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  1. Article ; Online: Spotlight on New Hallmarks of Drug-Resistance towards Personalized Care for Epithelial Ovarian Cancer.

    Frezzini, Simona / Lonardi, Sara

    Cells

    2024  Volume 13, Issue 7

    Abstract: Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy worldwide. Despite the latest advances, a major clinical issue in EOC is the disappointing prognosis related to chemoresistance in almost one-third of cases. Drug resistance relies ...

    Abstract Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy worldwide. Despite the latest advances, a major clinical issue in EOC is the disappointing prognosis related to chemoresistance in almost one-third of cases. Drug resistance relies on heterogeneous cancer stem cells (CSCs), endowed with tumor-initiating potential, leading to relapse. No biomarkers of chemoresistance have been validated yet. Recently, major signaling pathways, micro ribonucleic acids (miRNAs), and circulating tumor cells (CTCs) have been advocated as putative biomarkers and potential therapeutic targets for drug resistance. However, further investigation is mandatory before their routine implementation. In accordance with the increasing rate of therapeutic efforts in EOC, the need for biomarker-driven personalized therapies is growing. This review aims to discuss the emerging hallmarks of drug resistance with an in-depth insight into the underlying molecular mechanisms lacking so far. Finally, a glimpse of novel therapeutic avenues and future challenges will be provided.
    MeSH term(s) Humans ; Female ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/metabolism ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Drug Resistance, Neoplasm ; Neoplasm Recurrence, Local ; Signal Transduction ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New options for late-line treatment of metastatic colorectal cancer.

    Lonardi, Sara / Pietrantonio, Filippo

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 21, Issue 2, Page(s) 76–77

    MeSH term(s) Humans ; Colorectal Neoplasms/therapy ; Antibodies, Monoclonal/therapeutic use ; Rectal Neoplasms ; Intestine, Large ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-023-00881-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6020: Show issues Location:
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  3. Article: To resect or not to resect?-the dilemma in oligometastatic breast cancer.

    Lonardi, Sara / Guarneri, Valentina

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 4, Page(s) 623–625

    Language English
    Publishing date 2022-08-04
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-22-168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is upfront full molecular profiling needed in all patients with colorectal cancer in daily practice?

    Dienstmann, Rodrigo / Lonardi, Sara

    The Lancet. Oncology

    2022  Volume 23, Issue 9, Page(s) 1129–1131

    MeSH term(s) Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Humans ; Retrospective Studies
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00035-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Patient experience of medication administration and development of a Patient Experience and Preference Questionnaire (PEPQ) for patients with advanced or metastatic cancer.

    Skalicky, Anne / Bennett, Bryan / Raimbourg, Judith / Lonardi, Sara / Correll, Julia / Lugowska, Iwona / Dixon, Matthew / Sargalo, Nashmel / Martin, Mona L

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1310546

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1310546
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  6. Article ; Online: HER2 in Colorectal Cancer: The Long and Winding Road From Negative Predictive Factor to Positive Actionable Target.

    Ahcene Djaballah, Selma / Daniel, Francesca / Milani, Anna / Ricagno, Gianmarco / Lonardi, Sara

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2022  Volume 42, Page(s) 1–14

    Abstract: Human epidermal growth factor receptor 2 ( ...

    Abstract Human epidermal growth factor receptor 2 (
    MeSH term(s) Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Humans ; Prognosis ; Receptor, ErbB-2/metabolism
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_351354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mismatch repair status and gastro-oesophageal dysplasia: need for a dedicated gastrointestinal pathologist?

    Angerilli, Valentina / Lonardi, Sara / Farinati, Fabio / Savarino, Edoardo / Bergamo, Francesca / Fassan, Matteo

    Histopathology

    2022  Volume 80, Issue 7, Page(s) 1138–1140

    MeSH term(s) Carcinoma in Situ ; DNA Mismatch Repair ; Esophageal Neoplasms ; Gastroesophageal Reflux ; Humans ; Pathologists ; Stomach
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Letter
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1328: Show issues Location:
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  8. Article ; Online: New perspectives for TAS-102: TASK successful?

    Loupakis, Fotios / Lonardi, Sara

    The Lancet. Oncology

    2017  Volume 18, Issue 9, Page(s) 1139–1141

    MeSH term(s) Drug Combinations ; Trifluridine ; Uracil/analogs & derivatives
    Chemical Substances Drug Combinations ; TAS 102 ; Uracil (56HH86ZVCT) ; Trifluridine (RMW9V5RW38)
    Language English
    Publishing date 2017-07-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(17)30574-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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  9. Article ; Online: Correction to: Prevalence and type of MMR expression heterogeneity in colorectal adenocarcinoma: therapeutic implications and reporting.

    Grillo, Federica / Angerilli, Valentina / Parente, Paola / Vanoli, Alessandro / Luchini, Claudio / Sciallero, Stefania / Puccini, Alberto / Bergamo, Francesca / Lonardi, Sara / Valeri, Nicola / Mastracci, Luca / Fassan, Matteo

    Virchows Archiv : an international journal of pathology

    2024  

    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-024-03733-8
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  10. Article ; Online: Claudin-18.2 testing and its impact in the therapeutic management of patients with gastric and gastroesophageal adenocarcinomas: A literature review with expert opinion.

    Angerilli, Valentina / Ghelardi, Filippo / Nappo, Floriana / Grillo, Federica / Parente, Paola / Lonardi, Sara / Luchini, Claudio / Pietrantonio, Filippo / Ugolini, Clara / Vanoli, Alessandro / Fassan, Matteo

    Pathology, research and practice

    2024  Volume 254, Page(s) 155145

    Abstract: Claudin-18.2 (CLDN18.2) is a member of the tight junction protein family and is a highly selective biomarker with frequent abnormal expression during the occurrence and development of various primary malignant tumors, including gastric cancer (GC) and ... ...

    Abstract Claudin-18.2 (CLDN18.2) is a member of the tight junction protein family and is a highly selective biomarker with frequent abnormal expression during the occurrence and development of various primary malignant tumors, including gastric cancer (GC) and esophago-gastric junction adenocarcinomas (EGJA). For these reasons, CLDN18.2 has been investigated as a therapeutic target for GC/EGJA malignancies. Recently, zolbetuximab has been proposed as a new standard of care for patients with CLDN18.2-positive, HER2-negative, locally advanced and metastatic GC/EGJA. The use of CLDN18 IHC assays to select patients who might benefit from anti-CLDN18.2 therapy is currently entering clinical practice. In this setting, pathologists play a central role in therapeutic decision-making. Accurate biomarker assessment is essential to ensure the best therapeutic option for patients. In the present review, we provide a comprehensive overview of available evidence on CLDN18.2 testing and its impact on the therapeutic management of patients with GC/EGJA, as well as some practical suggestions for CLDN18.2 staining interpretation and potential pitfalls in the real-world setting.
    MeSH term(s) Humans ; Expert Testimony ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/metabolism ; Cell Adhesion Molecules ; Adenocarcinoma/pathology ; Claudins/metabolism ; Biomarkers
    Chemical Substances Cell Adhesion Molecules ; Claudins ; Biomarkers ; CLDN18 protein, human
    Language English
    Publishing date 2024-01-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2024.155145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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