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  1. Article ; Online: Artificial intelligence for home monitoring devices.

    Keenan, Tiarnan D L / Loewenstein, Anat

    Current opinion in ophthalmology

    2023  Volume 34, Issue 5, Page(s) 441–448

    Abstract: Purpose of review: Home monitoring in ophthalmology is appropriate for disease stages requiring frequent monitoring or rapid intervention, for example, neovascular age-related macular degeneration (AMD) and glaucoma, where the balance between frequent ... ...

    Abstract Purpose of review: Home monitoring in ophthalmology is appropriate for disease stages requiring frequent monitoring or rapid intervention, for example, neovascular age-related macular degeneration (AMD) and glaucoma, where the balance between frequent hospital attendance versus risk of late detection is a constant challenge. Artificial intelligence approaches are well suited to address some challenges of home monitoring.
    Recent findings: Ophthalmic data collected at home have included functional (e.g. perimetry), biometric (e.g. intraocular pressure), and imaging [e.g. optical coherence tomography (OCT)] data. Potential advantages include early detection/intervention, convenience, cost, and visual outcomes. Artificial intelligence can assist with home monitoring workflows by handling large data volumes from frequent testing, compensating for test quality, and extracting useful metrics from complex data. Important use cases include machine learning applied to hyperacuity self-testing for detecting neovascular AMD and deep learning applied to OCT data for quantifying retinal fluid.
    Summary: Home monitoring of health conditions is useful for chronic diseases requiring rapid intervention or frequent data sampling to decrease risk of irreversible vision loss. Artificial intelligence may facilitate accurate, frequent, large-scale home monitoring, if algorithms are integrated safely into workflows. Clinical trials and economic evaluations are important to demonstrate the value of artificial intelligence-based home monitoring, towards improved visual outcomes.
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000000981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Use of a Novel Beyeonics One Three-dimensional Head-mounted Digital Visualization Platform in Vitreoretinal surgeries.

    Schwartz, Shulamit / Gomel, Nir / Loewenstein, Anat / Barak, Adiel

    European journal of ophthalmology

    2024  , Page(s) 11206721241229115

    Abstract: Background: Ophthalmic microscopes have been crucial in visualizing surgical fields, but their limitations in enhancing the surgical view through digital image processing have prompted the development of digital surgical microscopes. The Beyeonics One ... ...

    Abstract Background: Ophthalmic microscopes have been crucial in visualizing surgical fields, but their limitations in enhancing the surgical view through digital image processing have prompted the development of digital surgical microscopes. The Beyeonics One microscope, a novel digital microscope, offers ophthalmic surgeons a 3D visualization platform and an augmented reality (AR) surgical headset, potentially improving surgical decision-making and outcomes. While its initial use has been described in cataract and corneal surgeries, its application in vitreoretinal surgery remains relatively unexplored.
    Methods: In this interventional case series, we collected data from the medical records of patients who underwent vitreoretinal surgery using the Beyeonics One 3D visualization platform at the Tel Aviv Medical Center. A total of 36 eyes from 36 subjects were included. Surgical techniques included retinal detachment surgeries and macular surgeries, performed by experienced surgeons. The surgical visualization was facilitated by the Beyeonics One 3D head-mounted display (HMD) platform.
    Results: The procedures were uneventful, and none intra- or postoperative complications were reported, and surgeons did not experience any signal delay in the real-time video.
    Discussion: The Beyeonics One microscope offers several potential advantages in vitreoretinal surgery, including digital image processing, enhanced depth perception through the 3D HMD platform, and hands-free image control using head gestures. While this study demonstrates the feasibility and safety of the Beyeonics One microscope, addressing limitations related to hazy views and optimizing image quality are crucial for consistent visualization.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721241229115
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  3. Article: Current and Future Treatments for Diabetic Retinopathy.

    Behar-Cohen, Francine / Loewenstein, Anat

    Pharmaceutics

    2022  Volume 14, Issue 4

    Abstract: The pathogenesis of diabetic retinopathy in humans remains imperfectly understood; in particular, the kinetics of the various pathogenic events in the very early stages of retinal damage are difficult to recognize [ ... ]. ...

    Abstract The pathogenesis of diabetic retinopathy in humans remains imperfectly understood; in particular, the kinetics of the various pathogenic events in the very early stages of retinal damage are difficult to recognize [...].
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14040812
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  4. Article ; Online: EURETINA White Paper: Facing up to Gender Inequality in the Field of Retina.

    Loewenstein, Anat / Conlon, Dara

    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

    2022  Volume 245, Issue 6, Page(s) 497–499

    MeSH term(s) Humans ; Gender Equity ; Retina
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 209735-7
    ISSN 1423-0267 ; 0030-3755
    ISSN (online) 1423-0267
    ISSN 0030-3755
    DOI 10.1159/000526173
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  5. Article ; Online: Future perspectives for treating patients with geographic atrophy.

    Loewenstein, Anat / Trivizki, Omer

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 261, Issue 6, Page(s) 1525–1531

    Abstract: Purpose: Geographic atrophy (GA) is a late-stage form of age-related macular degeneration (AMD) characterized by the expansion of atrophic lesions in the outer retina. There are currently no approved pharmacological treatments to prevent or slow the ... ...

    Abstract Purpose: Geographic atrophy (GA) is a late-stage form of age-related macular degeneration (AMD) characterized by the expansion of atrophic lesions in the outer retina. There are currently no approved pharmacological treatments to prevent or slow the progression of GA. This review describes the progression and assessment of GA, predictive imaging features, and complement-targeting investigational drugs for GA.
    Methods: A literature search on GA was conducted.
    Results: Expansion of atrophic lesions in patients with GA is associated with a decline in several measures of visual function. GA lesion size has been moderately associated with measures obtained through microperimetry, whereas GA lesion size in the 1-mm diameter area centered on the fovea has been associated with visual acuity. Optical coherence tomography (OCT) can provide 3-dimensional quantitative assessment of atrophy and is useful for identifying early atrophy in GA. Features that have been found to predict the development of GA include certain drusen characteristics and pigmentary abnormalities. Specific OCT features, including hyper-reflective foci and OCT-reflective drusen substructures, have been associated with AMD disease progression. Lesion characteristics, including focality, regularity of shape, location, and perilesional fundus autofluorescence patterns, have been identified as predictors of faster GA lesion growth. Certain investigational complement-targeting drugs have shown efficacy in slowing the progression of GA.
    Conclusion: GA is a progressive disease associated with irreversible vision loss. Therefore, the lack of treatment options presents a significant unmet need. OCT and drugs under investigation for GA are promising future tools for disease management.
    MeSH term(s) Humans ; Geographic Atrophy/diagnosis ; Geographic Atrophy/drug therapy ; Macular Degeneration/pathology ; Fundus Oculi ; Fovea Centralis/pathology ; Tomography, Optical Coherence/methods ; Atrophy ; Disease Progression ; Fluorescein Angiography
    Language English
    Publishing date 2022-12-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05931-z
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  6. Article ; Online: The roadmap to geographic atrophy treatment: A journey of trials and promise.

    Trivizki, Omer / Loewenstein, Anat / Zur, Dinah

    Acta ophthalmologica

    2023  Volume 101, Issue 8, Page(s) 891–895

    Abstract: This review covers advancements in geographic atrophy (GA) research. It discusses genetic contributions to AMD, explores treatment strategies, including complement inhibition, and highlights recent FDA approvals, safety concerns and promising future ... ...

    Abstract This review covers advancements in geographic atrophy (GA) research. It discusses genetic contributions to AMD, explores treatment strategies, including complement inhibition, and highlights recent FDA approvals, safety concerns and promising future directions.
    MeSH term(s) Humans ; Geographic Atrophy ; Macular Degeneration/genetics
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.15801
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  7. Book: Optical coherence tomography

    Coscas, Gabriel / Loewenstein, Anat / Bandello, Francesco

    9 tables

    (ESASO course series ; 4)

    2014  

    Author's details vol. ed. Gabriel Coscas ; Anat Loewenstein ; Francesco Bandello
    Series title ESASO course series ; 4
    Collection
    Keywords Tomography, Optical Coherence
    Language English
    Size XI, 134 S. : zahlr. Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018288272
    ISBN 978-3-31802-563-7 ; 3-31802-563-1 ; 9783318025644 ; 331802564X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 A 2620 available for loan (reading room) Lesesaal EG

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  8. Article ; Online: Should we still be performing macular laser for non-centre involving diabetic macular oedema? Yes.

    Zur, Dinah / Loewenstein, Anat

    Eye (London, England)

    2021  Volume 36, Issue 3, Page(s) 483–484

    MeSH term(s) Diabetes Mellitus ; Diabetic Retinopathy/surgery ; Humans ; Laser Coagulation ; Lasers ; Macular Edema/surgery ; Tomography, Optical Coherence
    Language English
    Publishing date 2021-10-13
    Publishing country England
    Document type Editorial
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-021-01793-7
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  9. Article: Intravitreal Anti-Vascular Endothelial Growth Factor Agents for the Treatment of Diabetic Retinopathy: A Review of the Literature.

    Chatziralli, Irini / Loewenstein, Anat

    Pharmaceutics

    2021  Volume 13, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13081137
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  10. Article ; Online: Development in Smartphone Technologies and the Advancement of Home Vision Monitoring.

    Zur, Dinah / Loewenstein, Anat

    JAMA ophthalmology

    2021  Volume 140, Issue 2, Page(s) 161

    MeSH term(s) Humans ; Smartphone
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2021.5270
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