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  1. Article ; Online: Acute graft versus host disease after liver transplantation: where do we stand?

    Izzo, Alessandro / Pellegrino, Roberta A / Locci, Giorgia / Cesaretti, Manuela

    Minerva surgery

    2023  Volume 78, Issue 5, Page(s) 537–544

    Abstract: Graft-versus-host disease (GVHD) is a rare complication after liver transplantation (LT), with an estimated incidence rate of 0.5% to 2% and a mortality rate as high as 75%. The classical target organs of GVHD include the intestines, liver, and skin. The ...

    Abstract Graft-versus-host disease (GVHD) is a rare complication after liver transplantation (LT), with an estimated incidence rate of 0.5% to 2% and a mortality rate as high as 75%. The classical target organs of GVHD include the intestines, liver, and skin. The damage of these organs is not easy to detect for the clinician as there is no widely accepted clinical or laboratory diagnostic tests; as a result, diagnosis and initiation of therapy are often delayed. Moreover, without prospective clinical trials to reference, evidence guiding therapy is limited. This review summarized the current knowledge, the potential applications and the clinical relevance of GVHD after LT, highlighting novel approaches in grading and management of GVHD.
    Language English
    Publishing date 2023-03-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.09868-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 25: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Complicated enterocele: timely resolution with bowel resection via a vaginal approach: case report.

    Abis, Paola / Madeddu, Clelia / Magro Malosso, Giovanni / Sole, Gabriele / Mereu, Alessia / Locci, Giorgia / Macciò, Antonio

    Frontiers in surgery

    2023  Volume 10, Page(s) 1228981

    Abstract: Background: Enterocele is an uncommon, serious condition that requires accurate and early diagnosis to prevent complications such as intestinal obstruction, incarceration, and strangulation, with consequent intestinal ischemia, necrosis, and ... ...

    Abstract Background: Enterocele is an uncommon, serious condition that requires accurate and early diagnosis to prevent complications such as intestinal obstruction, incarceration, and strangulation, with consequent intestinal ischemia, necrosis, and evisceration. We report a rare case of a patient with a voluminous enterocele and initial signs of intestinal ischemia who underwent urgent vaginal surgery.
    Case description: An 80-year-old woman presented with a voluminous mass protruding from the vagina, associated abdominopelvic pain, a 10-day history of bowel sub-occlusion, and numerous episodes of profuse vaginal bleeding. She was diagnosed with an enterocele with early signs of complications. Owing to her advanced clinical condition and comorbidities, we opted for an urgent vaginal procedure. Intestinal loops with initial signs of ischemia were resected via a transvaginal approach, leading to good clinical outcomes. She was discharged on postoperative day 5.
    Conclusions: This rare case highlights a surgical emergency that was managed with transvaginal resection of the intestine. Early identification of the initial signs of complications allowed for this less invasive approach, resulting in reduced morbidity and length of hospital stay.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1228981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characterization of the Protein Components of Matrix Stones Sheds Light on S100-A8 and S100-A9 Relevance in the Inflammatory Pathogenesis of These Rare Renal Calculi.

    Martelli, Claudia / Marzano, Valeria / Iavarone, Federica / Huang, Liling / Vincenzoni, Federica / Desiderio, Claudia / Messana, Irene / Beltrami, Paolo / Zattoni, Filiberto / Ferraro, Pietro Manuel / Buchholz, Noor / Locci, Giorgia / Faa, Gavino / Castagnola, Massimo / Gambaro, Giovanni

    The Journal of urology

    2016  Volume 196, Issue 3, Page(s) 911–918

    Abstract: Purpose: Among the different types of kidney stones, matrix stones are uncommon urinary calculi composed of a soft, pliable, amorphous substance with little crystalline content. To gain insight into the pathogenesis we investigated the protein component ...

    Abstract Purpose: Among the different types of kidney stones, matrix stones are uncommon urinary calculi composed of a soft, pliable, amorphous substance with little crystalline content. To gain insight into the pathogenesis we investigated the protein component by analyzing the proteomic profiles of surgically removed matrix stones.
    Materials and methods: A total of 5 stones were harvested from 4 patients who underwent surgery for medical reasons at 3 clinical centers during a 7-year period. Matrix stone proteome characterization was performed by mass spectrometry based techniques using an integrated top-down/bottom-up proteomic platform.
    Results: We identified 142 nonredundant proteins and peptides across all samples. Neutrophil defensin 1, and proteins S100-A8 and S100-A9 were the main components of these renal calculi.
    Conclusions: The abundance of identified inflammatory molecules points to an inflammatory process as the event that initializes soft calculi formation rather than as a consequence of such formation. The post-translational oxidative changes in S100-A8 and A9, and the presence of thymosin β-4, granulins and ubiquitin also suggest the intervention of host defenses through a superimposed, vigorous counter inflammatory process. The post-translational changes seen in the proteins and peptides, and the known self-assembling capability of S100-A8 and S100-A9 probably explain the gelatinous consistency of these stones.
    MeSH term(s) Calgranulin A/metabolism ; Calgranulin B/metabolism ; Chromatography, Liquid ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Inflammation/metabolism ; Male ; Middle Aged ; Proteomics/methods ; Retrospective Studies ; Time Factors ; Urinary Calculi/chemistry
    Chemical Substances Calgranulin A ; Calgranulin B
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2016.04.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.91: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 331: Show issues

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  4. Article ; Online: Effects of Erythropoietin Administration on Adrenal Glands of Landrace/Large White Pigs after Ventricular Fibrillation.

    Faa, Armando / Faa, Gavino / Papalois, Apostolos / Obinu, Eleonora / Locci, Giorgia / Pais, Maria Elena / Lelovas, Pavlos / Barouxis, Dimitrios / Pantazopoulos, Charalampos / Vasileiou, Panagiotis V / Iacovidou, Nicoletta / Xanthos, Theodoros

    BioMed research international

    2016  Volume 2016, Page(s) 7261960

    Abstract: Aim. To evaluate the effects of erythropoietin administration on the adrenal glands in a swine model of ventricular fibrillation and resuscitation. Methods. Ventricular fibrillation was induced via pacing wire forwarded into the right ventricle in 20 ... ...

    Abstract Aim. To evaluate the effects of erythropoietin administration on the adrenal glands in a swine model of ventricular fibrillation and resuscitation. Methods. Ventricular fibrillation was induced via pacing wire forwarded into the right ventricle in 20 female Landrace/Large White pigs, allocated into 2 groups: experimental group treated with bolus dose of erythropoietin (EPO) and control group which received normal saline. Cardiopulmonary resuscitation (CPR) was performed immediately after drug administration as per the 2010 European Resuscitation Council (ERC) guidelines for Advanced Life Support (ALS) until return of spontaneous circulation (ROSC) or death. Animals who achieved ROSC were monitored, mechanically ventilated, extubated, observed, and euthanized. At necroscopy, adrenal glands samples were formalin-fixed, paraffin-embedded, and routinely processed. Sections were stained with hematoxylin-eosin. Results. Oedema and apoptosis were the most frequent histological changes and were detected in all animals in the adrenal cortex and in the medulla. Mild and focal endothelial lesions were also detected. A marked interindividual variability in the degree of the intensity of apoptosis and oedema at cortical and medullary level was observed within groups. Comparing the two groups, higher levels of pathological changes were detected in the control group. No significant difference between the two groups was observed regarding the endothelial changes. Conclusions. In animals exposed to ventricular fibrillation, EPO treatment has protective effects on the adrenal gland.
    MeSH term(s) Adrenal Cortex/drug effects ; Adrenal Glands/drug effects ; Adrenal Medulla/drug effects ; Animals ; Apoptosis/drug effects ; Cardiopulmonary Resuscitation/methods ; Disease Models, Animal ; Erythropoietin/administration & dosage ; Female ; Protective Agents/administration & dosage ; Swine ; Ventricular Fibrillation/drug therapy
    Chemical Substances Protective Agents ; Erythropoietin (11096-26-7)
    Keywords covid19
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2016/7261960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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