particle Size ; Peptides/analysis ; Porosity ; Silicon Dioxide/chemistry ; Surface Properties
    Chemical Substances Methacrylates ; Molecularly Imprinted Polymers ; Organosilicon Compounds ; Peptides ; SBA-15 ; Silicon Dioxide (7631-86-9) ; 3-(trimethoxysilyl)propyl methacrylate (JV48X1M2EQ)
    Language English
    Publishing date 2022-02-07
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-022-05192-x
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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
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  9. Article ; Online: Preparation of arctiin moleculary imprinted polymers with 4-vinylpyridine and Allyl-β-cyclodextrin as binary monomers under molecular crowding conditions.

    Zhang, Xue / Yang, Jian / Liu, Zhaosheng / Huang, Yanping / Akber Aisa, Haji

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2022  Volume 1193, Page(s) 123172

    Abstract: This paper reported a feasible method to prepare molecularly imprinted polymer (MIPs) using 4-vinylpyridine (4-VP) and Allyl-β-cyclodextrin (β-CD) as binary functional monomer in the presence of polystyrene (PS). This is the first time that a surrounding ...

    Abstract This paper reported a feasible method to prepare molecularly imprinted polymer (MIPs) using 4-vinylpyridine (4-VP) and Allyl-β-cyclodextrin (β-CD) as binary functional monomer in the presence of polystyrene (PS). This is the first time that a surrounding of macromolecular crowding was established to improve the imprinting effect of cyclodextrins as monomer in organic solvents. The morphological and characteristics of the polymers with macromolecular crowding reagents were investigated by scanning electron microscope (SEM), fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and nitrogen adsorption experiments. The MIPs were synthesized with 4-VP and β-CD as binary functional monomers, a series of experiments were conducted to compare with the control groups. Furthermore, the selectivity of MIP for analogues experiment showed that the β-CD/4-VP MIP has higher specific recognition for arctiin than β-CD/4-VP NIP. A purification method by β-CD/4-VP MIPs coupled with macromolecular crowding reagents was developed for extraction arctiin from Arctium lappa L. In the MIP-SPE process, the optimal washing and eluting reagents are methanol/water (5:5) and methanol/acid (9:1), respectively. When using the β-CD/4-VP MIPs as SPE absorbent, the mean recoveries for arctiin were 87% with purity of 95%. All the results indicate that this synthetic method using 4-VP and β-CD as binary functional monomers in the presence of PS is a promising method for the preparation of selective adsorbents for arctiin analysis in Arctium lappa L.
    Language English
    Publishing date 2022-02-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2022.123172
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Optimizing the preparative capacity of two-dimensional liquid chromatography based on analytes retention behaviors.

    Sun, Guangying / Zhang, Zheng / Yang, Liying / Jiang, Jianming / Yao, Wu / Pan, Le / Chen, Long / Li, Changjiang / Liu, Zhaosheng

    Journal of chromatography. A

    2023  Volume 1690, Page(s) 463786

    Abstract: In this work, a solute retention optimization method (SRO) was proposed to exploit the purification potential of two-dimensional liquid chromatography (2D-LC). According to our findings, the complementarity of 2D-LC correlates with some specific ... ...

    Abstract In this work, a solute retention optimization method (SRO) was proposed to exploit the purification potential of two-dimensional liquid chromatography (2D-LC). According to our findings, the complementarity of 2D-LC correlates with some specific impurities. In the two methods used in 2D-LC, the retention order of these impurities and target compound is completely opposite. Taking full advantage of the complementarity is crucial to enhance the saturation capacity (w
    MeSH term(s) Caffeine ; Chromatography, Reverse-Phase/methods ; Hydrophobic and Hydrophilic Interactions
    Chemical Substances Caffeine (3G6A5W338E)
    Language English
    Publishing date 2023-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2023.463786
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    In stock of ZB MED Cologne/Königswinter

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