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  1. Book: Vascular mechanisms in CNS trauma

    Lo, Eng H.

    (Springer series in translational stroke research)

    2014  

    Author's details Eng H. Lo ... ed
    Series title Springer series in translational stroke research
    Keywords Central nervous system/Blood-vessels ; Central nervous system/Wounds and injuries
    Subject code 612.824
    Language English
    Size XX, 518 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017905656
    ISBN 978-1-4614-8689-3 ; 9781461486909 ; 1-4614-8689-0 ; 1461486904
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 3754 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease.

    Lo, Eng H / Faraci, Frank M

    Circulation research

    2024  Volume 134, Issue 6, Page(s) 615–617

    MeSH term(s) Humans ; Cardiovascular System ; Circadian Rhythm ; Heart ; Cerebrovascular Disorders
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.124.324462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer's disease.

    Li, Wenlu / Tiedt, Steffen / Lo, Eng H

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 447

    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Diabetes Mellitus, Type 2/genetics ; Pancreas ; tau Proteins/genetics
    Chemical Substances tau Proteins
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01701-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche.

    Arai, Ken / Lo, Eng H

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2021  Volume 41, Issue 8, Page(s) 2132–2133

    Abstract: For efficient stroke recovery, the entire neurovascular unit must be repaired. A recent study underscores this concept by highlighting the importance of cellular crosstalk for white mater remodeling. In developing brains and in brains injured by hypoxia, ...

    Abstract For efficient stroke recovery, the entire neurovascular unit must be repaired. A recent study underscores this concept by highlighting the importance of cellular crosstalk for white mater remodeling. In developing brains and in brains injured by hypoxia, interactions between oligodendrocyte precursors and endothelium play an essential role for physiological and compensatory angiogenesis. Further studies are warranted to build on these emerging findings in the oligovascular niche in order to identify novel therapeutic targets for stroke and other CNS diseases.
    MeSH term(s) Animals ; Cell Communication ; Mice ; Mice, Knockout ; Neovascularization, Physiologic ; Oligodendrocyte Precursor Cells/cytology ; Oligodendrocyte Precursor Cells/metabolism ; White Matter/blood supply ; White Matter/growth & development ; Wnt Proteins/deficiency ; Wnt Proteins/genetics
    Chemical Substances Wnt Proteins
    Language English
    Publishing date 2021-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X211014979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Circadian Biology and the Neurovascular Unit.

    Li, Wenlu / Tiedt, Steffen / Lawrence, Jennifer H / Harrington, Mary E / Musiek, Erik S / Lo, Eng H

    Circulation research

    2024  Volume 134, Issue 6, Page(s) 748–769

    Abstract: Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this ... ...

    Abstract Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this review, we attempt to survey and synthesize emerging studies that investigate how circadian biology may influence the neurovascular unit. We examine how circadian clocks may operate in neural, glial, and vascular compartments, review how circadian mechanisms regulate cell-cell signaling, assess interactions with aging and vascular comorbidities, and finally ask whether and how circadian effects and disruptions in rhythms may influence the risk and progression of pathophysiology in cerebrovascular disease. Overcoming identified challenges and leveraging opportunities for future research might support the development of novel circadian-based treatments for stroke.
    MeSH term(s) Animals ; Aging/physiology ; Circadian Clocks ; Circadian Rhythm ; Mammals
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.124.323514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.70: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Leaky memories: Impact of

    Li, Wenlu / Lo, Eng H

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2020  Volume 40, Issue 9, Page(s) 1912–1914

    Abstract: A new study suggests that the leading genetic risk factor for Alzheimer's disease, apolipoprotein E4 ( ...

    Abstract A new study suggests that the leading genetic risk factor for Alzheimer's disease, apolipoprotein E4 (
    MeSH term(s) Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Blood-Brain Barrier/metabolism ; Cognitive Dysfunction ; Humans
    Chemical Substances Apolipoprotein E4
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X20938146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endoplasmic Reticulum Interaction Supports Energy Production and Redox Homeostasis in Mitochondria Released from Astrocytes.

    Park, Ji-Hyun / Lo, Eng H / Hayakawa, Kazuhide

    Translational stroke research

    2021  Volume 12, Issue 6, Page(s) 1045–1054

    Abstract: Mitochondria can be released by astrocytes as part of a help-me signaling process in stroke. In this study, we investigated the molecular mechanisms that underlie mitochondria secretion, redox status, and functional regulation in the extracellular ... ...

    Abstract Mitochondria can be released by astrocytes as part of a help-me signaling process in stroke. In this study, we investigated the molecular mechanisms that underlie mitochondria secretion, redox status, and functional regulation in the extracellular environment. Exposure of rat primary astrocytes to NAD or cADPR elicited an increase in mitochondrial calcium through ryanodine receptor (RyR) in the endoplasmic reticulum (ER). Importantly, CD38 stimulation with NAD accelerated ATP production along with increasing glutathione reductase (GR) and dipicolinic acid (DPA) in intracellular mitochondria. When RyR was blocked by Dantrolene, all effects were clearly diminished. Mitochondrial functional assay showed that these activated mitochondria appeared to be resistant to H
    MeSH term(s) Animals ; Astrocytes/metabolism ; Endoplasmic Reticulum/metabolism ; Homeostasis ; Hydrogen Peroxide/metabolism ; Mitochondria/metabolism ; Oxidation-Reduction ; Rats
    Chemical Substances Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2541897-X
    ISSN 1868-601X ; 1868-4483
    ISSN (online) 1868-601X
    ISSN 1868-4483
    DOI 10.1007/s12975-021-00892-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Meningeal Multipotent Cells: A Hidden Target for CNS Repair?

    Hayakawa, Kazuhide / Snyder, Evan Y / Lo, Eng H

    Neuromolecular medicine

    2021  Volume 23, Issue 3, Page(s) 339–343

    Abstract: Traditionally, the primary role of the meninges is thought to be structural, i.e., to act as a surrounding membrane that contains and cushions the brain with cerebrospinal fluid. During development, the meninges is formed by both mesenchymal and neural ... ...

    Abstract Traditionally, the primary role of the meninges is thought to be structural, i.e., to act as a surrounding membrane that contains and cushions the brain with cerebrospinal fluid. During development, the meninges is formed by both mesenchymal and neural crest cells. There is now emerging evidence that subsets of undifferentiated stem cells might persist in the adult meninges. In this mini-review, we survey representative studies of brain-meningeal interactions and discuss the hypothesis that the meninges are not just protective membranes, but instead contain multiplex stem cell subsets that may contribute to central nervous system (CNS) homeostasis. Further investigations into meningeal multipotent cells may reveal a "hidden" target for promoting neurovascular remodeling and repair after CNS injury and disease.
    MeSH term(s) Adapalene/analysis ; Adult Stem Cells/physiology ; Animals ; Brain Ischemia/physiopathology ; Central Nervous System/injuries ; Central Nervous System/physiopathology ; Central Nervous System Diseases/therapy ; Glymphatic System/cytology ; Homeostasis ; Humans ; Male ; Meninges/cytology ; Meninges/embryology ; Multipotent Stem Cells/physiology ; Neural Crest/cytology ; Neural Stem Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Regeneration/physiology
    Chemical Substances Adapalene (1L4806J2QF)
    Language English
    Publishing date 2021-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2077809-0
    ISSN 1559-1174 ; 1535-1084
    ISSN (online) 1559-1174
    ISSN 1535-1084
    DOI 10.1007/s12017-021-08663-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5818: Show issues Location:
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  9. Article: Role of A-Kinase Anchoring Protein 12 in the Central Nervous System.

    Kimura, Shintaro / Lok, Josephine / Gelman, Irwin H / Lo, Eng H / Arai, Ken

    Journal of clinical neurology (Seoul, Korea)

    2023  Volume 19, Issue 4, Page(s) 329–337

    Abstract: A-kinase anchoring protein (AKAP) 12 is a scaffolding protein that anchors various signaling proteins to the plasma membrane. These signaling proteins include protein kinase A, protein kinase C, protein phosphatase 2B, Src-family kinases, cyclins, and ... ...

    Abstract A-kinase anchoring protein (AKAP) 12 is a scaffolding protein that anchors various signaling proteins to the plasma membrane. These signaling proteins include protein kinase A, protein kinase C, protein phosphatase 2B, Src-family kinases, cyclins, and calmodulin, which regulate their respective signaling pathways. AKAP12 expression is observed in the neurons, astrocytes, endothelial cells, pericytes, and oligodendrocytes of the central nervous system (CNS). Its physiological roles include promoting the development of the blood-brain barrier, maintaining white-matter homeostasis, and even regulating complex cognitive functions such as long-term memory formation. Under pathological conditions, dysregulation of AKAP12 expression levels may be involved in the pathology of neurological diseases such as ischemic brain injury and Alzheimer's disease. This minireview aimed to summarize the current literature on the role of AKAP12 in the CNS.
    Language English
    Publishing date 2023-07-05
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Introduction to the special issue honoring Richard Traystman.

    Lo, Eng H / Moskowitz, Michael A

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2019  Volume 38, Issue 12, Page(s) 2055–2056

    MeSH term(s) History, 20th Century ; History, 21st Century ; Neurology/history
    Language English
    Publishing date 2019-01-13
    Publishing country United States
    Document type Editorial ; Historical Article ; Introductory Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X18803702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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