Result 1 - 10 of total 1108
2023
| Keywords | Life Science |
|---|---|
| Language | English |
| Publisher | Wageningen University |
| Publishing country | nl |
| Document type | Thesis ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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Journal of proteomics. 2022 Mar. 30, v. 256 p.104506-
2022
Abstract: Bioadhesion is a critical process for many marine and freshwater invertebrate animals. Bioadhesives mainly made of proteins have remarkable adhesive ability underwater. Unraveling the molecular composition of bioadhesives is fundamental to understanding ... ...
| Abstract | Bioadhesion is a critical process for many marine and freshwater invertebrate animals. Bioadhesives mainly made of proteins have remarkable adhesive ability underwater. Unraveling the molecular composition of bioadhesives is fundamental to understanding their physiological roles as well as their potential for biotechnology applications and antibiofouling strategies. With the development of high-throughput methods such as proteomics, bioadhesive protein data in diverse taxa are rapidly accumulating, but the common mechanism across species is elusive due to the vast variety of bioadhesives. In this review, bioadhesive proteins from various taxa are reviewed, with the aim of facilitating researchers to appreciate the diversity of bioadhesive proteins (mostly 20–40) across species. By comparing proteomes across species, it was found that glycine-rich, epidermal growth factor, peroxidase, and DOPA together with typical extracellular domains are the most commonly used domains. Additionally, permanent and temporary adhesion show obvious differences in terms of domains or proteins. A basic recipe for bioadhesives composed of six components is proposed: structural elements, extracellular domains, modification enzymes, proteinase inhibitors, cytoskeletal proteins, and others. The extracellular domains are mostly related to interactions with other macromolecules (proteins, carbohydrates, and lipids), suggesting that domain shuffling and macromolecule interaction might be fundamental for bioadhesive evolution. |
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| Keywords | Animalia ; bioadhesion ; bioadhesives ; biotechnology ; cytoskeleton ; dihydroxyphenylalanine ; epidermal growth factor ; evolution ; freshwater ; glycine (amino acid) ; invertebrates ; peroxidase ; proteinases ; proteome ; proteomics |
| Language | English |
| Dates of publication | 2022-0330 |
| Publishing place | Elsevier B.V. |
| Document type | Article ; Online |
| ZDB-ID | 2400835-7 |
| ISSN | 1876-7737 ; 1874-3919 |
| ISSN (online) | 1876-7737 |
| ISSN | 1874-3919 |
| DOI | 10.1016/j.jprot.2022.104506 |
| Database | NAL-Catalogue (AGRICOLA) |
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bioRxiv : the preprint server for biology
2024
Abstract: New experimental findings continue to challenge our understanding of protein allostery. Recent deep mutational scanning study showed that allosteric hotspots in the tetracycline repressor (TetR) and its homologous transcriptional factors are broadly ... ...
| Abstract | New experimental findings continue to challenge our understanding of protein allostery. Recent deep mutational scanning study showed that allosteric hotspots in the tetracycline repressor (TetR) and its homologous transcriptional factors are broadly distributed rather than spanning well-defined structural pathways as often assumed. Moreover, hotspot mutation-induced allostery loss was rescued by distributed additional mutations in a degenerate fashion. Here, we develop a two-domain thermodynamic model for TetR, which readily rationalizes these intriguing observations. The model accurately captures the in vivo activities of various mutants with changes in physically transparent parameters, allowing the data-based quantification of mutational effects using statistical inference. Our analysis reveals the intrinsic connection of intra- and inter-domain properties for allosteric regulation and illustrate epistatic interactions that are consistent with structural features of the protein. The insights gained from this study into the nature of two-domain allostery are expected to have broader implications for other multidomain allosteric proteins. |
|---|---|
| Language | English |
| Publishing date | 2024-02-14 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2023.08.06.552196 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Medical Review, Vol 3, Iss 2, Pp 188-
2023 Volume 192
Abstract: Cancer immunotherapy comprising of immune checkpoint blockade (ICB) therapy, immune cell therapies, cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers. However, their overall clinical objective ... ...
| Abstract | Cancer immunotherapy comprising of immune checkpoint blockade (ICB) therapy, immune cell therapies, cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers. However, their overall clinical objective response rates, particularly against most solid tumors, are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens, limited tumor infiltration of effector immune cells, acquired tumor immunosuppression and some other factors. In recent years, various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms, presenting new promises in many published studies. This perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy. |
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| Keywords | cancer immunotherapy ; in situ cancer vaccine ; nanomedicine ; nanovaccine ; tumor microenvironment ; Medicine ; R |
| Language | English |
| Publishing date | 2023-04-01T00:00:00Z |
| Publisher | De Gruyter |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2024
| Language | English |
|---|---|
| Publishing date | 2024-03-22 |
| Publishing country | Netherlands |
| Document type | Letter |
| ZDB-ID | 1068461-x |
| ISSN | 0219-3108 ; 1015-9584 |
| ISSN (online) | 0219-3108 |
| ISSN | 1015-9584 |
| DOI | 10.1016/j.asjsur.2024.03.070 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 2831: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Journal of Environmental Sciences.
2023
Abstract: A series of novel chitosan-based magnetic flocculants FS@CTS-P(AM-DMC) was prepared by molecular structure control. The characterization results showed that FS@CTS-P(AM-DMC) had a uniform size of about 21.46 nm, featuring a typical core-shell structure, ... ...
| Abstract | A series of novel chitosan-based magnetic flocculants FS@CTS-P(AM-DMC) was prepared by molecular structure control. The characterization results showed that FS@CTS-P(AM-DMC) had a uniform size of about 21.46 nm, featuring a typical core-shell structure, and the average coating layer thickness of CTS-P(AM-DMC) was about 5.03 nm. FS@CTS-P(AM-DMC) exhibited excellent flocculation performance for kaolin suspension, achieved 92.54% turbidity removal efficiency under dosage of 150 mg/L, pH 7.0, even at high turbidity (2000 NTU) with a removal efficiency of 96.96%. The flocculation mechanism was revealed to be dominated by charge neutralization under acidic and neutral conditions, while adsorption and bridging effects play an important role in alkaline environments. The properties of magnetic aggregates during flocculation, breakage, and regeneration were studied at different pH levels and dosages. In the process of magnetophoretic, magnetic particles collide and adsorb with kaolin particles continuously due to magnetic and electrostatic attraction, transform into magnetic chain clusters, and then further form three-dimensional network magnetic aggregates that can capture free kaolin particles and other chain clusters. Particle image velocimetry confirmed the formation of eddy current of magnetic flocs and experienced three stages: acceleration, stabilization, and deceleration. |
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| Keywords | adsorption ; chemical structure ; electrostatic interactions ; flocculants ; flocculation ; kaolin ; magnetism ; neutralization ; pH ; particle image velocimetry ; turbidity ; Magnetic flocculation ; Chitosan ; Fe3O4 ; Graft copolymerization ; PIV |
| Language | English |
| Publishing place | Elsevier B.V. |
| Document type | Article ; Online |
| Note | Pre-press version |
| ZDB-ID | 1092300-7 |
| ISSN | 1878-7320 ; 1001-0742 |
| ISSN (online) | 1878-7320 |
| ISSN | 1001-0742 |
| DOI | 10.1016/j.jes.2023.05.031 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 7630: Show issues |
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2023 Volume 15, Issue 4, Page(s) 1861–1871
Abstract: Background: We aimed to report the experience of robotic-assisted cardiac surgery (RACS) using the Da Vinci robotic surgical system, meanwhile its efficacy and safety was also evaluated by comparing with traditional open-heart surgery (TOHS), thus to ... ...
| Abstract | Background: We aimed to report the experience of robotic-assisted cardiac surgery (RACS) using the Da Vinci robotic surgical system, meanwhile its efficacy and safety was also evaluated by comparing with traditional open-heart surgery (TOHS), thus to provide evidence for a broader application of RACS in clinical practice. Methods: From July 2017 to May 2022, a total of 255 patients who underwent cardiac surgery assisted by Da Vinci robotic surgery system in the First Affiliated Hospital of Anhui Medical University, which included 134 males with an average age of 52.6±6.3 years and 121 females with an average age of 51.8±5.4 years. They were defined as the RACS group. By searching the hospital's electronic medical record information system, 736 patients with the same disease types who underwent median sternotomy and had complete data in the same period were selected as the TOHS group. Intra- and postoperative clinical results of the both groups were compared, and we focused the following indices including surgery time, reoperation rate for postoperative bleeding, length of intensive care unit (ICU) stay, postoperative hospitalization day, the number of died and withdrawing treatments, and the time of patients back to normal daily activities after discharge. Results: In RACS group, 2 patients were scheduled to undergo mitral valvuloplasty (MVP), but they had to change to mitral valve replacement (MVR) due to unsatisfactory results; furthermore, 1 patient who received atrial septal defect (ASD) repair experienced abdominal hemorrhage because a rupture of abdominal aorta which were induced by the femoral arterial cannulation, and this patient eventually died of invalid rescue. As for the comparison of clinical results between both groups, there were no significant statistical differences in reoperation rate for postoperative bleeding, and the number of died and withdrawing treatments between both groups. However, length ICU stay, postoperative hospitalization day, and the time of patients back to normal daily activities after discharge was lower in RACS group in addition to the surgery time. Conclusions: Compared with TOHS, RACS is safe and effective in clinical and is worthy of promotion in an appropriate place. |
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| Language | English |
| Publishing date | 2023-03-20 |
| Publishing country | China |
| Document type | Journal Article |
| ZDB-ID | 2573571-8 |
| ISSN | 2077-6624 ; 2072-1439 |
| ISSN (online) | 2077-6624 |
| ISSN | 2072-1439 |
| DOI | 10.21037/jtd-23-197 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
2023 Volume 52, Issue 3, Page(s) 259–266
Abstract: The application of intraocular drug delivery is usually limited due to special anatomical and physiological barriers, and the elimination mechanisms in the eye. Organic nano-drug delivery carriers exhibit excellent adhesion, permeability, targeted ... ...
| Title translation | 用于眼内药物递送的有机纳米载体研究. |
|---|---|
| Abstract | The application of intraocular drug delivery is usually limited due to special anatomical and physiological barriers, and the elimination mechanisms in the eye. Organic nano-drug delivery carriers exhibit excellent adhesion, permeability, targeted modification and controlled release abilities to overcome the obstacles and improve the efficiency of drug delivery and bioavailability. Solid lipid nanoparticles can entrap the active components in the lipid structure to improve the stability of drugs and reduce the production cost. Liposomes can transport hydrophobic or hydrophilic molecules, including small molecules, proteins and nucleic acids. Compared with linear macromolecules, dendrimers have a regular structure and well-defined molecular mass and size, which can precisely control the molecular shape and functional groups. Degradable polymer materials endow nano-delivery systems a variety of size, potential, morphology and other characteristics, which enable controlled release of drugs and are easy to modify with a variety of ligands and functional molecules. Organic biomimetic nanocarriers are highly optimized through evolution of natural particles, showing better biocompatibility and lower toxicity. In this article, we summarize the advantages of organic nanocarriers in overcoming multiple barriers and improving the bioavailability of drugs, and highlight the latest research progresses on the application of organic nanocarriers for treatment of ocular diseases. |
| MeSH term(s) | Drug Carriers ; Delayed-Action Preparations ; Drug Delivery Systems ; Nanoparticles/chemistry |
| Chemical Substances | Drug Carriers ; Delayed-Action Preparations |
| Language | Chinese |
| Publishing date | 2023-07-20 |
| Publishing country | China |
| Document type | Journal Article |
| ISSN | 1008-9292 |
| ISSN | 1008-9292 |
| DOI | 10.3724/zdxbyxb-2023-0035 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Materials (Basel, Switzerland)
2023 Volume 16, Issue 19
Abstract: Superhydrophobic coatings are limited by complex preparation processes and poor mechanical durability in practical applications. In this study, a mechanically robust superhydrophobic composite coating was applied to an aluminum surface that underwent ... ...
| Abstract | Superhydrophobic coatings are limited by complex preparation processes and poor mechanical durability in practical applications. In this study, a mechanically robust superhydrophobic composite coating was applied to an aluminum surface that underwent processing with a nanosecond laser (referred to as a superhydrophobic aluminum surface). It exhibits a high water contact angle (WCA) of 158.81°, a low sliding angle (SA) of less than 5°, and excellent self-cleaning ability. The wear test shows its durability, and the corrosion test shows its excellent corrosion resistance. This study provides a framework for the preparation of robust superhydrophobic surfaces that may have potential applications in many fields. |
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| Language | English |
| Publishing date | 2023-09-29 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2487261-1 |
| ISSN | 1996-1944 |
| ISSN | 1996-1944 |
| DOI | 10.3390/ma16196485 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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JACS Au
2023 Volume 3, Issue 7, Page(s) 1820–1834
Abstract: During immune responses, activating ligands would trigger dynamic spatiotemporal organization of immunoreceptors at the cell interface, governing the fate and effector functions of immune cells. To understand the biophysical mechanisms of immunoreceptor ... ...
| Abstract | During immune responses, activating ligands would trigger dynamic spatiotemporal organization of immunoreceptors at the cell interface, governing the fate and effector functions of immune cells. To understand the biophysical mechanisms of immunoreceptor signaling, diverse tools, including DNA technologies, have been developed to manipulate receptor-ligand interactions during the immune activation process. With great capability in the controllable assembly of biomolecules, functional DNA-based precise arrangement of immune molecules at cell interfaces has provided a powerful means in revealing the principles of immunoreceptor triggering, even at the single-molecule level. In addition, precisely regulating immunoreceptor-ligand interactions with functional DNA has been applied in immunotherapies of major diseases. This Perspective will focus on the recent advances in exploring immunoreceptor signaling with functional DNA as the molecular tool as well as the applications of functional DNA mediated regulation of immunoreceptor activation. We also outline the challenges and opportunities of applying functional DNA in immune modulation and immunotherapy. |
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| Language | English |
| Publishing date | 2023-07-11 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2691-3704 |
| ISSN (online) | 2691-3704 |
| DOI | 10.1021/jacsau.3c00291 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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