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  1. AU="Longo, Lauren O"
  2. AU="Ogawa, Kumiko"
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  1. Article: Thiopeptide Defense by an Ant’s Bacterial Symbiont

    Chang, Preston T / Rao, Krithika / Longo, Lauren O / Lawton, Elisabeth S / Scherer, Georgia / Van Arnam, Ethan B

    Journal of natural products. 2020 Jan. 21, v. 83, no. 3

    2020  

    Abstract: Fungus-growing ants and their microbial symbionts have emerged as a model system for understanding antibiotic deployment in an ecological context. Here we establish that bacterial symbionts of the ant Trachymyrmex septentrionalis antagonize their most ... ...

    Abstract Fungus-growing ants and their microbial symbionts have emerged as a model system for understanding antibiotic deployment in an ecological context. Here we establish that bacterial symbionts of the ant Trachymyrmex septentrionalis antagonize their most likely competitors, other strains of ant-associated bacteria, using the thiopeptide antibiotic GE37468. Genomic analysis suggests that these symbionts acquired the GE37468 gene cluster from soil bacteria. This antibiotic, with known activity against human pathogens, was previously identified in a biochemical screen but had no known ecological role. GE37468’s host-associated defense role in this insect niche intriguingly parallels the function of similar thiopeptides in the human microbiome.
    Keywords Trachymyrmex septentrionalis ; animal pathogens ; antibiotics ; genomics ; humans ; insects ; microbiome ; models ; multigene family ; soil bacteria ; symbionts
    Language English
    Dates of publication 2020-0121
    Size p. 725-729.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b00897
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Thiopeptide Defense by an Ant's Bacterial Symbiont.

    Chang, Preston T / Rao, Krithika / Longo, Lauren O / Lawton, Elisabeth S / Scherer, Georgia / Van Arnam, Ethan B

    Journal of natural products

    2020  Volume 83, Issue 3, Page(s) 725–729

    Abstract: Fungus-growing ants and their microbial symbionts have emerged as a model system for understanding antibiotic deployment in an ecological context. Here we establish that bacterial symbionts of the ... ...

    Abstract Fungus-growing ants and their microbial symbionts have emerged as a model system for understanding antibiotic deployment in an ecological context. Here we establish that bacterial symbionts of the ant
    MeSH term(s) Animals ; Antibiosis ; Ants/microbiology ; Molecular Structure ; Peptides, Cyclic/chemistry ; Pseudonocardia/chemistry ; Symbiosis ; Thiazoles/chemistry
    Chemical Substances GE 37468 A ; Peptides, Cyclic ; Thiazoles
    Language English
    Publishing date 2020-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b00897
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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