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  1. Article ; Online: Cost-effectiveness analysis of ritonavir boosted nirmatrelvir for adult outpatients with mild to moderate COVID-19 in a European health system.

    Wikman-Jorgensen, Philip / Ibarra, José María / Devesa, Carlos / Peris, Jorge / Llenas-García, Jara

    European journal of internal medicine

    2023  Volume 118, Page(s) 133–135

    MeSH term(s) Humans ; Adult ; Ritonavir/therapeutic use ; Cost-Effectiveness Analysis ; Outpatients ; COVID-19 ; COVID-19 Drug Treatment ; Lactams ; Nitriles ; Antiviral Agents/therapeutic use
    Chemical Substances Ritonavir (O3J8G9O825) ; Lactams ; Nitriles ; Antiviral Agents
    Language English
    Publishing date 2023-10-07
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.09.025
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    Zs.A 2608: Show issues Location:
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  2. Article ; Online: A Review on Strongyloidiasis in Pregnant Women.

    Wikman-Jorgensen, Philip / Requena-Méndez, Ana / Llenas-García, Jara

    Research and reports in tropical medicine

    2021  Volume 12, Page(s) 219–225

    Abstract: Strongyloidiasis is a parasitic infection distributed worldwide, with an estimated 614 million people infected. Strongyloidiasis usually presents asymptomatically or with aspecific and mild clinical symptoms, mainly cutaneous, respiratory, or ... ...

    Abstract Strongyloidiasis is a parasitic infection distributed worldwide, with an estimated 614 million people infected. Strongyloidiasis usually presents asymptomatically or with aspecific and mild clinical symptoms, mainly cutaneous, respiratory, or gastrointestinal. Disseminated disease and hyperinfection syndrome are the most serious complications, have a high mortality rate, usually occur in immunosuppressed patients, and are particularly associated with the use of corticosteroids. Strongyloidiasis is the most neglected of the neglected diseases, and its occurrence in pregnancy has been neglected and understudied. In this review, we focus on the effects of strongyloidiasis during pregnancy and highlight the knowledge shortage and the need for more research on the subject. There are few studies addressing strongyloidiasis prevalence during pregnancy and hyperinfection incidence during pregnancy is practically unknown, with only isolated case reports published. Although data are scarce, the infection has been associated with developmental disabilities and anemia during pregnancy, while hyperinfection may cause both maternal and neonatal death. Data on the best screening and diagnostic strategies during pregnancy are lacking. There is insufficient evidence on ivermectin safety in pregnancy, complicating treatment recommendations.
    Language English
    Publishing date 2021-09-21
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2578572-2
    ISSN 1179-7282 ; 1179-7282
    ISSN (online) 1179-7282
    ISSN 1179-7282
    DOI 10.2147/RRTM.S282268
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  3. Article ; Online: Multisystem inflammatory syndrome in adults associated to SARS-CoV-2.

    Llenas-García, Jara / Paredes-Martínez, Mari Luz / Boils-Arroyo, Pedro Luis / Pérez-Gómez, Isabel María

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 40, Issue 7, Page(s) 407–409

    MeSH term(s) COVID-19/complications ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-05-02
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2022.04.006
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  4. Article ; Online: [Comments to the document

    Wikman-Jorgensen, Philip / Requena-Méndez, Ana / Navarro, Miriam / Llenas-García, Jara

    Enfermedades infecciosas y microbiologia clinica

    2022  Volume 40, Issue 7, Page(s) 411–412

    Title translation Comentarios al documento
    Language Spanish
    Publishing date 2022-04-20
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2022.02.011
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  5. Article ; Online: Comments to the document GEPI-SEIMC screening recommendations for patients with suspected strongyloidosis.

    Wikman-Jorgensen, Philip / Requena-Méndez, Ana / Navarro, Miriam / Llenas-García, Jara

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 40, Issue 7, Page(s) 411–412

    MeSH term(s) Antiviral Agents/therapeutic use ; Humans ; Strongyloidiasis/diagnosis
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-05-24
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2022.05.004
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  6. Article ; Online: Síndrome inflamatorio multisistémico del adulto asociado a SARS-CoV-2.

    Llenas-García, Jara / Paredes-Martínez, Mari Luz / Boils-Arroyo, Pedro Luis / Pérez-Gómez, Isabel María

    Enfermedades infecciosas y microbiologia clinica

    2021  Volume 40, Issue 7, Page(s) 407–409

    Title translation Multisystem inflammatory syndrome in adults associated to SARS-CoV-2.
    Language Spanish
    Publishing date 2021-12-06
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2021.10.009
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  7. Article ; Online: Reingresos por la COVID-19 durante los tres primeros periodos epidémicos en Orihuela, España: incidencia, factores de riesgo y letalidad.

    Roig-Sánchez, Nuria / Talaya Peñalver, Alberto / Poveda Ruiz, Noemí / Del Pozo, Alfonso / Hernández Campillo, Ana María / Pérez Bernabéu, Alicia / Martínez-López, Belén / González-Cuello, Inmaculada / García-López, María / Borrajo Brunete, Emilio / Wikman-Jorgensen, Philip / Llenas-García, Jara

    Revista espanola de salud publica

    2024  Volume 98

    Abstract: Objective: Readmission for COVID-19 is associated with high mortality, saturation of health services, and high costs. This study aimed to assess the incidence and risk factors of readmissions in COVID-19 patients in a regional hospital of Spain from ... ...

    Title translation COVID-19 readmissions during the first three epidemic periods in Orihuela, Spain: incidence, risk factors and letality.
    Abstract Objective: Readmission for COVID-19 is associated with high mortality, saturation of health services, and high costs. This study aimed to assess the incidence and risk factors of readmissions in COVID-19 patients in a regional hospital of Spain from February 2020 to March 2021.
    Methods: A retrospective cohort study describing the characteristics of adult patients readmitted within thirty days of discharge after being infected with SARS-CoV-2 was carried out. Readmission associated risk factors were analysed using a binary logistic regression model.
    Results: Of the 967 patients who survived their first COVID-19 admission, 70 (7.2%) were readmitted within thirty days. Of these, 34.3% presented pneumonia progression, 15.7% functional deterioration, and 12.9% other infections. The mortality rate during readmission was 28.6%. There were no statistically significant differences in the cumulative incidence of readmissions between the epidemic periods (p=0.241). Factors independently associated with readmission were: diabetes mellitus (aOR 1.96, 95%CI 1.07-3.57, p=0.030); acute kidney failure (aOR 2.69, 95%CI 1.43-5.07, p=0.002); not being a candidate for intensive care (aOR 7.68, 95% CI 4.28-13.80, p<0.001); and not being prescribed corticosteroids at discharge (aOR 2.15, 95% CI 1.04-4.44; p=0.039).
    Conclusions: A substantial proportion of patients admitted due to COVID-19 are readmitted, and they carry a high letality. Diabetes mellitus, acute kidney failure, not being a candidate for ICU admission, and not being prescribed corticosteroids on discharge are independently associated with an increased risk of readmission.
    MeSH term(s) Adult ; Humans ; Incidence ; Patient Readmission ; COVID-19/epidemiology ; Retrospective Studies ; Spain/epidemiology ; SARS-CoV-2 ; Risk Factors ; Diabetes Mellitus ; Acute Kidney Injury ; Adrenal Cortex Hormones
    Chemical Substances Adrenal Cortex Hormones
    Language Spanish
    Publishing date 2024-03-19
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
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    Zs.A 483: Show issues Location:
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  8. Article ; Online: Ivermectin Effect on In-Hospital Mortality and Need for Respiratory Support in COVID-19 Pneumonia: Propensity Score-Matched Retrospective Study.

    Llenas-García, Jara / Del Pozo, Alfonso / Talaya, Alberto / Roig-Sánchez, Nuria / Poveda Ruiz, Noemí / Devesa García, Carlos / Borrajo Brunete, Emilio / González Cuello, Inmaculada / Lucas Dato, Ana / Navarro, Miriam / Wikman-Jorgensen, Philip

    Viruses

    2023  Volume 15, Issue 5

    Abstract: Introduction: There is negligible evidence on the efficacy of ivermectin for treating COVID-19 pneumonia. This study aimed to assess the efficacy of ivermectin for pre-emptively treating : Methods: This single-center, observational, retrospective ... ...

    Abstract Introduction: There is negligible evidence on the efficacy of ivermectin for treating COVID-19 pneumonia. This study aimed to assess the efficacy of ivermectin for pre-emptively treating
    Methods: This single-center, observational, retrospective study included patients admitted with COVID-19 pneumonia at Hospital Vega Baja from 23 February 2020 to 14 March 2021. Because strongyloidiasis is endemic to our area, medical criteria support empiric administration of a single, 200 μg/kg dose of ivermectin to prevent
    Results: Of 1167 patients in the cohort, 96 received ivermectin. After propensity score matching, we included 192 patients. The composite outcome of in-hospital mortality or need for respiratory support occurred in 41.7% of the control group (40/96) and 34.4% (33/96) of the ivermectin group. Ivermectin was not associated with the outcome of interest (adjusted odds ratio [aOR] 0.77, 95% confidence interval [CI] 0.35, 1.69;
    Conclusions: In hospitalized patients with COVID-19 pneumonia, ivermectin at a single dose for pre-emptively treating
    MeSH term(s) Animals ; Humans ; Ivermectin/therapeutic use ; Ivermectin/pharmacology ; Retrospective Studies ; Hospital Mortality ; Propensity Score ; COVID-19 ; Strongyloides stercoralis
    Chemical Substances Ivermectin (70288-86-7)
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15051138
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  9. Article ; Online: Cytokine profile levels and their relationship with parasitemia and cardiomyopathy in people with Chagas disease in Spain. A prospective observational study.

    Ramos-Rincon, Jose-Manuel / Torrús-Tendero, Diego / García-Morante, Hilarion / Gimeno-Gascón, Adelina / Marco, Francisco / Gil-Anguita, Concepción / Wikman-Jorgensen, Philip / Lucas-Dato, Ana / Rodriguez-Diaz, Juan-Carlos / Amador, Concepción / Llenas-García, Jara

    Parasitology research

    2023  Volume 123, Issue 1, Page(s) 66

    Abstract: Immunoregulatory networks may have a role in controlling parasitemia in the chronic phase of human Chagas disease. The aim was to describe the serum cytokine profile of Trypanosoma cruzi in chronically infected patients and to evaluate its relationship ... ...

    Abstract Immunoregulatory networks may have a role in controlling parasitemia in the chronic phase of human Chagas disease. The aim was to describe the serum cytokine profile of Trypanosoma cruzi in chronically infected patients and to evaluate its relationship with parasitemia and Chagas cardiomyopathy.This prospective observational study included adult patients with chronic Chagas disease. Demographic and clinical data were collected, and peripheral blood samples were used to perform T. cruzi real-time polymerase chain reaction (RT-PCR) and determine the serum cytokine profile.Fifty-eight patients were included; 17 (29.3%) had positive RT-PCR results. This group had a higher median concentration of TNF-α (p = 0.003), IL-6 (p = 0.021), IL-4 (p = 0.031), IL-1β (p = 0.036), and IL-17A (p = 0.043) than those with a negative RT-PCR. Patients with cardiac involvement had a higher median concentration of IL-5 (p = 0.016) than those without.These results reinforce the key role that cytokines play in Chagas disease patients with parasitemia and cardiac involvement.
    MeSH term(s) Adult ; Humans ; Parasitemia ; Spain ; Chagas Disease/complications ; Trypanosoma cruzi ; Chagas Cardiomyopathy ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-12-22
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-023-08042-8
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  10. Article: A retrospective real-world study of early short-course remdesivir in non-hospitalized COVID-19 patients at high risk for progression: low rate of hospitalization or death, regardless of immunocompetence status.

    Ramos-Rincón, José Manuel / Pinargote-Celorio, Héctor / Llenas-García, Jara / Moreno-Pérez, Oscar / González-Cuello, Inmaculada / Gonzalez-de-la-Aleja, Pilar / Martínez-López, Belén / Reus, Sergio / García-López, María / Rodríguez, Juan Carlos / Boix, Vicente / Merino, Esperanza

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1218650

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1218650
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