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  1. Article ; Online: Systemic arterial air embolism following CT-guided lung biopsy.

    Long, Fangyuan / Zhang, Liming / Hu, Ronghang

    Wiener klinische Wochenschrift

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-024-02337-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 902: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Update on the treatment of multisystem inflammatory syndrome in children associated with COVID-19.

    Long, Fangyuan / Zhu, Shiheng / Wang, Zeguang / Zhang, Shungeng / He, Jinlong / Ge, Xinbin / Ning, Jun

    Future virology

    2023  

    Abstract: In late 2019, SARS-CoV-2 was detected in China and spread worldwide. In rare cases, children who were infected with COVID-19 may develop multisystem inflammatory syndrome (MIS-C), which could have higher mortality than COVID-19 itself. Therefore, ... ...

    Abstract In late 2019, SARS-CoV-2 was detected in China and spread worldwide. In rare cases, children who were infected with COVID-19 may develop multisystem inflammatory syndrome (MIS-C), which could have higher mortality than COVID-19 itself. Therefore, diagnosis and management are critical for treatment. Specifically, most of the initial treatment options of MIS-C choose intravenous immunoglobulin (IVIG) and steroids as the first-line treatment for patients. Moreover, antagonists of some cytokines are used as potential future therapeutics. Of note, therapeutic plasmapheresis can be used as a treatment for refractory severe MIS-C. We believe that each patient, especially those with comorbid conditions, should have individualized treatment based on both multidisciplinary consensus approach and expert opinion.
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254606-6
    ISSN 1746-0808 ; 1746-0794
    ISSN (online) 1746-0808
    ISSN 1746-0794
    DOI 10.2217/fvl-2022-0048
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  3. Article ; Online: Effect of SARS-CoV-2 infection and vaccine on ovarian reserve: A systematic review.

    Zhu, Shiheng / Luan, Chun / Zhang, Shungeng / Wang, Xinqing / Long, Fangyuan / Zhang, Qian / Yan, Junhao

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 292, Page(s) 63–70

    Abstract: Objective: To evaluate the effect of SARS-CoV-2 infection and vaccination on ovarian reserve.: Methods: Relevant articles were identified in the EMBASE, PubMed, and Web of Science databases from January 2020 to May 2023. Available clinical indicators ...

    Abstract Objective: To evaluate the effect of SARS-CoV-2 infection and vaccination on ovarian reserve.
    Methods: Relevant articles were identified in the EMBASE, PubMed, and Web of Science databases from January 2020 to May 2023. Available clinical indicators of ovarian reserve, such as anti-Müllerian hormone (AMH), antral follicle count (AFC), follicle-stimulating hormone (FSH), and estradiol (E2), as well as the time interval from infection or vaccination to measurements, were assessed.
    Results: Only 2 studies provided evidence that SARS-CoV-2 infection could damage ovarian function. In a comparison of the vaccinated and unvaccinated groups, although 1 prospective cohort study observed the transient statistically significant decrease on serum AMH levels at 3 or 6 months of follow-up, serum AMH levels remained within the normal reserve range (>1.1 ng/dl) throughout the study period.
    Conclusion: Overall, whether ovarian reserve may be affected by SARS-CoV-2 infection remains controversial and further investigations are warranted to clarify this issue. Based on the current evidence, it is safe to assume that COVID-19 vaccination does not exert any adverse effect on ovarian reserve parameters such as AMH, AFC, FSH, and E2, which will provide reassurance for women attempting to fall pregnant.
    MeSH term(s) Pregnancy ; Female ; Humans ; Ovarian Reserve ; Ovarian Follicle ; Prospective Studies ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; SARS-CoV-2 ; Follicle Stimulating Hormone ; Anti-Mullerian Hormone
    Chemical Substances COVID-19 Vaccines ; Follicle Stimulating Hormone (9002-68-0) ; Anti-Mullerian Hormone (80497-65-0)
    Language English
    Publishing date 2023-10-27
    Publishing country Ireland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.10.029
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    Zs.A 837: Show issues Location:
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  4. Article ; Online: Local injection of low-dose ixekizumab for the treatment of palmoplantar pustular psoriasis.

    He, Fang / Long, FangYuan / Yin, Zhi / Yin, ZhiQiang

    International journal of dermatology

    2022  Volume 61, Issue 6, Page(s) 742–743

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Psoriasis/drug therapy ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; ixekizumab (BTY153760O)
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16185
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  5. Article ; Online: Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation.

    Long, Fangyuan / Wei, Xuecui / Chen, Yujie / Li, Min / Lian, Ni / Yu, Shanshan / Chen, Sihan / Yang, Yong / Gu, Heng / Chen, Xu

    Cell death & disease

    2024  Volume 15, Issue 3, Page(s) 180

    Abstract: Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate GSDME-mediated pyroptosis, the role of keratinocyte GSDME in psoriatic dermatitis remains poorly characterized. ... ...

    Abstract Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate GSDME-mediated pyroptosis, the role of keratinocyte GSDME in psoriatic dermatitis remains poorly characterized. Through analysis of GEO datasets, we found elevated GSDME levels in psoriatic lesional skin. Additionally, GSDME levels correlated with both psoriasis severity and response to biologics treatments. Single-cell RNA sequencing (scRNA-seq) from a GEO dataset revealed GSDME upregulation in keratinocytes of psoriasis patients. In the imiquimod (IMQ)-induced psoriasis-like dermatitis mouse model, both full-length and cleaved forms of caspase-3 and GSDME were elevated in the epidermis. Abnormal proliferation and differentiation of keratinocytes and dermatitis were attenuated in Gsdme
    MeSH term(s) Animals ; Humans ; Mice ; Dermatitis/metabolism ; Dermatitis/pathology ; Gasdermins/metabolism ; Imiquimod/adverse effects ; Inflammation/pathology ; Keratinocytes/pathology ; Psoriasis/metabolism ; Psoriasis/pathology ; Transcription Factor RelA/metabolism ; Proto-Oncogene Proteins c-jun/metabolism
    Chemical Substances Gasdermins ; Imiquimod (P1QW714R7M) ; GSDME protein, human ; Gsdme protein, mouse ; Transcription Factor RelA ; Proto-Oncogene Proteins c-jun
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-024-06545-5
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  6. Article ; Online: Intramatricial low-dose secukinumab injection for nail psoriasis.

    He, Fang / Long, FangYuan / Tu, Jie / Yin, ZhiQiang

    Indian journal of dermatology, venereology and leprology

    2020  Volume 87, Issue 1, Page(s) 116–119

    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/administration & dosage ; Dermatologic Agents/administration & dosage ; Female ; Humans ; Injections ; Nail Diseases/drug therapy ; Psoriasis/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Dermatologic Agents ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.4103/ijdvl.IJDVL_124_20
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    Zs.A 85: Show issues Location:
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  7. Article ; Online: Dermoscopic features of nail psoriasis: Positive correlation with the severity of psoriasis.

    Long, FangYuan / Zhang, ZhiQin / He, Fang / Tu, Jie / Yin, Zhi / Xia, JiPing / Lu, Yan / Yin, ZhiQiang

    The Journal of dermatology

    2021  Volume 48, Issue 6, Page(s) 894–901

    Abstract: Dermoscopy is an efficient and non-invasive technique which has been widely used in the diagnosis of nail disorders including nail psoriasis (NP). Many nail dermoscopic features are considered as clues to NP. The aim of this study was to investigate ... ...

    Abstract Dermoscopy is an efficient and non-invasive technique which has been widely used in the diagnosis of nail disorders including nail psoriasis (NP). Many nail dermoscopic features are considered as clues to NP. The aim of this study was to investigate specific dermoscopic features of fingernail psoriasis and the correlation between the severity of nail lesions or systemic inflammation, and psoriasis severity of skin and nail. This observational study recruited 135 patients with fingernail psoriasis (1186 fingernails) and 30 patients with onychomycosis (80 fingernails). All of the involved fingernails were examined with a handheld dermatoscope. The Nail Psoriasis Severity Index score (NAPSI) score, Psoriasis Area and Severity Index (PASI) score, body surface area (BSA), and detailed history of patients with psoriasis were recorded. Mann-Whitney U-test, χ
    Language English
    Publishing date 2021-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15908
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    Zs.B 1950: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Acitretin inhibits IL-17A-induced IL-36 expression in keratinocytes by down-regulating IκBζ.

    Tu, Jie / Yin, Zhi / Guo, Jing / He, Fang / Long, FangYuan / Yin, ZhiQiang

    International immunopharmacology

    2019  Volume 79, Page(s) 106045

    Abstract: Background: IL-36 plays a critical role in aggravating psoriatic inflammation, which is significantly elevated in generalized pustular psoriasis (GPP) compared to psoriasis vulgaris. It is well known that acitretin brings about a rapid and significant ... ...

    Abstract Background: IL-36 plays a critical role in aggravating psoriatic inflammation, which is significantly elevated in generalized pustular psoriasis (GPP) compared to psoriasis vulgaris. It is well known that acitretin brings about a rapid and significant effect on the treatment of GPP but not psoriasis vulgaris, whereas the quick therapeutic mechanism of acitretin in GPP has not been fully clarified.
    Objectives: We conducted this study to investigate whether acitretin interferes IL-36 expression in keratinocytes.
    Method: We used 100 ng/mL IL-17A and/or various doses of acitretin (0, 0.1, 1, 10 μmol/L) to treat cultured HaCaT cells. We performed Real-time quantitative PCR and ELISA to detect gene and protein expression of IL-36 cytokines, real-time quantitative PCR and Western blot to examine IκBζ. Imiquimod (IMQ)-induced psoriasis-like mouse model was established to evaluate effect of gastrointestinal administrated acitretin. Immunohistochemistry was conducted for effect assessment.
    Results: Acitretin significantly down-regulated expression of IL-36β and IL-36γ induced by IL-17A stimulation at both gene and protein levels in HaCaT cells. Acitretin alone had no obvious effect on IL-36 expression in keratinocytes. In IMQ + acitretin group, the skin lesion severity was slightly relieved, however, immunohistochemistry showed IL-36β and IL-36γ expression in keratinocytes significantly declined in comparison with IMQ group. IL-17A stimulation induced significantly IκBζ expression in HaCaT cells, which could be inhibited by acitretin.
    Conclusion: Acitretin inhibits IL-36 expression induced by IL-17A stimulation in keratinocytes by down-regulating IκBζ, and acitretin significantly inhibits keratinocytes-expressed IL-36β and IL-36γ in psoriasis-like mouse model, which reveals a new possible mechanism of the notable and quick therapeutic action of acitretin on GPP.
    MeSH term(s) Acitretin/therapeutic use ; Animals ; Anti-Inflammatory Agents/therapeutic use ; Cell Line ; Disease Models, Animal ; Down-Regulation ; Female ; Humans ; I-kappa B Kinase/metabolism ; Imiquimod ; Interleukin-1/genetics ; Interleukin-1/metabolism ; Interleukin-17/metabolism ; Keratinocytes/drug effects ; Keratinocytes/immunology ; Mice ; Mice, Inbred BALB C ; Psoriasis/chemically induced ; Psoriasis/drug therapy ; Psoriasis/immunology
    Chemical Substances Anti-Inflammatory Agents ; Interleukin-1 ; Interleukin-17 ; interleukin-36, mouse ; I-kappa B Kinase (EC 2.7.11.10) ; Acitretin (LCH760E9T7) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2019-12-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2019.106045
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    Zs.A 5408: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model.

    Zhang, ZhiQin / Tang, ShouBin / Jiang, YuYing / Long, FangYuan / He, Fang / Liu, Jian / Gu, ShouYong / Lu, Yan / Yin, ZhiQiang

    Cell death & disease

    2022  Volume 13, Issue 5, Page(s) 474

    Abstract: Psoriasis, an immune-mediated inflammatory disease, is associated with poor pregnancy outcomes. Emerging evidence indicates that these defects are likely attributed to compromised oocyte competence. Nevertheless, little is known about the underlying ... ...

    Abstract Psoriasis, an immune-mediated inflammatory disease, is associated with poor pregnancy outcomes. Emerging evidence indicates that these defects are likely attributed to compromised oocyte competence. Nevertheless, little is known about the underlying associated mechanisms between psoriasis and poor oocyte quality. In this study, we construct an imiquimod-induced chronic psoriasis-like mouse model to review the effects of psoriasis on oocyte quality. We discover that oocytes from psoriasis-like mice display spindle/chromosome disorganization, kinetochore-microtubule mis-attachment, and aneuploidy. Importantly, our results show that melatonin supplement in vitro and in vivo not only increases the rate of matured oocytes but also significantly attenuates oxidative stress and meiotic defects by restoring mitochondrial function in oocytes from psoriasis-like mice. Altogether, our data uncover the adverse effects of psoriasis symptoms on oocytes, and melatonin supplement ameliorates oxidative stress and meiotic defects of oocytes from psoriatic mice.
    MeSH term(s) Animals ; Female ; Meiosis ; Melatonin/pharmacology ; Mice ; Mitochondria/metabolism ; Oocytes/metabolism ; Oxidative Stress ; Pregnancy ; Psoriasis/drug therapy ; Psoriasis/genetics ; Psoriasis/metabolism ; Spindle Apparatus/metabolism
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-022-04948-w
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