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Article ; Online: Efficacy of switching from teriparatide to zoledronic acid or denosumab on bone mineral density and biochemical markers of bone turnover in older patients with severe osteoporosis: a real-life study.

Dito, Giorgia / Lugaresi, Marina / Degradi, Chiara / Guabello, Gregorio / Longhi, Matteo / Corbetta, Sabrina

2023 Volume 82, Issue 1, Page(s) 181–189

Abstract: Purpose: Osteoporosis is characterized by loss of bone mass and susceptibility to fracture. Skeletal effects of teriparatide (TPT) are not persistent after drug withdrawal and sequential therapy with bisphosphonates or denosumab (Dmab) after TPT ... ...

Abstract	Purpose: Osteoporosis is characterized by loss of bone mass and susceptibility to fracture. Skeletal effects of teriparatide (TPT) are not persistent after drug withdrawal and sequential therapy with bisphosphonates or denosumab (Dmab) after TPT discontinuation represents a valid option. Here, the two sequential strategies were evaluated in severe osteoporotic patients. Methods: The study retrospectively enrolled 56 severe osteoporotic patients who received TPT for 24 months followed by 24 months of zoledronic acid (ZOL) (TPT + ZOL) or Dmab (TPT+Dmab). Clinical features, incident fractures, bone mineral density (BMD) measurements, and bone marker profiles were collected. One-way ANOVA analyzed the difference between mean T-scores at baseline, after 24 months of TPT, and after 2 doses of ZOL or after at least 3 doses of Dmab. Results: Twenty-three patients received TPT + ZOL (19 females, 4 males; median [IR] age, 74.3 [66.9, 78.6] years) and 33 patients received TPT+Dmab (31 females, 2 males; mean [IR] age, 66.6 ± 11.3 years). Mean lumbar and hip T-scores were increased after both TPT + ZOL and TPT+Dmab (all p < 0.05 vs baseline). The size effects induced by TPT + ZOL on the lumbar and hip BMD T-scores were similar to those observed with TPT+Dmab with mean T-scores increases of about 1 and 0.4 SD, respectively. No significant between-group differences were identified. Incident fragility fractures occurred in 3 (13%) patients treated with TPT + ZOL and in 5 (15%) patients treated with TPT+Dmab. Conclusions: Sequential TPT + ZOL therapy is likely to increase bone mineralization at the lumbar level and to stabilize it at the femoral level, similarly to what obtained with the sequential TPT+Dmab. Both ZOL and Dmab are suggested to be effective sequential treatments after TPT.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Middle Aged ; Zoledronic Acid/therapeutic use ; Zoledronic Acid/pharmacology ; Teriparatide/adverse effects ; Bone Density ; Denosumab/adverse effects ; Bone Density Conservation Agents/adverse effects ; Retrospective Studies ; Osteoporosis/drug therapy ; Osteoporosis/chemically induced ; Diphosphonates/adverse effects ; Fractures, Bone/chemically induced ; Bone Remodeling ; Biomarkers
Chemical Substances	Zoledronic Acid (6XC1PAD3KF) ; Teriparatide (10T9CSU89I) ; Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents ; Diphosphonates ; Biomarkers
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-023-03431-6
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Zs.A 3884: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Hypercalciuria in Postmenopausal Women With Reduced Bone Mineral Density Is Associated With Different Mineral Metabolic Profiles: Effects of Treatment With Thiazides and Anti-resorptives.

Nicoli, Federico / Dito, Giorgia / Guabello, Gregorio / Longhi, Matteo / Corbetta, Sabrina

Frontiers in medicine

2021 Volume 8, Page(s) 780087

Abstract: Hypercalciuria may represent a challenge during the workup for osteoporosis management. The present study aimed: (1) to describe the phenotype associated with hypercalciuria in vitamin D-sufficient (serum 25 hydroxyvitamin D (25OHD) > 20 ng/ml) patients ... ...

Abstract	Hypercalciuria may represent a challenge during the workup for osteoporosis management. The present study aimed: (1) to describe the phenotype associated with hypercalciuria in vitamin D-sufficient (serum 25 hydroxyvitamin D (25OHD) > 20 ng/ml) patients with osteopenia/osteoporosis; (2) to analyze the effects of thiazides and anti-resorptive drugs on urine calcium excretion (UCa), mineral metabolic markers, and bone mineral density. Seventy-seven postmenopausal women with hypercalciuria (Uca > 4.0 mg/kg body weight/24 h on two determinations) were retrospectively evaluated in a real-life setting. Median UCa was 5.39 (4.75-6.70) mg/kg/24 h. Kidney stones occurred in 32.9% of patients, who had median UCa similar to that of patients without kidney stones. Clustering analysis considering the three variables, such as serum calcium, phosphate, and parathormone (PTH), identified two main clusters of hypercalciuric patients. Cluster 1 (
Language	English
Publishing date	2021-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.780087
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Article ; Online: Identification of biomarkers in patients with rheumatoid arthritis responsive to DMARDs but with progressive bone erosion.

Marasco, Emiliano / Fabbriciani, Gianluigi / Rotunno, Laura / Longhi, Matteo / De Luca, Paola / de Girolamo, Laura / Colombini, Alessandra

Frontiers in immunology

2023 Volume 14, Page(s) 1254139

Abstract: Introduction: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that may cause joint destruction and disability. The pharmacological treatment of RA aims at obtaining disease remission by effectively ceasing joint inflammation and ... ...

Abstract	Introduction: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that may cause joint destruction and disability. The pharmacological treatment of RA aims at obtaining disease remission by effectively ceasing joint inflammation and arresting progressive bone erosions. Some patients present bone lesions accrual even after controlling joint inflammation with current therapies. Our study aimed to analyze lymphocyte subsets and levels of circulating cytokines in patients with RA with progressive bone erosions. Methods: We enrolled 20 patients with a diagnosis of RA and 12 healthy donors (HD). Patients with RA were divided into patients with bone erosions (RA-BE+) and without bone erosions (RA-BE-). Lymphocyte subsets in peripheral blood were evaluated by flow cytometry. Circulating cytokines levels were evaluated by protein array. Results: The distribution of lymphocyte subsets was not able to separate HD from AR patients and RA-BE+ and RA-BE- in cluster analysis. We observed a significant expansion of CXCR5 Conclusion: We show that patients with progressive erosive disease are characterized by abnormalities in B cells and in cytokines with a proven role in bone reabsorption. Understanding the role played by B cells and the cytokine IL-11 and IL-17A in progressive erosive disease can help identify novel biomarkers of erosive disease and design treatment approaches aimed at halting joint damage in RA.
MeSH term(s)	Humans ; Interleukin-11 ; Interleukin-17 ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Biomarkers ; Cytokines ; Inflammation/drug therapy
Chemical Substances	Interleukin-11 ; Interleukin-17 ; Antirheumatic Agents ; Biomarkers ; Cytokines
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1254139
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Article: Bone Features of Unaffected Skeletal Sites in Melorheostosis: A Case Report.

Indirli, Rita / Messina, Carmelo / Longhi, Matteo / Guabello, Gregorio / Corbetta, Sabrina

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

2020 Volume 23, Issue 4, Page(s) 690–694

Abstract: Background: Melorheostosis is a rare sporadic sclerosing bone dysplasia, which commonly affects appendicular skeleton with bone hyperostosis and soft tissues sclerosis; fragility fractures are rare in melorheostotic patients. We investigated bone ... ...

Abstract	Background: Melorheostosis is a rare sporadic sclerosing bone dysplasia, which commonly affects appendicular skeleton with bone hyperostosis and soft tissues sclerosis; fragility fractures are rare in melorheostotic patients. We investigated bone features at unaffected sites in a postmenopausal woman with melorheostosis of the right lower limb and with a fracture of the melorheostosis-free T11 vertebral. Methodology: Melorheostotic lesions were evaluated by plain radiography, magnetic resonance of the right lower limb, and whole-body bone scintigraphy. Dual X-ray absorptiometry, trabecular bone score, and quantitative computed tomography were performed to investigate unaffected bone sites. Biochemical assessment of bone metabolism was obtained. Results: Dual X-ray absorptiometry was indicative of normal mineralization at femoral sites and osteopenia at lumbar spine (T-score -1.1), which was confirmed by spinal quantitative computed tomography (volumetric bone mineral density 89 mg/cm Conclusions: Fragility fractures at apparently unaffected sites may occur in adults with melorheostosis, in absence of significant demineralization diagnosed by dual X-ray absorptiometry, trabecular bone score, and quantitative computed tomography, which may underestimate the fracture risk in this set of patients. Treatment with zoledronate could be considered also to prevent fragility fractures.
MeSH term(s)	Absorptiometry, Photon ; Aged ; Bone Density ; Bone and Bones/diagnostic imaging ; Bone and Bones/pathology ; Female ; Femur Neck/diagnostic imaging ; Femur Neck/pathology ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/pathology ; Melorheostosis/diagnostic imaging ; Melorheostosis/pathology
Language	English
Publishing date	2020-01-11
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2040951-5
ISSN	1094-6950
ISSN	1094-6950
DOI	10.1016/j.jocd.2020.01.002
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Zs.A 5425: Show issues

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Article ; Online: Hypertryptasemia and Mast Cell-Related Disorders in Severe Osteoporotic Patients.

Carosi, Giulia / Guabello, Gregorio / Longhi, Matteo / Grifoni, Federica / Passeri, Elena / Corbetta, Sabrina

Mediators of inflammation

2020 Volume 2020, Page(s) 5785378

Abstract: Purpose: Systemic mastocytosis (SM) is characterized by a clonal proliferation of neoplastic mast cells (MCs) in one or more extracutaneous organs including the bone marrow (BM). SM is often associated with osteoporosis (OP) and fractures. ... ...

Abstract	Purpose: Systemic mastocytosis (SM) is characterized by a clonal proliferation of neoplastic mast cells (MCs) in one or more extracutaneous organs including the bone marrow (BM). SM is often associated with osteoporosis (OP) and fractures. Hypertryptasemia usually occurs in SM. We investigated the prevalence of hypertryptasemia in a series of severe osteoporotic patients, the performance of the tryptase test in diagnosing SM in these patients, and their bone features. Methods: The medical records of 232 patients (168 females and 64 males) with a diagnosis of OP (50.4% with fractures) and a serum tryptase assessment were reviewed. BM assessment was performed in a subset of hypertryptasemic patients; clinical, biochemical, and radiographic data were collected. Results: Hypertryptasemia was detected in 33 patients. BM assessment ( Conclusions: The prevalence of MC-related disorders in severe OP was 3.0%, accounting for the 7.4% of the secondary causes of OP. MC-related disorders may be involved in bone fragility and assessment of serum tryptase is useful to detect MC-related disorders.
MeSH term(s)	Adult ; Aged ; Amino Acid Metabolism, Inborn Errors/blood ; Amino Acid Metabolism, Inborn Errors/physiopathology ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Female ; Humans ; Hypercalciuria/blood ; Hypercalciuria/physiopathology ; Male ; Mast Cells/pathology ; Mastocytosis, Systemic/blood ; Mastocytosis, Systemic/pathology ; Middle Aged ; Osteoporosis/blood ; Osteoporosis/physiopathology ; Tryptases/metabolism
Chemical Substances	Tryptases (EC 3.4.21.59)
Language	English
Publishing date	2020-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2020/5785378
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Zs.A 3575: Show issues

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Article ; Online: Hybrid Foot Vein Arterialization in No-Option Patients With Critical Limb Ischemia: A Preliminary Report.

Ferraresi, Roberto / Casini, Andrea / Losurdo, Fabrizio / Caminiti, Maurizio / Ucci, Alessandro / Longhi, Matteo / Schreve, Michiel / Lichtenberg, Michael / Kum, Steven / Clerici, Giacomo

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2018 Volume 26, Issue 1, Page(s) 7–17

Abstract: Purpose: To describe a preliminary experience in treating no-option critical limb ischemia (CLI) patients with a hybrid foot vein arterialization (HFVA) technique combining open plus endovascular approaches.: Materials and methods: Between May 2016 ... ...

Abstract	Purpose: To describe a preliminary experience in treating no-option critical limb ischemia (CLI) patients with a hybrid foot vein arterialization (HFVA) technique combining open plus endovascular approaches. Materials and methods: Between May 2016 and January 2018, 35 consecutive patients (mean age 68±12 years; 28 men) with 36 no-option CLI limbs underwent HFVA in our center. All limbs had grade 3 WIfI (Wound, Ischemia, and foot Infection) ischemia, and the wound classification was grade 1 in 4 (11%) limbs, grade 2 in 4 (11%), and grade 3 in 28 (78%). Surgical bypass was done on the medial marginal vein or a posterior tibial vein, followed by endovascular removal of foot vein valves and embolization of foot vein collaterals. A "tension-free" surgical approach was used to treat foot lesions. Results: At a mean follow-up of 10.8±2 months, limb salvage was achieved in 25 (69%) limbs and wound healing in 16 (44%); 9 patients presented an unhealed wound. Eleven (31%) patients underwent a major amputation (2 below the knee and 9 thigh). One patient with an unhealed wound and open bypass died of myocardial infarction. Conclusion: HFVA is a promising technique able to achieve acceptable rates of limb salvage and wound healing in no-option patients generally considered candidates for an impending major amputation. Further studies are needed to standardize the technique and better identify patients who can benefit from this approach.
MeSH term(s)	Aged ; Aged, 80 and over ; Amputation ; Critical Illness ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/mortality ; Endovascular Procedures/adverse effects ; Endovascular Procedures/mortality ; Female ; Foot/blood supply ; Humans ; Ischemia/diagnostic imaging ; Ischemia/mortality ; Ischemia/physiopathology ; Ischemia/surgery ; Limb Salvage ; Male ; Middle Aged ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/mortality ; Peripheral Arterial Disease/physiopathology ; Peripheral Arterial Disease/surgery ; Preliminary Data ; Regional Blood Flow ; Reoperation ; Risk Factors ; Time Factors ; Treatment Outcome ; Veins/diagnostic imaging ; Veins/physiopathology ; Veins/surgery ; Wound Healing
Language	English
Publishing date	2018-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/1526602818820792
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Zs.A 4547: Show issues

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Article ; Online: The Value of Carotid Endarterectomy as a Learning Tool for Trainees.

Cacioppa, Laura Maria / Pini, Rodolfo / Longhi, Matteo / Vacirca, Andrea / Gallitto, Enrico / Faggioli, Gianluca / Gargiulo, Mauro / Stella, Andrea

Annals of vascular surgery

2017 Volume 47, Page(s) 195–199

Abstract: Background: Carotid endarterectomy (CEA) intervention needs a specific training and a sufficient learning curve to obtain optimal results in terms of outcome. A formative program was settled up in a single academic center to optimize training of ... ...

Abstract	Background: Carotid endarterectomy (CEA) intervention needs a specific training and a sufficient learning curve to obtain optimal results in terms of outcome. A formative program was settled up in a single academic center to optimize training of standard CEA procedures. This study aims to evaluate the 11-year results of the teaching CEA program. Methods: The trainees CEA teaching program is carried on during the 5-year vascular surgery residency period, and it is stratified as follows: learning theory and intervention assistance (minimum 50 procedures per year) in the first and second residency year; performing CEA as second operator in the third and fourth residency year (minimum 50 procedures per year); CEA execution as first operator with attending supervision in the last residency year. All CEA procedures from 2005 to 2015 were retrospectively collected and the 30-day results were compared according to the expertise of the first operator: experienced vascular surgeons (EVSs) versus trainees. All CEA procedures were performed in general anesthesia, with routine shunting and patching. Results: In the study period, 1,379 (361 [26.2%] symptomatic; 1,018 [73.8%] asymptomatic) CEAs were performed. Trainees performed 199 (14.4%) CEAs as first operator. Patients submitted to CEA by trainees were similar in terms of preoperative clinical characteristics except for the patients' age (trainees 72.4 years versus EVS 70.8 years, P = 0.02) and smoking history (trainees 30.7% versus EVS 24.1%, P = 0.04). The 30-day complication rates were similar in CEA performed by trainees versus EVS: stroke 0.5% vs. 1.1%, P = 0.5; death 0.0% vs. 0.5%, P = 0.6; stroke/death 0.5% vs. 1.7%, P = 0.24; hematoma 3.0% vs. 2.2%, P = 0.48; and cranial nerve injury 9.0% vs. 7.8%, P = 0.47, respectively. The intervention time was significantly longer in CEAs performed by trainees compared with EVS: 104 ± 1.9 min versus 98 ± 1.0 min, P = 0.02. Conclusions: With a defined CEA teaching program, trainees can obtain results similar to those of more experienced surgeons in terms of clinical outcome at the price of an increased intervention time.
MeSH term(s)	Aged ; Aged, 80 and over ; Carotid Artery Diseases/diagnosis ; Carotid Artery Diseases/mortality ; Carotid Artery Diseases/surgery ; Clinical Competence ; Cranial Nerve Injuries/etiology ; Curriculum ; Education, Medical, Graduate/methods ; Endarterectomy, Carotid/adverse effects ; Endarterectomy, Carotid/education ; Endarterectomy, Carotid/mortality ; Female ; Hematoma/etiology ; Humans ; Internship and Residency ; Learning Curve ; Male ; Middle Aged ; Operative Time ; Program Evaluation ; Retrospective Studies ; Risk Factors ; Stroke/etiology ; Surgeons/education ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2017-09-07
Publishing country	Netherlands
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2017.08.024
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Zs.A 2882: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Relationship between Calcification and Vulnerability of the Carotid Plaques.

Pini, Rodolfo / Faggioli, Gianluca / Fittipaldi, Silvia / Vasuri, Francesco / Longhi, Matteo / Gallitto, Enrico / Pasquinelli, Gianandrea / Gargiulo, Mauro / Stella, Andrea

Annals of vascular surgery

2017 Volume 44, Page(s) 336–342

Abstract: Background: Carotid plaques with a high degree of calcification are usually considered at low embolic risk. However, since a precise evaluation of the extent of calcification is not possible preoperatively through duplex ultrasound and postoperatively ... ...

Abstract	Background: Carotid plaques with a high degree of calcification are usually considered at low embolic risk. However, since a precise evaluation of the extent of calcification is not possible preoperatively through duplex ultrasound and postoperatively by conventional histological examination due to the decalcification process, the relationship between the amount of calcium involvement and plaque vulnerability has not been evaluated yet. This study aims to correlate the extent of carotid plaque calcification with clinical, radiological, and histological complications. Methods: Symptomatic and asymptomatic consecutive patients submitted to carotid endarterectomy between January to December 2014 were included in the study. The amount of carotid calcification was assessed at preoperative computed tomography (CT) through measurement of thickness and circumferential calcium extension and graded from 1 to 8 accordingly (Babiarz classification). Patients were then categorized into 2 groups (low-level group: grade 1-5; high-level group: grade 6-8) and correlated with clinical characteristics and ipsilateral cerebral ischemic lesions at CT. Vulnerability of the plaque was assessed histologically according with American Heart Association (AHA) Classification. Results were overall blindly correlated. Results: One hundred five patients (81% male; age: 73 ± 8 years) were enrolled in the study. Forty (38%) were symptomatic and 43 (40%) had an ipsilateral focal lesion at preoperative cerebral CT. Thirty-six (38%) patients had high-level carotid calcification degree at CT scan. At histological analysis, 56 (56%) plaques were considered complicated (AHA type VI). Patients with high-level and low-level carotid calcification had similar epidemiological risk factors, preoperative neurological symptoms, and histological complications (17% vs. 15%, P = 0.76 and 50% vs. 55%, P = 0.62, respectively). The high-level calcification group showed a significantly higher incidence of ipsilateral cerebral lesions at preoperative CT (56% vs. 32%, P = 0.01). Conclusions: A high level of calcification of the carotid plaque is not necessarily associated with lower vulnerability: the incidence of preoperative neurological symptoms and histological complications is similar in patients with and without extensive carotid plaque calcification. Cerebral ischemic lesions may be even more frequent in the presence of highly calcified plaques.
Language	English
Publishing date	2017-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2017.04.017
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Zs.A 2882: Show issues

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Article ; Online: Impact of acute cerebral ischemic lesions and their volume on the revascularization outcome of symptomatic carotid stenosis.

Pini, Rodolfo / Faggioli, Gianluca / Longhi, Matteo / Ferrante, Liborio / Vacirca, Andrea / Gallitto, Enrico / Gargiulo, Mauro / Stella, Andrea

Journal of vascular surgery

2017 Volume 65, Issue 2, Page(s) 390–397

Abstract: Background: The influence of acute cerebral ischemic lesions (CILs) on the revascularization outcome of symptomatic carotid stenosis has been scarcely investigated in the literature. This study evaluated the effect of CILs and their volume on the ... ...

Abstract	Background: The influence of acute cerebral ischemic lesions (CILs) on the revascularization outcome of symptomatic carotid stenosis has been scarcely investigated in the literature. This study evaluated the effect of CILs and their volume on the results of carotid revascularization in symptomatic patients. Methods: All patients with symptomatic carotid artery stenosis who underwent carotid endarterectomy (CEA) or carotid artery stenting (CAS) between 2005 and 2014 were considered. CILs ipsilateral to the stenosis were identified in the preoperative cerebral computed tomography. The volume was quantified in mm Results: A total of 489 symptomatic patients were treated by CEA (327 [67%]) or CAS (162 [33%]), 186 (38%) ≤2 weeks and 303 (62%) >2 weeks from symptom onset. CEA and CAS patients had statistically similar rates of stroke (3.3% vs 5.5%; P = .27) and stroke/death (3.8% vs 5.9%; P = .22). CILs were identified in 251 patients (53%) and were associated with similar stroke and stroke/death rate compared with patients without CIL (12 [4.8%] vs 8 [3.5%], P = .46; and 14 [5.6%] vs 8 [3.5%]; P = .26, respectively). The median CIL volume was 1000 mm Conclusions: CIL volume in symptomatic carotid stenosis seems to influence the 30-day outcome independently from the timing of carotid revascularization. A CIL volume of ≥4000 mm
MeSH term(s)	Acute Disease ; Aged ; Aged, 80 and over ; Angioplasty/adverse effects ; Angioplasty/instrumentation ; Angioplasty/mortality ; Area Under Curve ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/etiology ; Brain Ischemia/mortality ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/mortality ; Carotid Stenosis/therapy ; Cerebral Angiography/methods ; Chi-Square Distribution ; Computed Tomography Angiography ; Endarterectomy, Carotid/adverse effects ; Endarterectomy, Carotid/mortality ; Female ; Humans ; Ischemic Attack, Transient/etiology ; Ischemic Attack, Transient/mortality ; Male ; Multivariate Analysis ; Odds Ratio ; ROC Curve ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Stents ; Stroke/etiology ; Stroke/mortality ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2016.08.077
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Zs.A 1933: Show issues

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Article ; Online: Increased frequency of activated CD8

Diani, Marco / Casciano, Fabio / Marongiu, Laura / Longhi, Matteo / Altomare, Andrea / Pigatto, Paolo D / Secchiero, Paola / Gambari, Roberto / Banfi, Giuseppe / Manfredi, Angelo A / Altomare, Gianfranco / Granucci, Francesca / Reali, Eva

Scientific reports

2019 Volume 9, Issue 1, Page(s) 10870

Abstract: The aim of this study is to identify subsets of T cells differentially represented in the circulation of patients with psoriatic arthritis and to evaluate the possibility that they can recirculate between peripheral blood and the inflamed joints. We ... ...

Abstract	The aim of this study is to identify subsets of T cells differentially represented in the circulation of patients with psoriatic arthritis and to evaluate the possibility that they can recirculate between peripheral blood and the inflamed joints. We analyzed the phenotype and cytokine expression in circulating CD8
MeSH term(s)	Adult ; Aged ; Antigens, CD/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Arthritis, Psoriatic/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Movement ; Cells, Cultured ; Female ; Humans ; Immunologic Memory ; Interleukin-17/metabolism ; Joints/pathology ; Lectins, C-Type/metabolism ; Lymphocyte Activation ; Male ; Middle Aged ; Receptors, CXCR3/metabolism ; Synovial Fluid/metabolism ; T-Lymphocyte Subsets/immunology ; Young Adult
Chemical Substances	Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD69 antigen ; CXCR3 protein, human ; Interleukin-17 ; Lectins, C-Type ; Receptors, CXCR3
Language	English
Publishing date	2019-07-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-47310-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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