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  1. Article ; Online: Is neutrophilic inflammation treatable in COVID-19?

    Conrad, Catharina / Looney, Mark R

    The Lancet. Respiratory medicine

    2022  Volume 10, Issue 12, Page(s) 1100–1101

    MeSH term(s) Humans ; COVID-19/complications ; Inflammation ; Neutrophils
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(22)00293-4
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    Zs.A 7041: Show issues Location:
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  2. Article ; Online: The incomparable platelet: holy alveoli!

    Looney, Mark R

    Blood

    2018  Volume 132, Issue 11, Page(s) 1088–1089

    MeSH term(s) Animals ; Blood Platelets ; Lectins, C-Type ; Mice
    Chemical Substances CLEC-2 protein, mouse ; Lectins, C-Type
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-06-856351
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  3. Article ; Online: Chewing the fat on TRALI.

    Cleary, Simon J / Looney, Mark R

    Blood

    2021  Volume 137, Issue 5, Page(s) 586–587

    MeSH term(s) Acute Lung Injury ; Extracellular Vesicles ; Humans ; Sphingolipids ; Transfusion Reaction ; Transfusion-Related Acute Lung Injury
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020010034
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  4. Article ; Online: Selectin' for NETs.

    Looney, Mark R

    Blood

    2015  Volume 126, Issue 2, Page(s) 129–130

    MeSH term(s) Animals ; Extracellular Traps/genetics ; Female ; Male ; P-Selectin/physiology ; Thrombosis/genetics ; Vasculitis/genetics
    Chemical Substances P-Selectin
    Language English
    Publishing date 2015-07-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-05-646729
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  5. Article ; Online: Platelet Biogenesis in the Lung Circulation.

    Lefrançais, Emma / Looney, Mark R

    Physiology (Bethesda, Md.)

    2019  Volume 34, Issue 6, Page(s) 392–401

    Abstract: Megakaryocytes are normal cellular components of the blood returning to the heart and entering the lungs, and historical data has pointed to a role of the lungs in platelet production. Recent studies using intravital microscopy have demonstrated that ... ...

    Abstract Megakaryocytes are normal cellular components of the blood returning to the heart and entering the lungs, and historical data has pointed to a role of the lungs in platelet production. Recent studies using intravital microscopy have demonstrated that platelet release occurs in the lung from bone marrow megakaryocytes that embolize into the lung circulation.
    MeSH term(s) Animals ; Blood Platelets/physiology ; Bone Marrow/physiology ; Humans ; Lung/physiology ; Megakaryocytes/physiology
    Language English
    Publishing date 2019-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00017.2019
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    Zs.A 2164: Show issues Location:
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  6. Article ; Online: Live imaging of the pulmonary immune environment.

    Looney, Mark R / Headley, Mark B

    Cellular immunology

    2018  Volume 350, Page(s) 103862

    Abstract: The lung represents a unique immune environment. The primary function of the lung is to enable gas exchange by facilitating the transfer of oxygen into and carbon dioxide out of the blood. However, as a direct byproduct of this process the lung is also ... ...

    Abstract The lung represents a unique immune environment. The primary function of the lung is to enable gas exchange by facilitating the transfer of oxygen into and carbon dioxide out of the blood. However, as a direct byproduct of this process the lung is also constantly exposed to particles, allergens, and pathogens alongside air itself. Due to this, the pulmonary immune system exists in a fine balance between quiescence and inflammation, deviations from which can lead to a failure in respiratory function. A rich history exists attempting to define the critical features of lung immunity, and most recently advances in intravital microscopy have enabled the visualization of intercellular immune dynamics in both steady-state and a variety of disease conditions. In this review, we will summarize a variety of approaches to intravital lung imaging as well as how its application has advanced our understanding of normal lung function as well as disease states such as pulmonary metastasis, asthma, and lung injury.
    MeSH term(s) Allergens/immunology ; Asthma/immunology ; Humans ; Immune System/immunology ; Inflammation/pathology ; Intravital Microscopy/methods ; Lung/diagnostic imaging ; Lung/immunology ; Microscopy, Fluorescence, Multiphoton/methods
    Chemical Substances Allergens
    Language English
    Publishing date 2018-10-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2018.09.007
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    Zs.A 417: Show issues Location:
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  7. Article ; Online: GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

    De Giovanni, Marco / Tam, Hanson / Valet, Colin / Xu, Ying / Looney, Mark R / Cyster, Jason G

    Cell

    2022  Volume 185, Issue 6, Page(s) 1103–1104

    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.03.003
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    Zs.A 1167: Show issues Location:
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  8. Article ; Online: GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

    De Giovanni, Marco / Tam, Hanson / Valet, Colin / Xu, Ying / Looney, Mark R / Cyster, Jason G

    Cell

    2022  Volume 185, Issue 5, Page(s) 815–830.e19

    Abstract: Rapid neutrophil recruitment to sites of inflammation is crucial for innate immune responses. Here, we reveal that the G-protein-coupled receptor GPR35 is upregulated in activated neutrophils, and it promotes their migration. GPR35-deficient neutrophils ... ...

    Abstract Rapid neutrophil recruitment to sites of inflammation is crucial for innate immune responses. Here, we reveal that the G-protein-coupled receptor GPR35 is upregulated in activated neutrophils, and it promotes their migration. GPR35-deficient neutrophils are less recruited from blood vessels into inflamed tissue, and the mice are less efficient in clearing peritoneal bacteria. Using a bioassay, we find that serum and activated platelet supernatant stimulate GPR35, and we identify the platelet-derived serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) as a GPR35 ligand. GPR35 function in neutrophil recruitment is strongly dependent on platelets, with the receptor promoting transmigration across platelet-coated endothelium. Mast cells also attract GPR35
    MeSH term(s) Animals ; Hydroxyindoleacetic Acid/metabolism ; Inflammation/metabolism ; Ligands ; Mice ; Neutrophil Infiltration ; Neutrophils/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Serotonin/metabolism
    Chemical Substances GPR35 protein, mouse ; Ligands ; Receptors, G-Protein-Coupled ; Serotonin (333DO1RDJY) ; Hydroxyindoleacetic Acid (54-16-0)
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.01.010
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    Zs.A 1167: Show issues Location:
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  9. Article ; Online: Optimizing anesthesia and delivery approaches for dosing into lungs of mice.

    Seo, Yurim / Qiu, Longhui / Magnen, Mélia / Conrad, Catharina / Moussavi-Harami, S Farshid / Looney, Mark R / Cleary, Simon J

    American journal of physiology. Lung cellular and molecular physiology

    2023  Volume 325, Issue 2, Page(s) L262–L269

    Abstract: Microbes, toxins, therapeutics, and cells are often instilled into lungs of mice to model diseases and test experimental interventions. Consistent pulmonary delivery is critical for experimental power and reproducibility, but we observed variation in ... ...

    Abstract Microbes, toxins, therapeutics, and cells are often instilled into lungs of mice to model diseases and test experimental interventions. Consistent pulmonary delivery is critical for experimental power and reproducibility, but we observed variation in outcomes between handlers using different anesthetic approaches for intranasal dosing in mice. We therefore used a radiotracer to quantify lung delivery after intranasal dosing under inhalational (isoflurane) versus injectable (ketamine/xylazine) anesthesia in C57BL/6 mice. We found that ketamine/xylazine anesthesia resulted in delivery of a greater proportion (52 ± 9%) of an intranasal dose to lungs relative to isoflurane anesthesia (30 ± 15%). This difference in pulmonary dose delivery altered key outcomes in models of viral and bacterial pneumonia, with mice anesthetized with ketamine/xylazine for intranasal infection with influenza A virus or
    MeSH term(s) Animals ; Mice ; Anesthesia/methods ; Anesthetics ; Isoflurane ; Ketamine ; Lung ; Mice, Inbred C57BL ; Reproducibility of Results ; Xylazine
    Chemical Substances Anesthetics ; Isoflurane (CYS9AKD70P) ; Ketamine (690G0D6V8H) ; Xylazine (2KFG9TP5V8)
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00046.2023
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  10. Article: Optimizing anesthesia and delivery approaches for dosing into lungs of mice.

    Seo, Yurim / Qiu, Longhui / Magnen, Mélia / Conrad, Catharina / Moussavi-Harami, S Farshid / Looney, Mark R / Cleary, Simon J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Microbes, toxins, therapeutics and cells are often instilled into lungs of mice to model diseases and test experimental interventions. Consistent pulmonary delivery is critical for experimental power and reproducibility, but we observed variation in ... ...

    Abstract Microbes, toxins, therapeutics and cells are often instilled into lungs of mice to model diseases and test experimental interventions. Consistent pulmonary delivery is critical for experimental power and reproducibility, but we observed variation in outcomes between handlers using different anesthetic approaches for intranasal dosing into mice. We therefore used a radiotracer to quantify lung delivery after intranasal dosing under inhalational (isoflurane) versus injectable (ketamine/xylazine) anesthesia in C57BL/6 mice. We found that ketamine/xylazine anesthesia resulted in delivery of a greater proportion (52±9%) of an intranasal dose to lungs relative to isoflurane anesthesia (30±15%). This difference in pulmonary dose delivery altered key outcomes in models of viral and bacterial pneumonia, with mice anesthetized with ketamine/xylazine for intranasal infection with influenza A virus or Pseudomonas aeruginosa developing more robust lung inflammation responses relative to control animals randomized to isoflurane anesthesia. Pulmonary dosing efficiency through oropharyngeal aspiration was not affected by anesthetic method and resulted in delivery of 63±8% of dose to lungs, and a non-surgical intratracheal dosing approach further increased lung delivery to 92±6% of dose. Use of either of these more precise dosing methods yielded greater experimental power in the bacterial pneumonia model relative to intranasal infection. Both anesthetic approach and dosing route can impact pulmonary dosing efficiency. These factors affect experimental power and so should be considered when planning and reporting studies involving delivery of fluids to lungs of mice.
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.01.526706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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