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Article ; Online: The Influencing Mechanism and Motivation of the Bystander on the Choice of Chinese Address Forms.

Sun, Jing / Liu, Zhenqian

2024 Volume 53, Issue 1, Page(s) 8

Abstract: Chinese address terms exhibits a high degree of variability. Guided by the extended context of situation framework within the field of systemic functional linguistics, and taking the dialogues of the modern Chinese TV drama In the Name of People as ... ...

Abstract	Chinese address terms exhibits a high degree of variability. Guided by the extended context of situation framework within the field of systemic functional linguistics, and taking the dialogues of the modern Chinese TV drama In the Name of People as examples, this study investigated how the bystander influences the choice of address terms. It is found that the appearance of the bystander influences the choice of address terms. Yet, it is not a direct process but is mediated by conversational atmosphere. Specifically, the presence of a bystander triggers "situational synergy" or changes interpersonal relationship, and then change the conversational atmosphere, both paths ultimately impact the choice of address terms. The underlying forces that lead to the variability of Chinese address terms are guān běn wèi and miàn zǐ. This study suggests the intricate impact of context on language choice, as well as the interdependency of context variables. In addition, by taking the concept of face beyond its European/North American milieu, and relocating it following the Chinese point of view, group orientation is valued, which contributes to face study.
MeSH term(s)	Humans ; Motivation ; Language ; Communication ; Linguistics ; China
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	124517-x
ISSN	1573-6555 ; 0090-6905
ISSN (online)	1573-6555
ISSN	0090-6905
DOI	10.1007/s10936-024-10047-y
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Article ; Online: Evaluation Mechanism of Political Discourse: A Holistic Approach.

Sun, Jing / Liu, Zhenqian

Journal of psycholinguistic research

2023 Volume 52, Issue 6, Page(s) 2143–2179

Abstract: Taking the economic issue of Trump's First State of the Union Address (SUA) as original data, the present study examined the evaluation features of political speeches by adopting a holistic approach, which includes both macro and micro dimensions. At the ...

Abstract	Taking the economic issue of Trump's First State of the Union Address (SUA) as original data, the present study examined the evaluation features of political speeches by adopting a holistic approach, which includes both macro and micro dimensions. At the macro level, a series of semantic patterns were identified, with Goal-Achievement and General-Example Patterns being the most prevalent. They predetermine the evaluative tone, giving the surrounding statements evaluative meanings, exhibiting the radiating nature of evaluative meaning; at the micro level, a variety of resources have been identified, both explicit and implicit, lexical and syntactical, attitudinal and gradational, which collaborate to reinforce the subjective evaluation, revealing the holistic characteristic in the realization of evaluative meaning. Throughout the analysis, three evaluative mechanisms have been proposed, which are the coupling of meaning, semantic prosody, and tense switching. They collaborate and promote the subjective evaluation to be established and reinforced in a cumulative, gradient or hybrid pattern. In a narrow sense, the present study has partially revealed Trump's political discourse feature. Broadly speaking, it contributes to the theoretical development of the appraisal framework by refining existing evaluation systems through a holistic research paradigm, which in turn facilitates accurate interpretation of various types of discourse.
MeSH term(s)	Humans ; Semantics ; Speech
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	124517-x
ISSN	1573-6555 ; 0090-6905
ISSN (online)	1573-6555
ISSN	0090-6905
DOI	10.1007/s10936-023-09988-7
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Article ; Online: Optimisation of a Mouse Model of Cerebral Ischemia-Reperfusion to Address Issues of Survival and Model Reproducibility and Consistency.

Liu, Zhenqian / Chen, Mo / Duan, Xu / Zhai, Yujia / Ma, Bin / Duan, Zuowei / Xu, Jiang / Liu, Haiyan

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 7594969

Abstract: Middle cerebral artery occlusion (MCAO) induced brain ischemia-reperfusion model in Mice is essential for understanding the pathology of stroke and investigating potential treatments, in which a variety of methods may be employed to block the middle ... ...

Abstract	Middle cerebral artery occlusion (MCAO) induced brain ischemia-reperfusion model in Mice is essential for understanding the pathology of stroke and investigating potential treatments, in which a variety of methods may be employed to block the middle cerebral artery (MCA), the most common being through the insertion of a monofilament; however, in vivo ischemia-reperfusion models are associated, particularly in mice, with high variability in lesion volume and high mortality. We aimed to optimise a mouse model of cerebral ischemia-reperfusion, addressing issues of mouse survival, model reproducibility, and consistency. The model was optimised in two ways: first, insert the monofilament directly through the internal carotid artery rather than through the external or common carotid artery, and second, by extending the length of the silicone coating on the monofilament, the length of the silicone coating enables embolization of the beginning of the middle cerebral artery, as well as the anterior cerebral artery and part of the posterior communicating artery.
MeSH term(s)	Animals ; Brain Ischemia/complications ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/pathology ; Mice ; Reperfusion ; Reproducibility of Results ; Silicones ; Stroke/complications ; Stroke/pathology ; Stroke/surgery
Chemical Substances	Silicones
Language	English
Publishing date	2022-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/7594969
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Article ; Online: Tat-SynGAP improves angiogenesis and post-stroke recovery by inhibiting MST1/JNK signaling.

Yang, Hui / Liu, Zhenqian / Liu, Xiaomei / Cao, Xiaowei / Chen, Mo / Lou, Shiying / Rong, Liangqun / Xu, Yun / Zhang, Qingxiu

Brain research bulletin

2022 Volume 180, Page(s) 38–45

Abstract: Small G protein Ras induces the activation of apoptosis-related molecule mammalian Ste20-like kinase1 (MST1)/JNK signal pathway, which is involved in the regulation of tissue damage under pathological conditions such as ischemic stroke. Our previous ... ...

Abstract	Small G protein Ras induces the activation of apoptosis-related molecule mammalian Ste20-like kinase1 (MST1)/JNK signal pathway, which is involved in the regulation of tissue damage under pathological conditions such as ischemic stroke. Our previous study indicated that GTPase-activating protein for Ras (SynGAP), a negative regulator of Ras, could bind with postsynaptic density protein-93 (PSD-93) and Tat-SynGAP (670-685aa) small peptide to exhibit neuroprotective role. Here, we report that Tat-SynGAP (670-685aa) reduced cerebral edema at acute cerebral ischemia/reperfusion (I/R), improved integrity of blood-brain barrier, and decreased cortical and striatum neuronal injury. Mechanistically, Tat-SynGAP (670-685aa) not only inhibited the phosphorylation of MST1 and JNK and the cleavage of caspase-3, but also facilitated the expression of angiogenesis related molecules VEGF and Ang-1. In conclusion, Tat-SynGAP (670-685aa) reduces neuronal apoptosis and cerebral infarction volume and maintains vascular stability and blood-brain barrier integrity by inhibiting MST1/JNK signaling pathway.
MeSH term(s)	Animals ; Blood-Brain Barrier/drug effects ; Brain Edema/drug therapy ; Brain Ischemia/drug therapy ; Disease Models, Animal ; GTPase-Activating Proteins/pharmacology ; Guanylate Kinases/drug effects ; Hepatocyte Growth Factor ; MAP Kinase Signaling System/drug effects ; Membrane Proteins/drug effects ; Mice ; Neovascularization, Physiologic/drug effects ; Neuroprotective Agents/pharmacology ; Proto-Oncogene Proteins/drug effects ; Reperfusion Injury/drug therapy ; Twin-Arginine-Translocation System
Chemical Substances	GTPase-Activating Proteins ; Membrane Proteins ; Neuroprotective Agents ; Proto-Oncogene Proteins ; Twin-Arginine-Translocation System ; macrophage stimulating protein ; Hepatocyte Growth Factor (67256-21-7) ; Dlg2 protein, mouse (EC 2.7.4.8) ; Guanylate Kinases (EC 2.7.4.8)
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2021.12.013
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Article: Sex Differences of Acute Stroke Treatment and in Hospital Outcomes After Intravenous Thrombolysis in Patients With Ischemic Stroke.

Cai, Bin / Li, Sheng-de / Li, Hang / Liu, Zhen-Qian / Peng, Bin

Frontiers in neurology

2020 Volume 11, Page(s) 545860

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2020.545860
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Article: Association Between Admission Hyperglycemia and Outcomes After Endovascular Treatment in Acute Basilar Artery Occlusion.

Zhang, Lijiao / Gao, Fei / Tian, Yaoyu / Li, Linyu / Tian, Yan / Guo, Changwei / Yang, Dahong / Yue, Chengsong / Song, Jiaxing / Zi, Wenjie / Li, Jia / Liu, Zhenqian

Neurology and therapy

2023 Volume 12, Issue 4, Page(s) 1285–1297

Abstract: Introduction: Admission hyperglycemia and high admission blood glucose levels have been associated with poor outcomes in acute ischemic stroke. However, the relationship between admission hyperglycemia and outcomes after endovascular treatment (EVT) in ... ...

Abstract	Introduction: Admission hyperglycemia and high admission blood glucose levels have been associated with poor outcomes in acute ischemic stroke. However, the relationship between admission hyperglycemia and outcomes after endovascular treatment (EVT) in acute basilar artery occlusion (ABAO) still remain unclear. This study aimed to investigate the association between admission hyperglycemia and clinical outcomes in ABAO following EVT. Methods: Patients from the BASILAR registry with admission blood glucose levels treated with EVT were included. We defined admission hyperglycemia as blood glucose levels ≥ 7.8 mmol/L. The primary outcome was favorable outcome [defined as a modified Rankin Scale score (mRS) of 0-3] at 90 days, Secondary outcomes included other functional outcomes (mRS 0-2, mRS 0-1) at 90 days, symptomatic intracerebral hemorrhage (sICH) within 48 h, and mortality at 90 days. Results: Of 545 eligible patients included, the median age was 65 (IQR, 56-73) years, and median blood glucose level was 7.36 (IQR, 6.10-9.66) mmol/L. Multivariable logistic regression analysis showed that admission hyperglycemia was associated with decreased favorable outcome (mRS 0-3) (adjusted odds ratio = 0.52; 95% CI 0.35-0.79; P = 0.001), and increased mortality (adjusted odds ratio = 2.67; 95% CI 1.82-3.91; P < 0.001). Restricted cubic spline regression analysis showed that the blood glucose level had a non-linearity association with favorable outcome and mortality, and that there was no association between admission hyperglycemia and sICH. Conclusions: Our study suggest that admission hyperglycemia is associated with an increased risk of poor functional outcomes and mortality in patients with ABAO treated with EVT. Trial registration: Chinese Clinical Trial Registry ( http://www.chictr.org.cn ), ChiCTR180001475.
Language	English
Publishing date	2023-06-02
Publishing country	New Zealand
Document type	Journal Article
ISSN	2193-8253
ISSN	2193-8253
DOI	10.1007/s40120-023-00502-8
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Article ; Online: Early blood pressure changes during systemic thrombolysis and its association with unexplained early neurological deterioration in small subcortical infarct.

Wei, Xiu'e / Duan, Zuowei / Zhai, Yujia / Zhang, Cuicui / Zhang, Jun / Hu, Ting / Liu, Tengfei / Liu, Zhenqian / Xu, Jiang / Liu, Haiyan / Rong, Liangqun

Journal of clinical hypertension (Greenwich, Conn.)

2022 Volume 24, Issue 8, Page(s) 1086–1094

Abstract: Early neurological deterioration (END), observed in the acute phase of small subcortical infarct treated with intravenous thrombolysis (IVT), is not uncommon in these patients. However, in over half of the END cases, the exact cause is yet incompletely ... ...

Abstract	Early neurological deterioration (END), observed in the acute phase of small subcortical infarct treated with intravenous thrombolysis (IVT), is not uncommon in these patients. However, in over half of the END cases, the exact cause is yet incompletely understood, which is so-called unexplained END (unEND). Our aim was to investigate the association of early blood pressure (BP) changes with unEND in patients with small subcortical infarct in the perforator territory of middle cerebral artery treated with IVT. Consecutive patients with acute small subcortical infarct treated with IVT were enrolled in this study. unEND was defined as≧2-point increase of NIHSS from baseline to 24 hours, without straightforward causes. BP excursions and BP variability were calculated and compared between patients with unNED and those without. A total of 168 patients with acute small subcortical infarct were included. Of them, there were 29 patients with unEND and 139 without END. During the first 24 hours following IVT, 66 (39.29%) patients had at least one BP excursion. Logistic regression analyses indicated that BP excursion presence (OR = 3.185, 95% CI: 1.238-8.198), SBP excursion presence (OR = 3.535, 95% CI: 1.366-9.143), and number of SBP excursion (OR = 1.466, 95% CI: 1.090-1.973) were independently associated with unEND. Although SBP
MeSH term(s)	Blood Pressure/physiology ; Brain Ischemia/drug therapy ; Cerebral Infarction/drug therapy ; Cerebral Infarction/etiology ; Humans ; Hypertension/drug therapy ; Hypertension/etiology ; Stroke ; Thrombolytic Therapy ; Treatment Outcome
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.14515
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Article ; Online: Mesenchymal Stem Cells Modified with Heme Oxygenase-1 Have Enhanced Paracrine Function and Attenuate Lipopolysaccharide-Induced Inflammatory and Oxidative Damage in Pulmonary Microvascular Endothelial Cells.

Chen, Xuxin / Zhang, Yinliang / Wang, Wenjing / Liu, Zhenqian / Meng, Jiguang / Han, Zhihai

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

2018 Volume 49, Issue 1, Page(s) 101–122

Abstract: Background/aims: Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has therapeutic effects on endothelial damage during acute lung injury (ALI). Heme oxygenase-1 (HO-1) can restore homeostasis and implement cytoprotective defense ... ...

Abstract	Background/aims: Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has therapeutic effects on endothelial damage during acute lung injury (ALI). Heme oxygenase-1 (HO-1) can restore homeostasis and implement cytoprotective defense functions in many pathologic states. Therefore, we explored whether transduction of HO-1 into BM-MSCs (MSCs-HO-1) would have an increased beneficial effect on lipopolysaccharide (LPS)-induced inflammatory and oxidative damage in human pulmonary microvascular endothelial cells (PVECs). Methods: MSCs were isolated from rat bone marrow and transfected with the HO-1 gene by a lentivirus vector. The phenotype and multilineage differentiation of MSCs were assessed. MSCs or MSCs-HO-1 were co-cultured with PVECs using a transwell system, and LPS was added to induce PVEC injury. The production of reactive oxygen species (ROS), and the activities of lipid peroxide (LPO), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in PVECs were determined by flow cytometry and colorimetric assays, respectively. The levels of human PVEC-derived tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 in the supernatants of the co-culture system, and the activity of nuclear transcription factor-κB and NF-E2-related factor 2 (Nrf2) in PVECs were examined by enzyme-linked immunosorbent assay (ELISA). The mRNA expression of TNF-α, IL-1β and IL-6 in PVECs was detected by quantitative real-time polymerase chain reaction (qRT-PCR), HO-1 expression and enzymatic activity in PVECs and the influence of zinc protoporphyrin (ZnPP) or HO-1 small interfering RNA on the above inflammatory and oxidative stress markers were evaluated. In addition, the expression of rat MSC-derived hepatocyte growth factor (HGF) and IL-10 was determined by ELISA and qRT-PCR. Results: MSCs showed no significant changes in phenotype or multilineage differentiation after transduction. LPS strongly increased the production of inflammatory and oxidative stress indicators, as well as decreased the levels of antioxidant components and the activity of Nrf2 in PVECs. MSC co-cultivation ameliorated these detrimental effects in PVECs and MSCs-HO-1 further improved the damage to PVECs induced by LPS when compared with MSCs alone. The beneficial effects of MSCs-HO-1 were dependent on HO-1 overexpression and may be attributed to the enhanced paracrine production of HGF and IL-10. Conclusion: MSCs-HO-1 have an enhanced ability to improve LPS-induced inflammatory and oxidative damage in PVECs, and the mechanism may be partially associated with the enhanced paracrine function of the stem cells. These data encourage further testing of the beneficial effects of MSCs-HO-1 in ALI animal models.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Survival ; Cytokines/analysis ; Cytokines/metabolism ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Heme Oxygenase-1/antagonists & inhibitors ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Humans ; Inflammation/prevention & control ; Lipopolysaccharides/toxicity ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Paracrine Communication ; RNA Interference ; RNA, Small Interfering/metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	Cytokines ; Lipopolysaccharides ; NF-E2-Related Factor 2 ; NF-kappa B ; NFE2L2 protein, human ; RNA, Small Interfering ; Reactive Oxygen Species ; Heme Oxygenase-1 (EC 1.14.14.18) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2018-08-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000492847
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Article: Multiple structural aberrations and physical mapping of rye chromosome 2R introgressed into wheat

Zhuang, Lifang / Liu, Peng / Liu, Zhenqian / Chen, Tingting / Wu, Nan / Sun, Ling / Qi, Zengjun

Molecular breeding. 2015 June, v. 35, no. 6

2015

Abstract: Multiple structural aberrations produced by chromosome breakage and reunion not only provide new germplasm for enriching genetic diversity but are also helpful for physical mapping of alien chromosomes introgressed into wheat. In this study, mass ... ...

Abstract	Multiple structural aberrations produced by chromosome breakage and reunion not only provide new germplasm for enriching genetic diversity but are also helpful for physical mapping of alien chromosomes introgressed into wheat. In this study, mass structural aberrations of rye chromosome 2R were induced by means of spontaneous breakage and reunion, gametocidal chromosome action and irradiation. A total of 88 chromosome 2R aberrations were identified in 65 plants. From the self-pollinated progenies of plants carrying these aberrations, 19 stable lines with different segments of chromosome 2R which included seven whole arm, six small segmental and three large segmental translocations, one deletion and two ditelosomic additions, were subsequently identified and characterized using cytogenetic and molecular markers. Based on these lines, 88 markers specific for chromosome 2R were physically mapped to 13 different blocks of 2R with three in arm 2RS and 10 in arm 2RL. The powdery mildew resistance gene PmJZHM2RL was located to a region corresponding to the block 2RL-7. A total of eighteen 2R-specific EST markers were located in the same block where ten were derived from genes that were up-regulated during powdery mildew infection. Potential use of these stable aberrations and the colinearity of chromosome 2R with corresponding chromosomes in the other model monocot species were discussed.
Keywords	Secale cereale ; chromosome breakage ; chromosome mapping ; chromosome translocation ; chromosomes ; disease resistance ; expressed sequence tags ; gene expression regulation ; genes ; genetic markers ; genetic variation ; germplasm ; introgression ; irradiation ; powdery mildew ; rye ; self-pollination ; wheat
Language	English
Dates of publication	2015-06
Size	p. 333.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1230924-2
ISSN	1572-9788 ; 1380-3743
ISSN (online)	1572-9788
ISSN	1380-3743
DOI	10.1007/s11032-015-0333-2
Database	NAL-Catalogue (AGRICOLA)

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Article: Mesenchymal Stem Cells Modified with Heme Oxygenase-1 Have Enhanced Paracrine Function and Attenuate Lipopolysaccharide-Induced Inflammatory and Oxidative Damage in Pulmonary Microvascular Endothelial Cells

Chen, Xuxin / Zhang, Yinliang / Wang, Wenjing / Liu, Zhenqian / Meng, Jiguang / Han, Zhihai

Cellular Physiology and Biochemistry

2018 Volume 49, Issue 1, Page(s) 101–122

Abstract: Background/Aims: Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has therapeutic effects on endothelial damage during acute lung injury (ALI). Heme oxygenase-1 (HO-1) can restore homeostasis and implement cytoprotective defense ... ...

Institution	Department of Respiratory Medicine, Navy General Hospital of the PLA, Beijing, China Department of Respiratory Medicine, Xi’an XD Group Hospital, Xi’an, China Cardiothoracic Surgery ICU, Anqing Municipal Hospital, Anqing, China
Abstract	Background/Aims: Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has therapeutic effects on endothelial damage during acute lung injury (ALI). Heme oxygenase-1 (HO-1) can restore homeostasis and implement cytoprotective defense functions in many pathologic states. Therefore, we explored whether transduction of HO-1 into BM-MSCs (MSCs-HO-1) would have an increased beneficial effect on lipopolysaccharide (LPS)-induced inflammatory and oxidative damage in human pulmonary microvascular endothelial cells (PVECs). Methods: MSCs were isolated from rat bone marrow and transfected with the HO-1 gene by a lentivirus vector. The phenotype and multilineage differentiation of MSCs were assessed. MSCs or MSCs-HO-1 were co-cultured with PVECs using a transwell system, and LPS was added to induce PVEC injury. The production of reactive oxygen species (ROS), and the activities of lipid peroxide (LPO), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in PVECs were determined by flow cytometry and colorimetric assays, respectively. The levels of human PVEC-derived tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 in the supernatants of the co-culture system, and the activity of nuclear transcription factor-κB and NF-E2-related factor 2 (Nrf2) in PVECs were examined by enzyme-linked immunosorbent assay (ELISA). The mRNA expression of TNF-α, IL-1β and IL-6 in PVECs was detected by quantitative real-time polymerase chain reaction (qRT-PCR), HO-1 expression and enzymatic activity in PVECs and the influence of zinc protoporphyrin (ZnPP) or HO-1 small interfering RNA on the above inflammatory and oxidative stress markers were evaluated. In addition, the expression of rat MSC-derived hepatocyte growth factor (HGF) and IL-10 was determined by ELISA and qRT-PCR. Results: MSCs showed no significant changes in phenotype or multilineage differentiation after transduction. LPS strongly increased the production of inflammatory and oxidative stress indicators, as well as decreased the levels of antioxidant components and the activity of Nrf2 in PVECs. MSC co-cultivation ameliorated these detrimental effects in PVECs and MSCs-HO-1 further improved the damage to PVECs induced by LPS when compared with MSCs alone. The beneficial effects of MSCs-HO-1 were dependent on HO-1 overexpression and may be attributed to the enhanced paracrine production of HGF and IL-10. Conclusion: MSCs-HO-1 have an enhanced ability to improve LPS-induced inflammatory and oxidative damage in PVECs, and the mechanism may be partially associated with the enhanced paracrine function of the stem cells. These data encourage further testing of the beneficial effects of MSCs-HO-1 in ALI animal models.
Keywords	Mesenchymal Stem Cells (MSCs) ; Acute lung injury (ALI) ; Lipopolysaccharide (LPS) ; Heme Oxygenase-1 (HO-1) ; Paracrine ; Inflammation ; Oxidative Stress
Language	English
Publishing date	2018-08-28
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Paper ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000492847
Database	Karger publisher's database

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