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  1. Article ; Online: A change of paradigm in PBC: Pursuing normal alkaline phosphatase.

    Lleo, Ana

    EBioMedicine

    2022  Volume 82, Page(s) 104150

    MeSH term(s) Alkaline Phosphatase ; Humans ; Liver Cirrhosis, Biliary ; Ursodeoxycholic Acid
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2022-07-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  2. Article ; Online: Biomarkers in neurological disorders: a fast-growing market.

    Lleó, Alberto

    Brain communications

    2021  Volume 3, Issue 2, Page(s) fcab086

    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Editorial
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcab086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The COSMIC-312 study: will it shape future combination therapies for advanced hepatocellular carcinoma?

    Saborowski, Anna / Lleo, Ana

    The lancet. Gastroenterology & hepatology

    2024  Volume 9, Issue 4, Page(s) 275–276

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Sorafenib ; Combined Modality Therapy
    Chemical Substances Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(24)00007-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Survival After Liver Transplantation for Autoimmune Hepatitis: Are We Messing With the Immune System?

    Lleo, Ana

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2020  Volume 26, Issue 7, Page(s) 861–862

    MeSH term(s) Hepatitis, Autoimmune/surgery ; Humans ; Immune System ; Liver Transplantation/adverse effects ; Registries
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4702: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment.

    Milardi, Giulia / Lleo, Ana

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially ...

    Abstract Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially explained by the characteristics of the tumor microenvironment (TME), where adaptive and innate immune system cells are the main components. Pioneering studies of primary liver cancers revealed that tumor-infiltrating immune cells and their dynamic interaction with cancer cells significantly impacted carcinogenesis, playing an important role in cancer immune evasion and responses to immunotherapy treatment. In particular, B cells may play a prominent role and have a controversial function in the TME. In this work, we highlight the effect of B lymphocytes as tumor infiltrates in relation to primary liver cancers and their potential prognostic value. We also present the key pathways underlying B-cell interactions within the TME, as well as the way that a comprehensive characterization of B-cell biology can be exploited to develop novel immune-based therapeutic approaches.
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Early Motor Changes in Genetic Frontotemporal Dementia.

    Lleó, Alberto / Illán-Gala, Ignacio

    Neurology

    2022  Volume 99, Issue 10, Page(s) 409–410

    MeSH term(s) C9orf72 Protein/genetics ; Frontotemporal Dementia/genetics ; Humans ; Pick Disease of the Brain
    Chemical Substances C9orf72 Protein
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.153: Show issues Location:
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    Zs.MG 18: Show issues
    Zs.MO 374: Show issues

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  7. Article ; Online: Immune checkpoint inhibitors in malignancies after liver transplantation: Better safe or sorry?

    Vogel, Arndt / Lleo, Ana

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 43, Issue 1, Page(s) 6–7

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Liver Transplantation ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/drug therapy ; Immunotherapy
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1632: Show issues Location:
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  8. Article ; Online: Cognitive symptoms after COVID-19.

    Altuna, M / Sánchez-Saudinós, Mª B / Lleó, A

    Neurology perspectives

    2021  Volume 1, Page(s) S16–S24

    Abstract: Introduction: SARS-CoV-2 infection frequently causes neurological symptoms. Cognitive alterations are among the most frequent symptoms, and may persist beyond the acute phase of infection.: Methods: We conducted a narrative review of the literature.!# ...

    Abstract Introduction: SARS-CoV-2 infection frequently causes neurological symptoms. Cognitive alterations are among the most frequent symptoms, and may persist beyond the acute phase of infection.
    Methods: We conducted a narrative review of the literature.
    Results: Hospitalised patients, and especially critically ill patients, are at greater risk of developing cognitive symptoms. Post-COVID-19 cognitive symptoms, unlike those associated with other viral illnesses, have been observed in patients with mild infection, and present some atypical features. Cognitive symptoms may last longer in COVID-19 than in other infectious processes, and more frequently affect young people. Post-COVID-19 cognitive symptoms share common features with those described in chronic fatigue syndrome, including a similar profile with affective symptoms. Brief screening tests for cognitive impairment present suboptimal diagnostic performance, and standardised criteria are needed to ensure correct diagnosis.Post-COVID-19 cognitive impairment can have a significant impact on the patient's quality of life and functional independence, regardless of other post-COVID-19 symptoms. Currently, no specific treatments have been approved for post-COVID-19 cognitive impairment, although cognitive stimulation may be useful in some patients.
    Conclusions: Post-COVID-19 cognitive symptoms are common and are often associated with other systemic symptoms. Neuropsychological evaluation may be useful for diagnosis and to quantify their severity and long-term prognosis. Detailed, and individualised assessment of cognitive impairment may enable the design of treatment plans.
    Language English
    Publishing date 2021-12-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2667-0496
    ISSN (online) 2667-0496
    DOI 10.1016/j.neurop.2021.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales.

    Colapietro, Francesca / Gershwin, M Eric / Lleo, Ana

    Journal of translational autoimmunity

    2023  Volume 6, Page(s) 100188

    Abstract: Introduction: Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis. Ursodeoxycholic Acid (UDCA) is the standard of ... ...

    Abstract Introduction: Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis. Ursodeoxycholic Acid (UDCA) is the standard of care treatment, Obeticholic Acid (OCA) has been approved as second-line therapy for those non responder or intolerant to UDCA. However, due to moderate rate of UDCA-non responders and to warnings recently issued against OCA use in patients with cirrhosis, further therapies are needed.Areas covered. Deep investigations into the pathogenesis of PBC is leading to proposal of new therapeutic agents, among which peroxisome proliferator-activated receptor (PPAR) ligands seem to be highly promising given the preliminary, positive results in Phase 2 and 3 trials. Bezafibrate, the most evaluated, is currently used in clinical practice in combination with UDCA in referral centers. We herein describe completed and ongoing trials involving PPAR agonists use in PBC, analyzing pits and falls.
    Expert opinion: Testing new therapeutic opportunities in PBC is challenging due to its low prevalence and slow progression. However, new drugs including PPAR agonists, are currently under investigation and should be considered for at-risk PBC patients.
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2023.100188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Alzheimer's disease: An ignored condition.

    Lleó, Alberto

    Medicina clinica

    2017  Volume 150, Issue 11, Page(s) 432–433

    Title translation El Alzheimer, la enfermedad ignorada.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/drug therapy ; Alzheimer Disease/epidemiology ; Amyloid/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Disease Management ; Early Diagnosis ; Female ; Forecasting ; Health Policy ; Health Services Needs and Demand ; Health Services for the Aged/supply & distribution ; Health Services for the Aged/trends ; Humans ; Life Expectancy ; Male ; Morbidity/trends ; Spain/epidemiology
    Chemical Substances Amyloid ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; solanezumab (5D6PWO0333) ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language Spanish
    Publishing date 2017-11-28
    Publishing country Spain
    Document type Editorial
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2017.10.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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