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Article ; Online: Role of HIF1α and HIF2α in Cre Recombinase-Induced Retinal Pigment Epithelium Pathology and Its Secondary Effect on Choroidal Neovascularization.

Cristante, Enrico / Liyanage, Sidath E / Smith, Alexander J / Ali, Robin R / Bainbridge, James W B

2023 Volume 193, Issue 11, Page(s) 1694–1705

Abstract: ... ...

Abstract	Cre
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/j.ajpath.2023.05.017
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Article ; Online: Retinal detachment after post-operative endophthalmitis: clinical characteristics, outcomes and risk factors.

Schimansky, Sarah / Schwember, Philipp / Chervenkoff, Jordan / Liyanage, Sidath E / Keller, Johannes

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2023 Volume 261, Issue 8, Page(s) 2181–2187

Abstract: Purpose: To describe clinical characteristics, risk factors, and outcomes of rhegmatogenous retinal detachment (RRD) following treatment of postoperative endophthalmitis (PE).: Methods: Analysis of cross-referenced data from two service reviews of ... ...

Abstract	Purpose: To describe clinical characteristics, risk factors, and outcomes of rhegmatogenous retinal detachment (RRD) following treatment of postoperative endophthalmitis (PE). Methods: Analysis of cross-referenced data from two service reviews of patients with RRD and bacterial PE treated between 01/01/2013 and 01/07/2020. The main outcome measure was final best-corrected visual acuity (BCVA). Secondary measures include proportion of patients with BCVA of ≤ 0.3 logMAR and ≥ 1.0 logMAR, rate of phthsis, and rate of eye removal. Results: Ninety-four cases of PE were analysed finding 21 cases of RRD (22%). Seven (35%) experienced recurrent RRD. Seven eyes (35%) were left with permanent silicone oil fill. All RRD cases had vitrectomy. After PE with RRD the median BCVA was 1.1 logMAR, compared with 0.4 logMAR for PE without RRD (p < 0.04). Fifty-seven percent (12/21) of RRD eyes attained BCVA of ≥ 1.0 logMAR vs. 29% (21/73) of PE without RRD (p = 0.01). Nineteen percent (4/21) of eyes with RRD attained BCVA of ≤ 0.3 logMAR, whereas those without RRD did so in 43% (31/73) of cases (p = 0.02). Five eyes with RRD (24%) and 2 eyes without RRD (3%) developed phthisis (p < 0.01). Three non-RRD cases required removal of the eye (4%, p = 0.46). Higher bacterial virulence was associated with worse final BCVA (2.1 logMAR vs. 0.3 logMAR; p < 0.01). RRD rate did not differ by bacterial virulence (OR 1.9; CI95: 0.6-6.9; p = 0.24). Conclusions: RRD following PE leads to worse clinical outcomes. Eyes which developed RRD were more likely to have undergone vitrectomy. Final BCVA was worse in cases with more virulent micro-organisms.
MeSH term(s)	Humans ; Retinal Detachment/surgery ; Postoperative Complications/surgery ; Endophthalmitis/complications ; Eye ; Vitrectomy/adverse effects ; Risk Factors ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2023-03-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-023-06021-4
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Article ; Online: Comparison of Perfluorodecalin and Silicone Oil as Initial Tamponade for Giant Retinal Tear-Associated Retinal Detachment.

Keller, Johannes / Govetto, Andrea / Ramasamy, Pathma / Liyanage, Sidath E

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

2021 Volume 244, Issue 3, Page(s) 218–222

Abstract: Introduction: To compare visual outcomes and complication rates of giant retinal tear-associated retinal detachment (GRT-RD) cases treated with short-term perfluorodecalin (PFD) tamponade versus silicone oil (SiO).: Methods: Database analysis of ... ...

Abstract	Introduction: To compare visual outcomes and complication rates of giant retinal tear-associated retinal detachment (GRT-RD) cases treated with short-term perfluorodecalin (PFD) tamponade versus silicone oil (SiO). Methods: Database analysis of patients with GRT-RD operated on in the period from 1 January 2014 to 31 December 2019. Results: Forty-five patients were operated for GRT-RD using PFD or SiO during this period. Two children, 7 patients receiving gas tamponade, and 2 lost to follow-up were excluded. Eighteen eyes (40%) received PFD and 27 (60%) received SiO. There were 15/18 (83%) macula-sparing cases in the PFD group and 18/27 (67%) in the SiO group (p = 0.13). The mean duration of oil tamponade was 91 days for SiO and 7.6 days for PFD (p < 0.0001). The mean length of follow-up was 274.5 days for PFD and 668.9 days for SiO. The mean BCVA was 6/18 (63.4 ± 26.0 ETDRS letters) for SiO and 6/12 (72.9 ± 12.7 ETDRS letters) for PFD (p = 0.42). Analysing macula-sparing pseudophakic eyes, the BCVA was 6/12 (67.4 ± 25.9 letters, n = 18) for SiO eyes and 6/9 (76.8 ± 9.9 letters, n = 11) for PFD eyes (p = 0.54). The recurrence rate was 22% (6/27) for SiO and 6% (1/18) for PFD (p = 0.12). The rate of cystoid macular oedema (CMO) was 22% for SiO and 22% for PFD. Epiretinal membrane (ERM) was found in 26% of SiO cases and 22% of PFD cases. Loss of vision after oil removal was not observed. Seven eyes (26%) receiving SiO and none receiving PFD developed chronic ocular hypertension (OHT) (p = 0.02). Conclusions: Short-term tamponade with PFD for GRT-RD appears similar to tamponade with SiO in terms of the visual outcomes and complication rates.
MeSH term(s)	Child ; Fluorocarbons ; Follow-Up Studies ; Humans ; Retinal Detachment/diagnosis ; Retinal Detachment/etiology ; Retinal Detachment/surgery ; Retinal Perforations ; Silicone Oils ; Visual Acuity ; Vitrectomy
Chemical Substances	Fluorocarbons ; Silicone Oils ; perfluorodecalin (54A06VV62N)
Language	English
Publishing date	2021-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	209735-7
ISSN	1423-0267 ; 0030-3755
ISSN (online)	1423-0267
ISSN	0030-3755
DOI	10.1159/000516520
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Article ; Online: RHEGMATOGENOUS RETINAL DETACHMENT AFTER INJECTION OF TISSUE PLASMINOGEN ACTIVATOR AND GAS FOR SUBMACULAR HEMORRHAGE SECONDARY TO AGE-RELATED MACULAR DEGENERATION.

Manrique-Lipa, Roslyn / Jasim, Haneen / Safi, Antoine / Liyanage, Sidath E / Keller, Johannes

Retinal cases & brief reports

2022 Volume 18, Issue 1, Page(s) 131–134

Abstract: Purpose: The purpose of this study was to describe the rate, clinical characteristics, and outcomes of rhegmatogenous retinal detachment (RRD) after injection of tissue plasminogen activator (TPA) and gas for submacular hemorrhage displacement.: ... ...

Abstract	Purpose: The purpose of this study was to describe the rate, clinical characteristics, and outcomes of rhegmatogenous retinal detachment (RRD) after injection of tissue plasminogen activator (TPA) and gas for submacular hemorrhage displacement. Methods: Retrospective analysis of consecutive cases developing RRD after TPA injection and gas for submacular hemorrhage displacement. The rate of RRD was calculated, and a description of RRD clinical characteristics was performed. Anatomic and visual outcomes after RRD repair were analyzed. Results: Ninety eyes of 90 patients were analyzed. Tissue plasminogen activator was given intravitreally in 53 eyes (59%) and subretinally in 37 eyes (41%). RRD occurred in 6 of 90 eyes (7%). Of these, one had intravitreal TPA and five had vitrectomy with subretinal TPA ( P = 0.04). The mean age was 75 (64-93) years. The median time of RRD occurrence was 42 (1-134) days. All cases had macular involvement. Two cases had PVR at presentation. Vitrectomy was performed in all cases and silicone oil used in five, all of which resulted in permanent silicone oil retention. One case (17%) achieved primary single surgery success. The median final visual acuity was 1.8 logMAR (20/1,260 Snellen). Conclusion: The RRD rate after submacular hemorrhage displacement was 7% in our case series. Rhegmatogenous retinal detachment occurred more commonly after vitrectomy with subretinal TPA injection. The visual and anatomic outcomes were poor, with a high rate of retained silicone oil and recurrent RRD.
MeSH term(s)	Humans ; Aged ; Tissue Plasminogen Activator/adverse effects ; Fibrinolytic Agents/adverse effects ; Retinal Detachment/diagnosis ; Retinal Detachment/etiology ; Retinal Detachment/surgery ; Retrospective Studies ; Silicone Oils ; Retinal Hemorrhage/etiology ; Retinal Hemorrhage/drug therapy ; Macular Degeneration/drug therapy ; Vitrectomy/adverse effects
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68) ; Fibrinolytic Agents ; Silicone Oils
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article
ISSN	1937-1578
ISSN (online)	1937-1578
DOI	10.1097/ICB.0000000000001333
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Article ; Online: Probability of encountering Covid-19 patients based on prevalence and testing during resumption of ophthalmology services.

Keller, Johannes / Liyanage, Sidath E / Hingorani, Melanie / Hingorani, Aroon

Eye (London, England)

2020 Volume 35, Issue 4, Page(s) 1275–1276

MeSH term(s)	Asymptomatic Infections ; Biometry/methods ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19 Testing ; Carrier State/diagnosis ; Health Services/supply & distribution ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Ophthalmology/trends ; Prevalence ; Probability ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	England
Document type	Letter
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-020-1089-4
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Article: Probability of encountering Covid-19 patients based on prevalence and testing during resumption of ophthalmology services

Keller, Johannes / Liyanage, Sidath E / Hingorani, Melanie / Hingorani, Aroon

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #653736
Database	COVID19

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Article ; Online: Probability of encountering Covid-19 patients based on prevalence and testing during resumption of ophthalmology services

Keller, Johannes / Liyanage, Sidath E. / Hingorani, Melanie / Hingorani, Aroon

Eye ; ISSN 0950-222X 1476-5454

2020

Keywords	Ophthalmology ; General Arts and Humanities ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1038/s41433-020-1089-4
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiple regression analysis in myopic wavefront laser in situ keratomileusis nomogram development.

Liyanage, Sidath E / Allan, Bruce D

Journal of cataract and refractive surgery

2012 Volume 38, Issue 7, Page(s) 1232–1239

Abstract: Purpose: To develop a systematic method for quantifying pretreatment adjustments to the treatment sphere in patients having myopic wavefront laser in situ keratomileusis (LASIK).: Setting: Moorfields Eye Hospital, London, United Kingdom.: Design: ... ...

Abstract	Purpose: To develop a systematic method for quantifying pretreatment adjustments to the treatment sphere in patients having myopic wavefront laser in situ keratomileusis (LASIK). Setting: Moorfields Eye Hospital, London, United Kingdom. Design: Comparative case series. Methods: Preoperative and 3-month postoperative data from consecutive cases of myopic wavefront LASIK (<10.0 diopters [D] sphere; <4.5 D cylinder) treated in 2008-2009 were tabulated. Multiple regression modeling was used to derive a weighted relationship between the achieved manifest refraction spherical equivalent (MRSE) and several possible influences. A new nomogram was derived from the resultant regression equation in which the percentage treatment boost was based on the partial correlation coefficient for the 4.0 mm pupil wavefront refraction spherical equivalent (SE), and pretreatment adjustment to the treatment sphere was based on the sum of the other weighted independent variables. The MRSE results in eyes treated using the new nomogram in 2009-2010 were compared with those from the original data set. Results: The variance in postoperative MRSE error was significantly reduced using the new nomogram (0.10 D in 2009-2010 versus 0.16 D in 2008-2009; P<.0001, Bartlett test). The R(2) measure of linear fit increased from 0.967 in 2008-2009 to 0.983 in 2009-2010. Conclusions: Multiple regression modeling can be used to take account of several possible influences in enhancing the accuracy of wavefront LASIK. Nomograms developed through multiple regression modeling can be used to derive eye-specific pretreatment adjustments to the treatment sphere. Financial disclosure: Neither author has a financial or proprietary interest in any material or method mentioned.
MeSH term(s)	Aberrometry ; Accommodation, Ocular/physiology ; Adult ; Humans ; Keratomileusis, Laser In Situ/methods ; Lasers, Excimer/therapeutic use ; Models, Statistical ; Myopia/physiopathology ; Myopia/surgery ; Nomograms ; Postoperative Period ; Refraction, Ocular/physiology ; Regression Analysis ; Treatment Outcome ; Visual Acuity/physiology
Language	English
Publishing date	2012-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1016/j.jcrs.2012.02.043
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Article ; Online: Macular burns resulting from the accidental use of selective laser trabeculoplasty mode during a laser capsulotomy.

Liyanage, Sidath E / Kumaran, Neruban / De Alwis, Dilogen

The British journal of ophthalmology

2014 Volume 98, Issue 1, Page(s) 141–142

MeSH term(s)	Aged ; Eye Burns/etiology ; Female ; Humans ; Laser Therapy/adverse effects ; Lasers, Solid-State/adverse effects ; Lens Capsule, Crystalline/surgery ; Macula Lutea/injuries ; Medical Errors/adverse effects ; Trabeculectomy/methods
Language	English
Publishing date	2014-01
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2013-303489
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Article ; Online: Assessing visible aerosol generation during vitrectomy in the era of Covid-19

Liyanage, Sidath E / Ramasamy, Pathma / Elhaddad, Omar / Darcy, Kieren / Hudson, Andrew / Keller, Johannes

medRxiv

Abstract: Objective: To assess visible aerosol generation during simulated vitrectomy surgery. Methods: A model comprising a human cadaveric corneoscleral rim mounted on an artificial anterior chamber was used. Three-port 25 gauge vitrectomy simulated surgery was ... ...

Abstract	Objective: To assess visible aerosol generation during simulated vitrectomy surgery. Methods: A model comprising a human cadaveric corneoscleral rim mounted on an artificial anterior chamber was used. Three-port 25 gauge vitrectomy simulated surgery was performed with any visible aerosol production recorded using high speed 4K camera. The following were assessed: (1) vitrector at maximum cut rate in static and dynamic conditions inside the model, (2) vitrector at air-fluid interface in physical model, (3) passive fluid-air exchange with a backflush hand piece, (4) valved cannulas under air, and (5) defective valved cannula under air. Results: No visible aerosol or droplets were identified when the vitrector was used within the model. In the physical model, no visible aerosol or droplets were seen when the vitrector was engaged at the air-fluid interface. Droplets were produced from the opening of backflush hand piece during passive fluid-air exchange. No visible aerosol was produced from the intact valved cannulas under air pressure, but droplets were seen at the beginning of fluid-air exchange when the valved cannula was defective. Conclusions: We found no evidence of visible aerosol generation during simulated vitrectomy surgery with competent valved cannulas. In the physical model, no visible aerosol was generated by the high-speed vitrector despite cutting at the air-fluid interface.
Keywords	covid19
Language	English
Publishing date	2020-05-30
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.05.30.20117572
Database	COVID19

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