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Article: Hula as a physical activity and social support intervention for sustained activity in female breast and gynecologic cancer survivors.

Bantum, Erin O / Yamada, Paulette M / Makolo, TeMoana / Yu, Herbert / Pagano, Ian / Subia, Natalie / Walsh, Catherine / Loo, Lenora W M

Frontiers in psychology

2023 Volume 14, Page(s) 1190532

Abstract: Background: Physical activity improves health and psychosocial functioning for people who have been diagnosed with cancer. Native Hawaiians face disparities for some cancers, including breast cancer. Delivering culturally grounded interventions has the ... ...

Abstract	Background: Physical activity improves health and psychosocial functioning for people who have been diagnosed with cancer. Native Hawaiians face disparities for some cancers, including breast cancer. Delivering culturally grounded interventions has the potential to improve enjoyment and adherence to the intervention. We sought to test the adherence and impact of a 6 month randomized wait-list controlled trial of hula. Methods: In this randomized wait-list controlled design people who had been diagnosed with breast or gynecologic cancers were invited to participate with other cancer survivors in a group based setting. Participants were randomized to begin hula immediately or after six months. Attendance was collected and heart-rate measured three times per session. In addition, demographic data, self-report psychosocial data, and biological data (findings will be reported elsewhere) were collected at three time points: baseline, 6 months, and 12 months. The study included six months of hula, twice per week, 60 min each session. In addition, participants committed to practice 60 min per week at home. Results: Participants in the study ( Conclusion: Sustainable physical activity is crucial to improve both the survival and quality of life of cancer survivors. Culturally grounded interventions, such as hula have the potential to increase the maintenance of physical activity. In addition, they create a support group where the benefits of people who have all experienced cancer can gather and garner those benefits of social support, too. This study was registered as a clinical trial through the National Cancer Institute (NCT02351479). Clinical trial registration: Clinicaltrails.gov, NCT02351479.
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1190532
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Article ; Online: Racial and Ethnic Disparities in Rates of Invasive Second Breast Cancer Among Women With Ductal Carcinoma In Situ in Hawai'i.

Taparra, Kekoa / Fukui, Jami / Killeen, Jeffrey / Sumida, Kenneth / Loo, Lenora W M / Hernandez, Brenda Y

JAMA network open

2021 Volume 4, Issue 10, Page(s) e2128977

Abstract: Importance: Women with ductal carcinoma in situ (DCIS) may develop a subsequent invasive second breast cancer (SBC). Understanding the association of racial and ethnic factors with the development of invasive SBC may help reduce overtreatment and ... ...

Abstract	Importance: Women with ductal carcinoma in situ (DCIS) may develop a subsequent invasive second breast cancer (SBC). Understanding the association of racial and ethnic factors with the development of invasive SBC may help reduce overtreatment and undertreatment of women from minority groups. Objective: To evaluate risk factors associated with developing invasive ipsilateral SBC (iiSBC) and invasive contralateral SBC (icSBC) among women with an initial diagnosis of DCIS who are from racial and ethnic minority populations. Design, setting, and participants: This retrospective cohort study used deidentified data from the Hawai'i Tumor Registry of 6221 female Hawai'i residents aged 20 years or older who received a diagnosis of DCIS between January 1, 1973, and December 31, 2017. The 5 most populous ethnic groups were compared (Chinese, Filipino, Japanese, Native Hawaiian, and White). Data analysis was performed from 2020 to 2021. Exposures: Patient demographic and clinical characteristics and the first course of treatment. Main outcome and measures: The a priori study outcome was the development of invasive SBC. Logistic regression was used to identify factors associated with invasive SBC. Factors that were significant on unadjusted analyses were included in the adjusted models (ie, age, race and ethnicity, diagnosis year, DCIS histologic characteristics, laterality, hormone status, and treatment). Results: The racial and ethnic distribution of patients with DCIS across the state's most populous groups were 2270 Japanese women (37%), 1411 White women (23%), 840 Filipino women (14%), 821 Native Hawaiian women (13%), and 491 Chinese women (8%). Women of other minority race and ethnicity collectively comprised 6% of cases (n = 388). A total of 6221 women (age range, 20 to ≥80 years) were included in the study; 4817 (77%) were 50 years of age or older, 4452 (72%) received a diagnosis between 2000 and 2017, 2581 (42%) had well or moderately differentiated histologic characteristics, 2383 (38%) had noninfiltrating intraductal DCIS, and 2011 (32%) were treated with mastectomy only. Of these 6221 women, 444 (7%) developed invasive SBC; 190 developed iiSBC (median time to SBC diagnosis, 7.8 years [range, 0.5-30 years]) and 254 developed icSBC (median time to SBC diagnosis, 5.9 years [range, 0.5-28.8 years]). On adjusted analysis, women who developed iiSBC were more likely to be younger than 50 years (adjusted odds ratio [aOR], 1.49; 95% CI, 1.08-2.06), Native Hawaiian (aOR, 3.28; 95% CI, 2.01-5.35), Filipino (aOR, 1.94; 95% CI, 1.11-3.42), Japanese (aOR, 1.58; 95% CI, 1.01-2.48), and untreated (aOR, 2.29; 95% CI, 1.09-4.80). Compared with breast-conserving surgery (BCS) alone, there was a decreased likelihood of iiSBC among women receiving BCS and radiotherapy (aOR, 0.45; 95% CI, 0.27-0.75), BCS and systemic treatment with or without radiotherapy (aOR, 0.40; 95% CI, 0.23-0.69), mastectomy only (aOR, 0.23; 95% CI, 0.13-0.39), and mastectomy and systemic treatment (aOR, 0.57; 95% CI, 0.33-0.96). Women who developed an icSBC were more likely to be Native Hawaiian (aOR, 1.69; 95% CI, 1.10-2.61) or Filipino (aOR, 1.70; 95% CI, 1.10-2.63). Risk of both iiSBC and icSBC decreased in the later years of diagnosis (2000-2017) compared with the earlier years (1973-1999). Conclusions and relevance: This study suggests that Native Hawaiian and Filipino women who initially received a diagnosis of DCIS were more likely to subsequently develop both iiSBC and icSBC. Japanese women and younger women were more likely to develop iiSBC. Subpopulation disaggregation may help guide clinical treatment and screening decisions for at-risk subpopulations.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/complications ; Breast Neoplasms/epidemiology ; Breast Neoplasms/ethnology ; Carcinoma, Ductal/epidemiology ; Carcinoma, Ductal/etiology ; Female ; Hawaii/epidemiology ; Hawaii/ethnology ; Humans ; Middle Aged ; Native Hawaiian or Other Pacific Islander/ethnology ; Native Hawaiian or Other Pacific Islander/statistics & numerical data ; Odds Ratio ; Race Factors/statistics & numerical data ; Recurrence
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2021.28977
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Article ; Online: The high and heterogeneous burden of breast cancer in Hawaii: A unique multiethnic U.S. Population.

Loo, Lenora W M / Williams, Makana / Hernandez, Brenda Y

Cancer epidemiology

2018 Volume 58, Page(s) 71–76

Abstract: Background: While breast cancer incidence and mortality rates differ across racial/ethnic populations in the U.S., little is known about Asian and Pacific Island subpopulations. Hawaii is one of the most racially/ethnically diverse states in the U.S. ... ...

Abstract	Background: While breast cancer incidence and mortality rates differ across racial/ethnic populations in the U.S., little is known about Asian and Pacific Island subpopulations. Hawaii is one of the most racially/ethnically diverse states in the U.S. Overall, Hawaii ranks 5 Methods: We examined incidence and mortality trends from 1984-2013 across the five major racial/ethnic populations of Hawaii (Native Hawaiian, White, Japanese, Chinese, and Filipino) using Hawaii's Surveillance, Epidemiology, and End Results (SEER) registry data. Results: With the exception of Chinese, all groups experienced increasing incidence over the thirty year period. While Japanese experienced the most pronounced recent increase, with incidence now exceeding that of Whites, their mortality rates have remained low for decades. Native Hawaiians have consistently had the highest incidence and mortality rates in the state. The incidence rates of hormone receptor (HR)-positive breast cancer were higher among Japanese and Native Hawaiians as compared to Whites. Relative to Whites, Native Hawaiians also had a higher incidence rate of the HER2-positive subtype and, Japanese, of the triple-negative (HR-/HER2-) subtype of breast cancer. Conclusions: Studies such as this underscore the importance of considering the heterogeneity in breast cancer rates and subtypes across the different racial/ethnic populations.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/epidemiology ; Breast Neoplasms/ethnology ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Continental Population Groups ; Ethnic Groups ; Female ; Hawaii/epidemiology ; Humans ; Incidence ; Middle Aged ; Neoplasm Staging ; Registries
Language	English
Publishing date	2018-11-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2018.11.006
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Zs.A 1427: Show issues

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Article ; Online: Characterizing breast cancer incidence and trends among Asian American, Native Hawaiian, and non-Hispanic White women in Hawai'i, 1990-2014.

Ihenacho, Ugonna / McKinley, Meg A / Vu, Annie / Hernandez, Brenda Y / Loo, Lenora W M / Gomez, Scarlett Lin / Wu, Anna H / Cheng, Iona

Cancer causes & control : CCC

2022 Volume 34, Issue 3, Page(s) 241–249

Abstract: Purpose: To characterize breast cancer (BC) incidence by age at diagnosis and BC subtype among disaggregated Asian American, Native Hawaiian, and Pacific Islander (AANHPI) women and non-Hispanic White (NHW) women in Hawai'i.: Methods: Using 1990-2014 ...

Abstract	Purpose: To characterize breast cancer (BC) incidence by age at diagnosis and BC subtype among disaggregated Asian American, Native Hawaiian, and Pacific Islander (AANHPI) women and non-Hispanic White (NHW) women in Hawai'i. Methods: Using 1990-2014 data from the Hawai'i tumor registry, we estimated age-adjusted incidence rates (AAIR) of BC and the annual percent change in BC incidence by age (<50 and ≥50 years) and BC subtype (hormone receptor [HR]+/human epidermal growth factor receptor 2 [HER2]-, HR+/HER2+, HR-/HER2+, triple negative BC) for Filipino American (FA), Japanese American (JA), Native Hawaiian (NH), and NHW women. Results: Among young (<50 years) women, annual BC incidence increased 2.9% (1994-2014) among JA and 1.0% (1990-2014) among NHW women. Incidence was highest among young JA women (2010-2014 AAIR 52.0 per 100,000; 95% confidence interval [CI] 45.6, 58.9). HR+/HER2- BC, the major BC subtype, was similarly highest among young JA women (AAIR 39.5; 95% CI 33.9, 45.4). Among older (≥50 years) women, annual BC incidence increased 1.6% (1990-2014) among FA and 4.2% (2006-2014) for JA women. BC incidence was highest among older NH women (AAIR 137.6, 95% CI 128.2, 147.4), who also displayed highest incidence of two subtypes: HR+/HER2- (AAIR 106.9; 95% CI 98.6, 115.5) and HR+/HER2+ (AAIR 12.1; 95% CI 9.4, 15.1). Conclusion: We observed high and increasing BC incidence among JA women ages <50 years and high incidence among NH women ages ≥50 years. These results highlight racial and ethnic differences in BC incidence among disaggregated AANHPI populations in Hawai'i by age and BC subtype.
MeSH term(s)	Female ; Humans ; Middle Aged ; Breast Neoplasms/epidemiology ; Hawaii/epidemiology ; Incidence ; Triple Negative Breast Neoplasms/epidemiology ; White/statistics & numerical data ; Asian American Native Hawaiian and Pacific Islander/statistics & numerical data
Language	English
Publishing date	2022-12-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-022-01659-7
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Zs.A 3375: Show issues

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Article ; Online: In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants.

Loo, Lenora W M / Lemire, Mathieu / Le Marchand, Loïc

BMC genomics

2017 Volume 18, Issue 1, Page(s) 381

Abstract: Background: Genome-wide association studies have identified 55 genetic variants associated with colorectal cancer risk to date. However, potential causal genes and pathways regulated by these risk variants remain to be characterized. Therefore, we ... ...

Abstract	Background: Genome-wide association studies have identified 55 genetic variants associated with colorectal cancer risk to date. However, potential causal genes and pathways regulated by these risk variants remain to be characterized. Therefore, we performed gene ontology enrichment and pathway analyses to determine if there was an enrichment of genes in proximity to the colorectal cancer risk variants that could further elucidate the probable causal genes and pathways involved in colorectal cancer biology. Results: For the 65 unique genes that either contained, or were immediately neighboring up- and downstream, of these variants there was a significant enrichment for the KEGG pathway, Pathways in Cancer (p-value = 2.67 × 10 Conclusions: Our data reaffirm the potential to identify an enrichment for biological processes and candidate causal genes based on expression profiles correlated with genetic risk alleles of colorectal cancer, however, the identification of these significant cis-eQTLs is context and tissue specific.
Language	English
Publishing date	2017-05-15
Publishing country	England
Document type	Journal Article
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/s12864-017-3750-2
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Article ; Online: Cholesterol lowering drug use and breast cancer survival: the Multiethnic Cohort Study.

Moksud, Nafeesa / Loo, Lenora W M / Yang, Juan / Huang, Chiung-Yu / Haiman, Christopher A / Le Marchand, Loïc / Wilkens, Lynne R / Cheng, Iona

Breast cancer research and treatment

2021 Volume 190, Issue 1, Page(s) 165–173

Abstract: Purpose: Prior studies conducted primarily in white populations have suggested that pre-diagnostic cholesterol lowering drugs (CLDs) improved survival among women with breast cancer (BC). However, this association had not been well characterized in ... ...

Abstract	Purpose: Prior studies conducted primarily in white populations have suggested that pre-diagnostic cholesterol lowering drugs (CLDs) improved survival among women with breast cancer (BC). However, this association had not been well characterized in diverse racial/ethnic populations. We investigated whether pre-diagnostic CLD use is associated with all-cause and BC-specific mortality among female BC cases of the Multiethnic Cohort (MEC). Methods: CLD use was ascertained through questionnaires administered in 2003-2008. A total of 1448 incident BC cases were identified by linkage to SEER cancer registries in Hawaii and California from 2003 to 2014. Multivariable Cox regression was conducted to estimate hazard ratios (HR) and 95% confidence intervals (CI) of the associations of pre-diagnostic CLD use with all-cause and BC-specific mortality, adjusting for tumor characteristics, first course of treatment, health behaviors, co-morbidities, and demographics. Subgroup analyses by stage and hormone receptor status were conducted for all-cause mortality. Results: There were 224 all-cause and 87 BC-specific deaths among the 1448 BC cases during a median follow-up of 4.5 years after diagnosis. Women with BC who ever used CLDs had a 27% lower hazard of all-cause mortality (HR 0.73, 95% CI 0.54-0.98) and 17% lower hazard of BC-specific mortality (HR 0.83, 95% CI 0.49-1.39) compared to never users. CLD use reduced mortality among women with advanced-stage tumors and hormone receptor-positive breast tumors (HR 0.54 95% CI 0.33-0.90; HR 0.69, 95% CI 0.48-0.99, respectively). Conclusion: These findings demonstrate an improved survival associated with CLD use prior to diagnosis in a multiethnic population of women with BC.
MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Cholesterol ; Cohort Studies ; Female ; Humans ; Pharmaceutical Preparations ; Proportional Hazards Models
Chemical Substances	Pharmaceutical Preparations ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2021-08-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-021-06360-y
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Zs.A 1655: Show issues

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Article ; Online: Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case-control study of the Multiethnic Cohort Study.

DeRouen, Mindy C / Yang, Juan / Li, Yuqing / Franke, Adrian A / Tome, Anne N / White, Kami K / Hernandez, Brenda Y / Shvetsov, Yurii / Setiawan, Veronica / Wu, Anna H / Wilkens, Lynne R / Le Marchand, Loïc / Loo, Lenora W M / Cheng, Iona

Breast cancer research : BCR

2023 Volume 25, Issue 1, Page(s) 95

Abstract: Background: Laboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations between obesity and postmenopausal ... ...

Abstract	Background: Laboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations between obesity and postmenopausal breast cancer risk. Epidemiologic evidence for 27HC in breast cancer risk is limited, particularly in multiethnic populations. Methods: In a nested case-control study of 1470 breast cancer cases and 1470 matched controls within the Multiethnic Cohort Study, we examined associations of pre-diagnostic circulating 27HC with breast cancer risk among African American, Japanese American, Native Hawaiian, Latino, and non-Latino White postmenopausal females. We used multivariable logistic regression adjusted for age, education, parity, body mass index, and smoking status. Stratified analyses were conducted across racial and ethnic groups, hormone receptor (HR) status, and use of lipid-lowering drugs. We assessed interactions of 27HC with steroid hormones. Results: 27HC levels were inversely related to breast cancer risk (odds ratio [OR] 0.80; 95% confidence interval [CI] 0.58, 1.12), but the association was not statistically significant in the full model. Directions of associations differed by racial and ethnic group. Results suggested an inverse association with HR-negative breast cancer (OR 0.46; 95% CI 0.20, 1.06). 27HC interacted with testosterone, but not estrone, on risk of breast cancer; 27HC was only inversely associated with risk among those with the highest levels of testosterone (OR 0.46; 95% CI 0.24, 0.86). Conclusion: This is the first US study to examine circulating 27HC and breast cancer risk and reports a weak inverse association that varies across racial and ethnic groups and testosterone level.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Cohort Studies ; Case-Control Studies ; Risk Factors ; Hydroxycholesterols ; Testosterone
Chemical Substances	27-hydroxycholesterol (6T2NA6P5SQ) ; Hydroxycholesterols ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-023-01693-6
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Zs.A 5494: Show issues

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Article ; Online: BRAF

Hernandez, Brenda Y / Rahman, Mobeen / Loo, Lenora W M / Chan, Owen T M / Horio, David / Morita, Shane / Bryant-Greenwood, Gillian

Journal of cancer research and clinical oncology

2020 Volume 147, Issue 1, Page(s) 183–194

Abstract: Purpose: BRAF: Methods: Immunohistochemical expressions of BRAF: Results: BRAF: Conclusions: Our study provides the first evidence of the potential interaction of ... ...

Abstract	Purpose: BRAF Methods: Immunohistochemical expressions of BRAF Results: BRAF Conclusions: Our study provides the first evidence of the potential interaction of BRAF
MeSH term(s)	Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/pathology ; Female ; Follow-Up Studies ; Humans ; Hypothyroidism/physiopathology ; Male ; Middle Aged ; Mutation ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics ; Relaxin/genetics ; Relaxin/metabolism ; Retrospective Studies ; Survival Rate ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; Relaxin (9002-69-1) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2020-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-020-03401-9
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Uh III Zs.10: Show issues

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Article ; Online: Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort.

Maskarinec, Gertraud / Ju, Dan / Shvetsov, Yurii B / Horio, David / Chan, Owen / Loo, Lenora W M / Hernandez, Brenda Y

Cancer epidemiology

2020 Volume 65, Page(s) 101685

Abstract: Background: This study investigated the association of breast lobular involution status and three inflammatory markers as predictors of survival among breast cancer patients in the Multiethnic Cohort.: Methods: Lobular involution was evaluated in ... ...

Abstract	Background: This study investigated the association of breast lobular involution status and three inflammatory markers as predictors of survival among breast cancer patients in the Multiethnic Cohort. Methods: Lobular involution was evaluated in tissue sections of normal breast tissue and COX-2, TNF-α, and TGF-β proteins were assessed by immunohistochemistry in tumor microarrays. A summary score added the expression levels of the three markers. Cox regression was applied to estimate hazard ratios (HRs) and 95 % confidence intervals (CI) with age as the time metric and adjustment for factors known to affect mortality. Results: Among 254 women (mean age = 61.7 ± 8.7 years) with pathologic blocks and follow-up information, 54 all-cause and 10 breast cancer-specific deaths were identified after a mean follow-up time of 16.0 ± 3.1 years. For 214 participants, an inflammatory score was available and 157 women had information on lobular involution. Lobular involution was not significantly associated with survival. Expression of both COX-2 and TNF-α were significant predictors of lower survival (p = 0.02 and 0.04), while the association for TGF-β was weaker (p = 0.09). When combined into one overall inflammation score, both intermediate (HR = 2.72; 95 % CI 0.90-8.28) and high (HR = 4.21; 95 % CI 1.51-11.8) scores were associated with higher mortality but only the latter was statistically significant. No significant association with breast cancer-specific mortality was detected. Conclusions: These results suggest that strong expression of inflammatory markers in breast tissue predicts a poorer prognosis possibly due to a system-wide state of chronic inflammation.
MeSH term(s)	Breast Neoplasms/ethnology ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cohort Studies ; Ethnic Groups/statistics & numerical data ; Female ; Hawaii/epidemiology ; Humans ; Inflammation/pathology ; Inflammatory Breast Neoplasms/ethnology ; Inflammatory Breast Neoplasms/mortality ; Inflammatory Breast Neoplasms/pathology ; Middle Aged ; Survival Analysis
Language	English
Publishing date	2020-02-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2020.101685
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Zs.A 1427: Show issues

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Article ; Online: Using a cultural dance program to increase sustainable physical activity for breast cancer survivors-A pilot study.

Loo, Lenora W M / Nishibun, Kryslin / Welsh, Leslie / Makolo, TeMoana / Chong, Clayton D / Pagano, Ian / Yu, Herbert / Bantum, Erin O

Complementary therapies in medicine

2019 Volume 47, Page(s) 102197

Abstract: Background: Studies have shown that physical activity can reduce the risk of mortality for female breast cancer patients and improve quality of life, reduce weight, and alter circulating biomarker levels. We conducted a pilot trial to determine the ... ...

Abstract	Background: Studies have shown that physical activity can reduce the risk of mortality for female breast cancer patients and improve quality of life, reduce weight, and alter circulating biomarker levels. We conducted a pilot trial to determine the feasibility of increasing physical activity through a cultural dance intervention to achieve similar benefits. Methods: Conducted a pilot trial implementing a cultural dance intervention to increase and sustain physical activity for breast cancer survivors, which consisted of a six-month group-based intervention of Hula Dance. Anthropometric measures, fasting blood draws, and self-reported questionnaires to assess physical activity, mood, and quality of life, were completed at baseline, at the end of the 6-month intervention (time point month-6), and at two additional post-intervention time points (month-12 and month-24) to assess sustainability. Results: A total of 11 women with a median age of 63 years were enrolled in the intervention trial. Eight of the 11 (73%) completed the trial to month-12 and demonstrated an overall significant increase in weekly moderate exercise. There were no significant changes in intra-individual body mass index (BMI). However, there was a sustained post-intervention reduction in waist circumference and significant changes in circulating biomarker levels. For the self-reported measures, there was a significant increase in vigor/activity (p < 0.001; Profile of Mood States-Short Form). Conclusion: Our intervention pilot trial demonstrated that a cultural dance program could achieve a sustainable increase in physical activity for breast cancer survivors, with potential to improve quality of life, increase vigor, and decrease levels of circulating cytokines associated with obesity and inflammation.
MeSH term(s)	Adult ; Anthropometry ; Biomarkers/blood ; Breast Neoplasms/therapy ; Cancer Survivors ; Dance Therapy/methods ; Exercise ; Female ; Humans ; Pilot Projects ; Quality of Life ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-09-21
Publishing country	Scotland
Document type	Clinical Trial ; Journal Article
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2019.102197
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Zs.A 3726: Show issues

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ab Jg. 2022: Lesesaal (EG)

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