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Book ; Online: Serious Games and AI

Pérez, Jaime / Castro, Mario / López, Gregorio

Challenges and Opportunities for Computational Social Science

2023

Abstract: The video game industry plays an essential role in the entertainment sphere of our society. However, from Monopoly to Flight Simulators, serious games have also been appealing tools for learning a new language, conveying values, or training skills. ... ...

Abstract	The video game industry plays an essential role in the entertainment sphere of our society. However, from Monopoly to Flight Simulators, serious games have also been appealing tools for learning a new language, conveying values, or training skills. Furthermore, the resurgence of Artificial Intelligence (AI) and data science in the last decade has created a unique opportunity since the amount of data collected through a game is immense, as is the amount of data needed to feed such AI algorithms. This paper aims to identify relevant research lines using Serious Games as a novel research tool, especially in Computational Social Sciences. To contextualize, we also conduct a (non-systematic) literature review of this field. We conclude that the synergy between games and data can foster the use of AI for good and open up new strategies to empower humanity and support social research with novel computational tools. We also discuss the challenges and new opportunities that arise from aspiring to such lofty goals.
Keywords	Computer Science - Human-Computer Interaction
Publishing date	2023-02-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Generation of Probabilistic Synthetic Data for Serious Games

Pérez, Jaime / Castro, Mario / Awad, Edmond / López, Gregorio

A Case Study on Cyberbullying

2023

Abstract: Synthetic data generation has been a growing area of research in recent years. However, its potential applications in serious games have not been thoroughly explored. Advances in this field could anticipate data modelling and analysis, as well as speed ... ...

Abstract	Synthetic data generation has been a growing area of research in recent years. However, its potential applications in serious games have not been thoroughly explored. Advances in this field could anticipate data modelling and analysis, as well as speed up the development process. To try to fill this gap in the literature, we propose a simulator architecture for generating probabilistic synthetic data for serious games based on interactive narratives. This architecture is designed to be generic and modular so that it can be used by other researchers on similar problems. To simulate the interaction of synthetic players with questions, we use a cognitive testing model based on the Item Response Theory framework. We also show how probabilistic graphical models (in particular Bayesian networks) can be used to introduce expert knowledge and external data into the simulation. Finally, we apply the proposed architecture and methods in a use case of a serious game focused on cyberbullying. We perform Bayesian inference experiments using a hierarchical model to demonstrate the identifiability and robustness of the generated data.
Keywords	Computer Science - Computers and Society
Subject code	330
Publishing date	2023-06-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Changes in biomarkers of redox status in serum and saliva of dogs with hypothyroidism.

Arostegui, Luis G González / Prieto, Alberto Muñoz / Marín, Luis Pardo / López, Gregorio García / Tvarijonaviciute, Asta / Madrigal, Jose Joaquín Cerón / Rubio, Camila Peres

BMC veterinary research

2023 Volume 19, Issue 1, Page(s) 33

Abstract: Background: Hypothyroidism is the most common endocrine disorder diagnosed in dogs, leading to deleterious effects on a dog's life quality. This study aims to evaluate changes in the redox status in canine hypothyroidism. For this purpose, a ... ...

Abstract	Background: Hypothyroidism is the most common endocrine disorder diagnosed in dogs, leading to deleterious effects on a dog's life quality. This study aims to evaluate changes in the redox status in canine hypothyroidism. For this purpose, a comprehensive panel of antioxidants and oxidants biomarkers were measured in serum and saliva of 23 dogs with hypothyroidism, 21 dogs with non-thyroidal illness, and 16 healthy dogs. Among the antioxidants, cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), thiol, paraoxonase type 1 (PON-1) and glutathione peroxidase (GPx) were determined in serum and CUPRAC, ferric reducing ability of saliva (FRAS) and TEAC in saliva. The oxidant biomarkers included were total oxidant status (TOS), peroxide-activity (POX-Act), reactive oxygen-derived compounds (d-ROMs), advanced oxidation protein products (AOPP), and thiobarbituric acid reactive substances (TBARS) in serum and AOPP and TBARS in saliva. Results: Results showed a significantly higher TEAC, PON-1, GPx, TOS, POX-Act, and d-ROMs, and a significantly lower AOPP in serum of dogs with hypothyroidism. Meanwhile, significantly lower FRAS and AOPP were observed in saliva of dogs with hypothyroidism. Once salivary concentrations were corrected based on their total protein concentrations, the only analyte showing significant changes was TBARS which was significantly higher in dogs with hypothyroidism. Conclusions: Our results show that dogs with hypothyroidism present alterations in the redox status in both serum and saliva. This study should be considered a preliminary study and further research addressing these changes should be made using larger populations.
MeSH term(s)	Dogs ; Animals ; Antioxidants/metabolism ; Saliva/metabolism ; Advanced Oxidation Protein Products ; Proto-Oncogene Proteins c-fos/metabolism ; Thiobarbituric Acid Reactive Substances ; Oxidation-Reduction ; Biomarkers ; Oxidants ; Peroxides ; Hypothyroidism/veterinary ; Aryldialkylphosphatase ; Oxidative Stress ; Dog Diseases
Chemical Substances	Antioxidants ; Advanced Oxidation Protein Products ; Proto-Oncogene Proteins c-fos ; Thiobarbituric Acid Reactive Substances ; Biomarkers ; Oxidants ; Peroxides ; Aryldialkylphosphatase (EC 3.1.8.1)
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2191675-5
ISSN	1746-6148 ; 1746-6148
ISSN (online)	1746-6148
ISSN	1746-6148
DOI	10.1186/s12917-023-03586-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of gynecological cancers on health-related quality of life: historical context, measurement instruments, and current knowledge.

Gil-Ibanez, Blanca / Davies-Oliveira, Jennifer / Lopez, Gregorio / Díaz-Feijoo, Berta / Tejerizo-Garcia, Alvaro / Sehouli, Jalid

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023 Volume 33, Issue 11, Page(s) 1800–1806

Abstract: Gynecologic cancers, comprising 14.4% of newly diagnosed cancer cases in women globally, are substantial causes of both mortality and morbidity, with a profound impact on the quality of life (QoL) of survivors. Over the past few decades, advancements in ... ...

Abstract	Gynecologic cancers, comprising 14.4% of newly diagnosed cancer cases in women globally, are substantial causes of both mortality and morbidity, with a profound impact on the quality of life (QoL) of survivors. Over the past few decades, advancements in interdisciplinary and interprofessional care have contributed to an increase in the average life expectancy of gynecological cancer patients. However, the disease and its treatments have a profound impact on patients, leading to physical changes and psychological consequences, including psychosocial and psychosexual effects, which negatively affect their QoL.The primary objective of management strategies is to minimize harm while improving survival rates and enhancing QoL during the survivorship stage. QoL measures play a crucial role in enhancing our comprehension of how cancer and its treatments affect individuals. Consequently, various measurement instruments, such as the EORTC QLQ 30, PROMIS-29, FACT-G, and QOL-CS, have been developed to assess health-related quality of life (HRQoL). Pre- and post-treatment HRQoL measurements have been shown to be predictive factors for post-operative complications and prognostic factors for overall survival and progression-free survival in gynecological oncology patients. Patient-reported outcomes related to HRQoL are essential tools for measuring patient outcomes and enabling patient-centered clinical decision-making.This article focuses on HRQoL, providing a historical context, summarizing measurement instruments, and discussing the current understanding of the impact of gynecological cancers on HRQoL.
MeSH term(s)	Humans ; Female ; Quality of Life/psychology ; Genital Neoplasms, Female/psychology ; Survivors ; Progression-Free Survival ; Survival Rate
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2023-004804
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Article ; Online: Changes in biomarkers of redox status in serum and saliva of dogs with hypothyroidism

Arostegui, Luis G. González / Prieto, Alberto Muñoz / Marín, Luis Pardo / García López, Gregorio / Tvarijonaviciute, Asta / Madrigal, Jose Joaquín Cerón / Rubio, Camila Peres

BMC Vet Res. 2023 Dec., v. 19, no. 1 p.33-33

2023

Abstract: BACKGROUND: Hypothyroidism is the most common endocrine disorder diagnosed in dogs, leading to deleterious effects on a dog’s life quality. This study aims to evaluate changes in the redox status in canine hypothyroidism. For this purpose, a ... ...

Abstract	BACKGROUND: Hypothyroidism is the most common endocrine disorder diagnosed in dogs, leading to deleterious effects on a dog’s life quality. This study aims to evaluate changes in the redox status in canine hypothyroidism. For this purpose, a comprehensive panel of antioxidants and oxidants biomarkers were measured in serum and saliva of 23 dogs with hypothyroidism, 21 dogs with non-thyroidal illness, and 16 healthy dogs. Among the antioxidants, cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), thiol, paraoxonase type 1 (PON-1) and glutathione peroxidase (GPx) were determined in serum and CUPRAC, ferric reducing ability of saliva (FRAS) and TEAC in saliva. The oxidant biomarkers included were total oxidant status (TOS), peroxide-activity (POX-Act), reactive oxygen-derived compounds (d-ROMs), advanced oxidation protein products (AOPP), and thiobarbituric acid reactive substances (TBARS) in serum and AOPP and TBARS in saliva. RESULTS: Results showed a significantly higher TEAC, PON-1, GPx, TOS, POX-Act, and d-ROMs, and a significantly lower AOPP in serum of dogs with hypothyroidism. Meanwhile, significantly lower FRAS and AOPP were observed in saliva of dogs with hypothyroidism. Once salivary concentrations were corrected based on their total protein concentrations, the only analyte showing significant changes was TBARS which was significantly higher in dogs with hypothyroidism. CONCLUSIONS: Our results show that dogs with hypothyroidism present alterations in the redox status in both serum and saliva. This study should be considered a preliminary study and further research addressing these changes should be made using larger populations.
Keywords	antioxidant activity ; aryldialkylphosphatase ; biomarkers ; blood serum ; dogs ; glutathione peroxidase ; hypothyroidism ; oxidants ; oxidation ; protein content ; quality of life ; saliva ; thiols
Language	English
Dates of publication	2023-12
Size	p. 33.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2191675-5
ISSN	1746-6148
ISSN	1746-6148
DOI	10.1186/s12917-023-03586-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Response to: Medical journals and editorial quality control by Erviti et al.

Rodil Fraile, Raquel / Malafarina, Vincenzo / López, Gregorio Tiberio

ESC heart failure

2019 Volume 6, Issue 5, Page(s) 1097–1098

MeSH term(s)	Aminobutyrates ; Drug Combinations ; Heart Failure ; Humans ; Multimorbidity ; Periodicals as Topic ; Quality Control ; Tetrazoles
Chemical Substances	Aminobutyrates ; Drug Combinations ; Tetrazoles ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2019-08-17
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.12492
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Article ; Online: IoT Platform for Energy Sustainability in University Campuses.

Moura, Pedro / Moreno, José Ignacio / López López, Gregorio / Alvarez-Campana, Manuel

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 2

Abstract: University campuses are normally constituted of large buildings responsible for high energy demand, and are also important as demonstration sites for new technologies and systems. This paper presents the results of achieving energy sustainability in a ... ...

Abstract	University campuses are normally constituted of large buildings responsible for high energy demand, and are also important as demonstration sites for new technologies and systems. This paper presents the results of achieving energy sustainability in a testbed composed of a set of four buildings that constitute the Telecommunications Engineering School of the Universidad Politécnica de Madrid. In the paper, after characterizing the consumption of university buildings for a complete year, different options to achieve more sustainable use of energy are presented, considering the integration of renewable generation sources, namely photovoltaic generation, and monitoring and controlling electricity demand. To ensure the implementation of the desired monitoring and control, an internet of things (IoT) platform based on wireless sensor network (WSN) infrastructure was designed and installed. Such a platform supports a smart system to control the heating, ventilation, and air conditioning (HVAC) and lighting systems in buildings. Furthermore, the paper presents the developed IoT-based platform, as well as the implemented services. As a result, the paper illustrates how providing old existing buildings with the appropriate technology can contribute to the objective of transforming such buildings into nearly zero-energy buildings (nZEB) at a low cost.
Language	English
Publishing date	2021-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21020357
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Article ; Online: Sacubitril-valsartan in heart failure and multimorbidity patients.

Rodil Fraile, Raquel / Malafarina, Vincenzo / Tiberio López, Gregorio

ESC heart failure

2018 Volume 5, Issue 5, Page(s) 956–959

Abstract: Aims: The poor control of symptoms in patients with advanced heart failure with reduced ejection function (HFrEF) can limit the functionality of patients. Sacubitril-valsartan, compared with enalapril, has been shown to reduce mortality and ... ...

Abstract	Aims: The poor control of symptoms in patients with advanced heart failure with reduced ejection function (HFrEF) can limit the functionality of patients. Sacubitril-valsartan, compared with enalapril, has been shown to reduce mortality and hospitalization, and nowadays, there is still little evidence about the improvement on functionality. The aim of our study is to analyse the improvement of the functional class and the 6 min walking test (6MWT) in patients with multiple pathologies and advanced heart failure. Methods and results: From September 2016 to March 2018, 65 multimorbidity patients with severe symptomatic HFrEF were initiated to receive sacubitril-valsartan. Mean age was 78.6 ± 7.4 years, and 68% were male. The Charlson co-morbidity index was 8 points. Seventy-four per cent had New York Heart Association (NYHA) Functional Class IV. After the treatment, patients were able to achieve 55.68 m or more on 6MWT, and 91% presented an improvement in the NYHA functional class. Conclusions: Sacubitril-valsartan relieves symptoms and improves functional class prognostic risk of patients with advanced HFrEF and co-morbidity.
MeSH term(s)	Aged ; Aminobutyrates/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Comorbidity ; Drug Combinations ; Female ; Heart Failure/drug therapy ; Heart Failure/epidemiology ; Humans ; Male ; Neprilysin ; Retrospective Studies ; Tetrazoles/therapeutic use ; Treatment Outcome
Chemical Substances	Aminobutyrates ; Angiotensin Receptor Antagonists ; Drug Combinations ; Tetrazoles ; Neprilysin (EC 3.4.24.11) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2018-07-24
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.12338
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Article ; Online: Security and Privacy Analysis of Youth-Oriented Connected Devices.

Solera-Cotanilla, Sonia / Vega-Barbas, Mario / Pérez, Jaime / López, Gregorio / Matanza, Javier / Álvarez-Campana, Manuel

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 11

Abstract: Under the Internet of Things paradigm, the emergence and use of a wide variety of connected devices and personalized telematics services have proliferated recently. As a result, along with the penetration of these devices in our daily lives, the users' ... ...

Abstract	Under the Internet of Things paradigm, the emergence and use of a wide variety of connected devices and personalized telematics services have proliferated recently. As a result, along with the penetration of these devices in our daily lives, the users' security and privacy have been compromised due to some weaknesses in connected devices and underlying applications. This article focuses on analyzing the security and privacy of such devices to promote safe Internet use, especially by young people. First, the connected devices most used by the target group are classified, and an exhaustive analysis of the vulnerabilities that concern the user is performed. As a result, a set of differentiated security and privacy issues existing in the devices is identified. The study reveals that many of these vulnerabilities are related to the fact that device manufacturers often prioritize functionalities and services, leaving security aspects in the background. These companies even exploit the data linked to the use of these devices for various purposes, ignoring users' privacy rights. This research aims to raise awareness of severe vulnerabilities in devices and to encourage users to use them correctly. Our results help other researchers address these issues with a more global perspective.
MeSH term(s)	Adolescent ; Computer Security ; Humans ; Privacy
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22113967
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Article ; Online: Step-by-step total pelviperitonectomy with modified posterior pelvic exenteration.

Tejerizo-Garcia, Alvaro / Olloqui, Alejandro / Lopez, Gregorio / Alvarez-Conejo, Carmen / Caso-Maestro, Oscar / Diez, Alvaro

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2020 Volume 30, Issue 4, Page(s) 558

MeSH term(s)	Cytoreduction Surgical Procedures/methods ; Female ; Humans ; Middle Aged ; Ovarian Neoplasms/surgery ; Ovariectomy/methods ; Pelvic Exenteration/methods ; Peritoneum/surgery
Language	English
Publishing date	2020-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2019-000984
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