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Article ; Online: Misdiagnosed giant parathyroid cyst: differential diagnosis of a neck mass of the central region.

D'amore, Annamaria / Langellotti, Lodovica / Bocale, Raffaella / Lombardi, Celestino Pio

BMJ case reports

2022 Volume 15, Issue 6

Abstract: Parathyroid cysts (PCs) are rare benign lesions representing between the 0.08% and the 0.34% of the neck masses going on surgery. They should be considered in the differential diagnosis of neck masses, especially in the differential diagnosis of the ... ...

Abstract	Parathyroid cysts (PCs) are rare benign lesions representing between the 0.08% and the 0.34% of the neck masses going on surgery. They should be considered in the differential diagnosis of neck masses, especially in the differential diagnosis of the cystic anterior neck masses.Approximately 300 cases of PC are reported within the international literature.The gold standard for diagnosis is the evidence of high-level intact parathyroid hormone in cystic fluid. It is important to diagnose PCs before surgery, not intraoperatively, in order to avoid unnecessary surgeries or superfluous excision of part of the thyroid gland and prevent the patient from iatrogenic hypothyroidism.A surgical approach is required in those patients with large-sized cysts, relapses despite needle aspirations or if it causes hyperparathyroidism.We describe a case report of a patient, initially misdiagnosed with a thyroid cyst swelling, who instead had a giant non-functioning PC, which produced dyspnoea or dysphagia.
MeSH term(s)	Cysts/diagnosis ; Cysts/pathology ; Cysts/surgery ; Diagnosis, Differential ; Diagnostic Errors ; Humans ; Neoplasm Recurrence, Local/diagnosis ; Parathyroid Diseases/diagnosis ; Parathyroid Diseases/pathology ; Parathyroid Diseases/surgery
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-245501
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Article: Thyroid Cancer: Toward Surgical Evolution.

D'Amore, Annamaria / Patrone, Renato / Docimo, Ludovico / Conzo, Giovanni / Lombardi, Celestino Pio

Journal of clinical medicine

2021 Volume 10, Issue 16

Abstract: It has been more than five years since the American Thyroid Association (ATA) and the Italian consensus on thyroid cancer was published [ ... ]. ...

Abstract	It has been more than five years since the American Thyroid Association (ATA) and the Italian consensus on thyroid cancer was published [...].
Language	English
Publishing date	2021-08-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10163582
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Article: Long-Term Adherence to Levothyroxine Replacement Therapy in Thyroidectomized Patients.

Bocale, Raffaella / Desideri, Giovambattista / Barini, Angelina / D'Amore, Annamaria / Boscherini, Mauro / Necozione, Stefano / Lombardi, Celestino Pio

Journal of clinical medicine

2022 Volume 11, Issue 15

Abstract: 1) Background: We evaluated the long term adherence to two distinct formulations of levothyroxine (L-T4), liquid or solid, which are differently influenced by concomitant food ingestion. (2) Methods: A total of 106 thyroidectomized patients (82 female, ... ...

Abstract	(1) Background: We evaluated the long term adherence to two distinct formulations of levothyroxine (L-T4), liquid or solid, which are differently influenced by concomitant food ingestion. (2) Methods: A total of 106 thyroidectomized patients (82 female, mean age 58.2 ± 13.3 years) on L-T4 replacement therapy in either liquid (n = 52) or solid formulation (n = 54) were administered the four-item Medication Adherence Questionnaire (MAQ). (3) Results: The study population had 59.4% adherers and 40.6% non-adherers. The global MAQ score was significantly better in patients under liquid L-T4 in comparison to those under solid L-T4 (0.42 ± 0.82 vs. 0.83 ± 0.95, respectively, p = 0.0085). The patients on tablet L-T4 forgot to take their medication more frequently than those on liquid LT4 treatment (p = 0.0159) and were more often careless at times about taking their medication (p = 0.007), whilst about one in two thyroidectomized patients preferred tablets for lifetime medication therapy. The global MAQ score was directly correlated with the circulating TSH levels in the whole study population (0.700, p < 0.0001) and inversely correlated with both the FT3 (−0.220, p = 0.0232) and FT4 (−0.327, p = 0.0006) serum concentrations. (4) Conclusions: Long-term adherence to L-T4 treatment was globally satisfactory although it was better for the liquid formulation, which appears to represent an easier-to-manage L-T4 replacement therapy for most thyroidectomized patients, particularly for those with difficulties in taking L-T4 while fasting.
Language	English
Publishing date	2022-07-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11154296
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Article ; Online: WELCOME ADDRESS - XLI Annual ESAO Congress - 17-20 September 2014, Rome, Italy.

Catapano, Gerardo / Lombardi, Celestino Pio

The International journal of artificial organs

2014 Volume 37, Issue 8, Page(s) 568

Language	English
Publishing date	2014-09-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	80456-3
ISSN	1724-6040 ; 0391-3988
ISSN (online)	1724-6040
ISSN	0391-3988
DOI	10.5301/IJAO.2014.12635
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Article: Total thyroidectomy versus thyroid lobectomy in the treatment of papillary carcinoma.

Raffaelli, Marco / Tempera, Serena Elisa / Sessa, Luca / Lombardi, Celestino Pio / De Crea, Carmela / Bellantone, Rocco

Gland surgery

2020 Volume 9, Issue Suppl 1, Page(s) S18–S27

Abstract: Extent of thyroidectomy for papillary thyroid carcinoma is still matter of debate. Indeed, recently, international guidelines endorsed thyroid lobectomy as initial surgical approach for low risk, small medium-sized (T1-T2), N0 papillary thyroid carcinoma ...

Abstract	Extent of thyroidectomy for papillary thyroid carcinoma is still matter of debate. Indeed, recently, international guidelines endorsed thyroid lobectomy as initial surgical approach for low risk, small medium-sized (T1-T2), N0 papillary thyroid carcinoma in absence of extrathyroidal extension. When dealing with a conservative surgery for oncologic disease is of utmost importance to exclude effectively more advanced disease, which could benefit from a more aggressive initial operation. However, in the setting of surgery for papillary thyroid carcinoma, despite an accurate preoperative work up could led to identify some suspicious characteristics as macroscopic evidence of multifocality or extrathyroidal extension, and/or evidence of lateral neck lymph node metastases, it is difficult to reliably assess the central neck nodal status both pre- and intra-operatively. Frozen section examination of the central neck nodes ipsilateral to the side of the tumor has been proposed in patients scheduled for thyroid lobectomy, in order to modulate the extension of both thyroidectomy and central neck dissection. Future molecular and genetic evidences are needed to establish high-risk patients with small papillary thyroid carcinoma in which thyroid lobectomy could be not and adequate surgical treatment.
Language	English
Publishing date	2020-01-31
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.21037/gs.2019.11.09
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Article: Updates from Our Institutional Experience with Thyroid Nodules Diagnosed as Metastases.

Rossi, Esther Diana / Bruno, Carmine / Tralongo, Pietro / Policardo, Federica / Vegni, Federica / Feraco, Angela / Zhang, Qianqian / Pontecorvi, Alfredo / Fadda, Guido / Lombardi, Celestino Pio / Raffaelli, Marco / Mulè, Antonino / Larocca, Luigi Maria

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 14

Abstract: Background: Thyroid metastases (TMs) are a rare entity, ranging between 0 and 24% in the autopsy series. In the assessment of the best management, the discrimination between a primary and a metastatic thyroid lesion is crucial. In this regard, fine ... ...

Abstract	Background: Thyroid metastases (TMs) are a rare entity, ranging between 0 and 24% in the autopsy series. In the assessment of the best management, the discrimination between a primary and a metastatic thyroid lesion is crucial. In this regard, fine needle aspiration cytology (FNAC) is likely to play a crucial role especially when ancillary techniques (i.e., immunocytochemistry (ICC) and molecular testing) are carried out. Methods: We searched for all the TMs diagnosed using FNAC and analyzed between 2014 and 2023. The cases were processed with liquid-based (LBC) and ICC and molecular testing performed on LBC-stored material. Results: We reported 2.2% (19 cases) of TMs out of 1022 malignancies. TMs included: 1 larynx carcinoma (LX-Ca), 1 melanoma, 2 breast carcinomas (B-Ca), 3 lung carcinomas (LG-Ca), 4 gastro-intestinal carcinomas (GI-Ca), and 8 clear cell renal carcinomas (CCRC). All patients had a previous cancer history, between 300 and 2 months from the primary cancers. The morphological features were supported by ICC, which were contributive in 100% of cases. All TMs cases were characterized by multiple thyroid nodules except the melanoma case. Four cases underwent total thyroidectomy (1 B, 1 LX, 1 melanoma, and 1 CCRC) whilst 15 TMs were treated with radio-chemotherapy. Conclusions: FNAC empowered the diagnostic workup of patients with TMs avoiding useless surgery. The low sensitivity of cytology might be reinforced by the application of ancillary techniques. We found a predominant rate of kidney metastatic carcinomas, followed by lung and breast. TMs are frequently multifocal and in a context of a systemic disease so a tailored therapy seems to be the best treatment.
Language	English
Publishing date	2023-07-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13142388
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Article ; Online: Endocrine surgery: an update.

Bellantone, Rocco / Lombardi, Celestino Pio / Miccoli, Paolo

Updates in surgery

2017 Volume 69, Issue 2, Page(s) 117

Language	English
Publishing date	2017
Publishing country	Italy
Document type	Editorial
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-017-0473-5
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Article ; Online: Diagnostic role of FNA cytology in the evaluation of cervical lymph nodes in thyroid cancers: Combined evaluation of thyroglobulin in eluate from FNA cytology.

Tralongo, Pietro / Bruno, Carmine / Policardo, Federica / Vegni, Federica / Feraco, Angela / Carlino, Angela / Ferraro, Giulia / Milardi, Domenico / Navarra, Elena / Pontecorvi, Alfredo / Lombardi, Celestino Pio / Raffaelli, Marco / Larocca, Luigi Maria / Pantanowitz, Liron / Rossi, Esther Diana

Cancer cytopathology

2023 Volume 131, Issue 11, Page(s) 693–700

Abstract: Background: The presurgical evaluation of cervical lymph nodes (CLNs) in the management of thyroid malignant lesions is crucial for the extent of surgery or detection of metastases. In these last decades, fine-needle aspiration cytology (FNAC) has been ... ...

Abstract	Background: The presurgical evaluation of cervical lymph nodes (CLNs) in the management of thyroid malignant lesions is crucial for the extent of surgery or detection of metastases. In these last decades, fine-needle aspiration cytology (FNAC) has been shown to have a central role in the detection of nodal thyroid metastases. It is adopted for the possibility of confirming suspected metastases either in the presurgical phase or in the follow-up of patients after thyroidectomy. However, FNAC from CLNs can be challenging, especially in cystic lesions. In this regard, the combination of FNAC with thyroglobulin measurement in the eluate from FNAC (Tg-FNAC) seems to increase the sensitivity of FNAC in the detection of CLN metastases. The role of FNAC and Tg-FNAC was investigated in this series. Methods: One hundred fifty-three prospective cytological samples of CLNs were studied along with surgical follow-up in the period between 2020 and 2022. Immunocytochemistry (ICC) was performed on liquid-based cytology-stored material. Results: One hundred fifty-nine enlarged CLNs included 19 central lymph nodes and 140 CLNs. Forty-two thyroidal CLN metastases and 117 reactive lymph nodes were found. Thirty-one CLN dissections were performed in patients with a previous diagnosis of thyroid carcinoma (mostly papillary thyroid carcinoma [PTC]), whereas 128 CLNs with a concomitant suspicious and/or malignant thyroid nodule were found. There was one false-positive case among all the malignant histologically confirmed cases, and two of 117 reactive CLNs (1.7%) had a diagnosis of metastatic PTC. Markedly high Tg-FNAC was found in all metastatic CLNs, including 11 cystic metastatic CLNs detected by Tg-FNAC with a negative FNAC. ICC (including Tg, CK-19, and LCA) recognized nine cases with low Tg-FNAC and scant suspicious thyrocytes. Tg-FNAC plus FNAC diagnosed 94.2% of malignancies. Conclusions: FNAC represents a valid method for the evaluation of CLNs, especially combined with ICC. Tg-FNAC is an additional method with a useful role in FNAC.
MeSH term(s)	Humans ; Thyroglobulin ; Biopsy, Fine-Needle/methods ; Prospective Studies ; Carcinoma, Papillary/diagnosis ; Carcinoma, Papillary/surgery ; Carcinoma, Papillary/pathology ; Lymphatic Metastasis/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Lymph Nodes/pathology ; Thyroid Cancer, Papillary/diagnosis ; Thyroid Cancer, Papillary/pathology ; Sensitivity and Specificity
Chemical Substances	Thyroglobulin (9010-34-8)
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2594979-2
ISSN	1934-6638 ; 1934-662X
ISSN (online)	1934-6638
ISSN	1934-662X
DOI	10.1002/cncy.22745
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Article ; Online: COVID-19 pandemic: new rules of engagement in endocrine surgery.

Lombardi, C P / Gordini, L / D'Amore, A / Bocale, R / Boscherini, M / Bellantone, R

The British journal of surgery

2020 Volume 107, Issue 9, Page(s) e322

MeSH term(s)	COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Cross Infection/prevention & control ; Endocrine Surgical Procedures/methods ; Health Priorities ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control
Keywords	covid19
Language	English
Publishing date	2020-07-11
Publishing country	England
Document type	Letter
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1002/bjs.11777
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Article ; Online: p53 expression in cytology samples may represent a marker of early-stage cancer.

Policardo, Federica / Tralongo, Pietro / Arciuolo, Damiano / Fiorentino, Vincenzo / Cardasciani, Lina / Pierconti, Francesco / Carlino, Angela / Curatolo, Mariangela / Pontecorvi, Alfredo / Fadda, Guido / De Crea, Carmela / Lombardi, Celestino Pio / Raffaelli, Marco / Larocca, Luigi Maria / Pantanowitz, Liron / Rossi, Esther Diana

Cancer cytopathology

2023 Volume 131, Issue 6, Page(s) 392–401

Abstract: Background: TP53 gene plays a major role in the negative control of cell proliferation and in the regulation of signaling cascades. TP53 mutation may have a relevant role in the malignant transformation of thyroid cells as well as thyroid tumor ... ...

Abstract	Background: TP53 gene plays a major role in the negative control of cell proliferation and in the regulation of signaling cascades. TP53 mutation may have a relevant role in the malignant transformation of thyroid cells as well as thyroid tumor progression. TP53 mutation has been detected only in few well differentiated thyroid carcinomas and is absent in benign conditions. Methods: A total of 162 prospective thyroid cytology and corresponding histological samples diagnosed from atypia of indeterminate significance (AUS) to malignant, were studied via immunocytochemistry for p53. Hence, 50 benign lesions (B) were used as negative control. Molecular analysis for p53 only was performed. Results: The cytology resulted in 50 B, 48 AUS, 40 follicular neoplasms (FNs), 23 suspicious for malignancy (SFM), and 1 malignant (M) case. The authors reported 102 negative and 60 positive p53 cases. The 60 positive cases included 27 cases with weak and/or focal cytoplasmic positivity (+1) and 33 with cases moderate (2+) to strong (3+) cytoplasmic and/or nuclear expression. Overall, 71 cases had histology (2 B, 11 AUS, 37 FN, 20 SFM, and 1 M) including 61.7% benign and 38.2% malignant diagnoses. Only 16 of 71 (5 FN, 10 SFM, and 1 M) were p53-positive. Furthermore, 100% AUS and 86.5% FN cases were p53-negative, none of which had malignant histology. All p53-positive cases were associated with a larger nodule size, tall-cell variant subtype, multifocality, extra thyroidal infiltration, and nodal metastases. Noninvasive follicular thyroid neoplasm with papillary like nuclear features were negative for p53. Few discrepancies in p53 intensity were observed on histology; there were no differences with the molecular testing. Conclusions: p53 might be useful in discriminating thyroid follicular lesions. p53 is likely to be a useful diagnostic marker in recognizing indeterminate lesions that are well-differentiated thyroid cancers.
MeSH term(s)	Humans ; Thyroid Nodule/pathology ; Thyroid Cancer, Papillary/pathology ; Genes, p53 ; Tumor Suppressor Protein p53/genetics ; Prospective Studies ; Biopsy, Fine-Needle/methods ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Adenocarcinoma, Follicular/diagnosis ; Adenocarcinoma, Follicular/genetics ; Adenocarcinoma, Follicular/pathology
Chemical Substances	Tumor Suppressor Protein p53
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2594979-2
ISSN	1934-6638 ; 1934-662X
ISSN (online)	1934-6638
ISSN	1934-662X
DOI	10.1002/cncy.22694
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