Article ; Online: Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages.
Disease models & mechanisms
2019 Volume 12, Issue 7
Abstract: Laterality defects are developmental disorders resulting from aberrant left/right patterning. In the most severe cases, such as in heterotaxy, they are associated with complex malformations of the heart. Advances in understanding the underlying ... ...
| Abstract | Laterality defects are developmental disorders resulting from aberrant left/right patterning. In the most severe cases, such as in heterotaxy, they are associated with complex malformations of the heart. Advances in understanding the underlying physiopathological mechanisms have been hindered by the lack of a standardised and exhaustive procedure in mouse models for phenotyping left/right asymmetries of all visceral organs. Here, we have developed a multimodality imaging pipeline, which combines non-invasive micro-ultrasound imaging, micro-computed tomography (micro-CT) and high-resolution episcopic microscopy (HREM) to acquire 3D images at multiple stages of development and at multiple scales. On the basis of the position in the uterine horns, we track in a single individual, the progression of organ asymmetry, the |
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| MeSH term(s) | Animals ; Body Patterning ; Disease Models, Animal ; Fetus/diagnostic imaging ; Heart/diagnostic imaging ; Heart/embryology ; Heart Defects, Congenital/diagnostic imaging ; Imaging, Three-Dimensional ; Mice ; Phenotype ; Ultrasonography ; X-Ray Microtomography |
| Language | English |
| Publishing date | 2019-07-09 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1754-8411 |
| ISSN (online) | 1754-8411 |
| DOI | 10.1242/dmm.038356 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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