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  1. Article ; Online: Síndrome de las uñas amarillas. Presentación de un caso con estudio autópsico.

    Bosch Taltavull, Toni / Beltrán, Javier Gimeno / Puche Gallego, Adrián / Cos Esquius, María Lourdes / Martín Ezquerra, Gemma / Lloveras Rubio, Belén

    Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

    2022  Volume 56, Issue 3, Page(s) 191–195

    Abstract: Yellow nail syndrome is a rare disease of unknown aetiology. Patients with YNS have a characteristic yellowish-coloured nails, pulmonary alterations and primary lymphedema. To the best of our knowledge, only a few reports of autopsy findings in these ... ...

    Title translation Yellow nail syndrome. A case report with postmortem study.
    Abstract Yellow nail syndrome is a rare disease of unknown aetiology. Patients with YNS have a characteristic yellowish-coloured nails, pulmonary alterations and primary lymphedema. To the best of our knowledge, only a few reports of autopsy findings in these patients have been published. Its aetiology possibly involves a primary malformation of larger lymph vessels. We describe autopsy findings not previously associated with yellow nail syndrome, such as expansion of mediastinal lymph-nodes and splenic sinusoids. The present autopsy reveals hitherto unreported findings associated with YNS, such as alterations in splenic sinusoids and mediastinal lymph-node sinuses.
    MeSH term(s) Humans ; Yellow Nail Syndrome/complications ; Lymph Nodes
    Language Spanish
    Publishing date 2022-02-21
    Publishing country Spain
    Document type Case Reports ; English Abstract
    ZDB-ID 2463888-2
    ISSN 1988-561X ; 1988-561X
    ISSN (online) 1988-561X
    ISSN 1988-561X
    DOI 10.1016/j.patol.2021.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: THSD7A-positive membranous nephropathy after kidney transplantation: A case report.

    Solà-Porta, Eulàlia / Buxeda, Anna / Lop, Joan / Naranjo-Hans, Dolores / Gimeno, Javier / Lloveras-Rubio, Belén / Pérez-Sáez, María José / Redondo-Pachón, Dolores / Crespo, Marta

    Nefrologia

    2023  Volume 43 Suppl 2, Page(s) 85–90

    Abstract: Membranous nephropathy (MN) is a common cause of nephrotic syndrome after kidney transplantation (KT); however, scarce is known regarding post-KT thrombospondin type-1 domain-containing 7A (THSD7A)-positive MN. Herein, we report on a 72-year-old woman ... ...

    Abstract Membranous nephropathy (MN) is a common cause of nephrotic syndrome after kidney transplantation (KT); however, scarce is known regarding post-KT thrombospondin type-1 domain-containing 7A (THSD7A)-positive MN. Herein, we report on a 72-year-old woman with end-stage kidney disease due to chronic interstitial nephritis (1996). In February 2020, she received a second deceased-donor KT, achieving optimal kidney function but presenting early post-KT proteinuria, reaching up to 1800mg/24h six months after transplantation, controlled with renin-angiotensin-aldosterone system (RAAS) blockade. In July 2021, a kidney allograft biopsy revealed features consistent with MN. Immunohistochemical stains showed diffuse and granular THSD7A and C4d deposition in glomerular capillary walls and negative PLA2R and IgG4 staining. No anti-THSD7A antibodies were detected in the serum. The pre-implantation biopsy showed no MN-associated lesions and negative THSD7A staining. Secondary triggers such as malignancy were discarded. The present report illustrates a THSD7A-positive MN in a KT recipient. Despite lacking native kidney biopsy and early presentation, a recurrent MN seemed unprovable due to documented native kidney disease and a long time span between native kidney disease and MN diagnosis. We, therefore, presumed primary de novo disease. Two years after KT, kidney function remains stable, and the patient has reached complete remission of proteinuria.
    MeSH term(s) Female ; Humans ; Aged ; Glomerulonephritis, Membranous/diagnosis ; Kidney Transplantation/adverse effects ; Thrombospondins ; Kidney Glomerulus ; Proteinuria
    Chemical Substances Thrombospondins
    Language English
    Publishing date 2023-01-19
    Publishing country Spain
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2022.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fecal pulmonary embolism: a case report and literature review.

    Santiago Díaz, Pablo / Gimeno Beltrán, Javier / Lop Gros, Joan / Tuñas Solà, Diego / Parini Trapani, Gina María / Montcusí Ventura, Blanca / Arias López, Ana / Lloveras Rubio, Belén

    Forensic science, medicine, and pathology

    2023  

    Abstract: Pulmonary embolism (PE) is a common cause of death in hospitalized patients. These emboli are usually related to deep venous thrombosis, but other etiologic factors may be the cause. A 60-year-old male was diagnosed with rectal adenocarcinoma and treated ...

    Abstract Pulmonary embolism (PE) is a common cause of death in hospitalized patients. These emboli are usually related to deep venous thrombosis, but other etiologic factors may be the cause. A 60-year-old male was diagnosed with rectal adenocarcinoma and treated by surgical rectal resection. After surgery, he presented with a decreased level of consciousness and hypoxia with no signs of bleeding. PE was ruled out by pulmonary angiography. Given the hemodynamic instability, contrast-enhanced CT was performed, showing a discrete leak related to the rectal anastomosis, which required urgent surgery. The patient suffered cardiorespiratory arrest prior to surgery, and once resolved, the surgical procedure was limited to disconnecting the intestinal anastomosis, leaving the colon and rectal stumps free in the abdomen and keeping the abdominal cavity open with negative-pressure therapy. The patient suffered from another cardiorespiratory arrest after surgery, with abdominal distension and serous-hemorrhagic material discharge through the negative-pressure device. On a new surgical revision, no bleeding was identified, so the symptoms were attributed to coagulopathy. The patient died and autopsy was performed. The autopsy revealed no surgery-related complications. The lungs were increased in weight and showed a normal macroscopic appearance; in contrast, the histological study revealed multiple and bilateral thrombo-embolisms affecting small distal arteries. Those thrombi were composed of intestinal contents, including vegetal particles, mucinous and biliary material, fibrin, and bacterial structures. Fecal PE is an extremely infrequent event. Isolated cases have been described in association with communications between the digestive tract lumen and the systemic circulation, with a generally fatal prognosis.
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2195904-3
    ISSN 1556-2891 ; 1547-769X
    ISSN (online) 1556-2891
    ISSN 1547-769X
    DOI 10.1007/s12024-023-00615-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Concordance of p16

    Mena, Marisa / Wang, Xin / Tous, Sara / Quiros, Beatriz / Clavero, Omar / Alejo, Maria / Morey, Francisca / Taberna, Miren / Leon Vintro, Xavier / Lloveras Rubio, Belén / Alos, Llúcia / Mehanna, Hisham / Quint, Wim / Pawlita, Michael / Tommasino, Massimo / Pavón, Miguel Angel / Muñoz, Nubia / De Sanjose, Silvia / Bosch, Francesc Xavier /
    Alemany, Laia / On Behalf Of The Ico International Hpv In Head And Neck Cancer Study Group

    Cancers

    2022  Volume 14, Issue 15

    Abstract: Background: Tests or test algorithms for diagnosing HPV-driven oral cavity and laryngeal head and neck carcinomas (HNC) have not been yet validated, and the differences among oral cavity and laryngeal sites have not been comprehensively evaluated. We ... ...

    Abstract Background: Tests or test algorithms for diagnosing HPV-driven oral cavity and laryngeal head and neck carcinomas (HNC) have not been yet validated, and the differences among oral cavity and laryngeal sites have not been comprehensively evaluated. We aimed to assess the utility of a diagnostic algorithm for the detection of HPV-driven oral cavity (OCC), oropharyngeal (OPC) and laryngeal (LC) carcinomas using HPV-DNA testing followed by p16INK4a immunohistochemistry, taking E6*I mRNA detection as the reference standard. Methods: Formalin-fixed paraffin-embedded OCC, OPC, and LC carcinomas were collected from pathology archives in 29 countries. All samples were subjected to histopathological evaluation, DNA quality control, and HPV-DNA detection. All HPV-DNA-positive samples (including 78 OCC, 257 OPC, and 51 LC out of 3680 HNC with valid HPV-DNA results) were also tested for p16INK4a immunohistochemistry and E6*I mRNA. Three different cutoffs of nuclear and cytoplasmic staining were evaluated for p16INK4a: (a) >25%, (b) >50%, and (c) ≥70%. The concordance of p16INK4a and E6*I mRNA among HPV-DNA-positive OCC, OPC, and LC cases was assessed. Results: A total of 78 OCC, 257 OPC, and 51 LC were HPV-DNA-positive and further tested for p16INK4a and E6*I mRNA. The percentage of concordance between p16INK4a (cutoff ≥ 70%) and E6*I mRNA among HPV-DNA-positive OCC, OPC, and LC cases was 79.5% (95% CI 69.9−89.1%), 82.1% (95% CI 77.2−87.0%), and 56.9% (95% CI 42.3−71.4%), respectively. A p16INK4a cutoff of >50% improved the concordance although the improvement was not statistically significant. For most anatomical locations and p16INK4a cutoffs, the percentage of discordant cases was higher for HPV16- than HPV-non16-positive cases. Conclusions: The diagnostic algorithm of HPV-DNA testing followed by p16INK4a immunohistochemistry might be helpful in the diagnosis of HPV-driven OCC and OPC, but not LC. A different p16INK4a expression pattern was observed in those cases HPV-DNA-positive for types other than HPV16, as compared to HPV16-positive cases. Our study provides new insights into the use HPV-DNA, p16INK4a, and HPV-E6*I mRNA for diagnosing an HPV-driven HNC, including the optimal HPV test or p16INK4a cutoffs to be used. More studies are warranted to clarify the role of p16INK4a and HPV status in both OPC and non-OPC HNC.
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14153787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Role of Human Papillomavirus Infection in Head and Neck Cancer in Italy: The HPV-AHEAD Study.

    Tagliabue, Marta / Mena, Marisa / Maffini, Fausto / Gheit, Tarik / Quirós Blasco, Beatriz / Holzinger, Dana / Tous, Sara / Scelsi, Daniele / Riva, Debora / Grosso, Enrica / Chu, Francesco / Lucas, Eric / Ridder, Ruediger / Rrehm, Susanne / Bogers, Johannes Paul / Lepanto, Daniela / Lloveras Rubio, Belén / Vijay Kumar, Rekha / Gangane, Nitin /
    Clavero, Omar / Pawlita, Michael / Anantharaman, Devasena / Radhakrishna Pillai, Madhavan / Brennan, Paul / Sankaranarayanan, Rengaswamy / Arbyn, Marc / Lombardi, Francesca / Taberna, Miren / Gandini, Sara / Chiesa, Fausto / Ansarin, Mohssen / Alemany, Laia / Tommasino, Massimo / Chiocca, Susanna / The Hpv-Ahead Study Group

    Cancers

    2020  Volume 12, Issue 12

    Abstract: Literature on the role of human papillomavirus (HPV) in head and neck cancer (HNC) in Italy is limited, especially for non-oropharyngeal tumours. Within the context of the HPV-AHEAD study, we aimed to assess the prognostic value of different tests or ... ...

    Abstract Literature on the role of human papillomavirus (HPV) in head and neck cancer (HNC) in Italy is limited, especially for non-oropharyngeal tumours. Within the context of the HPV-AHEAD study, we aimed to assess the prognostic value of different tests or test algorithms judging HPV carcinogenicity in HNC and factors related to HPV positivity at the European Institute of Oncology. We conducted a retrospective cohort study (2000-2010) on a total of 696 primary HNC patients. Formalin-fixed, paraffin-embedded cancer tissues were studied. All HPV-DNA-positive and a random sample of HPV-DNA-negative cases were subjected to HPV-E6*I mRNA detection and p16
    Language English
    Publishing date 2020-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12123567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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