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  1. Article ; Online: Boosting the Exhausted Vasculature-SIRT3 (to the) Rescue.

    Ljubojevic-Holzer, Senka / Crnkovic, Slaven

    American journal of respiratory cell and molecular biology

    2023  Volume 69, Issue 5, Page(s) 497–499

    MeSH term(s) Humans ; Sirtuin 3/genetics ; Hypertension, Pulmonary ; Mitochondria ; Fibroblasts
    Chemical Substances Sirtuin 3 (EC 3.5.1.-) ; SIRT3 protein, human (EC 3.5.1.-)
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2023-0199ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact.

    Kiessling, Mara / Djalinac, Nataša / Voglhuber, Julia / Ljubojevic-Holzer, Senka

    Biomedicines

    2023  Volume 11, Issue 3

    Abstract: The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium ( ... ...

    Abstract The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium (Ca
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11030960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Secret of the Kissing Cousins: an ER-mitochondrial tethering protein regulates Ca2+ crosstalk in mammalian neurons.

    Ljubojevic-Holzer, Senka

    Cardiovascular research

    2018  Volume 114, Issue 3, Page(s) e17–e18

    MeSH term(s) Animals ; Calcium ; Endoplasmic Reticulum ; Mitochondria ; Mitochondrial Proteins ; Neurons
    Chemical Substances Mitochondrial Proteins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-03-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvy020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Cellular Heterogeneity of the Heart.

    Anto Michel, Nathaly / Ljubojevic-Holzer, Senka / Bugger, Heiko / Zirlik, Andreas

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 868466

    Abstract: Recent advances in technology such as the introduction of high throughput multidimensional tools like single cell sequencing help to characterize the cellular composition of the human heart. The diversity of cell types that has been uncovered by such ... ...

    Abstract Recent advances in technology such as the introduction of high throughput multidimensional tools like single cell sequencing help to characterize the cellular composition of the human heart. The diversity of cell types that has been uncovered by such approaches is by far greater than ever expected before. Accurate identification of the cellular variety and dynamics will not only facilitate a much deeper understanding of cardiac physiology but also provide important insights into mechanisms underlying its pathological transformation. Distinct cellular patterns of cardiac cell clusters may allow differentiation between a healthy heart and a sick heart while potentially predicting future disease at much earlier stages than currently possible. These advances have already extensively improved and will ultimately revolutionize our knowledge of the mechanisms underlying cardiovascular disease as such. In this review, we will provide an overview of the cells present in the human and rodent heart as well as genes that may be used for their identification.
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.868466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The unexpected intelligence: what is the naked mole-rat's secret to surviving oxygen deprivation?

    Ljubojevic-Holzer, Senka

    Cardiovascular research

    2017  Volume 113, Issue 10, Page(s) e27–e28

    MeSH term(s) Animals ; Fructose ; Glycolysis ; Hypoxia ; Intelligence ; Mole Rats ; Oxygen
    Chemical Substances Fructose (30237-26-4) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2017-10-03
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvx114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics.

    Voglhuber, Julia / Ljubojevic-Holzer, Senka / Abdellatif, Mahmoud / Sedej, Simon

    Frontiers in nutrition

    2021  Volume 8, Page(s) 758058

    Abstract: The average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension, ... ...

    Abstract The average human life expectancy continues to rise globally and so does the prevalence and absolute burden of cardiovascular disease. Dietary restriction promotes longevity and improves various cardiovascular risk factors, including hypertension, obesity, diabetes mellitus, and metabolic syndrome. However, low adherence to caloric restriction renders this stringent dietary intervention challenging to adopt as a standard practice for cardiovascular disease prevention. Hence, alternative eating patterns and strategies that recapitulate the salutary benefits of caloric restriction are under intense investigation. Here, we first provide an overview of alternative interventions, including intermittent fasting, alternate-day fasting and the Mediterranean diet, along with their cardiometabolic effects in animal models and humans. We then present emerging pharmacological alternatives, including spermidine, NAD
    Language English
    Publishing date 2021-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2021.758058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Autophagy in cardiovascular health and disease.

    Abdellatif, Mahmoud / Ljubojevic-Holzer, Senka / Madeo, Frank / Sedej, Simon

    Progress in molecular biology and translational science

    2020  Volume 172, Page(s) 87–106

    Abstract: Autophagy is a cellular housekeeping and quality control mechanism that is essential for homeostasis and survival. By virtue of this role, any perturbations to the flow of this process in cardiac or vascular cells can elicit harmful effects on the ... ...

    Abstract Autophagy is a cellular housekeeping and quality control mechanism that is essential for homeostasis and survival. By virtue of this role, any perturbations to the flow of this process in cardiac or vascular cells can elicit harmful effects on the cardiovascular system, and subsequently affect whole organismal health. In this chapter, we summarize the preclinical evidence supporting the role of autophagy in sustaining cardiovascular health during homeostasis and disease. Furthermore, we discuss how autophagy activation by dietary, genetic and pharmaceutical interventions can be exploited to counteract common cardiovascular disorders, including atherosclerosis, coronary artery disease, diabetic cardiomyopathy, arrhythmia, chemotherapy-induced cardiotoxicity and heart failure.
    Language English
    Publishing date 2020-05-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2020.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs 357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: HDL Isolated by Immunoaffinity, Ultracentrifugation, or Precipitation is Compositionally and Functionally Distinct.

    Holzer, Michael / Ljubojevic-Holzer, Senka / Souza Junior, Douglas Ricardo / Stadler, Julia T / Rani, Alankrita / Scharnagl, Hubert / Ronsein, Graziella Eliza / Marsche, Gunther

    Journal of lipid research

    2022  Volume 63, Issue 12, Page(s) 100307

    Abstract: The HDL proteome has been widely recognized as an important mediator of HDL function. While a variety of HDL isolation methods exist, their impact on the HDL proteome and its associated function remain largely unknown. Here, we compared three of the most ...

    Abstract The HDL proteome has been widely recognized as an important mediator of HDL function. While a variety of HDL isolation methods exist, their impact on the HDL proteome and its associated function remain largely unknown. Here, we compared three of the most common methods for HDL isolation, namely immunoaffinity (IA), density gradient ultracentrifugation (UC), and dextran-sulfate precipitation (DS), in terms of their effects on the HDL proteome and associated functionalities. We used state-of-the-art mass spectrometry to identify 171 proteins across all three isolation methods. IA-HDL contained higher levels of paraoxonase 1, apoB, clusterin, vitronectin, and fibronectin, while UC-HDL had higher levels of apoA2, apoC3, and α-1-antytrypsin. DS-HDL was enriched with apoA4 and complement proteins, while the apoA2 content was very low. Importantly, size-exclusion chromatography analysis showed that IA-HDL isolates contained subspecies in the size range above 12 nm, which were entirely absent in UC-HDL and DS-HDL isolates. Analysis of these subspecies indicated that they primarily consisted of apoA1, IGκC, apoC1, and clusterin. Functional analysis revealed that paraoxonase 1 activity was almost completely lost in IA-HDL, despite high paraoxonase content. We observed that the elution conditions, using 3M thiocyanate, during IA resulted in an almost complete loss of paraoxonase 1 activity. Notably, the cholesterol efflux capacity of UC-HDL and DS-HDL was significantly higher compared to IA-HDL. Together, our data clearly demonstrate that the isolation procedure has a substantial impact on the composition, subclass distribution, and functionality of HDL. In summary, our data show that the isolation procedure has a significant impact on the composition, subclass distribution and functionality of HDL. Our data can be helpful in the comparison, replication and analysis of proteomic datasets of HDL.
    Language English
    Publishing date 2022-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2022.100307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes.

    Helmstadter, Kathryn G / Ljubojevic-Holzer, Senka / Wood, Brent M / Taheri, Khanha D / Sedej, Simon / Erickson, Jeffrey R / Bossuyt, Julie / Bers, Donald M

    Basic research in cardiology

    2021  Volume 116, Issue 1, Page(s) 11

    Abstract: Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription, implicated in the development of heart failure. CaMKII-dependent phosphorylation drives nucleus-to-cytoplasm HDAC4 shuttling, but protein kinase A (PKA) is also linked to HDAC4 ... ...

    Abstract Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription, implicated in the development of heart failure. CaMKII-dependent phosphorylation drives nucleus-to-cytoplasm HDAC4 shuttling, but protein kinase A (PKA) is also linked to HDAC4 translocation. However, the interplay of CaMKII and PKA in regulating adult cardiomyocyte HDAC4 translocation is unclear. Here we sought to determine the interplay of PKA- and CaMKII-dependent HDAC4 phosphorylation and translocation in adult mouse, rabbit and human ventricular myocytes. Confocal imaging and protein analyses revealed that inhibition of CaMKII-but not PKA, PKC or PKD-raised nucleo-to-cytoplasmic HDAC4 fluorescence ratio (F
    MeSH term(s) Active Transport, Cell Nucleus ; Adrenergic beta-Agonists/pharmacology ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cardiomegaly/enzymology ; Cardiomegaly/genetics ; Cardiomegaly/pathology ; Cardiomegaly/physiopathology ; Cells, Cultured ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Disease Models, Animal ; Female ; Heart Failure/enzymology ; Heart Failure/genetics ; Heart Failure/pathology ; Heart Failure/physiopathology ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/pathology ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Rabbits ; Repressor Proteins ; Signal Transduction ; Ventricular Remodeling
    Chemical Substances Adrenergic beta-Agonists ; Protein Kinase Inhibitors ; Repressor Proteins ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Camk2g protein, mouse (EC 2.7.11.17) ; HDAC4 protein, human (EC 3.5.1.98) ; Hdac5 protein, mouse (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2021-02-15
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-021-00850-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.30: Show issues Location:
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  10. Article: β-Adrenergic Receptor Stimulation Maintains NCX-CaMKII Axis and Prevents Overactivation of

    Matzer, Ingrid / Voglhuber, Julia / Kiessling, Mara / Djalinac, Nataša / Trummer-Herbst, Viktoria / Mabotuwana, Nishani / Rech, Lavinia / Holzer, Michael / Sossalla, Samuel / Rainer, Peter P / Zirlik, Andreas / Ljubojevic-Holzer, Senka

    Biomedicines

    2022  Volume 10, Issue 7

    Abstract: Excessive β-adrenergic stimulation and tachycardia are potent triggers of cardiac remodeling; however, their exact cellular effects remain elusive. Here, we sought to determine the potency of β-adrenergic stimulation and tachycardia to modulate gene ... ...

    Abstract Excessive β-adrenergic stimulation and tachycardia are potent triggers of cardiac remodeling; however, their exact cellular effects remain elusive. Here, we sought to determine the potency of β-adrenergic stimulation and tachycardia to modulate gene expression profiles of cardiomyocytes. Using
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10071648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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