LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: An annotated human blastocyst dataset to benchmark deep learning architectures for in vitro fertilization.

    Kromp, Florian / Wagner, Raphael / Balaban, Basak / Cottin, Véronique / Cuevas-Saiz, Irene / Schachner, Clara / Fancsovits, Peter / Fawzy, Mohamed / Fischer, Lukas / Findikli, Necati / Kovačič, Borut / Ljiljak, Dejan / Martínez-Rodero, Iris / Parmegiani, Lodovico / Shebl, Omar / Min, Xie / Ebner, Thomas

    Scientific data

    2023  Volume 10, Issue 1, Page(s) 271

    Abstract: Medical Assisted Reproduction proved its efficacy to treat the vast majority forms of infertility. One of the key procedures in this treatment is the selection and transfer of the embryo with the highest developmental potential. To assess this potential, ...

    Abstract Medical Assisted Reproduction proved its efficacy to treat the vast majority forms of infertility. One of the key procedures in this treatment is the selection and transfer of the embryo with the highest developmental potential. To assess this potential, clinical embryologists routinely work with static images (morphological assessment) or short video sequences (time-lapse annotation). Recently, Artificial Intelligence models were utilized to support the embryo selection procedure. Even though they have proven their great potential in different in vitro fertilization settings, there is still considerable room for improvement. To support the advancement of algorithms in this research field, we built a dataset consisting of static blastocyst images and additional annotations. As such, Gardner criteria annotations, depicting a morphological blastocyst rating scheme, and collected clinical parameters are provided. The presented dataset is intended to be used to train deep learning models on static morphological images to predict Gardner's criteria and clinical outcomes such as live birth. A benchmark of human expert's performance in annotating Gardner criteria is provided.
    MeSH term(s) Humans ; Artificial Intelligence ; Benchmarking ; Blastocyst ; Deep Learning ; Fertilization in Vitro ; Female ; Pregnancy
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-023-02182-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Undetectable Serum Levels of Anti-Müllerian Hormone in Women with Ovarian Hyperstimulation Syndrome During In Vitro Fertilization and Successful Pregnancy Outcome: Case Report.

    Grbavac, Ivan / Zec, Ivana / Ljiljak, Dejan / Rakoš Justament, Romina / Bukovec Megla, Željka / Kuna, Krunoslav

    Acta clinica Croatica

    2018  Volume 57, Issue 1, Page(s) 177–180

    Abstract: We report a unique case of undetectable serum levels of anti-müllerian hormone (AMH) in women with polycystic ovary syndrome (PCOS) who developed ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF). A case is described of a 28- ... ...

    Abstract We report a unique case of undetectable serum levels of anti-müllerian hormone (AMH) in women with polycystic ovary syndrome (PCOS) who developed ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF). A case is described of a 28-year-old woman with clinical symptoms of PCOS and AMH serum level below analytical sensitivity (<1.0 pmol/L). After undergoing controlled ovarian stimulation, the patient developed OHSS. After follicle aspiration, seven oocytes were recovered. Three of them were used for intracytoplasmic sperm injection (ICSI) and fertilized, but with unsuccessful pregnancy outcome. A successful pregnancy was achieved in the second IVF/ICSI cycle with six oocytes retrieved and three embryos transferred. At 39 weeks of gestation, the patient delivered a healthy baby weighing 3930 g and 50 cm long. In conclusion, although AMH is considered a useful tool in ovarian reserve assessment and in predicting response to controlled ovarian hyperstimulation, the case presented shows that AMH should not be used as an independent ovarian marker.
    MeSH term(s) Adult ; Anti-Mullerian Hormone/blood ; Female ; Fertilization in Vitro ; Humans ; Ovarian Hyperstimulation Syndrome ; Ovulation Induction ; Polycystic Ovary Syndrome ; Pregnancy ; Pregnancy Outcome ; Sperm Injections, Intracytoplasmic
    Chemical Substances Anti-Mullerian Hormone (80497-65-0)
    Language English
    Publishing date 2018-09-26
    Publishing country Croatia
    Document type Case Reports ; Journal Article
    ZDB-ID 1478635-7
    ISSN 0353-9466
    ISSN 0353-9466
    DOI 10.20471/acc.2018.57.01.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5057: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Synergetic Effects of K, Ca, Cu and Zn in Human Semen in Relation to Parameters Indicative of Spontaneous Hyperactivation of Spermatozoa.

    Bolanca, Ivan / Obhodas, Jasmina / Ljiljak, Dejan / Matjacic, Lidija / Kuna, Krunoslav

    PloS one

    2016  Volume 11, Issue 3, Page(s) e0152445

    Abstract: We have observed that sperm quality parameters indicative of spermatozoa hyperactivation such are lower "linearity" and "straightness", and as showed by this research "elongation", were more pronounced in patients with normal spermiogram compared to the ... ...

    Abstract We have observed that sperm quality parameters indicative of spermatozoa hyperactivation such are lower "linearity" and "straightness", and as showed by this research "elongation", were more pronounced in patients with normal spermiogram compared to the group of men with reduced sperm motility who were undergoing routine in vitro fertilisation. The research encompassed 97 men diagnosed with normozoospermia (n = 20), asthenozoospermia (n = 54) and oligoasthenozoospermia (n = 23). The findings indicate that sperm quality of patients with normal spermiogram diagnosed according to WHO criteria, may be compromised by showing premature spontaneous hyperactivation which can decrease the chances of natural conception. We assessed synergistic effects of multiple chemical elements in ejaculated semen to find if premature spontaneous hyperactivation of spermatozoa can be a sign of imbalanced semen composition especially of elements K, Ca, Cu and Zn. Human semen samples showing low or high baseline status of chemical elements concentrations were found in samples from all three diagnostic groups. However, correlation of K/Ca and Cu/Zn ratios, taking into account samples from all three groups of men, were negative at statistical significance level p = 0.01. We tested if the negative correlation between K/Ca and Cu/Zn ratio works for greater number of semen samples. We found the negative correlation to be valid for 175 semen samples at statistical significance of p = 0.00002. The ratio of K/Ca and Cu/Zn, i.e. increased concentrations of K and Zn in comparison to concentrations of Ca and Cu, were associated with a decrease of "straightness" in the group of men with normal spermiogram and pronounced spontaneous hyperactivation of spermatozoa, implying that these elements act in synergy and that the balance of elements and not their absolute concentrations plays the major role in premature spermatozoa hyperactivation in ejaculated semen.
    MeSH term(s) Calcium/physiology ; Case-Control Studies ; Copper/physiology ; Humans ; Infertility, Male ; Male ; Potassium/physiology ; Semen/physiology ; Sperm Motility ; Spermatozoa/physiology ; Zinc/physiology
    Chemical Substances Copper (789U1901C5) ; Zinc (J41CSQ7QDS) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0152445
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia.

    Abramovic, Irena / Vrhovec, Borna / Skara, Lucija / Vrtaric, Alen / Nikolac Gabaj, Nora / Kulis, Tomislav / Stimac, Goran / Ljiljak, Dejan / Ruzic, Boris / Kastelan, Zeljko / Kruslin, Bozo / Bulic-Jakus, Floriana / Ulamec, Monika / Katusic-Bojanac, Ana / Sincic, Nino

    Cancers

    2021  Volume 13, Issue 9

    Abstract: Prostate cancer (PCa) is the most commonly diagnosed neoplasm among men. Since it often resembles benign prostate hyperplasia (BPH), biomarkers with a higher differential value than PSA are required. Epigenetic biomarkers in liquid biopsies, especially ... ...

    Abstract Prostate cancer (PCa) is the most commonly diagnosed neoplasm among men. Since it often resembles benign prostate hyperplasia (BPH), biomarkers with a higher differential value than PSA are required. Epigenetic biomarkers in liquid biopsies, especially miRNA, could address this challenge. The absolute expression of miR-375-3p, miR-182-5p, miR-21-5p, and miR-148a-3p were quantified in blood plasma and seminal plasma of 65 PCa and 58 BPH patients by digital droplet PCR. The sensitivity and specificity of these microRNAs were determined using ROC curve analysis. The higher expression of miR-182-5p and miR-375-3p in the blood plasma of PCa patients was statistically significant as compared to BPH (
    Language English
    Publishing date 2021-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13092068
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Follicular fluid anti-Müllerian hormone: a predictive marker of fertilization capacity of MII oocytes.

    Tramišak Milaković, Tamara / Panić Horvat, Linda / Čavlović, Kristina / Smiljan Severinski, Neda / Vlašić, Hrvoje / Vlastelić, Ivan / Ljiljak, Dejan / Radojčić Badovinac, Anđelka

    Archives of gynecology and obstetrics

    2015  Volume 291, Issue 3, Page(s) 681–687

    Abstract: Purpose: The present study aimed to correlate anti-Müllerian hormone (AMH) levels in follicular fluid (FF) with oocyte maturity stages, morphological quality of metaphase II (MII) oocyte and fertilization capacity of MII oocytes.: Methods: A total of ...

    Abstract Purpose: The present study aimed to correlate anti-Müllerian hormone (AMH) levels in follicular fluid (FF) with oocyte maturity stages, morphological quality of metaphase II (MII) oocyte and fertilization capacity of MII oocytes.
    Methods: A total of 92 infertile women undergoing controlled ovarian stimulation and intracytoplasmic sperm injection were analyzed. Patients were divided into two groups according to age: <35 years (n = 43) and ≥35 years (n = 49). An FF sample was obtained from a single dominant follicle in each patient for a total of 92 follicular fluid samples analyzed. AMH levels in serum and follicular fluid were measured by enzyme-linked immunosorbent assay. Mature MII oocytes, zygotes, and embryos were assessed for morphological quality.
    Results: Serum AMH levels were significantly higher in patients aged <35 years. No correlation was observed between FF AMH level and oocyte maturation stages or morphological quality of MII oocyte. Significantly lower FF AMH levels were observed in fertilized MII oocytes than in non-fertilized MII oocytes in patients aged <35 years (2.56 ± 2.0 ng/ml vs. 4.81 ± 4.14 ng/ml; p = 0.032).
    Conclusions: The present study revealed no correlation between FF AMH and oocyte maturity stage or morphological quality of MII oocyte. However, FF AMH might be a predictive marker for fertilization capacity of MII oocytes.
    MeSH term(s) Adult ; Age Factors ; Anti-Mullerian Hormone/analysis ; Anti-Mullerian Hormone/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Fertilization in Vitro ; Follicular Fluid/chemistry ; Follicular Fluid/metabolism ; Humans ; Infertility, Female/therapy ; Metaphase ; Oocytes/cytology ; Oocytes/physiology ; Oogenesis ; Ovarian Follicle/metabolism ; Ovulation Induction ; Predictive Value of Tests ; Pregnancy ; Pregnancy Rate ; Sperm Injections, Intracytoplasmic
    Chemical Substances Anti-Mullerian Hormone (80497-65-0)
    Language English
    Publishing date 2015-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-014-3460-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um I Zs.55: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: CROATIAN SOCIETY OF CLINICAL EMBRYOLOGISTS – GUIDELINES ON THE EPIDEMIOLOGICAL FRAMEWORK FOR THE IMPLEMENTATION OF MEDICALLY ASSISTED REPRODUCTION (MAR) PROCEDURES DURING THE COVID-19 PANDEMIC REGARDING THE SAFETY OF PATIENTS AND MEDICAL HEALTH WORKERS

    Vujisic Zivkovic, Sanja / Baricevic, Marijana / Cavlovic, Kristina / Cerina, Mia / Cukusic Kalajzic, Andrea / Dundovic, Marija / Hafner, Daria / Gelo, Nina / Ljiljak, Dejan / Matkovic, Katarina / Smolcic, Ana / Sogoric Sevo, Sonja / Stimac, Davor / Tramisak Milakovic, Tamara / Zovkic, Sanja / Stanic, Patrik

    Molecular and Experimental Biology in Medicine ; ISSN 2584-671X (Online) ; Volume 3 ; Issue 1

    2020  

    Abstract: Due to the high virulence of the SARS-CoV-2 virus, the infection rate in the community has led to a state of pandemic, leading to the introduction of new emergency measures all over the world. With the aim of controlling and preventing the SARS-CoV-2 ... ...

    Abstract Due to the high virulence of the SARS-CoV-2 virus, the infection rate in the community has led to a state of pandemic, leading to the introduction of new emergency measures all over the world. With the aim of controlling and preventing the SARS-CoV-2 viral epidemic, the health institutions performing medically assisted reproduction (MAR) suspended any new MAR treatments in order to reduce the burden on the health care system and implement current social distancing recommendations. Considering the favorable epidemiological situation in Croatia, our perspective is that it is time to conceive, plan and bring forth guidelines for restarting work in MAR centres, taking into account the selection of patients and organization of good laboratory and clinical practices with emphasis on the safety of patients and health workers. In regard to epidemiological knowledge, it is important to establish the reorganization of work in MAR centres including epidemiological measures of reducing unnecessary stays in closed spaces, the usage of protective gear by patients and health workers and disinfection of the working spaces and equipment.
    Keywords Croatian Society of Clinical Embryologists ; IVF laboratory ; medically assisted reproduction ; health epidemiological framework ; Covid-19 pandemic ; covid19
    Subject code 360
    Language English
    Publisher Croatian Society of Biologists in Health Care
    Publishing country hr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top