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  1. Article ; Online: A cross-lagged twin study of emotional symptoms, social isolation and peer victimisation from early adolescence to emerging adulthood.

    Morneau-Vaillancourt, Geneviève / Oginni, Olakunle / Assary, Elham / Krebs, Georgina / Thompson, Ellen J / Palaiologou, Elisavet / Lockhart, Celestine / Arseneault, Louise / Eley, Thalia C

    Journal of child psychology and psychiatry, and allied disciplines

    2023  Volume 64, Issue 11, Page(s) 1569–1582

    Abstract: Background: Emotional symptoms, such as anxiety and depressive symptoms, are common during adolescence, often persist over time, and can precede the emergence of severe anxiety and depressive disorders. Studies suggest that a vicious cycle of reciprocal ...

    Abstract Background: Emotional symptoms, such as anxiety and depressive symptoms, are common during adolescence, often persist over time, and can precede the emergence of severe anxiety and depressive disorders. Studies suggest that a vicious cycle of reciprocal influences between emotional symptoms and interpersonal difficulties may explain why some adolescents suffer from persisting emotional symptoms. However, the role of different types of interpersonal difficulties, such as social isolation and peer victimisation, in these reciprocal associations is still unclear. In addition, the lack of longitudinal twin studies conducted on emotional symptoms during adolescence means that the genetic and environmental contributions to these relationships during adolescence remain unknown.
    Methods: Participants (N = 15,869) from the Twins Early Development Study completed self-reports of emotional symptoms, social isolation and peer victimisation at 12, 16 and 21 years old. A phenotypic cross-lagged model examined reciprocal associations between variables over time, and a genetic extension of this model examined the aetiology of the relationships between variables at each timepoint.
    Results: First, emotional symptoms were reciprocally and independently associated with both social isolation and peer victimisation over time, indicating that different forms of interpersonal difficulties uniquely contributed to emotional symptoms during adolescence and vice versa. Second, early peer victimisation predicted later emotional symptoms via social isolation in mid-adolescence, indicating that social isolation may constitute an intermediate pathway through which peer victimisation predicts longer-term emotional symptoms. Finally, individual differences in emotional symptoms were mostly accounted for by non-shared environmental factors at each timepoint, and both gene-environment and individual-specific environmental mechanisms were involved in the relationships between emotional symptoms and interpersonal difficulties.
    Conclusions: Our study highlights the necessity to intervene early in adolescence to prevent the escalation of emotional symptoms over time and to consider social isolation and peer victimisation as important risk factors for the long-term persistence of emotional symptoms.
    MeSH term(s) Adolescent ; Humans ; Young Adult ; Anxiety/psychology ; Bullying/psychology ; Emotions ; Longitudinal Studies ; Peer Group ; Social Isolation
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Twin Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218136-8
    ISSN 1469-7610 ; 0021-9630 ; 0373-8086
    ISSN (online) 1469-7610
    ISSN 0021-9630 ; 0373-8086
    DOI 10.1111/jcpp.13847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genetics of environmental sensitivity and its association with variations in emotional problems, autistic traits, and wellbeing.

    Assary, Elham / Oginni, Olakunle A / Morneau-Vaillancourt, Genevieve / Krebs, Georgina / Peel, Alicia J / Palaiologou, Elisavet / Lockhart, Celestine / Ronald, Angelica / Eley, Thalia C

    Molecular psychiatry

    2024  

    Abstract: Greater environmental sensitivity has been associated with increased risk of mental health problems, especially in response to stressors, and lower levels of subjective wellbeing. Conversely, sensitivity also correlates with lower risk of emotional ... ...

    Abstract Greater environmental sensitivity has been associated with increased risk of mental health problems, especially in response to stressors, and lower levels of subjective wellbeing. Conversely, sensitivity also correlates with lower risk of emotional problems in the absence of adversity, and in response to positive environmental influences. Additionally, sensitivity has been found to correlate positively with autistic traits. Individual differences in environmental sensitivity are partly heritable, but it is unknown to what extent the aetiological factors underlying sensitivity overlap with those on emotional problems (anxiety and depressive symptoms), autistic traits and wellbeing. The current study used multivariate twin models and data on sensitivity, emotional problems, autistic traits, and several indices of psychological and subjective wellbeing, from over 2800 adolescent twins in England and Wales. We found that greater overall sensitivity correlated with greater emotional problems, autistic traits, and lower subjective wellbeing. A similar pattern of correlations was found for the Excitation and Sensory factors of sensitivity, but, in contrast, the Aesthetic factor was positively correlated with psychological wellbeing, though not with emotional problems nor autistic traits. The observed correlations were largely due to overlapping genetic influences. Importantly, genetic influences underlying sensitivity explained between 2 and 12% of the variations in emotional problems, autistic traits, and subjective wellbeing, independent of trait-specific or overlapping genetic influences. These findings encourage incorporating the genetics of environmental sensitivity in future genomic studies aiming to delineate the heterogeneity in emotional problems, autistic traits, and wellbeing.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02508-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Twins Early Development Study (TEDS): A genetically sensitive investigation of mental health outcomes in the mid-twenties.

    Lockhart, Celestine / Bright, Joanna / Ahmadzadeh, Yasmin / Breen, Gerome / Bristow, Shannon / Boyd, Andy / Downs, Johnny / Hotopf, Matthew / Palaiologou, Elisavet / Rimfeld, Kaili / Maxwell, Jessye / Malanchini, Margherita / McAdams, Tom A / McMillan, Andrew / Plomin, Robert / Eley, Thalia C

    JCPP advances

    2023  Volume 3, Issue 2, Page(s) e12154

    Abstract: The Twins Early Development Study (TEDS) is a longitudinal study following a cohort of twins born 1994-1996 in England and Wales. Of the 13,759 families who originally consented to take part, over 10,000 families remain enrolled in the study. The current ...

    Abstract The Twins Early Development Study (TEDS) is a longitudinal study following a cohort of twins born 1994-1996 in England and Wales. Of the 13,759 families who originally consented to take part, over 10,000 families remain enrolled in the study. The current focus of TEDS is on mental health in the mid-twenties. Making use of over 25 years of genetically sensitive data, TEDS is uniquely placed to explore the longitudinal genetic and environmental influences on common mental health disorders in early adulthood. This paper outlines recent data collection efforts supporting this work, including a cohort-wide mental health assessment at age 26 and a multi-phase Covid-19 study. It will also provide an update on data linkage efforts and the Children of TEDS (CoTEDS) project.
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ISSN 2692-9384
    ISSN (online) 2692-9384
    DOI 10.1002/jcv2.12154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A multivariate genetic analysis of anxiety sensitivity, environmental sensitivity and reported life events in adolescents.

    Peel, Alicia J / Oginni, Olakunle / Assary, Elham / Krebs, Georgina / Lockhart, Celestine / McGregor, Thomas / Palaiologou, Elisavet / Ronald, Angelica / Danese, Andrea / Eley, Thalia C

    Journal of child psychology and psychiatry, and allied disciplines

    2022  Volume 64, Issue 2, Page(s) 289–298

    Abstract: Background: Despite being considered a measure of environmental risk, reported life events are partly heritable. One mechanism that may contribute to this heritability is genetic influences on sensitivity, relating to how individuals process and ... ...

    Abstract Background: Despite being considered a measure of environmental risk, reported life events are partly heritable. One mechanism that may contribute to this heritability is genetic influences on sensitivity, relating to how individuals process and interpret internal and external signals. The aim of this study was to explore the genetic and environmental overlap between self-reported life events and measures of sensitivity.
    Methods: At age 17, 2,939 individuals from the Twins Early Development Study (TEDS) completed measures of anxiety sensitivity (Children's Anxiety Sensitivity Index), environmental sensitivity (Highly Sensitive Child Scale) and reported their experience of 20 recent life events. Using multivariate Cholesky decomposition models, we investigated the shared genetic and environmental influences on the associations between these measures of sensitivity and the number of reported life events, as well as both negative and positive ratings of life events.
    Results: The majority of the associations between anxiety sensitivity, environmental sensitivity and reported life events were explained by shared genetic influences (60%-75%), with the remainder explained by nonshared environmental influences (25%-40%). Environmental sensitivity showed comparable genetic correlations with both negative and positive ratings of life events (r
    Conclusion: Differences in how individuals process the contextual aspects of the environment or interpret their own physical and emotional response to environmental stimuli may be one mechanism through which genetic liability influences the subjective experience of life events.
    MeSH term(s) Child ; Humans ; Adolescent ; Anxiety/genetics ; Anxiety/psychology ; Anxiety Disorders ; Twins/genetics ; Diseases in Twins/genetics ; Self Report
    Language English
    Publishing date 2022-12-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218136-8
    ISSN 1469-7610 ; 0021-9630 ; 0373-8086
    ISSN (online) 1469-7610
    ISSN 0021-9630 ; 0373-8086
    DOI 10.1111/jcpp.13725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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