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Article ; Online: Sex differences in tissue immunity.

Puttur, Franz / Lloyd, Clare M

2024 Volume 384, Issue 6692, Page(s) 159–160

Abstract: Androgen signaling skews skin immunity toward reduced inflammation in male mice. ...

Abstract	Androgen signaling skews skin immunity toward reduced inflammation in male mice.
MeSH term(s)	Male ; Female ; Mice ; Animals ; Androgens ; Sex Characteristics ; Immunity, Innate ; Lymphocytes ; Dendritic Cells
Chemical Substances	Androgens
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.ado8542
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: Breathing easy: Dopamine quenches the ILC2 flame.

Puttur, Franz / Lloyd, Clare M

Immunity

2023 Volume 56, Issue 2, Page(s) 229–231

Abstract: Communication between nerves and group 2 innate lymphoid cells (ILC2s) is thought to regulate allergic airway inflammation, but the molecular mechanisms are unclear. In this issue of Immunity, Cao et al. uncover an essential role for dopamine in ... ...

Abstract	Communication between nerves and group 2 innate lymphoid cells (ILC2s) is thought to regulate allergic airway inflammation, but the molecular mechanisms are unclear. In this issue of Immunity, Cao et al. uncover an essential role for dopamine in inhibiting ILC2 function via metabolic restriction, thereby ameliorating key features of asthma pathogenesis.
MeSH term(s)	Humans ; Immunity, Innate ; Dopamine ; Lymphocytes ; Asthma ; Inflammation ; Cytokines/metabolism
Chemical Substances	Dopamine (VTD58H1Z2X) ; Cytokines
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2023.01.019
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Early-life respiratory infections and developmental immunity determine lifelong lung health.

Lloyd, Clare M / Saglani, Sejal

Nature immunology

2023 Volume 24, Issue 8, Page(s) 1234–1243

Abstract: Respiratory infections are common in infants and young children. However, the immune system develops and matures as the child grows, thus the effects of infection during this time of dynamic change may have long-term consequences. The infant immune ... ...

Abstract	Respiratory infections are common in infants and young children. However, the immune system develops and matures as the child grows, thus the effects of infection during this time of dynamic change may have long-term consequences. The infant immune system develops in conjunction with the seeding of the microbiome at the respiratory mucosal surface, at a time that the lungs themselves are maturing. We are now recognizing that any disturbance of this developmental trajectory can have implications for lifelong lung health. Here, we outline our current understanding of the molecular mechanisms underlying relationships between immune and structural cells in the lung with the local microorganisms. We highlight the importance of gaining greater clarity as to what constitutes a healthy respiratory ecosystem and how environmental exposures influencing this network will aid efforts to mitigate harmful effects and restore lung immune health.
MeSH term(s)	Infant ; Child ; Humans ; Child, Preschool ; Lung ; Respiratory Tract Infections ; Microbiota ; Immune System ; Respiratory Mucosa
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01550-w
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article ; Online: T helper 2 cells in asthma.

Harker, James A / Lloyd, Clare M

The Journal of experimental medicine

2023 Volume 220, Issue 6

Abstract: Allergic asthma is among the most common immune-mediated diseases across the world, and type 2 immune responses are thought to be central to pathogenesis. The importance of T helper 2 (Th2) cells as central regulators of type 2 responses in asthma has, ... ...

Abstract	Allergic asthma is among the most common immune-mediated diseases across the world, and type 2 immune responses are thought to be central to pathogenesis. The importance of T helper 2 (Th2) cells as central regulators of type 2 responses in asthma has, however, become less clear with the discovery of other potent innate sources of type 2 cytokines and innate mediators of inflammation such as the alarmins. This review provides an update of our current understanding of Th2 cells in human asthma, highlighting their many guises and functions in asthma, both pathogenic and regulatory, and how these are influenced by the tissue location and disease stage and severity. It also explores how biologics targeting type 2 immune pathways are impacting asthma, and how these have the potential to reveal hitherto underappreciated roles for Th2 cell in lung inflammation.
MeSH term(s)	Humans ; Th2 Cells ; Asthma ; Cytokines/metabolism ; Inflammation/pathology ; Pneumonia/pathology ; Immunity, Innate
Chemical Substances	Cytokines
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20221094
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

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Article ; Online: Pseudomonas aeruginosa: a pathogen making itself at home.

Stölting, Helen / Lloyd, Clare M

Trends in immunology

2022 Volume 43, Issue 7, Page(s) 497–499

Abstract: Upon bacterial infection, mounting the appropriate immune response is paramount to effective pathogen clearance. In a recent study, Agaronyan et al. show how Pseudomonas aeruginosa can divert host immunity to boost type 2 responses and drive mucus ... ...

Abstract	Upon bacterial infection, mounting the appropriate immune response is paramount to effective pathogen clearance. In a recent study, Agaronyan et al. show how Pseudomonas aeruginosa can divert host immunity to boost type 2 responses and drive mucus production, which can then act as a nutrient source for bacteria.
MeSH term(s)	Humans ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/physiology
Language	English
Publishing date	2022-05-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2022.05.002
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Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Immunoregulation of asthma by type 2 cytokine therapies: Treatments for all ages?

Saglani, Sejal / Yates, Laura / Lloyd, Clare M

European journal of immunology

2023 Volume 53, Issue 8, Page(s) e2249919

Abstract: Asthma is classically considered to be a disease of type 2 immune dysfunction, since many patients exhibit the consequences of excess secretion of cytokines such as IL-4, IL-5, and IL-13 concomitant with inflammation typified by eosinophils. Mouse and ... ...

Abstract	Asthma is classically considered to be a disease of type 2 immune dysfunction, since many patients exhibit the consequences of excess secretion of cytokines such as IL-4, IL-5, and IL-13 concomitant with inflammation typified by eosinophils. Mouse and human disease models have determined that many of the canonical pathophysiologic features of asthma may be caused by these disordered type 2 immune pathways. As such considerable efforts have been made to develop specific drugs targeting key cytokines. There are currently available multiple biologic agents that successfully reduce the functions of IL-4, IL-5, and IL-13 in patients, and many improve the course of severe asthma. However, none are curative and do not always minimize the key features of disease, such as airway hyperresponsiveness. Here, we review the current therapeutic landscape targeting type 2 immune cytokines and discuss evidence of efficacy and limitations of their use in adults and children with asthma.
MeSH term(s)	Adult ; Child ; Humans ; Animals ; Mice ; Interleukin-13 ; Interleukin-5 ; Interleukin-4 ; Asthma ; Eosinophils ; Cytokines
Chemical Substances	Interleukin-13 ; Interleukin-5 ; Interleukin-4 (207137-56-2) ; Cytokines
Language	English
Publishing date	2023-04-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202249919
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

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Article ; Online: Overlapping and distinct features of viral and allergen immunity in the human lung.

Harker, James A / Lloyd, Clare M

Immunity

2021 Volume 54, Issue 4, Page(s) 617–631

Abstract: Immunity in the human respiratory tract is provided by a diverse range of tissue-resident cells, including specialized epithelial and macrophage populations and a network of innate and innate-like lymphocytes, such as natural killer cells, innate ... ...

Abstract	Immunity in the human respiratory tract is provided by a diverse range of tissue-resident cells, including specialized epithelial and macrophage populations and a network of innate and innate-like lymphocytes, such as natural killer cells, innate lymphoid cells, and invariant T cells. Lung-resident memory T and B cells contribute to this network following initial exposure to antigenic stimuli. This review explores how advances in the study of human immunology have shaped our understanding of this resident immune network and its response to two of the most commonly encountered inflammatory stimuli in the airways: viruses and allergens. It discusses the many ways in which pathogenic infection and allergic inflammation mirror each other, highlighting the key checkpoints at which they diverge and how this can result in a lifetime of allergic exacerbation versus protective anti-viral immunity.
MeSH term(s)	Allergens/immunology ; Animals ; Humans ; Immunity, Innate/immunology ; Inflammation/immunology ; Inflammation/virology ; Lung/immunology ; Lung/virology ; Lymphocytes/immunology ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/virology ; Virus Diseases/immunology
Chemical Substances	Allergens
Language	English
Publishing date	2021-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2021.03.010
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Regulation of immune responses by the airway epithelial cell landscape.

Hewitt, Richard J / Lloyd, Clare M

Nature reviews. Immunology

2021 Volume 21, Issue 6, Page(s) 347–362

Abstract: The community of cells lining our airways plays a collaborative role in the preservation of immune homeostasis in the lung and provides protection from the pathogens and pollutants in the air we breathe. In addition to its structural attributes that ... ...

Abstract	The community of cells lining our airways plays a collaborative role in the preservation of immune homeostasis in the lung and provides protection from the pathogens and pollutants in the air we breathe. In addition to its structural attributes that provide effective mucociliary clearance of the lower airspace, the airway epithelium is an immunologically active barrier surface that senses changes in the airway environment and interacts with resident and recruited immune cells. Single-cell RNA-sequencing is illuminating the cellular heterogeneity that exists in the airway wall and has identified novel cell populations with unique molecular signatures, trajectories of differentiation and diverse functions in health and disease. In this Review, we discuss how our view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems.
MeSH term(s)	Animals ; Apoptosis/immunology ; Cellular Microenvironment/genetics ; Cellular Microenvironment/immunology ; Circadian Rhythm/genetics ; Circadian Rhythm/immunology ; Epithelial Cells/classification ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Genetic Markers ; Humans ; Immunologic Memory ; Mice ; Models, Immunological ; Neuroendocrine Cells/immunology ; Neuroendocrine Cells/metabolism ; Neuroimmunomodulation ; RNA-Seq ; Respiratory Mucosa/cytology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism ; Single-Cell Analysis
Chemical Substances	Genetic Markers
Language	English
Publishing date	2021-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-00477-9
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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 34: Show issues

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Article ; Online: Regulatory cytokine function in the respiratory tract.

Branchett, William J / Lloyd, Clare M

Mucosal immunology

2019 Volume 12, Issue 3, Page(s) 589–600

Abstract: The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert ...

Abstract	The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert to control pulmonary immune responses and maintain tolerance in the respiratory tract, including regulatory and effector T cells, airway and interstitial macrophages, dendritic cells and the airway epithelium. The cytokines transforming growth factor β, interleukin (IL-) 10, IL-27, and IL-35 are key coordinators of immune regulation in tissues such as the lung. Here, we discuss the role of these cytokines during respiratory infection and allergic airway disease, highlighting the critical importance of cellular source and immunological context for the effects of these cytokines in vivo.
MeSH term(s)	Animals ; Cytokines/metabolism ; Dendritic Cells/immunology ; Homeostasis ; Humans ; Hypersensitivity/immunology ; Immune Tolerance ; Lung/immunology ; Respiratory Mucosa/immunology ; Respiratory System/immunology ; Respiratory Tract Infections/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2019-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1038/s41385-019-0158-0
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Zs.A 6796: Show issues

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Article ; Online: Opening the Window of Immune Opportunity: Treating Childhood Asthma.

Lloyd, Clare M / Saglani, Sejal

Trends in immunology

2019 Volume 40, Issue 9, Page(s) 786–798

Abstract: Asthma is an increasingly common childhood disease and although most patients can control their symptoms with medication, a proportion experience life-threatening symptoms. The advent of novel biologic therapies represents a giant leap forward for asthma ...

Abstract	Asthma is an increasingly common childhood disease and although most patients can control their symptoms with medication, a proportion experience life-threatening symptoms. The advent of novel biologic therapies represents a giant leap forward for asthma treatment, but efficacy is rarely tested in children. Recent mechanistic work in mice suggests that early life is a key period for immune development and, therefore, allergen sensitization. Although children with severe asthma experience significant comorbidities and are at increased risk for serious diseases such as chronic obstructive pulmonary disease as adults, no specific investigation into tailored treatment for young children with severe asthma exists. Here, we propose how new information regarding early life immunity could be used to inform modified treatments for children.
MeSH term(s)	Asthma/immunology ; Asthma/therapy ; Child ; Humans
Language	English
Publishing date	2019-08-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2019.07.004
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Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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