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  1. Article ; Online: Modern immunology is crucial to revealing the biological mechanisms of traditional Chinese medicine

    Liya Ju / Jian Jiang / Ye Jin / Jean-Pierre Armand / Dominique Charron

    Journal of Traditional Chinese Medical Sciences, Vol 10, Iss 4, Pp 383-

    2023  Volume 394

    Abstract: Traditional Chinese medicine (TCM), a major holistic approach to health and disease, has been used for a long time globally (>100 years) and in China (>1000 years) for various medical conditions. However, the contrast between TCM and modern medicine is ... ...

    Abstract Traditional Chinese medicine (TCM), a major holistic approach to health and disease, has been used for a long time globally (>100 years) and in China (>1000 years) for various medical conditions. However, the contrast between TCM and modern medicine is remarkable, and the underlying mechanisms of TCM remain unclear. In modern medicine, immunology is a complex, holistic defense system against pathogens, preserving homeostasis and influencing disease development. Notably, TCM and immunology share core concepts, such as holism, defense mechanisms, equilibrium, balance, and circadian rhythms. This review focuses on the similarities and distinctions between these two disciplines and sheds light on ancient TCM theories by leveraging modern immunological parameters. In addition, we emphasize the potential of advanced “omics” research methods to unravel TCM's mechanisms, providing compelling biological evidence for its therapeutic principles and effects using immunological data.
    Keywords Traditional Chinese medicine ; Immunology ; Holism ; Equilibrium ; Personalized medicine ; Miscellaneous systems and treatments ; RZ409.7-999
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: An international multicentric phase Ⅲ randomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer: a study protocol.

    Mahasti, Saghachian / Caroline, Barry / Bernard, Asselain / Yunfen, L I / Jianyun, Nie / Dequan, Liu / Dedian, Chen / Chunxin, Chen / Estevez, Laura / Wenhui, L I / Armand, Jean-Pierre / Miansheng, Zhu / Liya, J U

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2022  Volume 42, Issue 2, Page(s) 289–295

    Abstract: Objective: To determine the difference in prevention of chemotherapy-induced fatigue between time-acupoints-space acupuncture (ATAS) administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving ... ...

    Abstract Objective: To determine the difference in prevention of chemotherapy-induced fatigue between time-acupoints-space acupuncture (ATAS) administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide (EC) followed by paclitaxel, as measured by the multi-dimensional fatigue inventory (MFI) over the previous week and Visual Analogue Scale measuring fatigue (VAS-F), and to evaluate the effects of ATAS on self-reported neuropathy pain, sleep, anxiety and depression.
    Methods: In this multicenter clinical trial, we have randomized patients into 3 groups: ATAS, Sham and non-acupuncture with an unequal randomization of 2∶1∶1. A cloud related electronical clinical report form and smartphone platform was established for data entry. Patients with a history of stage Ⅰ-Ⅲ breast cancer scheduled to receive adjuvant chemotherapy. Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation. In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture, an evaluation of immune profiling was incorporate in this study.
    Results: The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment. Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly. Unfortunately, we do not have effective pharmacological interventions yet. And clinical trials of acupuncture in preventing chemotherapy-induced fatigue in patients with early breast cancer have not been reported.
    Conclusion: The findings of the trial will allow us to determine the effects of acupuncture treatment approach. We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments.
    MeSH term(s) Acupuncture Points ; Acupuncture Therapy/methods ; Antineoplastic Agents/adverse effects ; Breast Neoplasms/drug therapy ; Clinical Trials, Phase III as Topic ; Female ; Humans ; Multicenter Studies as Topic ; Quality of Life ; Randomized Controlled Trials as Topic
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-04-27
    Publishing country China
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603186-9
    ISSN 2589-451X ; 0254-6272 ; 0255-2922
    ISSN (online) 2589-451X ; 0254-6272
    ISSN 0255-2922
    DOI 10.19852/j.cnki.jtcm.2022.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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