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  1. Article ; Online: Where did that trial go? Unpublished clinical trials in rheumatology and potential implications.

    Lomanto Silva, Raisa / Sattui, Sebastian E

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 12, Page(s) 3778–3779

    MeSH term(s) Rheumatology ; Clinical Trials as Topic
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Editorial
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  2. Article: Association of patient copayment and medication adherence in systemic lupus erythematosus.

    Lomanto Silva, Raisa / Swabe, Gretchen M / Sattui, Sebastian Eduardo / Magnani, Jared W

    Lupus science & medicine

    2023  Volume 10, Issue 2

    Abstract: Objective: To investigate the association of medication copayment and treatment adherence to hydroxychloroquine and immunosuppressants for SLE.: Methods: We conducted a retrospective analysis of health claims data using Optum's de-identified ... ...

    Abstract Objective: To investigate the association of medication copayment and treatment adherence to hydroxychloroquine and immunosuppressants for SLE.
    Methods: We conducted a retrospective analysis of health claims data using Optum's de-identified Clinformatics Data Mart Database. Individuals with SLE continuously enrolled for 180 days from 1 July 2010 to 31 December 2019 were included. Adherence was defined as the proportion of days covered ≥80%. Copayment for a 30-day supply of medication was dichotomised as high (≥$10) or low (<$10). We examined the association between copayment and odds of adherence in multivariable-adjusted logistic regression models, including age, sex, race or ethnicity, comorbidities, educational attainment and household income.
    Results: We identified 12 510 individuals (age 54.2±15.5 years; 88.2% female sex), of whom 9510 (76%) were prescribed hydroxychloroquine and 1880 (15%) prescribed hydroxychloroquine and an additional immunosuppressant (azathioprine, methotrexate or mycophenolate mofetil). Median (IQR) 30-day copayments were $8 (4-10) for hydroxychloroquine, $7 (2-10) for azathioprine, $8 (3-11) for methotrexate and $10 (5-20) for mycophenolate mofetil. High copayments were associated with OR of adherence of 0.61 (95% CI 0.55 to 0.68) for hydroxychloroquine, OR 0.44 (95% CI 0.30 to 0.66) for azathioprine and OR 0.69 (95% CI 0.49 to 0.96) for mycophenolate mofetil. For methotrexate, the association was not significant.
    Conclusion: In a large, administrative health claims database, we identified that high copayments were associated with reduced adherence to commonly prescribed medications for SLE. Incorporating awareness of the burden of copayments and its consequences into healthcare is essential to promote optimal medication adherence.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Aged ; Male ; Lupus Erythematosus, Systemic/drug therapy ; Hydroxychloroquine/therapeutic use ; Azathioprine/therapeutic use ; Methotrexate/therapeutic use ; Mycophenolic Acid/therapeutic use ; Retrospective Studies ; Immunosuppressive Agents/therapeutic use ; Medication Adherence
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Azathioprine (MRK240IY2L) ; Methotrexate (YL5FZ2Y5U1) ; Mycophenolic Acid (HU9DX48N0T) ; Immunosuppressive Agents
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2779620-6
    ISSN 2053-8790
    ISSN 2053-8790
    DOI 10.1136/lupus-2023-000966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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