Article ; Online: Bone mineral density in children and young adults with neurofibromatosis type 1.
2012 Volume 19, Issue 6, Page(s) 817–825
Abstract: Concern for impaired bone health in children with neurofibromatosis type 1 (NF-1) has led to increased interest in bone densitometry in this population. Our study assessed bone mineral apparent density (BMAD) and whole-body bone mineral content (BMC)/ ... ...
| Abstract | Concern for impaired bone health in children with neurofibromatosis type 1 (NF-1) has led to increased interest in bone densitometry in this population. Our study assessed bone mineral apparent density (BMAD) and whole-body bone mineral content (BMC)/height in pediatric patients with NF-1 with a high plexiform neurofibroma burden. Sixty-nine patients with NF-1 (age range 5.2-24.8; mean 13.7 ± 4.8 years) were studied. Hologic dual-energy X-ray absorptiometry scans (Hologic, Inc., Bedford, MA, USA) were performed on all patients. BMD was normalized to derive a reference volume by correcting for height through the use of the BMAD, as well as the BMC. BMAD of the lumbar spine (LS 2-4), femoral neck (FN), and total body BMC/height were measured and Z-scores were calculated. Impaired bone mineral density was defined as a Z-score ≤-2. Forty-seven percent of patients exhibited impaired bone mineral density at any bone site, with 36% at the LS, 18% at the FN, and 20% total BMC/height. BMAD Z-scores of the LS (-1.60 ± 1.26) were more impaired compared with both the FN (-0.54 ± 1.58; P=0.0003) and the whole-body BMC/height Z-scores (-1.16 ± 0.90; P=0.036). Plexiform neurofibroma burden was negatively correlated with LS BMAD (r(s)=-0.36, P=0.01). In pediatric and young adult patients with NF-1, LS BMAD was more severely affected than the FN BMAD or whole-body BMC/height. |
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| MeSH term(s) | Adolescent ; Adult ; Bone Density ; Child ; Child, Preschool ; Female ; Femur Neck/physiopathology ; Humans ; Lumbar Vertebrae/physiopathology ; Male ; Neurofibroma, Plexiform/physiopathology ; Neurofibromatosis 1/physiopathology ; Young Adult | |||||
| Language | English | |||||
| Publishing date | 2012-11-19 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural | |||||
| ZDB-ID | 1218450-0 | |||||
| ISSN | 1479-6821 ; 1351-0088 | |||||
| ISSN (online) | 1479-6821 | |||||
| ISSN | 1351-0088 | |||||
| DOI | 10.1530/ERC-12-0293 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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