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Article: The {332}<113> Twinning Behavior of a Ti-15Mo Medical Alloy during Cyclic Deformation and Its Effect on Microstructure and Performance.

Xu, Tiewei / Sun, Bingqing / Zhang, Shanshan / Liu, Yuancai / Sun, Wei / Cui, Ning / Lv, Binjiang

2024 Volume 17, Issue 7

Abstract: In this study, the microstructural evolution of a Ti-15Mo medical alloy was investigated, when the in situ cyclic tensile strain had 2% amplitude and the tension-compression cyclic deformation had 1%, 2%, and 3% amplitude. The Vickers hardness and wear ... ...

Abstract	In this study, the microstructural evolution of a Ti-15Mo medical alloy was investigated, when the in situ cyclic tensile strain had 2% amplitude and the tension-compression cyclic deformation had 1%, 2%, and 3% amplitude. The Vickers hardness and wear resistance of the alloy were also optimized due to the grain-refining effect after cyclic deformation and annealing. The twinning-induced plasticity (TWIP) was considered the main deformation mechanism of the Ti-15Mo alloy during the tensile-compressive cycle deformation with suitable strain amplitude. The {332}<113> twins and boundaries were the main contributors to the grain refinement. The optimal microstructure, hardness, and wear resistance were obtained in the alloy deformed by tension-compression cyclic strain with a 3% strain amplitude. The wear resistance of the annealed alloy in Hank's solution was excellent in contrast to the original Ti-15Mo alloy due to its reasonable microstructure and hardness. It is clear that abundant twins were formed and retained in the coarse grains of the original alloy after cyclic deformation and annealing, which provided the expected refined grains and performance.
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17071462
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sulforaphene suppressed cell proliferation and promoted apoptosis of COV362 cells in endometrioid ovarian cancer.

Yu, Hui-Yan / Yang, Li / Liu, Yuan-Cai / Yu, Ai-Jun

PeerJ

2023 Volume 11, Page(s) e16308

Abstract: Aim: N6-methyladenosine (m6A) RNA methylation exerts a regulatory effect on endometrioid ovarian cancer (EOC), but the specific m6A regulator genes in EOC remain to be explored. This study investigated that sulforaphene (Sul) is implicated in EOC ... ...

Abstract	Aim: N6-methyladenosine (m6A) RNA methylation exerts a regulatory effect on endometrioid ovarian cancer (EOC), but the specific m6A regulator genes in EOC remain to be explored. This study investigated that sulforaphene (Sul) is implicated in EOC development by regulating methyltransferase-like 3 (METTL3). Methods: The dysregulated m6A RNA methylation genes in EOC were determined by methylated RNA immunoprecipitation (MeRIP-seq) and RNA sequencing. The roles of METTL3 and/or Sul on viability, proliferative ability, cell cycle, and apoptosis of EOC cells were determined by MTT, colony formation, flow cytometry, and TUNEL staining assay, respectively. The expression of METTL3 and apoptosis-related proteins in EOC cells was detected by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays. Results: Five m6A RNA methylation regulators (METTL3, ELF3, IGF2BP2, FTO, and METTL14) were differentially expressed in EOC, among which METTL3 had the highest expression level. Silencing METTL3 reduced the clonal expansion and viability of EOC cells, and caused the cells to arrest in the G0/G1 phase. This also promoted apoptosis in the EOC cells and activated the FAS/FADD and mitochondrial apoptosis pathways. In contrast, overexpressing METTL3 had the opposite effect. Sul, in a dose-dependent manner, reduced the viability of EOC cells but promoted their apoptosis. Sul also increased the levels of IGF2BP2 and FAS, while decreasing the levels of KRT8 and METTL3. Furthermore, Sul was able to reverse the effects of METTL3 overexpression on EOC cells. Conclusions: Sul could suppress cell proliferation and promote apoptosis of EOC cells by inhibiting the METTL3 to activate the FAS/FADD and apoptosis-associated pathways.
MeSH term(s)	Female ; Humans ; Cell Proliferation/genetics ; Apoptosis/genetics ; Carcinoma, Endometrioid/genetics ; Carcinoma, Ovarian Epithelial ; Ovarian Neoplasms/genetics ; RNA ; Methyltransferases/genetics ; RNA-Binding Proteins ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Chemical Substances	sulphoraphene (NCO9MC39IO) ; RNA (63231-63-0) ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-) ; IGF2BP2 protein, human ; RNA-Binding Proteins ; FTO protein, human (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33)
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16308
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Research on Short-term Aging of Lignin Modified Asphalt

Fu Xin / He Mao / Liu Yuancai

E3S Web of Conferences, Vol 233, p

2021 Volume 01125

Abstract: In order to study the micro-aging mechanism of lignin-modified asphalt, different asphalt samples were prepared with lignin content of 0% and 12% by mass. The conventional asphalt index test and high-temperature dynamic shear rheological test were used ... ...

Abstract	In order to study the micro-aging mechanism of lignin-modified asphalt, different asphalt samples were prepared with lignin content of 0% and 12% by mass. The conventional asphalt index test and high-temperature dynamic shear rheological test were used to analyze the different asphalt samples. The change law of the performance of modified lignin modified asphalt with thermal oxygen aging time. The results show that adding appropriate amount of lignin to each asphalt will increase the penetration and ductility of the base asphalt, reduce the softening point, and significantly improve the high-temperature stability; comparative analysis before and after DSR aging, the complex shear modulus G* increases and The decrease of phase angle δ indicates that lignin can improve the high-temperature rheological properties of asphalt.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on aging of lignin modified asphalt under thermogravimetric conditions

Fu Xin / He Mao / Liu Yuancai

E3S Web of Conferences, Vol 233, p

2021 Volume 01104

Abstract: In order to study the aging process of lignin-modified asphalt and explore the effect of lignin on the anti-aging performance of base asphalt, 4 sets of lignin-modified asphalt were prepared under different base asphalt, different dosage, temperature and ...

Abstract	In order to study the aging process of lignin-modified asphalt and explore the effect of lignin on the anti-aging performance of base asphalt, 4 sets of lignin-modified asphalt were prepared under different base asphalt, different dosage, temperature and time. Based on the thermal oxidation test (TFOT), dynamic shear rheological test (DSR), thermogravimetric test (TG), and infrared spectroscopy micro-performance test (FTIR), the high-temperature rheological properties and performance of aging lignin-based asphalt with different content were investigated. The changing law of the chemical properties of functional groups. The results show that the addition of lignin to the base asphalt sample increases the complex shear modulus G* and decreases the phase angle δ compared to the base asphalt sample prepared by the same sample preparation process. In the same sample, with the continuous increase of the test temperature, the complex shear modulus G* of the matrix asphalt before or after aging and the modified asphalt with different content of lignin showed a downward trend. The modification mechanism of lignin on asphalt is essentially that lignin decomposes and reacts with oxygen in the process of thermal oxidative aging, which delays the oxidation reaction of asphalt during aging, so as to achieve the anti-aging effect of asphalt.
Keywords	Environmental sciences ; GE1-350
Subject code	660
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of ultra-long fermentation time on the microbial community and flavor components of light-flavor Xiaoqu Baijiu based on fermentation tanks

Tang, Jie / Liu, Yuancai / Lin, Bin / Zhu, Hao / Jiang, Wei / Yang, Qiang / Chen, Shenxi

World journal of microbiology & biotechnology. 2022 Jan., v. 38, no. 1

2022

Abstract: Microbial structure and succession of fermented grains play a significant role in Baijiu’s flavor and quality. In this study, high-throughput sequencing (HTS) coupled with headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS- ... ...

Abstract	Microbial structure and succession of fermented grains play a significant role in Baijiu’s flavor and quality. In this study, high-throughput sequencing (HTS) coupled with headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) were used to analyze the microbial community structures and flavor components in the fermented grains at the end of fermentation from different fermentation time of light-flavor Xiaoqu Baijiu. HTS results showed that Lactobacillus acetotolerans, Lactobacillus helveticus, Lactobacillus buchneri, Wickerhamomyces, Saccharomyces, and Condenascus were identified as the dominant microbes, but Lactobacillus (96.28%) exhibited obvious advantages at the end of ultra-long fermentation time (day 98). HS-SPME-GC-MS analysis revealed that esters and alcohols had the most abundance in fermented grains of day 98, containing high concentrations of ethyl acetate, diethyl succinate, phenylethyl alcohol, isoamyl alcohol, and n-propanol, which were related to the succession of Lactobacillus and yeast communities. Interestingly, the content of n-propanol in the ultra-long fermentation time samples (day 98) was 6 times of that in normal fermented grains (day 14), which may be caused by higher abundance of Lactobacillus in day 98 samples. Monte Carlo permutation test showed residual starch, acidity, and amino nitrogen (p < 0.05) were important factors affecting the microbial community. Together, these results shed light on the physicochemical changes, microbial dynamics, and key flavor components of fermented grains at the end of fermentation from different fermentation time and provide a strategy for further improvement of Baijiu quality.
Keywords	1-propanol ; Lactobacillus acetotolerans ; Lactobacillus buchneri ; Lactobacillus helveticus ; Saccharomyces ; Wickerhamomyces ; acidity ; amino nitrogen ; biotechnology ; ethyl acetate ; fermentation ; flavor ; headspace analysis ; isoamyl alcohol ; microbial communities ; phenylethyl alcohol ; starch ; succinic acid ; yeasts
Language	English
Dates of publication	2022-01
Size	p. 3.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-021-03183-3
Database	NAL-Catalogue (AGRICOLA)

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Article: Characterization of Key Aroma Compounds in Xiaoqu Liquor and Their Contributions to the Sensory Flavor

Wang, Zhe / Sun, Xizhen / Liu, Yuancai / Yang, Hong

Beverages. 2020 July 01, v. 6, no. 3

2020

Abstract: The objective of this study was to investigate the aroma profile and major flavor compounds in Xiaoqu liquor by a combination of sensory profiling, GC-O/GC-MS analysis, and SBSE-GC-MS. A total of 57 important volatile compounds (FD ≥ 2) were screened ... ...

Abstract	The objective of this study was to investigate the aroma profile and major flavor compounds in Xiaoqu liquor by a combination of sensory profiling, GC-O/GC-MS analysis, and SBSE-GC-MS. A total of 57 important volatile compounds (FD ≥ 2) were screened based on the retention indices, aromatic characteristics, standard comparison, and aroma extract dilution analysis (AEDA). By calculating the odor activity values (OAVs), 32 aroma active compounds were identified in Xiaoqu liquor. In the aroma recombination experiments, these active compounds were dissolved in 46% ethanol water at their natural concentrations, resulting in successful simulations of the typical aromas of Xiaoqu liquor, including fruity aroma, sweet aroma, and grain aroma. Omission experiments showed that the critical compounds that contribute to the characteristic flavor of Xiaoqu liquor include ethyl octanoate, acetaldehyde, 1,1-diethoxyethane, isoamyl acetate, ethyl acetate, valeric acid, 1-octen-3-ol, and ethyl isovalerate. The results provide some guidance for upgrading the fermentation and microbial strain in the production of Xiaoqu liquor.
Keywords	acetaldehyde ; ethanol ; ethyl acetate ; fermentation ; flavor ; octanoic acid ; octenol ; odors ; valeric acid
Language	English
Dates of publication	2020-0701
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2785444-9
ISSN	2306-5710
ISSN	2306-5710
DOI	10.3390/beverages6030042
Database	NAL-Catalogue (AGRICOLA)

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Article: Qingfei mixture modulates the immune responses in lung cancer through modulating mTOR signaling and gut microbiota-derived short-chain fatty acids.

Qian, Xiang / Chen, Zhuo / Ji, Xu-Ming / Ji, Yong-Ling / Wang, Jin / Liu, Yuan-Cai / Zhou, Xia-Cheng / Li, Qing-Lin / Li, Chang-Yu / Zhang, Ai-Qin

Heliyon

2024 Volume 10, Issue 8, Page(s) e29404

Abstract: Lung cancer ranks among the primary contributors to cancer-related fatalities on a global scale. Multiple research investigations have demonstrated that there exists a dysbiosis within the intestinal bacteria and short-chain fatty acids (SCFAs) is linked ...

Abstract	Lung cancer ranks among the primary contributors to cancer-related fatalities on a global scale. Multiple research investigations have demonstrated that there exists a dysbiosis within the intestinal bacteria and short-chain fatty acids (SCFAs) is linked with immune responses in lung cancer. Qingfei mixture (QFM) has been widely used in treating lung cancer, yet the active ingredients and roles of the QFM on immune responses by targeting gut microbiota remain to be elucidated. The chemical constituents of QFM were qualitatively examined by UPLC/Q-TOF-MS. Additionally, we evaluated the therapeutic impact of the organic substance QFM on lung cancer, aiming to elucidate its mechanisms for improving the tumor-immune microenvironment. Herein, we constructed a Lewis lung carcinoma (LLC)-bearing mice model with QFM treatment to observe tumor growth and immune cell changes. Then, the feces were collected and a combinatory study using metagenomes, non-targeted metabonomics, and targeted metabonomics of SCFAs was performed. In vitro experiments have been conducted to estimate the roles of acetate and sodium propionate in CD8
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29404
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preparation of the Essential Oil from Artemisia Argyi Grown in Qichun, China and its application in Antibacterial effection

Hu Hui / Li Qingan / Chen Shenxi / Liu Yuancai / Gong Huameng / Jin Bukun

E3S Web of Conferences, Vol 189, p

2020 Volume 02016

Abstract: To evaluate the antibacterial activity and chemical constituents of the essential oil from the artemisia argyi grown in Qichun (China). METHODS: Steam distillation method was used to extract volatile oil from Artemisia argyi. The antibacterial effect of ... ...

Abstract	To evaluate the antibacterial activity and chemical constituents of the essential oil from the artemisia argyi grown in Qichun (China). METHODS: Steam distillation method was used to extract volatile oil from Artemisia argyi. The antibacterial effect of the volatile oil was investigated by the plate coating method and the double gradient liquid dilution method. Gas chromatography-mass spectrometry(GC-MS) was applied for the identification of chemical constituents in volatile oil from Artemisia argyi and the relative percentage of each component was calculated by area normalization. RESULTS: The essential oil from artemisia argyi grown in Qichun (China) has significant antibacterial activity against staphylococcus aureus, pseudomonas aeruginosa, salmonella, candida albicans, aspergillus niger and aspergillus flavus. And fifty chemical components were detected in the essential oil, and twenty compounds were identified, accounting for 95.95% of total essential oil. And the artemisol in artemisia argyi grown in Qichun (China) was found to be the highest compared with the same species from other producing areas. CONCLUSION: The essential oil from artemisia argyi grown in Qichun (China) was a potent antibacterial plant extract with potential applications as an antibacterial drugs or food preservative.
Keywords	Environmental sciences ; GE1-350
Subject code	571
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hangover headache and its behavioral changes in rats

Lu Shiguang / Zhang Ying / Yang Yuejun / Zhang Yafang / Qin Guangcheng / Fu Qingqing / Shi Yingying / Zhang Fan / Wang Zhe / Chen Yanhe / Liu Yuancai / chen Lixue

Iranian Journal of Basic Medical Sciences, Vol 26, Iss 3, Pp 326-

2023 Volume 334

Abstract: Objective(s): The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.Materials and Methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic ... ...

Abstract	Objective(s): The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.Materials and Methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic drinks (sample A, B, or C) to simulate hangover headache attacks. The withdrawal threshold for the hind paw/face and the thermal latency of hind paw withdrawal were detected after 24 hr. Serum was collected from the periorbital venous plexus of rats in each group, and enzymatic immunoassays were used to determine the serum levels of calcitonin gene-related peptide (CGRP), substance P (SP), and nitric oxide (NO).Results: Compared with the control group, the mechanical hind paw pain threshold was significantly lower in rats administered Samples A and B after 24 hr; however, no significant difference was observed across groups for the thermal pain threshold. The mechanical threshold for periorbital pain was only significantly reduced in rats administered Sample A. Immunoassays further indicated that serum levels of SP in the group administered Sample A were significantly higher than those in the control group; the serum levels of NO and CGRP were significantly higher in the group of rats receiving Sample B.Conclusion: We successfully developed an effective and safe rat model for investigating alcohol drink induced hangover headaches. This model could be used to investigate the mechanisms associated with hangover headaches for the development of novel and promising candidates for the future treatment or prophylaxis of hangover headaches.
Keywords	alcohol ; animal ; behavior ; central nervous system - sensitization ; disease models ; hangover ; headche ; Medicine ; R
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cytoprotection against Oxidative Stress by Methylnissolin-3-

Wu, Xiaohua / Xu, Jian / Cai, Yousheng / Yang, Yuejun / Liu, Yuancai / Cao, Shugeng

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 13

Abstract: Astragalus ... ...

Abstract	Astragalus membranaceus
MeSH term(s)	Astragalus propinquus/chemistry ; Chromones ; Cytoprotection/drug effects ; Heme Oxygenase-1/metabolism ; Hep G2 Cells ; Humans ; Morpholines ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Signal Transduction/drug effects
Chemical Substances	Chromones ; Morpholines ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Phytochemicals ; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (31M2U1DVID) ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2021-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26133852
Database	MEDical Literature Analysis and Retrieval System OnLINE

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