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  1. Article ; Online: Time to retire 'New daily persistent headache': Mode of onset of chronic migraine and tension-type headache.

    Lobo, Rhannon / Wang, Mu / Lobo, Sean / Bahra, Anish

    Cephalalgia : an international journal of headache

    2021  Volume 42, Issue 4-5, Page(s) 385–395

    Abstract: New daily persistent headache is described as an enigmatic condition with daily headache from onset. It has posed challenges diagnostically and therapeutically. ...

    Abstract New daily persistent headache is described as an enigmatic condition with daily headache from onset. It has posed challenges diagnostically and therapeutically.
    MeSH term(s) Female ; Headache ; Headache Disorders/psychology ; Humans ; Male ; Migraine Disorders/epidemiology ; Recurrence ; Tension-Type Headache/epidemiology
    Language English
    Publishing date 2021-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/03331024211044440
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    Zs.A 1645: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Vestibulo-perceptual influences upon the vestibulo-spinal reflex.

    Bonsu, Angela N / Nousi, Sofia / Lobo, Rhannon / Strutton, Paul H / Arshad, Qadeer / Bronstein, Adolfo M

    Experimental brain research

    2021  Volume 239, Issue 7, Page(s) 2141–2149

    Abstract: The vestibular system facilitates gaze and postural stability via the vestibulo-ocular (VOR) and vestibulo-spinal reflexes, respectively. Cortical and perceptual mechanisms can modulate long-duration VOR responses, but little is known about whether high- ... ...

    Abstract The vestibular system facilitates gaze and postural stability via the vestibulo-ocular (VOR) and vestibulo-spinal reflexes, respectively. Cortical and perceptual mechanisms can modulate long-duration VOR responses, but little is known about whether high-order neural phenomena can modulate short-latency vestibulo-spinal responses. Here, we investigate this by assessing click-evoked cervical vestibular myogenic-evoked potentials (VEMPS) during visual roll motion that elicited an illusionary sensation of self-motion (i.e. vection). We observed that during vection, the amplitude of the VEMPs was enhanced when compared to baseline measures. This modulation in VEMP amplitude was positively correlated with the subjective reports of vection strength. That is, those subjects reporting greater subjective vection scores exhibited a greater increase in VEMP amplitude. Control experiments showed that simple arousal (cold-induced discomfort) also increased VEMP amplitude but that, unlike vection, it did not modulate VEMP amplitude linearly. In agreement, small-field visual roll motion that did not induce vection failed to increase VEMP amplitude. Taken together, our results demonstrate that vection can modify the response of vestibulo-collic reflexes. Even short-latency brainstem vestibulo-spinal reflexes are influenced by high-order mechanisms, illustrating the functional importance of perceptual mechanisms in human postural control. As VEMPs are inhibitory responses, we argue that the findings may represent a mechanism whereby high-order CNS mechanisms reduce activity levels in vestibulo-collic reflexes, necessary for instance when voluntary head movements need to be performed.
    MeSH term(s) Head ; Humans ; Postural Balance ; Reflex, Vestibulo-Ocular ; Vestibular Evoked Myogenic Potentials ; Vestibule, Labyrinth
    Language English
    Publishing date 2021-05-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-021-06123-7
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    Zs.A 278: Show issues Location:
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  3. Article ; Online: Targeted detection and repair of a spinal dural defect associated with successful biochemical resolution of subarachnoid bleeding in classical infratentorial superficial siderosis.

    Lobo, Rhannon / Batbayar, Bilguun / Kharytaniuk, Natallia / Cowley, Peter / Sayal, Parag / Farmer, Simon / Werring, David J

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2022  Volume 43, Issue 9, Page(s) 5643–5646

    Abstract: BACKGROUND AND IMPORTANCE  : Classical infratentorial superficial siderosis (iSS) is characterised by repeated insidious bleeding into the subarachnoid space, leading to haemosiderin deposition within the subpial layers of the brainstem, cerebellum and ... ...

    Abstract BACKGROUND AND IMPORTANCE  : Classical infratentorial superficial siderosis (iSS) is characterised by repeated insidious bleeding into the subarachnoid space, leading to haemosiderin deposition within the subpial layers of the brainstem, cerebellum and spinal cord, sometimes with supratentorial involvement. Although nearly always associated with a dural defect (usually from previous trauma or neurosurgery) there is little evidence to support definitive investigation and management strategies. Here, we present a novel investigation strategy to identify a dural defect and subsequent successful surgical repair with biochemical resolution of subarachnoid bleeding. CLINICAL PRESENTATION: A 55-year-old gentleman presented with a 15-year progressive history of sensorineural deafness, followed by a slowly worsening gait ataxia. He had previously sustained cranio-spinal trauma. On examination there were features of myelopathy and ataxia. MRI demonstrated classical iSS, affecting cerebellum and cerebral cortices, with a cervicothoracic epidural CSF collection. Lumbar puncture (LP) revealed elevated ferritin 413 ng/mL and red cell count of 4160. Reverse CT myelography, a novel technique involving contrast injection into the collection, delineated a dural defect at the T9/T10 level that was not present on conventional myelography. Following surgical repair, repeat LP twelve months later demonstrated biochemical improvement (ferritin 18 ng/mL, red cells < 1). There was no further neurological deterioration in symptoms during eighteen months follow-up. CONCLUSION: We show the value of a rational targeted investigation pathway in identifying a surgically reparable dural defect underlying classical iSS. We also provide proof of concept that surgical repair can facilitate biochemical resolution of subarachnoid bleeding and might prevent progression of neurological disability.
    MeSH term(s) Ferritins ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Myelography ; Siderosis/complications ; Siderosis/diagnostic imaging ; Siderosis/surgery ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/surgery ; Subarachnoid Space/surgery
    Chemical Substances Ferritins (9007-73-2)
    Language English
    Publishing date 2022-06-13
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-022-06181-x
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    Zs.A 1877: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Dealing with emotions in medical school: are senior students preferable to mentors?

    Al-Khudairi, Rashed / Jameie-Oskooei, Sina / Lobo, Rhannon

    Medical education

    2017  Volume 51, Issue 4, Page(s) 452

    MeSH term(s) Education, Medical, Undergraduate ; Emotions ; Humans ; Mentors ; Schools, Medical ; Students ; Students, Medical/psychology
    Language English
    Publishing date 2017
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.13207
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    Zs.B 312: Show issues Location:
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  5. Article ; Online: iPads in clinical rotations: a student perspective.

    Jameie-Oskooei, Sina / Al-Khudairi, Rashed / Lobo, Rhannon

    The clinical teacher

    2017  Volume 14, Issue 1, Page(s) 75

    MeSH term(s) Computers, Handheld ; Humans ; Students
    Language English
    Publishing date 2017
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2151518-9
    ISSN 1743-498X ; 1743-4971
    ISSN (online) 1743-498X
    ISSN 1743-4971
    DOI 10.1111/tct.12592
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    Zs.A 6678: Show issues Location:
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  6. Article ; Online: Expected thrombectomy caseload.

    Gill, Dipender / Lobo, Rhannon / Sivakumaran, Prasanthi / Kar, Arindam

    International journal of stroke : official journal of the International Stroke Society

    2016  Volume 11, Issue 7, Page(s) NP76

    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1177/1747493016641115
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    Zs.A 6582: Show issues Location:
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  7. Article ; Online: Interhemispheric control of sensory cue integration and self-motion perception.

    Arshad, Qadeer / Ortega, Marta Casanovas / Goga, Usman / Lobo, Rhannon / Siddiqui, Shuaib / Mediratta, Saniya / Bednarczuk, Nadja F / Kaski, Diego / Bronstein, Adolfo M

    Neuroscience

    2019  Volume 408, Page(s) 378–387

    Abstract: Spatial orientation necessitates the integration of visual and vestibular sensory cues, in-turn facilitating self-motion perception. However, the neural mechanisms underpinning sensory integration remain unknown. Recently we have illustrated that spatial ...

    Abstract Spatial orientation necessitates the integration of visual and vestibular sensory cues, in-turn facilitating self-motion perception. However, the neural mechanisms underpinning sensory integration remain unknown. Recently we have illustrated that spatial orientation and vestibular thresholds are influenced by interhemispheric asymmetries associated with the posterior parietal cortices (PPC) that predominantly house the vestibulo-cortical network. Given that sensory integration is a prerequisite to both spatial orientation and motion perception, we hypothesized that sensory integration is similarly subject to interhemispheric influences. Accordingly, we explored the relationship between vestibulo-cortical dominance - assessed using a biomarker, the degree of vestibular-nystagmus suppression following transcranial direct current stimulation over the PPC - with visual dependence measures obtained during performance of a sensory integration task (the rod-and-disk task). We observed that the degree of visual dependence was correlated with vestibulo-cortical dominance. Specifically, individuals with greater right hemispheric vestibulo-cortical dominance had reduced visual dependence. We proceeded to assess the significance of such dominance on behavior by correlating measures of visual dependence with self-motion perception in healthy subjects. We observed that right-handed individuals experienced illusionary self-motion (vection) quicker than left-handers and that the degree of vestibular cortical dominance was correlated with the time taken to experience vection, only during conditions that induced interhemispheric conflict. To conclude, we demonstrate that interhemispheric asymmetries associated with vestibulo-cortical processing in the PPC functionally and mechanistically link sensory integration and self-motion perception, facilitating spatial orientation. Our findings highlight the importance of dynamic interhemispheric competition upon control of vestibular behavior in humans.
    MeSH term(s) Adult ; Cues ; Eye Movements/physiology ; Female ; Functional Laterality/physiology ; Humans ; Male ; Motion Perception/physiology ; Neural Pathways/physiology ; Parietal Lobe/physiology ; Transcranial Direct Current Stimulation ; Young Adult
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2019.04.027
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    Zs.A 1215: Show issues Location:
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  8. Article ; Online: Downregulation of early visual cortex excitability mediates oscillopsia suppression.

    Ahmad, Hena / Roberts, R Edward / Patel, Mitesh / Lobo, Rhannon / Seemungal, Barry / Arshad, Qadeer / Bronstein, Adolfo

    Neurology

    2017  Volume 89, Issue 11, Page(s) 1179–1185

    Abstract: Objective: To identify in an observational study the neurophysiologic mechanisms that mediate adaptation to oscillopsia in patients with bilateral vestibular failure (BVF).: Methods: We directly probe the hypothesis that adaptive changes that mediate ...

    Abstract Objective: To identify in an observational study the neurophysiologic mechanisms that mediate adaptation to oscillopsia in patients with bilateral vestibular failure (BVF).
    Methods: We directly probe the hypothesis that adaptive changes that mediate oscillopsia suppression implicate the early visual-cortex (V1/V2). Accordingly, we investigated V1/V2 excitability using transcranial magnetic stimulation (TMS) in 12 avestibular patients and 12 healthy controls. Specifically, we assessed TMS-induced phosphene thresholds at baseline and cortical excitability changes while performing a visual motion adaptation paradigm during the following conditions: baseline measures (i.e., static), during visual motion (i.e., motion before adaptation), and during visual motion after 5 minutes of unidirectional visual motion adaptation (i.e., motion adapted).
    Results: Patients had significantly higher baseline phosphene thresholds, reflecting an underlying adaptive mechanism. Individual thresholds were correlated with oscillopsia symptom load. During the visual motion adaptation condition, no differences in excitability at baseline were observed, but during both the motion before adaptation and motion adapted conditions, we observed significantly attenuated cortical excitability in patients. Again, this attenuation in excitability was stronger in less symptomatic patients.
    Conclusions: Our findings provide neurophysiologic evidence that cortically mediated adaptive mechanisms in V1/V2 play a critical role in suppressing oscillopsia in patients with BVF.
    MeSH term(s) Adaptation, Physiological/physiology ; Adult ; Aged ; Disability Evaluation ; Female ; Humans ; Male ; Middle Aged ; Motion Perception/physiology ; Perceptual Disorders/physiopathology ; Photic Stimulation ; Severity of Illness Index ; Surveys and Questionnaires ; Transcranial Magnetic Stimulation ; Vestibular Diseases/physiopathology ; Visual Cortex/physiopathology
    Language English
    Publishing date 2017-08-16
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000004360
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  9. Article: Biased numerical cognition impairs economic decision-making in Parkinson's disease.

    Arshad, Qadeer / Bonsu, Angela / Lobo, Rhannon / Fluri, Anne-Sophie / Sheriff, Rahuman / Bain, Peter / Pavese, Nicola / Bronstein, Adolfo M

    Annals of clinical and translational neurology

    2017  Volume 4, Issue 10, Page(s) 739–748

    Abstract: Objective: Previous findings suggest a context-dependent bihemispheric allocation of numerical magnitude. Accordingly, we predicted that lateralized motor symptoms in Parkinson's disease (PD), which reflect hemispheric asymmetries, would induce ... ...

    Abstract Objective: Previous findings suggest a context-dependent bihemispheric allocation of numerical magnitude. Accordingly, we predicted that lateralized motor symptoms in Parkinson's disease (PD), which reflect hemispheric asymmetries, would induce systematic lateralized biases in numerical cognition and have a subsequent influence on decision-making.
    Methods: In 20 PD patients and matched healthy controls we assessed numerical cognition using a number-pair bisection and random number generation task. Decision-making was assessed using both the dictator game and a validated questionnaire.
    Results: PD patients with predominant right-sided motor symptoms exhibited pathological biases toward smaller numerical magnitudes and formulated less favorable prosocial choices during a neuroeconomics task (i.e., dictator game). Conversely, patients with left-sided motor symptoms exhibited pathological biases toward larger numerical magnitudes and formulated more generous prosocial choices. Our account of context-dependent hemispheric allocation of numerical magnitude in PD was corroborated by applying our data to a pre-existing computational model and observing significant concordance. Notably, both numerical biasing and impaired decision-making were correlated with motor asymmetry.
    Interpretation: Accordingly, motor asymmetry and functional impairment of cognitive processes in PD can be functionally intertwined. To conclude, our findings demonstrate context-dependent hemispheric allocation and encoding of numerical magnitude in PD and how biases in numerical magnitude allocation in Parkinsonian patients can correspondingly impair economic decision-making.
    Language English
    Publishing date 2017-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740696-9
    ISSN 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.449
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  10. Article ; Online: Lateralisation of the Vestibular Cortex Is More Pronounced in Left-Handers.

    Nigmatullina, Yuliya / Siddiqui, Shuaib / Khan, Sarah / Sander, Kaija / Lobo, Rhannon / Bronstein, Adolfo M / Arshad, Qadeer

    Brain stimulation

    2016  Volume 9, Issue 6, Page(s) 942–944

    Language English
    Publishing date 2016-08-03
    Publishing country United States
    Document type Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2016.08.001
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