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  1. Article ; Online: Balancing B cell responses to the allograft: implications for vaccination.

    Crane, Clarkson / Loop, Lauren / Anterasian, Christine / Geng, Bob / Ingulli, Elizabeth

    Frontiers in immunology

    2022  Volume 13, Page(s) 948379

    Abstract: Balancing enough immunosuppression to prevent allograft rejection and yet maintaining an intact immune system to respond to vaccinations, eliminate invading pathogens or cancer cells is an ongoing challenge to transplant physicians. Antibody mediated ... ...

    Abstract Balancing enough immunosuppression to prevent allograft rejection and yet maintaining an intact immune system to respond to vaccinations, eliminate invading pathogens or cancer cells is an ongoing challenge to transplant physicians. Antibody mediated allograft rejection remains problematic in kidney transplantation and is the most common cause of graft loss despite current immunosuppressive therapies. The goal of immunosuppressive therapies is to prevent graft rejection; however, they prevent optimal vaccine responses as well. At the center of acute and chronic antibody mediated rejection and vaccine responses is the B lymphocyte. This review will highlight the role of B cells in alloimmune responses including the dependency on T cells for antibody production. We will discuss the need to improve vaccination rates in transplant recipients and present data on B cell populations and SARS-CoV-2 vaccine response rates in pediatric kidney transplant recipients.
    MeSH term(s) Allografts ; Antibodies ; B-Lymphocytes ; COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Humans ; SARS-CoV-2 ; T-Lymphocytes ; Vaccination
    Chemical Substances Antibodies ; COVID-19 Vaccines
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.948379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multidisciplinary atopic dermatitis program: A novel approach to managing difficult-to-control atopic dermatitis patients.

    Tracy, Alexis / Loop, Lauren / Bhatti, Safiyyah / Anterasian, Christine / Kellogg, Caitlyn / Smiley, Kathryn / Wu, Alyssa / Geng, Bob / Eichenfield, Lawrence

    Pediatric dermatology

    2024  Volume 41, Issue 2, Page(s) 210–214

    Abstract: Background/objectives: Disease improvement for difficult-to-control pediatric atopic dermatitis may be more challenging to achieve when directed by single specialties due to disjointed and conflicting dialogue with patients.: Methods: The ... ...

    Abstract Background/objectives: Disease improvement for difficult-to-control pediatric atopic dermatitis may be more challenging to achieve when directed by single specialties due to disjointed and conflicting dialogue with patients.
    Methods: The Multidisciplinary Atopic Dermatitis Program (MADP) was developed through collaborations with the Rady Children's Hospital and UC San Diego Health Divisions of Dermatology, Allergy & Immunology and Clinical Pharmacy, to create team-based evaluation and management of children and adolescents with atopic dermatitis (AD). The MADP allows concurrent, comprehensive evaluations by multiple specialists to develop treatment plans. The program includes extensive patient education to support shared decision making, incorporating patient and family's perspectives along with those of clinical experts into their care. Objective severity measures and patient reported outcome data were collected, along with assessment of patient and family satisfaction with the MADP.
    Results: Data showed significant improvement in AD severity as assessed by providers, patients and families by the first follow-up visit. BSA mean percentage decreased by up to 56% by the 7th visit, and pruritus (NRS), CLDQI and POEM mean scores decreased by more than 4 points, 12 points, and over 11 points, respectively. After management was initiated in the MADP, 72.73% of patients achieved an EASI 50 and 47.73% achieved an EASI 75 from a baseline mean of 21.7. Patients who continued in clinic beyond the second visit showed further clinically significant decreases in disease measures.
    Conclusions: The multidisciplinary approach shows success in the treatment of difficult-to-control AD patients with improvements in clinician and patient reported outcome measures.
    MeSH term(s) Adolescent ; Humans ; Child ; Dermatitis, Atopic/drug therapy ; Severity of Illness Index ; Pruritus ; Patient Reported Outcome Measures ; Hospitals, Pediatric ; Treatment Outcome ; Quality of Life
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15533
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Atopic dermatitisReview of comorbidities and therapeutics.

    Appiah, Margaret M / Haft, Michael A / Kleinman, Elana / Laborada, Jennifer / Lee, Stephanie / Loop, Lauren / Geng, Bob / Eichenfield, Lawrence F

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Volume 129, Issue 2, Page(s) 142–149

    Abstract: Atopic dermatitis (AD) is a very common skin disease associated with substantial burdens on patient health and quality of life. Knowledge regarding the pathogenesis of AD has expanded within recent years, leading to novel and efficacious therapeutic ... ...

    Abstract Atopic dermatitis (AD) is a very common skin disease associated with substantial burdens on patient health and quality of life. Knowledge regarding the pathogenesis of AD has expanded within recent years, leading to novel and efficacious therapeutic agents. Similarly, our knowledge of the impact of AD on patient's mental and physical health has also expanded. This review summarizes updates on the evolution, comorbidities, and therapeutic options of AD. AD is associated with increased cardiovascular risk, allergic diseases, and adverse mental health outcomes. Topical and systemic therapeutics have drastically altered the landscape of AD therapy in recent years.
    MeSH term(s) Comorbidity ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/epidemiology ; Humans ; Quality of Life
    Language English
    Publishing date 2022-05-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.05.015
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  4. Article ; Online: Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-

    Eagon, Scott / Hammill, Jared T / Sigal, Martina / Ahn, Kevin J / Tryhorn, Julia E / Koch, Grant / Belanger, Briana / Chaplan, Cory A / Loop, Lauren / Kashtanova, Anna S / Yniguez, Kenya / Lazaro, Horacio / Wilkinson, Steven P / Rice, Amy L / Falade, Mofolusho O / Takahashi, Rei / Kim, Katie / Cheung, Ashley / DiBernardo, Celine /
    Kimball, Joshua J / Winzeler, Elizabeth A / Eribez, Korina / Mittal, Nimisha / Gamo, Francisco-Javier / Crespo, Benigno / Churchyard, Alisje / García-Barbazán, Irene / Baum, Jake / Anderson, Marc O / Laleu, Benoît / Guy, R Kiplin

    Journal of medicinal chemistry

    2020  Volume 63, Issue 20, Page(s) 11902–11919

    Abstract: Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4- ...

    Abstract Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-
    MeSH term(s) Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Cell Line ; Dose-Response Relationship, Drug ; Hep G2 Cells ; Humans ; Models, Molecular ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium falciparum/drug effects ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyridines/pharmacology ; Structure-Activity Relationship
    Chemical Substances Antimalarials ; Pyrazoles ; Pyridines ; pyrazolo(3,4-b)pyridine
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c01152
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