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Article ; Online: Comprehensive Flow Cytometric Characterization of Bronchoalveolar Lavage Cells Indicates Comparable Phenotypes Between Asthmatic and Healthy Horses But Functional Lymphocyte Differences.

Gressler, A Elisabeth / Lübke, Sabrina / Wagner, Bettina / Arnold, Corinna / Lohmann, Katharina L / Schnabel, Christiane L

Frontiers in immunology

2022 Volume 13, Page(s) 896255

Abstract: Equine asthma (EA) is a highly relevant disease, estimated to affect up to 20% of all horses, and compares to human asthma. The pathogenesis of EA is most likely immune-mediated, yet incompletely understood. To study the immune response in the affected ... ...

Abstract	Equine asthma (EA) is a highly relevant disease, estimated to affect up to 20% of all horses, and compares to human asthma. The pathogenesis of EA is most likely immune-mediated, yet incompletely understood. To study the immune response in the affected lower airways, mixed leukocytes were acquired through bronchoalveolar lavage (BAL) and the cell populations were analyzed on a single-cell basis by flow cytometry (FC). Samples of 38 horses grouped as respiratory healthy or affected by mild to moderate (mEA) or severe EA (sEA) according to their history, clinical signs, and BAL cytology were analyzed. Using FC, BAL cells and PBMC were comprehensively characterized by cell surface markers
MeSH term(s)	Animals ; Asthma ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid ; CD8-Positive T-Lymphocytes ; Cytokines/metabolism ; Flow Cytometry ; Horses ; Leukocytes, Mononuclear ; Phenotype
Chemical Substances	Cytokines
Language	English
Publishing date	2022-07-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.896255
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020.

Ganzenberg, Stefanie / Sieg, Michael / Ziegler, Ute / Pfeffer, Martin / Vahlenkamp, Thomas W / Hörügel, Uwe / Groschup, Martin H / Lohmann, Katharina L

Viruses

2022 Volume 14, Issue 6

Abstract: West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study's overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and ... ...

Abstract	West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study's overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and public health- authorities understand the spread of WNV in Germany and direct protective measures. For this purpose, WNV seroprevalence was determined in counties with and without previously registered WNV infections in horses, and risk factors for seropositivity were estimated. The cohort consisted of privately owned horses from nine counties in Eastern Germany. A total of 940 serum samples was tested by competitive panflavivirus ELISA (cELISA), and reactive samples were further tested by WNV IgM capture ELISA and confirmed by virus neutralization test (VNT). Information about potential risk factors was recorded by questionnaire and analyzed by logistic regression. A total of 106 serum samples showed antibodies against flaviviruses by cELISA, of which six tested positive for WNV IgM. The VNT verified a WNV infection for 54 samples (50.9%), while 35 sera neutralized tick-borne encephalitis virus (33.0%), and eight sera neutralized Usutu virus (7.5%). Hence, seroprevalence for WNV infection was 5.8% on average and was significantly higher in counties with previously registered infections (
MeSH term(s)	Animals ; Antibodies, Viral ; Encephalitis Viruses, Tick-Borne ; Enzyme-Linked Immunosorbent Assay ; Horse Diseases/epidemiology ; Horses ; Humans ; Immunoglobulin M ; Risk Factors ; Seroepidemiologic Studies ; West Nile Fever/epidemiology ; West Nile Fever/veterinary ; West Nile virus
Chemical Substances	Antibodies, Viral ; Immunoglobulin M
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14061191
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chronic active interstitial pancreatitis as a cause of transverse colonic obstruction and colic in a horse.

Lohmann, Katharina L / Allen, Andrew L

The Canadian veterinary journal = La revue veterinaire canadienne

2015 Volume 56, Issue 11, Page(s) 1177–1180

Abstract: A mature Quarter horse was euthanized following colic of 3 days duration. Postmortem, the large intestine, except the descending colon, was diffusely distended and associated with adhesion of the transverse colon to the pancreas, which had changes ... ...

Abstract	A mature Quarter horse was euthanized following colic of 3 days duration. Postmortem, the large intestine, except the descending colon, was diffusely distended and associated with adhesion of the transverse colon to the pancreas, which had changes consistent with chronic active interstitial pancreatitis. Other lesions included hepatic fibrosis, erosive gastritis, and bilateral adrenal cortical hyperplasia.
MeSH term(s)	Animals ; Chronic Disease ; Colic/pathology ; Colic/veterinary ; Colonic Diseases/pathology ; Colonic Diseases/veterinary ; Horse Diseases/etiology ; Horse Diseases/pathology ; Horses ; Intestinal Obstruction/pathology ; Intestinal Obstruction/veterinary ; Male ; Pancreatitis/pathology ; Pancreatitis/veterinary
Language	English
Publishing date	2015-11
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020

Ganzenberg, Stefanie / Sieg, Michael / Ziegler, Ute / Pfeffer, Martin / Vahlenkamp, Thomas W. / Hörügel, Uwe / Groschup, Martin H. / Lohmann, Katharina L.

Viruses. 2022 May 30, v. 14, no. 6

2022

Abstract: West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study’s overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and ... ...

Abstract	West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study’s overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and public health- authorities understand the spread of WNV in Germany and direct protective measures. For this purpose, WNV seroprevalence was determined in counties with and without previously registered WNV infections in horses, and risk factors for seropositivity were estimated. The cohort consisted of privately owned horses from nine counties in Eastern Germany. A total of 940 serum samples was tested by competitive panflavivirus ELISA (cELISA), and reactive samples were further tested by WNV IgM capture ELISA and confirmed by virus neutralization test (VNT). Information about potential risk factors was recorded by questionnaire and analyzed by logistic regression. A total of 106 serum samples showed antibodies against flaviviruses by cELISA, of which six tested positive for WNV IgM. The VNT verified a WNV infection for 54 samples (50.9%), while 35 sera neutralized tick-borne encephalitis virus (33.0%), and eight sera neutralized Usutu virus (7.5%). Hence, seroprevalence for WNV infection was 5.8% on average and was significantly higher in counties with previously registered infections (p = 0.005). The risk factor analysis showed breed type (pony), housing in counties with previously registered infections, housing type (24 h turn-out), and presence of outdoor shelter as the main significant risk factors for seropositivity. In conclusion, we estimated the extent of WNV infection in the resident horse population in Eastern Germany and showed that seroprevalence was higher in counties with previously registered equine WNV infections.
Keywords	Tick-borne encephalitis virus ; Usutu virus ; West Nile virus ; blood serum ; factor analysis ; horses ; neutralization tests ; questionnaires ; regression analysis ; risk factors ; seroprevalence ; Germany
Language	English
Dates of publication	2022-0530
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14061191
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Horses as sentinels for the circulation of flaviviruses in eastern-central Germany

Gothe, Leonard M. R. / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L. / Sieg, Michael / Vahlenkamp, Thomas W. / Hörügel, Uwe / Pfeffer, Martin*

2023

Keywords	abstract_or_summary ; Text ; ddc:570 ; vector-borne zoonoses -- specific antibodies -- risk factors -- Usutu- ; West Nile- and Tick-Borne Encephalitis-Virus
Language	English
Publishing date	2023-10-09
Publisher	MDPI AG
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Horses as Sentinels for the Circulation of Flaviviruses in Eastern-Central Germany.

Gothe, Leonard M R / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L / Sieg, Michael / Vahlenkamp, Thomas W / Groschup, Martin H / Hörügel, Uwe / Pfeffer, Martin

Viruses

2023 Volume 15, Issue 5

Abstract: Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern-central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV ... ...

Abstract	Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern-central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV and related flaviviruses transmission, such as tick-borne encephalitis virus (TBEV) and Usutu virus (USUV), and consequently help to estimate the risk of human infections. Hence, the aim of our study was to follow the seropositive ratio against these three viruses in horses in Saxony, Saxony Anhalt, and Brandenburg and to describe their geographic distribution for the year 2021. In early 2022, i.e., before the virus transmission season, sera from 1232 unvaccinated horses were tested using a competitive pan-flavivirus ELISA (cELISA). In order to estimate the true seropositive ratio of infection with WNV, TBEV, and USUV for 2021, positive and equivocal results were confirmed by a virus neutralization test (VNT). In addition, possible risk factors for seropositivity using questionnaires were analyzed using logistic regression based on questionnaires similar to our previous study from 2020. In total, 125 horse sera reacted positive in the cELISA. Based on the VNT, 40 sera showed neutralizing antibodies against WNV, 69 against TBEV, and 5 against USUV. Three sera showed antibodies against more than one virus, and eight were negative based on the VNT. The overall seropositive ratio was 3.3% (95% CI: 2.38-4.40) for WNV, 5.6% (95% CI: 4.44-7.04) for TBEV, and 0.4% (95% CI: 0.14-0.98) for USUV infections. While age and number of horses on the holding were factors predicting TBEV seropositivity, no risk factors were discovered for WNV seropositivity. We conclude that horses are useful sentinels to determine the flavivirus circulation in eastern-central Germany, as long as they are not vaccinated against WNV.
MeSH term(s)	Horses ; Animals ; Humans ; West Nile virus ; Seroepidemiologic Studies ; Horse Diseases/epidemiology ; Antibodies, Viral ; Flavivirus ; West Nile Fever/epidemiology ; West Nile Fever/veterinary ; Encephalitis Viruses, Tick-Borne ; Flavivirus Infections/epidemiology ; Flavivirus Infections/veterinary
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-04-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Disease investigations for equine infectious anemia in Canada (2009-2012) - Retrospective evaluation and risk factor analysis.

Lohmann, Katharina L / James, Carolyn R / Higgins, Sara N / Howden, Krista J / Epp, Tasha

The Canadian veterinary journal = La revue veterinaire canadienne

2019 Volume 60, Issue 11, Page(s) 1199–1206

Abstract: This retrospective study describes the detection of equine infectious anemia (EIA) during Canadian Food Inspection Agency (CFIA) disease investigations in Canada, examines aspects of importance for disease control, and evaluates potential animal-level ... ...

Abstract	This retrospective study describes the detection of equine infectious anemia (EIA) during Canadian Food Inspection Agency (CFIA) disease investigations in Canada, examines aspects of importance for disease control, and evaluates potential animal-level risk factors for EIA in high-risk horses. Based on review of all EIA-positive samples and all samples collected during disease investigations (N = 4553) over a 4-year period (2009 to 2012), 409 EIA cases were detected. Horse owners with EIA cases owned between 1 and 60 affected animals, and 49 horses seroconverted during a disease investigation period. Twenty-nine percent of cases (
MeSH term(s)	Animals ; Canada ; Equine Infectious Anemia ; Factor Analysis, Statistical ; Horses ; Infectious Anemia Virus, Equine ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2019-11-06
Publishing country	Canada
Document type	Journal Article
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020

Ganzenberg, Stefanie / Sieg, Michael / Ziegler, Ute / Pfeffer, Martin / Vahlenkamp, Thomas W. / Hörügel, Uwe / Groschup, Martin H. / Lohmann, Katharina L.

2022

Abstract	West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study’s overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and public health- authorities understand the spread of WNV in Germany and direct protective measures. For this purpose, WNV seroprevalence was determined in counties with and without previously registered WNV infections in horses, and risk factors for seropositivity were estimated. The cohort consisted of privately owned horses from nine counties in Eastern Germany. A total of 940 serum samples was tested by competitive panflavivirus ELISA (cELISA), and reactive samples were further tested by WNV IgM capture ELISA and confirmed by virus neutralization test (VNT). Information about potential risk factors was recorded by questionnaire and analyzed by logistic regression. A total of 106 serum samples showed antibodies against flaviviruses by cELISA, of which six tested positive for WNV IgM. The VNT verified a WNV infection for 54 samples (50.9%), while 35 sera neutralized tick-borne encephalitis virus (33.0%), and eight sera neutralized Usutu virus (7.5%). Hence, seroprevalence for WNV infection was 5.8% on average and was significantly higher in counties with previously registered infections (p = 0.005). The risk factor analysis showed breed type (pony), housing in counties with previously registered infections, housing type (24 h turn-out), and presence of outdoor shelter as the main significant risk factors for seropositivity. In conclusion, we estimated the extent of WNV infection in the resident horse population in Eastern Germany and showed that seroprevalence was higher in counties with previously registered equine WNV infections.
Keywords	Text ; ddc:570 ; West Nile virus -- horses -- seroprevalence -- Germany -- epidemiology -- risk factors -- tick-borne encephalitis virus -- Usutu virus
Subject code	630
Language	English
Publishing date	2022-05-31
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mastitis in a neonatal filly.

Gilday, Rebecca / Lewis, Danyse / Lohmann, Katharina L

The Canadian veterinary journal = La revue veterinaire canadienne

2015 Volume 56, Issue 1, Page(s) 63–65

Abstract: Neonatal mastitis is a rare occurrence in the horse. This report documents a case of mastitis caused by an organism within the Streptococcus dysgalactiae group in a 1-week-old Paint filly. ...

Abstract	Neonatal mastitis is a rare occurrence in the horse. This report documents a case of mastitis caused by an organism within the Streptococcus dysgalactiae group in a 1-week-old Paint filly.
MeSH term(s)	Animals ; Animals, Newborn ; Anti-Bacterial Agents/therapeutic use ; Female ; Horse Diseases/diagnosis ; Horse Diseases/pathology ; Horses ; Mastitis/microbiology ; Mastitis/veterinary ; Streptococcal Infections/microbiology ; Streptococcal Infections/veterinary ; Streptococcus/isolation & purification ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
Language	English
Publishing date	2015-01
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Horses as Sentinels for the Circulation of Flaviviruses in Eastern–Central Germany

Gothe, Leonard M. R. / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L. / Sieg, Michael / Vahlenkamp, Thomas W. / Groschup, Martin H. / Hörügel, Uwe / Pfeffer, Martin

2023

Abstract: Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern–central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV ... ...

Abstract	Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern–central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV and related flaviviruses transmission, such as tick-borne encephalitis virus (TBEV) and Usutu virus (USUV), and consequently help to estimate the risk of human infections. Hence, the aim of our study was to follow the seropositive ratio against these three viruses in horses in Saxony, Saxony Anhalt, and Brandenburg and to describe their geographic distribution for the year 2021. In early 2022, i.e., before the virus transmission season, sera from 1232 unvaccinated horses were tested using a competitive pan-flavivirus ELISA (cELISA). In order to estimate the true seropositive ratio of infection with WNV, TBEV, and USUV for 2021, positive and equivocal results were confirmed by a virus neutralization test (VNT). In addition, possible risk factors for seropositivity using questionnaires were analyzed using logistic regression based on questionnaires similar to our previous study from 2020. In total, 125 horse sera reacted positive in the cELISA. Based on the VNT, 40 sera showed neutralizing antibodies against WNV, 69 against TBEV, and 5 against USUV. Three sera showed antibodies against more than one virus, and eight were negative based on the VNT. The overall seropositive ratio was 3.3% (95% CI: 2.38–4.40) for WNV, 5.6% (95% CI: 4.44–7.04) for TBEV, and 0.4% (95% CI: 0.14–0.98) for USUV infections. While age and number of horses on the holding were factors predicting TBEV seropositivity, no risk factors were discovered for WNV seropositivity. We conclude that horses are useful sentinels to determine the flavivirus circulation in eastern–central Germany, as long as they are not vaccinated against WNV.
Keywords	Text ; ddc:570 ; flaviviruses -- West Nile virus -- horses -- seroprevalence -- Germany -- risk factors -- tick-borne encephalitis virus -- Usutu virus -- virus neutralization test -- vector-borne zoonoses
Subject code	630
Language	English
Publishing date	2023-04-30
Publisher	MDPI AG
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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