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Article ; Online: Outcome of Darunavir-Cobicistat-Based Regimens in HIV-Infected People Who Have Experienced Virological Failure.

Alberton, Francesca / Galli, Laura / Lolatto, Riccardo / Candela, Caterina / Gianotti, Nicola / Chiurlo, Matteo / Ranzenigo, Martina / Strano, Martina / Uglietti, Alessia / Castagna, Antonella

Drug design, development and therapy

2024 Volume 18, Page(s) 1153–1163

Abstract: Objective: To evaluate the virological outcome of darunavir-cobicistat (DRVc)-based regimens in adults living with HIV who had experienced virological failure (VF) on any previous drug combination.: Methods: This was a retrospective cohort study ( ... ...

Abstract	Objective: To evaluate the virological outcome of darunavir-cobicistat (DRVc)-based regimens in adults living with HIV who had experienced virological failure (VF) on any previous drug combination. Methods: This was a retrospective cohort study (CSLHIV Cohort) of adults living with HIV who started a DRVc-based regimen with HIV-RNA >50 copies/mL after VF on any previous drug combination. Data on demographics, antiretroviral treatment since HIV diagnosis, and immunological and metabolic parameters from baseline (start of DRVc) to 48 weeks were analyzed in order to assess the cumulative proportion of those who achieved virological success (VS), defined as at least one instance of HIV-RNA <50 copies/mL within 12 months from baseline. Follow-up lasted from the start of the DRVc-based regimen (baseline) to the first instance of HIV-RNA <50 copies/mL, last available visit, or loss to follow-up or death, whichever occurred first. Univariate and multivariate Cox proportional-hazard regression models were used to identify baseline factors associated with VS. Results: A total of 176 individuals were included, and 120 (68.2%) achieved <50 HIV-RNA copies/mL within 12 months since baseline. On multivariate analysis, baseline HDL cholesterol was independently associated with the occurrence of VS (adjusted HR 1.021, 95% CI 1.004-1.038; Conclusion: Most individuals in this study achieved VS within 12 months from the beginning of a DRVc-based regimen; therefore, this treatment represent a viable option for people who have experienced VF on other regimens.
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Drug Combinations ; HIV Protease Inhibitors/therapeutic use ; RNA ; HIV Infections/drug therapy ; Darunavir ; Cobicistat
Chemical Substances	cobicistat mixture with darunavir ; Drug Combinations ; HIV Protease Inhibitors ; RNA (63231-63-0) ; Darunavir (YO603Y8113) ; Cobicistat (LW2E03M5PG)
Language	English
Publishing date	2024-04-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S443775
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Article ; Online: Information Retrieval from Photoplethysmographic Sensors: A Comprehensive Comparison of Practical Interpolation and Breath-Extraction Techniques at Different Sampling Rates.

Reali, Pierluigi / Lolatto, Riccardo / Coelli, Stefania / Tartaglia, Gabriella / Bianchi, Anna Maria

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 4

Abstract: The increasingly widespread diffusion of wearable devices makes possible the continuous monitoring of vital signs, such as heart rate (HR), heart rate variability (HRV), and breath signal. However, these devices usually do not record the "gold-standard" ... ...

Abstract	The increasingly widespread diffusion of wearable devices makes possible the continuous monitoring of vital signs, such as heart rate (HR), heart rate variability (HRV), and breath signal. However, these devices usually do not record the "gold-standard" signals, namely the electrocardiography (ECG) and respiratory activity, but a single photoplethysmographic (PPG) signal, which can be exploited to estimate HR and respiratory activity. In addition, these devices employ low sampling rates to limit power consumption. Hence, proper methods should be adopted to compensate for the resulting increased discretization error, while diverse breath-extraction algorithms may be differently sensitive to PPG sampling rate. Here, we assessed the efficacy of parabola interpolation, cubic-spline, and linear regression methods to improve the accuracy of the inter-beat intervals (IBIs) extracted from PPG sampled at decreasing rates from 64 to 8 Hz. PPG-derived IBIs and HRV indices were compared with those extracted from a standard ECG. In addition, breath signals extracted from PPG using three different techniques were compared with the gold-standard signal from a thoracic belt. Signals were recorded from eight healthy volunteers during an experimental protocol comprising sitting and standing postures and a controlled respiration task. Parabola and cubic-spline interpolation significantly increased IBIs accuracy at 32, 16, and 8 Hz sampling rates. Concerning breath signal extraction, the method holding higher accuracy was based on PPG bandpass filtering. Our results support the efficacy of parabola and spline interpolations to improve the accuracy of the IBIs obtained from low-sampling rate PPG signals, and also indicate a robust method for breath signal extraction.
MeSH term(s)	Algorithms ; Electrocardiography/methods ; Heart Rate/physiology ; Humans ; Information Storage and Retrieval ; Photoplethysmography/methods ; Respiratory Rate ; Signal Processing, Computer-Assisted
Language	English
Publishing date	2022-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22041428
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Article: Survival in People Living with HIV with or without Recurrence of Hepatocellular Carcinoma after Invasive Therapy.

Bertoni, Costanza / Galli, Laura / Lolatto, Riccardo / Hasson, Hamid / Siribelli, Alessia / Messina, Emanuela / Castagna, Antonella / Uberti Foppa, Caterina / Morsica, Giulia

Cancers

2023 Volume 15, Issue 6

Abstract: Background and aims: To address the overall survival (OS) and recurrence (RE) in people living with HIV (PLWH) treated with invasive therapy (IT) for hepatocellular carcinoma (HCC).: Methods: This is a retrospective cohort study on 41 PLWH with HCC ... ...

Abstract	Background and aims: To address the overall survival (OS) and recurrence (RE) in people living with HIV (PLWH) treated with invasive therapy (IT) for hepatocellular carcinoma (HCC). Methods: This is a retrospective cohort study on 41 PLWH with HCC receiving IT, defined as liver resection (LR), orthotopic liver transplantation (OLT), radiofrequency thermo-ablation (RFTA) trans arterial chemo, or radioembolization (CRE). OS and RE were investigated by Kaplan-Meier curves. The Cox proportional hazard regression model was used for multivariate analyses. Results: Recurrence occurred in 46.3% PLWH; in 36.7% of participants at 2 years and in 52% at 5 years from HCC diagnosis; it was less frequent in males, Conclusions: Fifty percent of PLWH survived five years after HCC diagnosis; 90.9% among OLT patients. Recurrence after IT was observed in 46% of HCC/PLWH. AFP cut-off levels of 28.8 ng/mL were the only independent variable associated with survival.
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061653
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Article: Should we expect weight changes in people with HIV and a reported weight gain only by switching antiretroviral therapy?

Muccini, Camilla / Ceccarelli, Daniele / Lolatto, Riccardo / Spagnuolo, Vincenzo / Oltolini, Chiara / Danise, Anna / Mainardi, Ilaria / Monardo, Roberta / Castagna, Antonella

The new microbiologica

2023 Volume 46, Issue 1, Page(s) 65–67

Abstract: Weight gain following the initiation or the switch of antiretroviral therapy (ART) is well documented and mainly associated with some of the most recent drugs, such as integrase strand transfer inhibitors and tenofovir alafenamide. However, limited data ... ...

Abstract	Weight gain following the initiation or the switch of antiretroviral therapy (ART) is well documented and mainly associated with some of the most recent drugs, such as integrase strand transfer inhibitors and tenofovir alafenamide. However, limited data have been published on weight trends in ART-experienced people living with HIV (PLWH) with a long exposure to HIV infection and antiretroviral drugs. In our study, we assessed changes in weight after switching ART among PLWH who reported weight gain under a previous regimen.
MeSH term(s)	Humans ; HIV Infections/drug therapy ; Anti-Retroviral Agents/therapeutic use ; Weight Gain
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2023-02-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	756168-4
ISSN	1121-7138 ; 0391-5352
ISSN	1121-7138 ; 0391-5352
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Article ; Online: Lower aids-related hospitalizations in women living with HIV multidrug resistance.

Papaioannu Borjesson, Rebecka / Galli, Laura / Lolatto, Riccardo / Menzaghi, Barbara / Feasi, Marcello / Gulminetti, Roberto / Fornabaio, Chiara / Cattelan, Anna Maria / Bonora, Stefano / Lagi, Filippo / Zazzi, Maurizio / Castagna, Antonella / Spagnuolo, Vincenzo

AIDS (London, England)

2024 Volume 38, Issue 3, Page(s) 435–438

MeSH term(s)	Female ; Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; Drug Resistance, Multiple, Viral ; Hospitalization/statistics & numerical data
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003781
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Article ; Online: Trends of Antimicrobial Susceptibility of Neisseria gonorrhoeae isolates between 2012 and 2023: results from an open Italian cohort.

Lucente, Maria Francesca / Raccagni, Angelo Roberto / Galli, Laura / Lolatto, Riccardo / Ranzenigo, Martina / Ripa, Marco / Ponta, Giacomo / Monardo, Roberta / Gona, Floriana / Clementi, Nicola / Burioni, Roberto / Carletti, Silvia / Castagna, Antonella / Nozza, Silvia

Sexually transmitted diseases

2024

Abstract: Background: Neisseria gonorrhoeae (Ng) is a public health priority due to the rapid evolution of antimicrobial resistance, the emergence of antibiotic resistance and the absence of a vaccine against Ng. The aim of this study was to investigate trends in ...

Abstract	Background: Neisseria gonorrhoeae (Ng) is a public health priority due to the rapid evolution of antimicrobial resistance, the emergence of antibiotic resistance and the absence of a vaccine against Ng. The aim of this study was to investigate trends in the minimum inhibitory concentration (MIC) and resistance (R) or reduced susceptibility (DS) of Ng cases to ceftriaxone (CRO), azithromycin (AZM), tetracycline (TET), benzylpenicillin (PenG), ciprofloxacin (CIP) over a 10-year period. Methods: Retrospective analysis on an open cohort of Ng cases diagnosed on rectal, urethral and pharyngeal samples at San Raffaele Scientific Institute, between September 2012-February 2023. MICs of antibiotics were determined by gradient-test strips. Bivariate linear regression models, applied on logarithmic MICs values; Cochran-Armitage test was used to determine a linear trend in the proportions of resistant strains. Results: 436 Ng isolates from 352 individuals were analyzed. MICs of CRO and PenG reduced over time (p < 0.001, p = 0.030), AZM increased (p = 0.001), CIP and TET did not change (p = 0.473, p = 0.272). The percentages of resistant strains were: PenG 89.9%, TET 90.8%, CIP 48.2%, AZM 4.4%; CRO-DS strains were 8.7%, only one CRO-R. The proportion of resistant strains increased over time for AZM (p = 0.007), TET (p = 0.001), CIP (p < 0.001), whereas decreased for PenG (p < 0.001) and CRO-DS/R strains (p < 0.001). Conclusions: Ng strains showed high susceptibility to CRO, although we identified cases of DS/R and observed high levels of susceptibility to AZM. Overall, the recommended primary regimen for Ng treatment confirmed to be effective.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001981
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Article ; Online: Risk of virological failure after drug burden reduction in people with 4-class drug-resistant HIV on virological suppression: a retrospective cohort analysis of data from the PRESTIGIO Registry.

Clemente, Tommaso / Diotallevi, Sara / Lolatto, Riccardo / Gagliardini, Roberta / Giacomelli, Andrea / Fiscon, Marta / Ferrara, Micol / Cervo, Adriana / Calza, Leonardo / Maggiolo, Franco / Rusconi, Stefano / Santoro, Maria Mercedes / Castagna, Antonella / Spagnuolo, Vincenzo

International journal of antimicrobial agents

2024 , Page(s) 107195

Language	English
Publishing date	2024-05-09
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107195
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Article ; Online: Sexually Transmitted Enteric Infections in Men Who Have Sex With Men Living With HIV Over 8 Years of Follow-up.

Raccagni, Angelo Roberto / Bruzzesi, Elena / Alberton, Francesca / Ceccarelli, Daniele / Lolatto, Riccardo / Canetti, Diana / Castagna, Antonella / Nozza, Silvia

Sexually transmitted diseases

2022 Volume 49, Issue 12, Page(s) 865

MeSH term(s)	Male ; Humans ; Homosexuality, Male ; Follow-Up Studies ; Sexual and Gender Minorities ; Sexual Behavior ; Sexually Transmitted Diseases/epidemiology ; HIV Infections/epidemiology
Language	English
Publishing date	2022-09-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001704
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Article: High-Risk Neutropenic Fever and Invasive Fungal Diseases in Patients with Hematological Malignancies.

Microorganisms

2024 Volume 12, Issue 1

Abstract: Invasive fungal diseases (IFDs) still represent a relevant cause of mortality in patients affected by hematological malignancies, especially acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) undergoing remission induction chemotherapy, and ...

Abstract	Invasive fungal diseases (IFDs) still represent a relevant cause of mortality in patients affected by hematological malignancies, especially acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) undergoing remission induction chemotherapy, and in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Mold-active antifungal prophylaxis (MAP) has been established as a standard of care. However, breakthrough IFDs (b-IFDs) have emerged as a significant issue, particularly invasive aspergillosis and non-
Language	English
Publishing date	2024-01-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12010117
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Article ; Online: Cohort profile: PRESTIGIO, an Italian prospective registry-based cohort of people with HIV-1 resistant to reverse transcriptase, protease and integrase inhibitors.

Clemente, Tommaso / Galli, Laura / Lolatto, Riccardo / Gagliardini, Roberta / Lagi, Filippo / Ferrara, Micol / Cattelan, Anna Maria / Focà, Emanuele / Di Biagio, Antonio / Cervo, Adriana / Calza, Leonardo / Maggiolo, Franco / Marchetti, Giulia / Cenderello, Giovanni / Rusconi, Stefano / Zazzi, Maurizio / Santoro, Maria Mercedes / Spagnuolo, Vincenzo / Castagna, Antonella

BMJ open

2024 Volume 14, Issue 2, Page(s) e080606

Abstract: Purpose: The PRESTIGIO Registry was established in 2017 to collect clinical, virological and immunological monitoring data from people living with HIV (PLWH) with documented four-class drug resistance (4DR). Key research purposes include the evaluation ... ...

Abstract	Purpose: The PRESTIGIO Registry was established in 2017 to collect clinical, virological and immunological monitoring data from people living with HIV (PLWH) with documented four-class drug resistance (4DR). Key research purposes include the evaluation of residual susceptibility to specific antiretrovirals and the validation of treatment and monitoring strategies in this population. Participants: The PRESTIGIO Registry collects annual plasma and peripheral blood mononuclear cell samples and demographic, clinical, virological, treatment and laboratory data from PLWH followed at 39 Italian clinical centres and characterised by intermediate-to-high genotypic resistance to ≥1 nucleoside reverse transcriptase inhibitors, ≥1 non-nucleoside reverse transcriptase inhibitors, ≥1 protease inhibitors, plus either intermediate-to-high genotypic resistance to ≥1 integrase strand transfer inhibitors (INSTIs) or history of virological failure to an INSTI-containing regimen. To date, 229 people have been recorded in the cohort. Most of the data are collected from the date of the first evidence of 4DR (baseline), with some prebaseline information obtained retrospectively. Samples are collected from the date of enrollment in the registry. Findings to date: The open-ended cohort has been used to assess (1) prognosis in terms of survival or development of AIDS-related or non-AIDS-related clinical events; (2) long-term efficacy and safety of different antiretroviral regimens and (3) virological and immunological factors predictive of clinical outcome and treatment efficacy, especially through analysis of plasma and cell samples. Future plans: The registry can provide new knowledge on how to implement an integrated approach to study PLWH with documented resistance to the four main antiretroviral classes, a population with a limited number of individuals characterised by a high degree of frailty and complexity in therapeutic management. Given the scheduled annual updates of PLWH data, the researchers who collaborate in the registry can send study proposals at any time to the steering committee of the registry, which evaluates every 3 months whether the research studies can be conducted on data and biosamples from the registry and whether they are aimed at a better understanding of a specific health condition, the emergence of comorbidities or the effect of potential treatments or experimental drugs that may have an impact on disease progression and quality of life. Finally, the research studies should aim to be inclusive, innovative and in touch with the communities and society as a whole. Trial registration number: NCT04098315.
MeSH term(s)	Humans ; Reverse Transcriptase Inhibitors/therapeutic use ; Reverse Transcriptase Inhibitors/pharmacology ; HIV-1/genetics ; Integrase Inhibitors/pharmacology ; Integrase Inhibitors/therapeutic use ; Peptide Hydrolases/pharmacology ; Peptide Hydrolases/therapeutic use ; Leukocytes, Mononuclear ; Quality of Life ; Retrospective Studies ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Registries ; Italy ; RNA-Directed DNA Polymerase/pharmacology ; RNA-Directed DNA Polymerase/therapeutic use
Chemical Substances	Reverse Transcriptase Inhibitors ; Integrase Inhibitors ; Peptide Hydrolases (EC 3.4.-) ; Anti-HIV Agents ; RNA-Directed DNA Polymerase (EC 2.7.7.49)
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-080606
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