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  1. Article: The Impact of Complex PTSD on Suicide Risk in Patients with Bipolar Disorder: A Cross-Sectional Study.

    Iazzolino, Anna Maria / Valenza, Marta / D'Angelo, Martina / Longobardi, Grazia / Stefano, Valeria Di / Visalli, Giulia / Steardo, Luca / Scuderi, Caterina

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Background: Patients with bipolar disorder (BD) are more likely than the general population to experience traumatic events, particularly during childhood, and these may predict and be a risk factor for the development of complex PTSD (cPTSD). The ... ...

    Abstract Background: Patients with bipolar disorder (BD) are more likely than the general population to experience traumatic events, particularly during childhood, and these may predict and be a risk factor for the development of complex PTSD (cPTSD). The presence of multiple traumas plays a relevant role from a psychopathological point of view, but little is known about the effect this may have on suicide attempts in patients with BD.
    Methods: A cross-sectional study was conducted comparing socio-demographic and clinical characteristics, recruiting 344 patients diagnosed with BD I and II, screened for the presence (or absence) of cPTSD using the International Trauma Questionnaire (ITQ). Suicide attempts were assessed directly during the clinical interview and from the patient's medical record.
    Results: The results emerging from the study indicate that cPTSD can be considered a risk factor for suicide attempts in patients with BD. Furthermore, evidence is provided to support the idea that cPTSD is highly prevalent in patients with BD and is related to a higher psychopathological burden.
    Conclusions: The results recommend an urgent and comprehensive assessment of suicidal risk in patients with comorbidity of both bipolar disorder and cPTSD. There is a crucial demand for early intervention initiatives and proactive prevention strategies to address the intricate intersection of these mental health challenges.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: How effective are mood stabilizers in treating bipolar patients comorbid with cPTSD? Results from an observational study.

    Iazzolino, Anna Maria / Valenza, Marta / D'Angelo, Martina / Longobardi, Grazia / Di Stefano, Valeria / Luca, Steardo / Scuderi, Caterina / Steardo, Luca

    International journal of bipolar disorders

    2024  Volume 12, Issue 1, Page(s) 9

    Abstract: Background: Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disorder (BP) are more likely to have ... ...

    Abstract Background: Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disorder (BP) are more likely to have suffered traumatic events than the general population. Consequently, cPTSD could be comorbid with BD, and this may negatively affect psychopathological manifestations. To date, no one has explored whether such comorbidity also affects the response to treatment with mood stabilizers in BD patients.
    Results: Here, a cross-sectional study was carried out by comparing the response to treatment, measured by the Alda scale, in a cohort of 344 patients diagnosed with BD type I and II, screened for the presence (or absence) of cPTSD using the International Trauma Questionnaire. The main result that emerged from the present study is the poorer response to mood stabilizers in BD patients with comorbid cPTSD compared with BD patients without cPTSD.
    Conclusions: The results collected suggest the need for an add-on therapy focused on trauma in BD patients. This could represent an area of future interest in clinical research, capable of leading to more precise and quicker diagnoses as well as suggesting better tailored and more effective treatments.
    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2732954-9
    ISSN 2194-7511
    ISSN 2194-7511
    DOI 10.1186/s40345-024-00330-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring the Interplay between Complex Post-Traumatic Stress Disorder and Obsessive-Compulsive Disorder Severity: Implications for Clinical Practice.

    D'Angelo, Martina / Valenza, Marta / Iazzolino, Anna Maria / Longobardi, Grazia / Di Stefano, Valeria / Visalli, Giulia / Steardo, Luca / Scuderi, Caterina / Manchia, Mirko

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 3

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Stress Disorders, Post-Traumatic/complications ; Cross-Sectional Studies ; Obsessive-Compulsive Disorder/complications ; Anxiety Disorders ; Anxiety/psychology ; Psychiatric Status Rating Scales
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60030408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Unraveling the Complexity: Exploring the Intersection of Panic Disorder, Dissociation, and Complex Post-Traumatic Stress Disorder.

    D'Angelo, Martina / Valenza, Marta / Iazzolino, Anna Maria / Longobardi, Grazia / Di Stefano, Valeria / Lanzara, Elena / Visalli, Giulia / Steardo, Luca / Scuderi, Caterina

    Behavioral sciences (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: Background: Patients with panic disorder (PD) may experience increased vulnerability to dissociative and anxious phenomena in the presence of repeated traumatic events, and these may be risk factors for the development of complex post-traumatic stress ... ...

    Abstract Background: Patients with panic disorder (PD) may experience increased vulnerability to dissociative and anxious phenomena in the presence of repeated traumatic events, and these may be risk factors for the development of complex post-traumatic stress disorder (cPTSD). The present study aims to find out whether the presence of cPTSD exacerbates anxiety symptoms in patients suffering from panic disorder and whether this is specifically associated with the occurrence of dissociative symptoms.
    Methods: One-hundred-and-seventy-three patients diagnosed with PD were recruited and divided into two groups based on the presence (or absence) of cPTSD using the International Trauma Questionnaire (ITQ) scale. Dissociative and anxious symptoms were assessed using the Cambridge Depersonalization Scale (CDS) and Hamilton Anxiety Scale (HAM-A), respectively.
    Results: Significant differences in re-experienced PTSD (
    Conclusions: This study highlights the potential link between dissociative symptoms and a more severe clinical course of anxiety-related conditions in patients with PD. Early intervention programs and prevention strategies are needed.
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs14030166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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