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  1. Article ; Online: Biomarkers in neurological disorders: a fast-growing market.

    Lleó, Alberto

    Brain communications

    2021  Volume 3, Issue 2, Page(s) fcab086

    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Editorial
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcab086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early Motor Changes in Genetic Frontotemporal Dementia.

    Lleó, Alberto / Illán-Gala, Ignacio

    Neurology

    2022  Volume 99, Issue 10, Page(s) 409–410

    MeSH term(s) C9orf72 Protein/genetics ; Frontotemporal Dementia/genetics ; Humans ; Pick Disease of the Brain
    Chemical Substances C9orf72 Protein
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Alzheimer's disease: An ignored condition.

    Lleó, Alberto

    Medicina clinica

    2017  Volume 150, Issue 11, Page(s) 432–433

    Title translation El Alzheimer, la enfermedad ignorada.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/drug therapy ; Alzheimer Disease/epidemiology ; Amyloid/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Disease Management ; Early Diagnosis ; Female ; Forecasting ; Health Policy ; Health Services Needs and Demand ; Health Services for the Aged/supply & distribution ; Health Services for the Aged/trends ; Humans ; Life Expectancy ; Male ; Morbidity/trends ; Spain/epidemiology
    Chemical Substances Amyloid ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; solanezumab (5D6PWO0333) ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language Spanish
    Publishing date 2017-11-28
    Publishing country Spain
    Document type Editorial
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2017.10.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Race and Alzheimer Disease Biomarkers: A Neglected Race.

    Lleó, Alberto / Suárez-Calvet, Marc

    Neurology. Genetics

    2021  Volume 7, Issue 2, Page(s) e574

    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 2818607-2
    ISSN 2376-7839
    ISSN 2376-7839
    DOI 10.1212/NXG.0000000000000574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist.

    Alcolea, Daniel / Beeri, Michal Schnaider / Rojas, Julio C / Gardner, Raquel C / Lleó, Alberto

    Neurology

    2023  Volume 101, Issue 4, Page(s) 172–180

    Abstract: Blood-based biomarkers offer a major advance in the clinical evaluation of neurodegenerative diseases. Currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to Alzheimer disease ...

    Abstract Blood-based biomarkers offer a major advance in the clinical evaluation of neurodegenerative diseases. Currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to Alzheimer disease (amyloid-β peptides, and p-tau) and nonspecific blood markers of neuronal (neurofilament light, β-synuclein, and ubiquitin-C-terminal-hydrolase-L1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiologic processes in several neurodegenerative diseases. In the near future, these markers may be used for screening, diagnosis, or disease and treatment response monitoring. Blood-based biomarkers for neurodegenerative diseases have been rapidly implemented in research, and they have the potential to enter clinical use soon in different clinical settings. In this review, we will describe the main developments and their potential implications for the general neurologist.
    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Neurodegenerative Diseases/diagnosis ; Neurologists ; Amyloid beta-Peptides ; Biomarkers/blood
    Chemical Substances Amyloid beta-Peptides ; Biomarkers
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dementia and epilepsy: Not a one-way street.

    Hauser, W Allen / Lleo, Alberto / Schmolck, Heike

    Neurology

    2020  Volume 95, Issue 24, Page(s) 1074–1075

    MeSH term(s) Atherosclerosis ; Dementia/epidemiology ; Epilepsy/epidemiology ; Humans
    Language English
    Publishing date 2020-10-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The cognitive aftermath of COVID-19

    Lleó, Alberto / Alcolea, Daniel

    Brain Communications

    2020  Volume 2, Issue 2

    Abstract: This scientific commentary refers to ‘The cognitive consequences of the COVID-19 epidemic: collateral damage?’, by Ritchie et al. (https://doi.org/10.1093/braincomms/fcaa069). ...

    Abstract This scientific commentary refers to ‘The cognitive consequences of the COVID-19 epidemic: collateral damage?’, by Ritchie et al. (https://doi.org/10.1093/braincomms/fcaa069).
    Keywords covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ISSN 2632-1297
    DOI 10.1093/braincomms/fcaa072
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer's disease continuum.

    Goossens, Julie / Cervantes González, Alba / Dewit, Nele / Lidón, Laia / Fortea, Juan / Alcolea, Daniel / Lleó, Alberto / Belbin, Olivia / Vanmechelen, Eugeen

    Alzheimer's research & therapy

    2023  Volume 15, Issue 1, Page(s) 186

    Abstract: Background: Synapse loss is an early event that precedes neuronal death and symptom onset and is considered the best neuropathological correlate of cognitive decline in Alzheimer's disease (AD). Vesicle-associated membrane protein 2 (VAMP-2) has emerged ...

    Abstract Background: Synapse loss is an early event that precedes neuronal death and symptom onset and is considered the best neuropathological correlate of cognitive decline in Alzheimer's disease (AD). Vesicle-associated membrane protein 2 (VAMP-2) has emerged as a promising biomarker of AD-related synapse degeneration in cerebrospinal fluid (CSF). The aim of this study was to explore the CSF profile of VAMP-2 across the AD continuum in relation to core AD biomarkers, other synaptic proteins, neurogranin (Ng) and synaptosomal-associated Protein-25 kDa (SNAP-25) and cognitive performance.
    Methods: We developed a digital immunoassay on the Single Molecule Array platform to quantify VAMP-2 in CSF and used existing immunoassays to quantify Ng, SNAP-25 and core CSF AD biomarkers. The clinical study included 62 cognitively unimpaired AD biomarker-negative subjects and 152 participants across the AD continuum from the SPIN cohort (Sant Pau Initiative on Neurodegeneration). Cognitive measures of episodic, semantic, executive and visuospatial domains and global cognition were included. Statistical methods included χ
    Results: The VAMP-2 assay had a good analytical performance (repeatability 8.9%, intermediate precision 10.3%). Assay antibodies detected native VAMP-2 protein in human brain homogenates. CSF concentrations of VAMP-2, neurogranin and SNAP-25 were lower in preclinical AD stage 1 compared to controls and higher at later AD stages compared to AD stage 1 and were associated with core AD biomarkers, particularly total tau (adj. r
    Conclusions: Our novel digital immunoassay accurately measures VAMP-2 changes in CSF, which reflect AD biomarkers and cognitive performance across multiple domains.
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/diagnosis ; Neurogranin/cerebrospinal fluid ; Synaptic Vesicles/pathology ; tau Proteins/cerebrospinal fluid ; Vesicle-Associated Membrane Protein 2
    Chemical Substances Amyloid beta-Peptides ; Biomarkers ; Neurogranin (132654-77-4) ; tau Proteins ; Vesicle-Associated Membrane Protein 2 ; VAMP2 protein, human
    Language English
    Publishing date 2023-10-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2506521-X
    ISSN 1758-9193 ; 1758-9193
    ISSN (online) 1758-9193
    ISSN 1758-9193
    DOI 10.1186/s13195-023-01336-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Has the time arrived for cerebrospinal fluid biomarkers in psychiatric disorders?

    Lleó, Alberto / Parnetti, Lucilla / Belbin, Olivia / Wiltfang, Jens

    Clinica chimica acta; international journal of clinical chemistry

    2019  Volume 491, Page(s) 81–84

    Abstract: Psychiatric disorders are currently classified, in the majority of cases, by clinical syndromes. However, advances over the last decade in imaging and biochemical biomarkers in several Central Nervous System (CNS) disorders anticipate the incorporation ... ...

    Abstract Psychiatric disorders are currently classified, in the majority of cases, by clinical syndromes. However, advances over the last decade in imaging and biochemical biomarkers in several Central Nervous System (CNS) disorders anticipate the incorporation of some of these markers in the diagnostic work-up of psychiatric conditions. In particular, CSF biomarkers offer the possibility of detecting a wide range of pathophysiological processes in the CNS. Newer CSF markers can measure axonal and synaptic damage, glial activation, and oxidative stress in CNS disorders with high precision. The possibility that these markers can be applied in the differential diagnosis of common psychiatric disorders such as Schizophrenia, Major Depressive or Bipolar Disorders not only to rule out neurodegenerative diseases but also to identify specific biomarker signatures has yet to be explored. In particular, synaptic proteins in CSF could be useful as markers of synaptic and neurotransmitter transmission impairment since these are key molecular features of psychiatric conditions. In this paper we outline the current and potential applications of CSF biomarkers in psychiatric disorders.
    MeSH term(s) Biomarkers/cerebrospinal fluid ; Humans ; Mental Disorders/cerebrospinal fluid ; Mental Disorders/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-01-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2019.01.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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