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  1. AU="Lohoff, Michael"
  2. AU="Shen, Yonggen"
  3. AU="Pervez, Muhammad Ijaz"
  4. AU="Laurence Decourty"

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  1. Article ; Online: Puppet masters of B-cell progenitor acute lymphoblastic leukemia: The preB cell receptor and the interleukin 7 receptor α.

    Das Gupta, Dennis / Lohoff, Michael

    European journal of immunology

    2023  Volume 53, Issue 4, Page(s) e2250093

    Abstract: B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) is enriched for a preB cell phenotype, hinting at a specific vulnerability of this cell stage. Two signaling pathways via the preB cell receptor (preBCR) and the interleukin 7 receptor α (IL-7Rα) ... ...

    Abstract B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) is enriched for a preB cell phenotype, hinting at a specific vulnerability of this cell stage. Two signaling pathways via the preB cell receptor (preBCR) and the interleukin 7 receptor α (IL-7Rα) chain govern the balance between differentiation and proliferation at this stage and both receptor pathways are routinely altered in human BCP-ALL. Here, we review the immunobiology of both the preBCR as well as the IL-7Rα and analyze the human BCP-ALL spectrum in the light of these signaling complexes. Finally, we present a terminology for preBCR signaling modules that distinguishes a pro-proliferative "phase-I" module from a pro-differentiative "phase-II" module. This terminology might serve as a framework to better address shared oncogenic mechanics of preB cell stage BCP-ALL.
    MeSH term(s) Humans ; Pre-B Cell Receptors/genetics ; Receptors, Interleukin-7/metabolism ; Burkitt Lymphoma ; B-Lymphocytes/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Interleukin-7/metabolism
    Chemical Substances Pre-B Cell Receptors ; Receptors, Interleukin-7 ; Interleukin-7
    Language English
    Publishing date 2023-03-09
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202250093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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  2. Book ; Thesis: Studien zur funktionalen Typisierung von murinen T-Helfer-Lymphozyten mit Hilfe von T-Zellklonen

    Lohoff, Michael

    1992  

    Author's details vorgelegt von Michael Lohoff
    Size 99 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Habil.-Schr., 1992
    HBZ-ID HT004344413
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: TMPRSS2, a novel host-directed drug target against SARS-CoV-2.

    Keller, Christian / Böttcher-Friebertshäuser, Eva / Lohoff, Michael

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 251

    MeSH term(s) COVID-19/drug therapy ; Humans ; SARS-CoV-2 ; Serine Endopeptidases/genetics
    Chemical Substances Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Language English
    Publishing date 2022-07-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01084-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Identifizierung funktioneller Untereinheiten des Transkriptionsfaktors interferon regulatory factor 4

    Staudenraus, Daniel [Verfasser] / Lohoff, Michael [Akademischer Betreuer]

    2023  

    Author's details Daniel Staudenraus ; Betreuer: Michael Lohoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: Die Bedeutung des Lymphozyten-Transkriptionsfaktors Interferon regulierender Faktor 4 in der Entstehung von präB Zell Leukämien der Maus

    Das Gupta, Dennis [Verfasser] / Lohoff, Michael [Akademischer Betreuer]

    2023  

    Author's details Dennis Das Gupta ; Betreuer: Michael Lohoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Ettal as the starting point of the Academy of Immunology

    Lohoff, Michael / Radbruch, Andreas

    Immunologie

    2021  Volume 5, Issue 4, Page(s) 250

    Language German
    Document type Article
    ZDB-ID 2935137-6
    ISSN 2625-3585 ; 2513-1583
    Database Current Contents Medicine

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    Zs.A 7237: Show issues Location:
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  7. Book ; Thesis: Herstellung und Anwendung eines hybriden monoklonalen Antikörpers durch Doppelfusion

    Lohoff, Michael

    1985  

    Size 55, II S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1985
    HBZ-ID HT003248798
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Endoscopic retrograde cholangiopancreatography-obtained bile culture in acute cholangitis: retrospective analysis of bile cultures and risk factors in a tertiary care center.

    Stathopoulos, Petros / Lerner, Paulina / Astheimer, Philipp / Breitling, Lutz P / Zumblick, Malte / Pararas, Michael / Lohoff, Michael / Gress, Thomas M / Denzer, Ulrike W

    Journal of gastroenterology and hepatology

    2024  Volume 39, Issue 5, Page(s) 935–941

    Abstract: Background: Collection of bile aspirate during endoscopic retrograde cholangiopancreatography (ERCP) is essential to identify pathogens responsible for acute cholangitis. Limited data are available on the risk factors for the presence of multidrug- ... ...

    Abstract Background: Collection of bile aspirate during endoscopic retrograde cholangiopancreatography (ERCP) is essential to identify pathogens responsible for acute cholangitis. Limited data are available on the risk factors for the presence of multidrug-resistant organisms (MDRO) in bile.
    Methods: We conducted this retrospective, single-center study to assess the prevalence and susceptibility rates of bacteria in bile cultures, and the risk factors for the presence of pathogens, MDRO, and fungi in bile. All consecutive patients who underwent biliary drainage for acute cholangitis from January 2017 to December 2019 were included.
    Results: 443/1610 ERCPs were performed for acute cholangitis. Bile culture was collected in 91.4% (405/443), of which 86.7% were positive. Most common isolates were Enterococcus faecalis (37.6%) and Escherichia coli (32.8%). Vancomycin resistance was found in 9.9% of Enterococcus species (spp.); extended-spectrum beta-lactamases (ESBL) and carbapenemases in 11.2% and 0.9% of Enterobacteriaceae, respectively. The empiric antimicrobial therapy was changed in 26.4% (n = 107) of cases, with a clinical response in 90.7%. In multivariate analysis, biliary stenting was an independent risk factor for positive bile culture (odds ratio [OR] 9.43; P < 0.01). Independent risk factors for MDRO in bile were patient age>60 years (OR 2.51; P = 0.03), previous sphincterotomy (OR 2.57; P = 0.02), and biliary stenting (OR 2.80; P < 0.01). Previous sphincterotomy was the only risk factor for isolation of fungi in bile (OR 1.61; P = 0.04).
    Conclusions: Our study showed an increasing prevalence of Enterococcus spp. and MDRO. Bile cultures should be routinely collected in cholangitis and in patients with repeated ERCPs to allow more efficient antimicrobial treatment.
    MeSH term(s) Humans ; Retrospective Studies ; Cholangitis/microbiology ; Cholangitis/epidemiology ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Male ; Acute Disease ; Risk Factors ; Female ; Bile/microbiology ; Aged ; Tertiary Care Centers ; Middle Aged ; Drug Resistance, Multiple, Bacterial ; Aged, 80 and over ; Escherichia coli/isolation & purification ; Prevalence ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-24
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.16492
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2180: Show issues Location:
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    Zs.MO 299: Show issues

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  9. Article ; Online: Organizing the 16th Spring School on Immunology during a pandemic.

    Lohoff, Michael / Wolf, Melanie / Durez, Tanja

    European journal of immunology

    2021  Volume 51, Issue 3, Page(s) 507–509

    MeSH term(s) Allergy and Immunology/education ; Humans ; Pandemics ; Schools/organization & administration ; Seasons
    Language English
    Publishing date 2021-03-02
    Publishing country Germany
    Document type News
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202170035
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Point mutation L116R in interferon-regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells.

    Staudenraus, Daniel / Porapu, Alekhya / Leister, Hanna / Gupta, Dennis Das / Lohoff, Michael

    European journal of immunology

    2022  Volume 52, Issue 10, Page(s) 1680–1683

    Abstract: IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of ... ...

    Abstract IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of Th9 cells in cells carrying the L116R mutated IRF4.
    MeSH term(s) Cell Differentiation/genetics ; Cytokines/genetics ; Cytokines/metabolism ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Interferons/genetics ; Interleukin-9/genetics ; Interleukin-9/metabolism ; Point Mutation ; Th17 Cells/metabolism ; Th2 Cells/metabolism
    Chemical Substances Cytokines ; Interferon Regulatory Factors ; Interleukin-9 ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-09-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202249869
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
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