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  1. Article ; Online: What Metadata? Defining Different Types of Digital Assets as Application Targets of Metadata in Clinical Research Informatics.

    Löbe, Matthias

    Studies in health technology and informatics

    2021  Volume 287, Page(s) 124–125

    Abstract: The term 'metadata' is mentioned in every one of the FAIR principles. Metadata is without question important for findability, accessibility, and reusability, but essential for interoperability. Standardized schemas have been developed by various ... ...

    Abstract The term 'metadata' is mentioned in every one of the FAIR principles. Metadata is without question important for findability, accessibility, and reusability, but essential for interoperability. Standardized schemas have been developed by various stakeholders for decades, but too rarely come to practical use. The reason for this is that the application domain is not clearly understood. In many bio-medical research projects, the need for metadata is recognized at some point, but there is not only a lack of overview of existing standards, but also a lack of correct assessment of what individual metadata schemas were actually made for. This paper differentiates different application scenarios for metadata in clinical research.
    MeSH term(s) Medical Informatics ; Metadata
    Language English
    Publishing date 2021-11-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI210829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Mechanical circulatory support

    Joyce, David L. / Joyce, Lyle D. / Loebe, Matthias

    principles and applications

    2012  

    Author's details ed. David L. Joyce ; Lyle D. Joyce ; Matthias Loebe
    Keywords Heart Failure / surgery ; Heart, Artificial ; Assisted Circulation
    Language English
    Size XV, 253 S. : Ill., graph. Darst.
    Publisher McGraw-Hill Med
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016990864
    ISBN 978-0-07-175344-9 ; 0-07-175344-3
    Database Catalogue ZB MED Medicine, Health

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  3. Article: User Expectations of Metadata Repositories for Clinical Research.

    Löbe, Matthias

    Studies in health technology and informatics

    2018  Volume 253, Page(s) 60–64

    Abstract: Metadata Repositories (MDR) are databases for data elements that can be utilized in research as well as in medical care. These data elements are not the actual patient data (facts), but a complete definition of the variables or characteristics used, ... ...

    Abstract Metadata Repositories (MDR) are databases for data elements that can be utilized in research as well as in medical care. These data elements are not the actual patient data (facts), but a complete definition of the variables or characteristics used, including coding, unit of measurement, data type and other aspects. The aim of the project described here was to evaluate possible application scenarios for MDRs by a larger group of experts. The focus was not on specific software, but on the community's basic expectation of such a database of data elements. To achieve this goal, a questionnaire was designed that contained questions on general aspects of setting up a registry for data elements in biomedical research as well as more specific points with regard to necessary functionalities, desired contents, tools for community work and the quality of data elements. One of the main results was that the users attach more importance to the quality of the content than to the efficiency in implementing their documentation concepts. At the same time, they consider the effort involved in using existing software systems to be too much compared with the benefits and have concerns about the use of their designs by third parties.
    MeSH term(s) Biomedical Research ; Databases, Factual ; Documentation ; Humans ; Metadata ; Software
    Language English
    Publishing date 2018-08-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 0926-9630
    ISSN 0926-9630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Should there be an age limit for advanced therapies?

    Loebe, Matthias / Bruckner, Brian A

    Journal of cardiac surgery

    2022  

    Abstract: Combined heart lung transplant has become a rare procedure. However, there is a significant number of patients potentially benefitting from replacement of both heart and lungs. This represents a quite diverse patient population. Decisions in patient ... ...

    Abstract Combined heart lung transplant has become a rare procedure. However, there is a significant number of patients potentially benefitting from replacement of both heart and lungs. This represents a quite diverse patient population. Decisions in patient selection have to be adjusted to individual needs and distinct constellation of the patient. Age may be a risk factor, but should be carefully integrated into the evaluation of perioperative and long term risks.
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.17018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-term survival: Achilles heel of lung transplantation.

    Manikavel, Suresh / Loebe, Matthias

    Journal of cardiac surgery

    2022  

    Abstract: Long-term survival after lung transplantation has dramatically increased over recent years. But it still falls short of providing a solid extended life expectancy of more than 10 to 15 years. Patients and their families have to informed about this ... ...

    Abstract Long-term survival after lung transplantation has dramatically increased over recent years. But it still falls short of providing a solid extended life expectancy of more than 10 to 15 years. Patients and their families have to informed about this observation so that they can make informed descisions.
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Conference proceedings: Datenqualitätsanalysen im Rahmen der MII-Projectathons

    Draeger, Christian / Löbe, Matthias

    2023  , Page(s) P25

    Event/congress SMITH Science Day 2022; Aachen; Smart Medical Information Technology for Healthcare; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2023-01-31
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22smith36
    Database German Medical Science

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  7. Article ; Online: Temporary Mechanical Circulatory Support: Left, Right, and Biventricular Devices.

    Dangl, Michael / Albosta, Michael / Butros, Hoda / Loebe, Matthias

    Current cardiology reviews

    2023  Volume 19, Issue 5, Page(s) 27–42

    Abstract: Temporary mechanical circulatory support (MCS) encompasses a wide array of invasive devices, which provide short-term hemodynamic support for multiple clinical indications. Although initially developed for the management of cardiogenic shock, indications ...

    Abstract Temporary mechanical circulatory support (MCS) encompasses a wide array of invasive devices, which provide short-term hemodynamic support for multiple clinical indications. Although initially developed for the management of cardiogenic shock, indications for MCS have expanded to include prophylactic insertion prior to high-risk percutaneous coronary intervention, treatment of acute circulatory failure following cardiac surgery, and bridging of end-stage heart failure patients to more definitive therapies, such as left ventricular assist devices and cardiac transplantation. A wide variety of devices are available to provide left ventricular, right ventricular, or biventricular support. The choice of a temporary MCS device requires consideration of the clinical scenario, patient characteristics, institution protocols, and provider familiarity and training. In this review, the most common forms of left, right, and biventricular temporary MCS are discussed, along with their indications, contraindications, complications, cannulations, hemodynamic effects, and available clinical data.
    MeSH term(s) Humans ; Shock, Cardiogenic/surgery ; Heart-Assist Devices/adverse effects ; Hemodynamics ; Extracorporeal Membrane Oxygenation/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2023-03-12
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/1573403X19666230314115853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bridge to retransplant with ECMO.

    Loebe, Matthias / Ghodsizad, Ali

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Volume 61, Issue 2, Page(s) 413–415

    MeSH term(s) Extracorporeal Membrane Oxygenation ; Humans ; Lung Transplantation ; Waiting Lists
    Language English
    Publishing date 2021-11-01
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Don't pig(!) the wrong heart!

    Loebe, Matthias / Parker, Brandon

    Journal of cardiac surgery

    2021  Volume 36, Issue 10, Page(s) 3802–3804

    Abstract: Cardiac xenotransplantation is believed to have approached clinical application. However, this approach to advanced heart failure is burdened with a multitude of ethical issues. These issues need to be addressed openly and be broadly discussed in public. ...

    Abstract Cardiac xenotransplantation is believed to have approached clinical application. However, this approach to advanced heart failure is burdened with a multitude of ethical issues. These issues need to be addressed openly and be broadly discussed in public. Only through an honest and transparent approach, it will be possible to engage the lay audience in the evaluation of pig to human transplant.
    MeSH term(s) Animals ; Heart ; Heart Transplantation ; Heterografts ; Swine ; Transplantation, Heterologous ; Transplants
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.15842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Assessing the use of HL7 FHIR for implementing the FAIR guiding principles: a case study of the MIMIC-IV Emergency Department module.

    van Damme, Philip / Löbe, Matthias / Benis, Nirupama / de Keizer, Nicolette F / Cornet, Ronald

    JAMIA open

    2024  Volume 7, Issue 1, Page(s) ooae002

    Abstract: Objectives: To provide a real-world example on how and to what extent Health Level Seven Fast Healthcare Interoperability Resources (FHIR) implements the Findable, Accessible, Interoperable, and Reusable (FAIR) guiding principles for scientific data. ... ...

    Abstract Objectives: To provide a real-world example on how and to what extent Health Level Seven Fast Healthcare Interoperability Resources (FHIR) implements the Findable, Accessible, Interoperable, and Reusable (FAIR) guiding principles for scientific data. Additionally, presents a list of FAIR implementation choices for supporting future FAIR implementations that use FHIR.
    Materials and methods: A case study was conducted on the Medical Information Mart for Intensive Care-IV Emergency Department (MIMIC-ED) dataset, a deidentified clinical dataset converted into FHIR. The FAIRness of this dataset was assessed using a set of common FAIR assessment indicators.
    Results: The FHIR distribution of MIMIC-ED, comprising an implementation guide and demo data, was more FAIR compared to the non-FHIR distribution. The FAIRness score increased from 60 to 82 out of 95 points, a relative improvement of 37%. The most notable improvements were observed in interoperability, with a score increase from 5 to 19 out of 19 points, and reusability, with a score increase from 8 to 14 out of 24 points. A total of 14 FAIR implementation choices were identified.
    Discussion: Our work examined how and to what extent the FHIR standard contributes to FAIR data. Challenges arose from interpreting the FAIR assessment indicators. This study stands out for providing a real-world example of a dataset that was made more FAIR using FHIR.
    Conclusion: To the best of our knowledge, this is the first study that formally assessed the conformance of a FHIR dataset to the FAIR principles. FHIR improved the accessibility, interoperability, and reusability of MIMIC-ED. Future research should focus on implementing FHIR in research data infrastructures.
    Language English
    Publishing date 2024-01-27
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2531
    ISSN (online) 2574-2531
    DOI 10.1093/jamiaopen/ooae002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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