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Article: A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties

Havas, Fabien / Krispin, Shlomo / Cohen, Moshe / Loing, Estelle / Farge, Morgane / Suere, Thierry / Attia-Vigneau, Joan

Marine drugs. 2022 Jan. 27, v. 20, no. 2

2022

Abstract: Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver of cumulative skin damage and skin aging. Dunaliella salina is a halophile microalga adapted to intense solar radiation through the production ... ...

Abstract	Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver of cumulative skin damage and skin aging. Dunaliella salina is a halophile microalga adapted to intense solar radiation through the production of carotenoids. We present a natural supercritical CO₂ extract of Dunaliella salina rich in the colorless carotenoids phytoene and phytofluene. The extract exhibited antiglycation and anti-inflammatory activities in ex vivo testing, showing strongly reduced formation of N--carboxy-methyl-lysine with exposure to methylglyoxal, reduced AGE receptor levels, and significantly reduced interleukins 6 and 8. In a placebo-controlled clinical study under intense solar exposure, the extract significantly reduced the skin’s glycation scores and its sensitivity to histamine; key skin aging parameters were also significantly improved vs. placebo, including wrinkle counts and spots. These results demonstrate the value of this Dunaliella salina extract, rich in colorless carotenoids, as an antiglycative, anti-inflammatory, and antiaging active ingredient, including in high-irradiation contexts.
Keywords	Dunaliella salina ; active ingredients ; carbon dioxide ; carotenoids ; glycation ; halophiles ; histamine ; interleukins ; microalgae ; placebos ; receptors ; solar radiation
Language	English
Dates of publication	2022-0127
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md20020104
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Polylysine dendrigraft is able to differentially impact Cutibacterium acnes strains preventing acneic skin.

Attia-Vigneau, Joan / Barreau, Magalie / Le Toquin, Esther / Feuilloley, Marc G J / Loing, Estelle / Lesouhaitier, Olivier

Experimental dermatology

2022 Volume 31, Issue 7, Page(s) 1056–1064

Abstract: With a view to reducing the impact of Cutibacterium acnes (C. acnes) on acne vulgaris, it now appears interesting to modify the balance between acneic and non-acneic strains of C. acnes using moderate approach. In the present study, we identified that a ... ...

Abstract	With a view to reducing the impact of Cutibacterium acnes (C. acnes) on acne vulgaris, it now appears interesting to modify the balance between acneic and non-acneic strains of C. acnes using moderate approach. In the present study, we identified that a G2 dendrigraft of lysine dendrimer (G2 dendrimer) was able to modify membrane fluidity and biofilm formation of a C. acnes acneic strain (RT5), whereas it appeared no or less active on a C. acnes non-acneic strain (RT6). Moreover, skin ex vivo data indicated that the G2 is able to decrease inflammation (IL1α and TLR-2) and improve skin desquamation after of C. acnes acneic strains colonization. Then, in vivo data confirmed, after C. acnes quantification by metagenomic analysis that the G2 cream after 28 days of treatment was able to increase the diversity of C. acnes strains versus placebo cream. The data also showed a modification of the balance expression between C. acnes phylotype IA1 and phylotype II abundances. Taken together, the results confirm the interest of using soft compounds in cosmetic product for modifying phylotype abundances and diversity of C. acnes strains could be a new strategy for prevent acne vulgaris outbreak.
MeSH term(s)	Acne Vulgaris/microbiology ; Acne Vulgaris/prevention & control ; Dendrimers ; Humans ; Polylysine ; Propionibacterium acnes ; Skin/microbiology
Chemical Substances	Dendrimers ; Polylysine (25104-18-1)
Language	English
Publishing date	2022-03-09
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.14554
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Havas, Fabien / Krispin, Shlomo / Cohen, Moshe / Loing, Estelle / Farge, Morgane / Suere, Thierry / Attia-Vigneau, Joan

Marine drugs

2022 Volume 20, Issue 2

Abstract: Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver of cumulative skin damage and skin aging. ...

Abstract	Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver of cumulative skin damage and skin aging.
MeSH term(s)	Adult ; Anti-Inflammatory Agents/pharmacology ; Biological Products/pharmacology ; Double-Blind Method ; Female ; Glycation End Products, Advanced/drug effects ; Histamine/metabolism ; Humans ; Microalgae/chemistry ; Middle Aged ; Skin Aging/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Biological Products ; Glycation End Products, Advanced ; Histamine (820484N8I3)
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md20020104
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Article ; Online: A Tissue-Engineered Human Psoriatic Skin Model to Investigate the Implication of cAMP in Psoriasis: Differential Impacts of Cholera Toxin and Isoproterenol on cAMP Levels of the Epidermis.

Simard, Mélissa / Morin, Sophie / Rioux, Geneviève / Séguin, Rachelle / Loing, Estelle / Pouliot, Roxane

International journal of molecular sciences

2020 Volume 21, Issue 15

Abstract: Pathological and healthy skin models were reconstructed using similar culture conditions according to well-known tissue engineering protocols. For both models, cyclic nucleotide enhancers were used as additives to promote keratinocytes' proliferation. ... ...

Abstract	Pathological and healthy skin models were reconstructed using similar culture conditions according to well-known tissue engineering protocols. For both models, cyclic nucleotide enhancers were used as additives to promote keratinocytes' proliferation. Cholera toxin (CT) and isoproterenol (ISO), a beta-adrenergic agonist, are the most common cAMP stimulators recommended for cell culture. The aim of this study was to evaluate the impact of either CT or ISO on the pathological characteristics of the dermatosis while producing a psoriatic skin model. Healthy and psoriatic skin substitutes were produced according to the self-assembly method of tissue engineering, using culture media supplemented with either CT (10
MeSH term(s)	Adenylyl Cyclases/metabolism ; Cholera Toxin/toxicity ; Cyclic AMP/metabolism ; Epidermis/metabolism ; Epidermis/pathology ; Female ; Humans ; Isoproterenol/administration & dosage ; Isoproterenol/pharmacology ; Male ; Middle Aged ; Models, Biological ; Psoriasis/metabolism ; Psoriasis/pathology ; Second Messenger Systems/drug effects ; Tissue Engineering
Chemical Substances	Cholera Toxin (9012-63-9) ; Cyclic AMP (E0399OZS9N) ; Adenylyl Cyclases (EC 4.6.1.1) ; adenylate cyclase 9 (EC 4.6.1.1) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2020-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21155215
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors.

Duroux, Romain / Mandeau, Anne / Guiraudie-Capraz, Gaelle / Quesnel, Yannick / Loing, Estelle

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 20

Abstract: Olfactory receptors (ORs) are expressed and active in various human tissues, including the skin. Although the sense of smell plays an important physiological role in the regulation of mood and stress, a link between olfactive compounds, ORs, and skin ... ...

Abstract	Olfactory receptors (ORs) are expressed and active in various human tissues, including the skin. Although the sense of smell plays an important physiological role in the regulation of mood and stress, a link between olfactive compounds, ORs, and skin stress has yet to be established. This study aims to investigate the role of newly identified skin ORs and agonists in the modulation of skin stress. Screening for odorant molecules was done with cAMP functional assay to identify OR agonists. RT-qPCR and immunofluorescence microscopy were conducted to identify and quantify ORs in epidermal keratinocytes (NHEKs) and human skin explants, as well as to evaluate specific markers (G6PDH, loricrin, and γH2AX) of stress-induced skin alterations. A randomized double-blinded, split-face clinical study was performed on a panel of stressed women to measure the benefits of OR agonist treatment for skin. Three new ORs (OR10A6, OR2AG2, and OR11H4) were identified in skin. A specific Rose extract and its major constituent (phenylethyl alcohol) were found to activate these ORs. The extract composition was revealed by both GC/FID and GC/MS analyses simultaneously and showed the presence of 34 volatiles molecules. Moreover, epinephrine induces a skin stress response characterized by increased expression of G6PD, loricrin, and γH2AX biomarkers, and a decrease of OR expression. These effects were prevented in the presence of rose extract and its benefits were confirmed clinically by a decrease in the appearance of under-eye dark circles. Altogether, our findings suggest that ORs may represent a new, promising way to treat stress-associated skin disorders.
MeSH term(s)	Gene Expression Regulation/drug effects ; Humans ; Keratinocytes/drug effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Protective Agents/chemistry ; Protective Agents/pharmacology ; Receptors, Odorant/genetics ; Rosa/chemistry ; Signal Transduction/drug effects ; Skin/drug effects ; Skin/metabolism ; Volatile Organic Compounds/chemistry ; Volatile Organic Compounds/pharmacology
Chemical Substances	Plant Extracts ; Protective Agents ; Receptors, Odorant ; Volatile Organic Compounds
Language	English
Publishing date	2020-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25204743
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Article: Unique natural exopolysaccharides for biomimetic protective effect against urban pollution.

Borel, Magali / Lamarque, Elisabeth / Loing, Estelle

Journal of cosmetic science

2017 Volume 68, Issue 1, Page(s) 126–132

Abstract: Through natural selection, living organisms have evolved well-adapted survival strategies over time. The shallow salt waters of Moorea lagoon are the site of accumulation of microbial mats called "Kopara," in the native Polynesian language. This unique ... ...

Abstract	Through natural selection, living organisms have evolved well-adapted survival strategies over time. The shallow salt waters of Moorea lagoon are the site of accumulation of microbial mats called "Kopara," in the native Polynesian language. This unique ecosystem is rich in film-forming exopolysaccharides (EPSs) secreted by microorganisms within the biofilm, as a mean to protect themselves from environmental stress (strong ultraviolet [UV], pH, salinity … ). Using blue biotechnology, a manufacturing process was developed to obtain an EPS with skin benefits. The active ingredient (EPS-229) protects against urban pollution, including free radicals, heavy metals, hydrocarbons, and PM Methods: The anti-lipid peroxidation action of EPS-229 was studied in an Results: In vitro Conclusion: Inspired by the French Polynesia Kopara unique ecosystem, a bioactive exopolysaccharide (EPS-229) has been developed that offers protection from environmental aggression. As a biomimetic shield at the surface of the skin, EPS-229 provides an immediate multiprotective action that efficiently fights the harmful effects of urban pollution and smog.
MeSH term(s)	Alteromonas/chemistry ; Alteromonas/metabolism ; Biomimetics ; Dermatologic Agents/chemistry ; Dermatologic Agents/pharmacology ; Environmental Pollutants/adverse effects ; Fermentation ; Free Radicals/adverse effects ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Lipid Peroxidation/drug effects ; Metals, Heavy/toxicity ; Polysaccharides/pharmacology ; Protective Agents/pharmacology ; Skin/drug effects ; Skin Care ; Urban Health
Chemical Substances	Dermatologic Agents ; Environmental Pollutants ; Free Radicals ; Metals, Heavy ; Polysaccharides ; Protective Agents
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1435667-3
ISSN	1525-7886 ; 0037-9832
ISSN	1525-7886 ; 0037-9832
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3474: Show issues

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Article: New targets in the battle against dandruff.

Loing, Estelle / Lamarque, Elisabeth / Borel, Magali

Journal of cosmetic science

2017 Volume 68, Issue 1, Page(s) 107–113

Abstract: Dandruff is a scalp disorder characterized by flaking skin and itch of an excessive oily scalp skin. It affects 55% of the global youth and adult population. Seborrheic dermatitis is a similar scalp skin disorder with aggravated itchy rashes and flaking. ...

Abstract	Dandruff is a scalp disorder characterized by flaking skin and itch of an excessive oily scalp skin. It affects 55% of the global youth and adult population. Seborrheic dermatitis is a similar scalp skin disorder with aggravated itchy rashes and flaking. Different factors are identified in the dandruff development: increased sebum production, uncontrolled fungal growth of
MeSH term(s)	Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Dandruff/drug therapy ; Epilobium/chemistry ; Female ; Fungi/drug effects ; Healthy Volunteers ; Humans ; Hydrolyzable Tannins/pharmacology ; Hydrolyzable Tannins/therapeutic use ; Lipids/biosynthesis ; Malassezia/drug effects ; Malassezia/metabolism ; Male ; Middle Aged ; Phytotherapy ; Plant Extracts/therapeutic use ; Primary Cell Culture ; Skin/cytology ; Skin/microbiology ; Young Adult
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants ; Hydrolyzable Tannins ; Lipids ; Plant Extracts ; ellagitannin ; oenothein B (104987-36-2)
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1435667-3
ISSN	1525-7886 ; 0037-9832
ISSN	1525-7886 ; 0037-9832
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A new strategy to modulate alopecia using a combination of two specific and unique ingredients.

Loing, Estelle / Lachance, Roger / Ollier, Virginie / Hocquaux, Michel

Journal of cosmetic science

2013 Volume 64, Issue 1, Page(s) 45–58

Abstract: Male pattern hair loss is a major cosmetic concern affecting both genders with a preference for men. Major causes of hair loss in genetically predisposed individuals include hormonal dysfunction, loss of extracellular matrix (ECM) proteins in the ... ...

Abstract	Male pattern hair loss is a major cosmetic concern affecting both genders with a preference for men. Major causes of hair loss in genetically predisposed individuals include hormonal dysfunction, loss of extracellular matrix (ECM) proteins in the follicular bed, and localized microinflammation. Few options are yet available to correct the problem. For this purpose, a cosmetic active ingredient was developed by combining a Trifolium pratense flower extract and a biomimetic peptide and tested clinically for the prevention of hair loss. Thirty volunteers with recessing hair were recruited for this randomized, placebo-controlled study. Clinical efficacy, following daily topical application of the mixture to the scalp, was checked using TrichoScan™ for the measurement of human hair. Within 4 months of application, anagen hair increased at an average by +13%, telogen hair density decreased by -29%, and the anagen/telogen (A/T) ratio increased by +46% over baseline in the treated group. Results strongly differed from those of the placebo group (anagen, -2%; telogen, +23%; A/T ratio, -33%). Investigation of the potential mechanisms involved in the positive effects of the test product on hair growth pointed at inhibition of 5-α-reductase activity, reduction of inflammatory reactions, and stimulation of ECM protein synthesis in the vicinity of the hair follicle.
MeSH term(s)	Adult ; Alopecia/drug therapy ; Female ; Fibroblasts/drug effects ; Genistein ; Hair/growth & development ; Hair Follicle/drug effects ; Humans ; Male ; Medicago/chemistry ; Middle Aged ; Oligopeptides/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
Chemical Substances	Oligopeptides ; Plant Extracts ; Genistein (DH2M523P0H) ; biochanin A (U13J6U390T)
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1435667-3
ISSN	1525-7886 ; 0037-9832
ISSN	1525-7886 ; 0037-9832
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of a new resistant liposome coated with polysaccharide film for cosmetic application.

Belhaj, Nabila / Arnaud, Jean Pierre / Loing, Estelle / Bézivin, Carine

Journal of cosmetic science

2014 Volume 65, Issue 4, Page(s) 225–238

Abstract: The aim of our study was to elaborate a resistant liposome that can be used in cosmetic formulations containing high amounts of surfactants and electrolytes. The stability of liposomes was increased via hydrophobized polysaccharide (Stearoyl Inulin) by ... ...

Abstract	The aim of our study was to elaborate a resistant liposome that can be used in cosmetic formulations containing high amounts of surfactants and electrolytes. The stability of liposomes was increased via hydrophobized polysaccharide (Stearoyl Inulin) by anchoring its stearic acid tail into liposome bilayer. Coated and noncoated liposomes were prepared under the same conditions and their morphology, size, and resistance to surfactants and electrolytes were evaluated. We established that coated lipbsomes were more resistant to surfactants and electrolytes. It seems that a coating of polysaccharides prevents liposome destabilization in the presence of high amounts of surfactants and electrolytes. Moreover, the ability of coated liposomes to improve the skin delivery of active molecules was evaluated. Coated liposomes increased the efficacy of magnesium chloride by improving its skin availability.
MeSH term(s)	Cosmetics ; Freeze Fracturing ; Hydrophobic and Hydrophilic Interactions ; Liposomes ; Polysaccharides/chemistry
Chemical Substances	Cosmetics ; Liposomes ; Polysaccharides
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1435667-3
ISSN	1525-7886 ; 0037-9832
ISSN	1525-7886 ; 0037-9832
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Article ; Online: Clinical efficacy of a serum integrating multiple cosmetic ingredients in the management of erythema of the face in aging skin.

Dupont, Eric / Léveillé, Claude / Gomez, Juan / Loigeret, Manuel / Loing, Estelle / Bilodeau, Diane

Journal of cosmetic dermatology

2012 Volume 11, Issue 3, Page(s) 207–212

Abstract: Background: Skin redness is a common cosmetic concern affecting predominantly fair-skin individuals and often leading to rosacea. On the basis of the current scientific knowledge of the physiological mechanisms underlying the problem, a complex and ... ...

Abstract	Background: Skin redness is a common cosmetic concern affecting predominantly fair-skin individuals and often leading to rosacea. On the basis of the current scientific knowledge of the physiological mechanisms underlying the problem, a complex and integral skin care serum (100RXED2025) was developed and tested clinically for efficacy. Method: Forty-five healthy men and women volunteers, age 30-65, were recruited. All subjects had fair skin (phototype I, II, or III) and presented some degree of skin redness with telangiectasia on the cheeks, the nose, or the nose sides, at baseline. In the course of this open label study, subjects applied the test product on their face, twice daily for 56 days. For each subject, skin redness was evaluated through colorimetric and visual analysis of photographs taken under cross-polarized light at T = 28 (week 4) and T = 56 (week 8), then compared to baseline measurements obtained at day 0. Results: Forty-four volunteers completed the study. On visual evaluation, skin redness had decreased in average by 32.2% at T = 28 (P < 0.001) and by 48.0% at T = 56 (P < 0.001). Importantly, 91% of the subjects showed improvement of skin redness at T = 28, reaching 100% at T = 56. Colorimetric analysis gave an average reduction in redness of 11.6% at T = 28 (P < 0.001) and 13.7% at T = 56 (P < 0.001). Conclusion: The anti-redness efficacy of the test product was demonstrated after 28 days with further increase following 56 days of application.
MeSH term(s)	Administration, Cutaneous ; Adult ; Aged ; Colorimetry ; Cosmetics/therapeutic use ; Erythema/drug therapy ; Facial Dermatoses/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Photography ; Skin Aging ; Statistics, Nonparametric ; Telangiectasis/drug therapy
Chemical Substances	Cosmetics
Language	English
Publishing date	2012-09
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/j.1473-2165.2012.00623.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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