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  1. Article ; Online: Inflammatory and vaso-occlusive ulcers: Part II - Management.

    Hines, Alex / Kody, Shannon / Shakshouk, Hadir / Fett, Nicole / Alavi, Afsaneh / Ortega-Loayza, Alex

    Journal of the American Academy of Dermatology

    2024  

    Abstract: In the second part of this CME, we present an approach for the management of inflammatory and vaso-occlusive ulcers and highlight the need for further research in this field. The three overarching principles for management are etiology-specific treatment, ...

    Abstract In the second part of this CME, we present an approach for the management of inflammatory and vaso-occlusive ulcers and highlight the need for further research in this field. The three overarching principles for management are etiology-specific treatment, ulcer care, and consideration of patient comorbidities and risk factors for poor healing. Both etiology-specific treatment and management of patient comorbidities and risk factors often require collaboration with providers from other specialties. Ulcer care is governed by TIME, or tissue debridement, infection control, management of moisture imbalance and epithelial edge advancement. As wound healing is a dynamic process, management should be adapted to changes in the status of the ulcer.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.12.077
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    Zs.A 1540: Show issues Location:
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  2. Article ; Online: Ustekinumab use in patients with severe psoriasis co-infected with hepatitis B and/or C.

    Siegel, S A R / Winthrop, K L / Ehst, B D / Ortega Loayza, A

    The British journal of dermatology

    2019  Volume 180, Issue 5, Page(s) 1232–1233

    MeSH term(s) Adult ; Coinfection/epidemiology ; Coinfection/immunology ; Coinfection/virology ; Female ; Hepacivirus/immunology ; Hepacivirus/isolation & purification ; Hepatitis B virus/immunology ; Hepatitis B virus/isolation & purification ; Hepatitis B, Chronic/epidemiology ; Hepatitis B, Chronic/immunology ; Hepatitis B, Chronic/virology ; Hepatitis C, Chronic/epidemiology ; Hepatitis C, Chronic/immunology ; Hepatitis C, Chronic/virology ; Humans ; Male ; Middle Aged ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Psoriasis/immunology ; Severity of Illness Index ; Ustekinumab/adverse effects ; Virus Activation/drug effects ; Young Adult
    Chemical Substances Ustekinumab (FU77B4U5Z0)
    Language English
    Publishing date 2019-01-16
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.17444
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  3. Article: Update on Hormonal Therapy in Hidradenitis Suppurativa.

    Karagaiah, Priyanka / Daveluy, Steven / Ortega-Loayza, Alex / Gulliver, Wayne / Szepietowski, Jacek / Grabbe, Stephan / Goldust, Mohamad

    Journal of drugs in dermatology : JDD

    2023  Volume 22, Issue 4, Page(s) 369–374

    Abstract: Hidradenitis suppurativa (HS), a chronic inflammatory disorder of the apocrine-bearing skin, presents with deep seated inflamed nodules, abscesses, draining sinus tracts, and scarring with a profound impact on quality of life. In this review of Pubmed, ... ...

    Abstract Hidradenitis suppurativa (HS), a chronic inflammatory disorder of the apocrine-bearing skin, presents with deep seated inflamed nodules, abscesses, draining sinus tracts, and scarring with a profound impact on quality of life. In this review of Pubmed, EMBASE, and Cochrane Central databases, we focus on the role of hormonal therapies in the treatment of HS, including finasteride, cyproterone acetate, spironolactone, oral contraceptive pills, and metformin. A detailed search was conducted on these databases using key words like ‘hidradenitis suppurativa’, ‘acne inversa’, ‘antiandrogens’, and ‘hormonal therapy’. J Drugs Dermatol. 2023;22(4): doi:10.36849/JDD.6235 Citation: Karagaiah P, Daveluy S, Ortega Loayza A, et al. Update on hormonal therapy in hidradenitis suppurativa. J Drugs Dermatol. 2023;22(4):369-374. doi:10.36849/JDD.6235.
    MeSH term(s) Humans ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/drug therapy ; Quality of Life ; Skin ; Finasteride/therapeutic use ; Abscess
    Chemical Substances Finasteride (57GNO57U7G)
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    DOI 10.36849/JDD.6235
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    Zs.A 5931: Show issues Location:
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  4. Article: Breast-Conserving Surgery Guided with Magnetic Seeds vs. Wires: A Single-Institution Experience.

    Moreno-Palacios, Elisa / Martí, Covadonga / Frías, Laura / Meléndez, Marcos / Loayza, Adolfo / Roca, María José / Córdoba, Vicenta / Oliver, José María / Hernández, Alicia / Sánchez-Méndez, José Ignacio

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Purpose: The aim of this study is to describe our initial experience using magnetic seeds (Magseed: Methods: We performed a retrospective study including all breast-conserving surgeries for non-palpable breast lesions under 16 mm from June 2018 to ... ...

    Abstract Purpose: The aim of this study is to describe our initial experience using magnetic seeds (Magseed
    Methods: We performed a retrospective study including all breast-conserving surgeries for non-palpable breast lesions under 16 mm from June 2018 to May 2021. We compared breast-conserving surgeries guided with magnetic seeds (Magseed
    Results: Data from 225 cases were collected, including 149 cases guided by magnetic seeds and 76 cases guided by wires. The breast lesion was localized in every case. Both cohorts were similar regarding clinical and pathological characteristics. We found significant statistical differences (
    Conclusion: In our experience, the use of magnetic seed (Magseed
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030566
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  5. Article ; Online: Tofacitinib for the treatment of refractory pyoderma gangrenosum.

    Orfaly, V E / Kovalenko, I / Tolkachjov, S N / Ortega-Loayza, A G / Nunley, J R

    Clinical and experimental dermatology

    2021  Volume 46, Issue 6, Page(s) 1082–1085

    Abstract: Pyoderma gangrenosum (PG) is a rare, debilitating, inflammatory skin disease associated with a variety of systemic diseases. Because of its rarity, PG is treated with miscellaneous immunosuppressive agents as there is no US Food and Drug Administration- ... ...

    Abstract Pyoderma gangrenosum (PG) is a rare, debilitating, inflammatory skin disease associated with a variety of systemic diseases. Because of its rarity, PG is treated with miscellaneous immunosuppressive agents as there is no US Food and Drug Administration-approved standardized treatment approach. We present four patients with PG treated with tofacitinib in the context of the six existing cases in the literature. Tofacitinib appeared to be beneficial in the small sample of patients (n = 10) who failed an average of four other systemic therapies. The majority of patients had classic PG located on the legs (80%, 8/10), while 20% of cases (2/10) were peristomal. The most common comorbidity was inflammatory bowel disease (78%, 7/9). There were no negative treatment results and 40% (4/10) of patients had complete healing of their ulcers, while the other 60% (6/10) had marked clinical improvement. From our observation, tofacitinib appears to be a promising steroid-sparing adjuvant treatment in patients with refractory PG who have failed on other systemic therapies.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/complications ; Leg Dermatoses/drug therapy ; Leg Dermatoses/pathology ; Male ; Middle Aged ; Piperidines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Pyoderma Gangrenosum/complications ; Pyoderma Gangrenosum/drug therapy ; Pyoderma Gangrenosum/pathology ; Pyrimidines/therapeutic use ; Surgical Stomas/pathology ; Treatment Outcome
    Chemical Substances Dermatologic Agents ; Immunosuppressive Agents ; Piperidines ; Protein Kinase Inhibitors ; Pyrimidines ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.14683
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    Zs.A 1278: Show issues Location:
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  6. Article ; Online: Ustekinumab as adjuvant treatment for all pyoderma gangrenosum subtypes.

    Westerdahl, J S / Nusbaum, K B / Chung, C G / Kaffenberger, B H / Ortega-Loayza, A G

    The Journal of dermatological treatment

    2021  Volume 33, Issue 4, Page(s) 2386–2390

    MeSH term(s) Adjuvants, Immunologic ; Dermatologic Agents/therapeutic use ; Humans ; Pyoderma Gangrenosum/drug therapy ; Ustekinumab/therapeutic use
    Chemical Substances Adjuvants, Immunologic ; Dermatologic Agents ; Ustekinumab (FU77B4U5Z0)
    Language English
    Publishing date 2021-06-14
    Publishing country England
    Document type Letter
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2021.1937475
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    Zs.A 2627: Show issues Location:
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  7. Article ; Online: Granuloma annulare following initiation of interleukin-17a antagonist.

    Gray, A R / Davies, O M T / White, K / Ortega-Loayza, A G

    Clinical and experimental dermatology

    2021  Volume 46, Issue 5, Page(s) 924–926

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Drug Eruptions/etiology ; Female ; Granuloma Annulare/chemically induced ; Humans ; Interleukin-17/antagonists & inhibitors ; Middle Aged ; Psoriasis/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Interleukin-17 ; ixekizumab (BTY153760O) ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.14579
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    Zs.A 1278: Show issues Location:
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  8. Article ; Online: Identification and evaluation of outcome measurement instruments in pyoderma gangrenosum: a systematic review.

    Lu, J D / Hobbs, M M / Huang, W W / Ortega-Loayza, A G / Alavi, A

    The British journal of dermatology

    2020  Volume 183, Issue 5, Page(s) 821–828

    Abstract: Background: Pyoderma gangrenosum (PG) is a rare autoinflammatory skin condition that causes tissue destruction and subsequent painful ulcers. To date, there are no core domains or instruments for assessing PG severity in clinical trials, and current ... ...

    Abstract Background: Pyoderma gangrenosum (PG) is a rare autoinflammatory skin condition that causes tissue destruction and subsequent painful ulcers. To date, there are no core domains or instruments for assessing PG severity in clinical trials, and current treatment paradigms rely on outcome measurements that have not been well characterized in the literature.
    Objectives: To perform two systematic reviews that (i) identify the outcome measurement instruments used in PG clinical trials and their corresponding domains and (ii) identify any associated validation studies and evaluate their measurement properties and methodological quality.
    Methods: We systematically searched the MEDLINE and Embase databases for PG outcome measurement instruments. We also systematically searched for PG instrument validation studies. We evaluated the measurement properties and methodological quality of validation studies using the 2018 COSMIN Risk of Bias checklist.
    Results: In total, seven clinical trials were included. These studies utilized a total of 20 different instruments, including 11 physician-reported instruments, eight patient-reported instruments and one composite instrument. Among these, 85% of the instruments lacked any validation data. Of the remaining three validated instruments (speed of healing, physician global assessment and resolution of inflammation), methodological quality was not available for half of the COSMIN categories.
    Conclusions: We identified 17 non-validated outcome measurement instruments used in PG clinical trials. We conclude that PG validation studies are required for existing instruments, and new instruments need to be developed to inform the consensus process for the development of a core outcome set for PG. What is already known about this topic? Pyoderma gangrenosum (PG) is a rare autoinflammatory skin condition that has been characterized by multiple outcome measurement instruments in clinical trials. However, there is no consensus on the most validated and appropriate outcome measurement instruments. What does this study add? This study identifies and evaluates 20 unique outcome measurement instruments for PG in the literature. Of these 20, 17 lack any instrument validation data, highlighting the need for future studies. What are the clinical implications of this work? Despite the current use of several outcome measurement instruments, future studies should explore the validation surrounding these instruments, as no instruments can currently be recommended.
    MeSH term(s) Checklist ; Consensus ; Databases, Factual ; Humans ; Pyoderma Gangrenosum/diagnosis
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.19027
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  9. Article ; Online: Reply to: pyoderma gangrenosum: a clinical conundrum.

    Gupta, A S / Greiling, T M / Ortega-Loayza, A G

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2018  Volume 32, Issue 10, Page(s) e382

    MeSH term(s) Humans ; Pyoderma Gangrenosum
    Language English
    Publishing date 2018-07-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.14977
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  10. Article ; Online: A systematic review of pyoderma gangrenosum with pulmonary involvement: clinical presentation, diagnosis and management.

    Gupta, A S / Greiling, T M / Ortega-Loayza, A G

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2018  Volume 32, Issue 7, Page(s) e295–e297

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Arthritis, Rheumatoid/complications ; Hematologic Diseases/complications ; Humans ; Inflammatory Bowel Diseases/complications ; Lung Diseases/diagnosis ; Lung Diseases/drug therapy ; Lung Diseases/etiology ; Pyoderma Gangrenosum/complications ; Pyoderma Gangrenosum/drug therapy
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2018-02-19
    Publishing country England
    Document type Letter ; Systematic Review
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.14828
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    Zs.MO 413: Show issues

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