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Article ; Online: Comparing second cancer risk for multiple radiotherapy modalities in survivors of hodgkin lymphoma.

Timlin, Claire / Loken, James / Kruse, Jon / Miller, Robert / Schneider, Uwe

2021 Volume 94, Issue 1121, Page(s) 20200354

Abstract: Objectives: To assess if excess absolute risk (EAR) of radiation-induced solid cancer can be used to rank radiotherapy plans for treatment of Hodgkin lymphoma (HL) in a statistically significant way.: Methods: EAR models, calibrated with data from ... ...

Abstract	Objectives: To assess if excess absolute risk (EAR) of radiation-induced solid cancer can be used to rank radiotherapy plans for treatment of Hodgkin lymphoma (HL) in a statistically significant way. Methods: EAR models, calibrated with data from the Life Span Study and HL survivors, have been incorporated into a voxelised risk-calculation software, which is used to compare four treatment modalities planned for five virtual HL patients. Organ-specific parameters are generated repeatedly in a Monte Carlo fashion to model their uncertainties. This in turn enables a quantitative estimation of the EAR uncertainties. Results: Parameter-driven uncertainties on total EAR are around 13%, decreasing to around 2-5% for relative EAR comparisons. Total EAR estimations indicate that intensity modulated proton therapy decreases the average risk by 40% compared to the intensity modulated radiation therapy plan, 28% compared to the volumetric modulated arc therapy plan whereas the three-dimensional conformal radiation therapy plan is equivalent within the uncertainty. Conclusion: Relative EAR is a useful metric for distinguishing between radiotherapy plans in terms of second cancer risk. Advances in knowledge: Relative EAR is not dominated by model or parameter uncertainties and can be used to guide the choice of radiotherapy for HL patients.
MeSH term(s)	Cancer Survivors ; Hodgkin Disease/mortality ; Hodgkin Disease/radiotherapy ; Humans ; Monte Carlo Method ; Neoplasms, Radiation-Induced/etiology ; Neoplasms, Second Primary/etiology ; Proton Therapy/adverse effects ; Proton Therapy/methods ; Radiotherapy, Conformal/adverse effects ; Radiotherapy, Conformal/methods ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Risk Assessment/methods ; Time Factors ; Uncertainty
Language	English
Publishing date	2021-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20200354
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Article ; Online: Effects of bouncing the barbell in bench press on throwing velocity and strength among handball players.

Løken, Jørund / Solstad, Tom Erik Jorung / Stien, Nicolay / Andersen, Vidar / Saeterbakken, Atle Hole

PloS one

2021 Volume 16, Issue 11, Page(s) e0260297

Abstract: Bench press is a popular training-exercise in throw related sports such as javelin, baseball and handball. Athletes in these sports often use bouncing (i.e., letting the barbell collide with the chest) to create an increased momentum to accelerate the ... ...

Abstract	Bench press is a popular training-exercise in throw related sports such as javelin, baseball and handball. Athletes in these sports often use bouncing (i.e., letting the barbell collide with the chest) to create an increased momentum to accelerate the barbell upwards before completing the movement by throwing the barbell. Importantly, the effects of the bouncing technique in bench press have not been examined. Therefore, the aim of this study was to compare the effects of bench press throw with (BPTbounce) or without bounce (BPT) on throwing velocity (penalty and 3-step), 1-repetition maximum (1-RM) and average power output (20-60kg) in bench press among handball players. Sixteen male amateur handball players (7.1±1.9 years of handball experience) were randomly allocated to an eight-week supplementary power training program (2 x week-1) with either the BPT or BPTbounce. Except for the bounce technique, the training programs were identical and consisted of 3 sets with 3-5 repetitions at 40-60% of 1-RM with maximal effort in free-weight barbell bench press throw. The results revealed no significant differences between the groups in any of the tests (p = 0.109-0.957). However, both groups improved penalty throw (BPT; 4.6%, p<0.001, ES = 0.57; BPTbounce; 5.1%, p = 0.008, ES = 0.91) and 1-RM (BPT; 9.7%, p<0.001, ES = 0.49; BPTbounce; 8.7%, p = 0.018, ES = 0.60), but only the BPT improved the 3-step throw (BPT; 2.9%, p = 0.060, ES = 0.38; BPTbounce; 2.3%, p = 0.216, ES = 0.40). The BPT improved power output only at 20kg and 30kg loads (9.1% and 12.7%; p = 0.018-0.048, ES = 0.43-0.51) whereas BPTbounce demonstrated no significant differences across the loads (p = 0.252-0.806). In conclusion, the bounce technique demonstrated similar effects on throwing velocity, muscle strength and muscle power output as conventional bench press throw without the bounce technique.
MeSH term(s)	Adolescent ; Adult ; Athletes ; Baseball/physiology ; Exercise/physiology ; Humans ; Male ; Motion ; Movement/physiology ; Muscle Strength/physiology ; Muscles/physiology ; Sports/physiology ; Young Adult
Language	English
Publishing date	2021-11-19
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0260297
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Article: Acute Effects of Barbell Bouncing and External Cueing on Power Output in Bench Press Throw in Resistance-Trained Men.

Saeterbakken, Atle Hole / Loken, Jorund / Solstad, Tom Erik Jorung / Stien, Nicolay / Prieske, Olaf / Scott, Suzanne / Andersen, Vidar

Frontiers in physiology

2022 Volume 13, Page(s) 899078

Abstract: The aims of this study were to compare power output during a bench press throw (BPT) executed with ( ... ...

Abstract	The aims of this study were to compare power output during a bench press throw (BPT) executed with (BPT
Language	English
Publishing date	2022-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.899078
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Article ; Online: 3D calculation of radiation-induced second cancer risk including dose and tissue response heterogeneities.

Timlin, C / Warren, D R / Rowland, B / Madkhali, A / Loken, J / Partridge, M / Jones, B / Kruse, J / Miller, R

Medical physics

2015 Volume 42, Issue 2, Page(s) 866–876

Abstract: Purpose: Tools for comparing relative induced second cancer risk, to inform choice of radiotherapy treatment plan, are becoming increasingly necessary as the availability of new treatment modalities expands. Uncertainties, in both radiobiological models ...

Abstract	Purpose: Tools for comparing relative induced second cancer risk, to inform choice of radiotherapy treatment plan, are becoming increasingly necessary as the availability of new treatment modalities expands. Uncertainties, in both radiobiological models and model parameters, limit the confidence of such calculations. The aim of this study was to develop and demonstrate a software tool to produce a malignant induction probability (MIP) calculation which incorporates patient-specific dose and allows for the varying responses of different tissue types to radiation. Methods: The tool has been used to calculate relative MIPs for four different treatment plans targeting a subtotally resected meningioma: 3D conformal radiotherapy (3DCFRT), volumetric modulated arc therapy (VMAT), intensity-modulated x-ray therapy (IMRT), and scanned protons. Results: Two plausible MIP models, with considerably different dose-response relationships, were considered. A fractionated linear-quadratic induction and cell-kill model gave a mean relative cancer risk (normalized to 3DCFRT) of 113% for VMAT, 16% for protons, and 52% for IMRT. For a linear no-threshold model, these figures were 105%, 42%, and 78%, respectively. The relative MIP between plans was shown to be significantly more robust to radiobiological parameter uncertainties compared to absolute MIP. Both models resulted in the same ranking of modalities, in terms of MIP, for this clinical case. Conclusions: The results demonstrate that relative MIP is a useful metric with which treatment plans can be ranked, regardless of parameter- and model-based uncertainties. With further validation, this metric could be used to discriminate between plans that are equivalent with respect to other planning priorities.
MeSH term(s)	Dose-Response Relationship, Radiation ; Humans ; Meningioma/radiotherapy ; Meningioma/surgery ; Models, Biological ; Neoplasms, Radiation-Induced/etiology ; Neoplasms, Second Primary/etiology ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Computer-Assisted/adverse effects ; Risk Assessment/methods ; Software ; Uncertainty
Language	English
Publishing date	2015-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1118/1.4905158
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Article: Predicting recovery from acute kidney injury in critically ill patients: development and validation of a prediction model.

Itenov, Theis S / Berthelsen, Rasmus Ehrenfried / Jensen, Jens-Ulrik / Gerds, Thomas A / Pedersen, Lars M / Strange, Ditte / Thormar, Katrin / Løken, Jesper / Andersen, Mads H / Tousi, Hamid / Reiter, Nanna / Lundgren, Jens D / Bestle, Morten H

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

2018 Volume 20, Issue 1, Page(s) 54–60

Abstract: Objective: Intensive care unit (ICU) patients with acute kidney injury (AKI) who recover kidney function within 28 days experience less severe chronic kidney impairment and have increased long term survival. The aims of this study were to develop and ... ...

Abstract	Objective: Intensive care unit (ICU) patients with acute kidney injury (AKI) who recover kidney function within 28 days experience less severe chronic kidney impairment and have increased long term survival. The aims of this study were to develop and validate a risk prediction model to identify these patients. Design: Observational study with development and validation of a risk prediction model. Setting: Nine academic ICUs in Denmark. Participants: Development cohort of critically ill patients with AKI at ICU admission from the Procalcitonin and Survival Study cohort (n = 568), validation cohort of adult patients with AKI admitted to two university hospitals in Denmark in 2012-13 (n = 766). Interventions: None. Main outcome measures: Recovery of kidney function was defined as living for 5 consecutive days with no renal replacement therapy and with creatinine plasma levels below 1.5-fold the levels determined before ICU admission. Results: A total of 266 patients (46.8%) recovered prior kidney function in the development cohort, and 453 patients (59.1%) in the validation cohort. The prediction model included elevation in creatinine, urinary output, sex and age. In the validation cohort, 69 patients (9.0%) had a predicted chance of recovery < 25%, and their observed rate of recovery was 21.5%. This observed rate of recovery was 81.7% among the 325 patients who had a predicted chance > 75%. The area under the receiver operations curves for predicting recovery in the validation cohort was 73.1%. Conclusion: We constructed and validated a simple model that can predict the chance of recovery from AKI in critically ill patients.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Adult ; Critical Illness ; Humans ; Intensive Care Units ; Kidney Function Tests ; Models, Statistical ; Predictive Value of Tests ; Renal Replacement Therapy ; Reproducibility of Results ; Risk Assessment/methods
Language	English
Publishing date	2018-02-19
Publishing country	Australia
Document type	Journal Article ; Observational Study
ZDB-ID	2401976-8
ISSN	1441-2772
ISSN	1441-2772
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Article: Accuracy of 1-, 5- and 10-year body weight recall given in a standard questionnaire.

Olivarius, N F / Andreasen, A H / Løken, J

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity

1997 Volume 21, Issue 1, Page(s) 67–71

Abstract: Objective: Estimation of the accuracy of 1, 5 and 10 y body weight recall.: Design: Comparison of information on body weight history from a patient questionnaire with measured body weights retrieved in general practitioners' records.: Subjects: ... ...

Abstract	Objective: Estimation of the accuracy of 1, 5 and 10 y body weight recall. Design: Comparison of information on body weight history from a patient questionnaire with measured body weights retrieved in general practitioners' records. Subjects: Among 729 newly diagnosed diabetic patients record information on measured body weight was found for 86, 141 and 122 patients recalling their body weight 1,5 and 10 y ago, respectively. Median age was 63.6 y. Median body mass index was 31.1 kg/m2. Results: No average deviation between 1 y body weight recall and the corresponding measured weights is observed, but 5 and 10 y recall underestimates the measured weights by 1.89 kg and 1.98 kg on an average, respectively. On the individual level the agreement is less satisfactory with increasing variability the further back in time you go. The recall does not vary with age and sex and it is independent of weight status, marital status, smoking habits and self-reported health status in this obese group of individuals. Conclusions: The findings suggest that data from three standard questions may contribute with useful information on near weight history, independent of age, sex and current body weight.
MeSH term(s)	Adult ; Aged ; Body Weight ; Humans ; Medical Records ; Mental Recall ; Middle Aged ; Reproducibility of Results ; Surveys and Questionnaires ; Time Factors
Language	English
Publishing date	1997-01
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1103255-8
ISSN	0307-0565
ISSN	0307-0565
DOI	10.1038/sj.ijo.0800365
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Article ; Online: Elongation dynamics of amyloid fibrils: a rugged energy landscape picture.

Lee, Chiu Fan / Loken, James / Jean, Létitia / Vaux, David J

Physical review. E, Statistical, nonlinear, and soft matter physics

2009 Volume 80, Issue 4 Pt 1, Page(s) 41906

Abstract: Protein amyloid fibrils are a form of linear protein aggregates that are implicated in many neurodegenerative diseases. Here, we study the dynamics of amyloid fibril elongation by performing Langevin dynamic simulations on a coarse-grained model of ... ...

Abstract	Protein amyloid fibrils are a form of linear protein aggregates that are implicated in many neurodegenerative diseases. Here, we study the dynamics of amyloid fibril elongation by performing Langevin dynamic simulations on a coarse-grained model of peptides. Our simulation results suggest that the elongation process is dominated by a series of local minimum due to frustration in monomer-fibril interactions. This rugged energy landscape picture indicates that the amount of recycling of monomers at the fibrils' ends before being fibrilized is substantially reduced in comparison to the conventional two-step elongation model. This picture, along with other predictions discussed, can be tested with current experimental techniques.
MeSH term(s)	Amyloid/chemistry ; Amyloid/metabolism ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Molecular Dynamics Simulation ; Protein Multimerization ; Protein Structure, Quaternary ; Thermodynamics
Chemical Substances	Amyloid
Language	English
Publishing date	2009-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1550-2376
ISSN (online)	1550-2376
DOI	10.1103/PhysRevE.80.041906
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Article: Rights and responsibilities. Who owns the cooperative?

Loken, J

Land O'Lakes mirror May 1977, 7 (5)

1977

Keywords	marketing ; government and administration ; agricultural economics
Language	English
Size	p. 12-13.
Document type	Article
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Elongation dynamics of amyloid fibrils

Lee, Chiu Fan / Loken, James / Jean, Letitia / Vaux, David J.

a rugged energy landscape picture

2009

Abstract	Protein amyloid fibrils are a form of linear protein aggregates that are implicated in many neurodegenerative diseases. Here, we study the dynamics of amyloid fibril elongation by performing Langevin dynamic simulations on a coarse-grained model of peptides. Our simulation results suggest that the elongation process is dominated by a series of local minimum due to frustration in monomer-fibril interactions. This rugged energy landscape picture indicates that the amount of recycling of monomers at the fibrils' ends before being fibrilized is substantially reduced in comparison to the conventional two-step elongation model. This picture, along with other predictions discussed, can be tested with current experimental techniques.
Keywords	Physics - Biological Physics ; Condensed Matter - Soft Condensed Matter ; Quantitative Biology - Biomolecules
Publishing date	2009-04-16
Publishing country	us
Document type	Book ; Online
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Article: Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial.

Jensen, Jens-Ulrik S / Itenov, Theis S / Thormar, Katrin M / Hein, Lars / Mohr, Thomas T / Andersen, Mads H / Løken, Jesper / Tousi, Hamid / Lundgren, Bettina / Boesen, Hans Christian / Johansen, Maria E / Ostrowski, Sisse R / Johansson, Pär I / Grarup, Jesper / Vestbo, Jørgen / Lundgren, Jens D

Annals of intensive care

2016 Volume 6, Issue 1, Page(s) 114

Abstract: Background: It is unclear whether biomarkers of alveolar damage (surfactant protein D, SPD) or conductive airway damage (club cell secretory protein 16, CC16) measured early after intensive care admittance are associated with one-month clinical ... ...

Abstract	Background: It is unclear whether biomarkers of alveolar damage (surfactant protein D, SPD) or conductive airway damage (club cell secretory protein 16, CC16) measured early after intensive care admittance are associated with one-month clinical respiratory prognosis. If patients who do not recover respiratory function within one month can be identified early, future experimental lung interventions can be aimed toward this high-risk group. We aimed to determine, in a heterogenous critically ill population, whether baseline profound alveolar damage or conductive airway damage has clinical respiratory impact one month after intensive care admittance. Methods: Biobank study of biomarkers of alveolar and conductive airway damage in intensive care patients was conducted. This was a sub-study of 758 intubated patients from a 1200-patient randomized trial. We split the cohort into a "learning cohort" and "validating cohort" based on geographical criteria: northern sites (learning) and southern sites (validating). Results: Baseline SPD above the 85th percentile in the "learning cohort" predicted low chance of successful weaning from ventilator within 28 days (adjusted hazard ratio 0.6 [95% CI 0.4-0.9], p = 0.005); this was confirmed in the validating cohort. CC16 did not predict the endpoint. The absolute risk of not being successfully weaned within the first month was 48/106 (45.3%) vs. 175/652 (26.8%), p < 0.0001 (high SPD vs. low SPD). The chance of being "alive and without ventilator ≥20 days within the first month" was lower among patients with high SPD (adjusted OR 0.2 [95% CI 0.2-0.4], p < 0.0001), confirmed in the validating cohort, and the risk of ARDS was higher among patients with high SPD (adjusted OR 3.4 [95% CI 1.0-11.4], p = 0.04)-also confirmed in the validating cohort. Conclusion: Early profound alveolar damage in intubated patients can be identified by SPD blood measurement at intensive care admission, and high SPD level is a strong independent predictor that the patient suffers from ARDS and will not recover independent respiratory function within one month. This knowledge can be used to improve diagnostic and prognostic models and to identify the patients who most likely will benefit from experimental interventions aiming to preserve alveolar tissue and therefore respiratory function. Trial registration This is a sub-study to the Procalcitonin And Survival Study (PASS), Clinicaltrials.gov ID: NCT00271752, first registered January 1, 2006.
Language	English
Publishing date	2016-11-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-016-0212-y
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